Clinical trials: sponsored by Vanderbilt University Medical Center
Influenza, Influenza, Human
Kinetics of the Immune Response to Inactivated Influenza Vaccine in Healthy Adults
The purpose of this study is to evaluate the body's immune response at different time points to an FDA-approved seasonal influenza vaccine.
- Conditions
- Influenza, Influenza, Human, Vaccine Reaction, Influenza A
- Trial name
- KIRV (NCT03743688)
- Testing
- Influenza Vaccine Recipients
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Spinal Degenerative Disorder
Postoperative Management for Degenerative Spinal Conditions
The overall objective of this study is to conduct a two-group randomized control trial (RCT) to compare which of two treatments provided by telephone - a cognitive-behavioral based physical therapy (CBPT) program focusing on…
- Trial name
- NCT02184143
- Testing
- CBPT, Education
- Where
- 2 sites in United States
- Volunteers
- 248 people
- Sponsor
- Vanderbilt University Medical Center
Discharge Follow-up Phone Calls
Discharge Follow-up Phone Call Program
The goal of this project is to quantify the impact of post-hospital discharge follow-up phone calls on hospital readmission, ED visits, patient satisfaction, and mortality in a general medicine inpatient population.
- Trial name
- FUTR-30 (NCT03050918)
- Testing
- Follow-up Phone Call
- Where
- United States
- Volunteers
- 3,054 people
- Sponsor
- Vanderbilt University Medical Center
Mechanical Ventilation Complication
Endotracheal Tube Securement Study
To evaluate the safety and efficacy of endotracheal tube securement techniques, a pragmatic, randomized controlled trial will compare the effect of adhesive tape versus endotracheal tube fastener on complications including lip…
- Trial name
- ETTS (NCT03760510)
- Testing
- Tube Fastener, Adhesive Tape
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Vanderbilt University Medical Center
Healthy, Lean
Diagnosing Natriuretic Peptide Deficiency
In this pilot study, the investigators will determine the response of the natriuretic peptide (NP) hormone system after a dose of intravenous dexamethasone (a steroid medication).
- Trial name
- NCT03035929
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Atrial Fibrillation
Genetically Determined Response to Atenolol in Patients With Persistent Atrial Fibrillation
Atrial fibrillation (AF), the most common sustained heart rhythm disorder, is becoming increasingly prevalent in the Western world.
- Trial name
- NCT01719367
- Testing
- Atenolol
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Vanderbilt University Medical Center
Surgery, Opioid Use
Opioid Prescribing After Cesarean Delivery
The number of opioid overdose deaths in the United States has quadrupled in 15 years, a dramatic manifestation of the current opioid abuse epidemic.
- Trial name
- NCT03168425
- Testing
- Tailored prescription, Control
- Where
- United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Hypotension
Decision Support for Intraoperative Low Blood Pressure
The purpose of this study is to determine whether a decision support system can improve the adherence to thresholds for low blood pressure by anesthesia providers, which in turn prevents their patients from having organ injury.
- Trial name
- NCT02726620
- Testing
- Attending real-time decision support, In-room real-time decision support, Attending feedback emails
- Where
- United States
- Volunteers
- 22,435 people
- Sponsor
- Vanderbilt University Medical Center
Ischemia
AMP as a Better Delivery System of Adenosine
Adenosine and AMP are substances normally present in the body. Adenosine is also given for the treatment of some heart rhythm problems and may be used to reduce heart damage during heart attacks.
- Trial name
- NCT00179010
- Testing
- Adenosine, Adenosine Mono Phosphate (AMP)
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Education, Medical, Education, Medical, Graduate
Discussing Death and Dying: An End of Life Curriculum to Empower Residents
This study will evaluate how the educational intervention utilized affects pediatric resident comfort level with EOL discussions.
- Conditions
- Education, Medical, Education, Medical, Graduate, Care, Palliative, Medicine, Palliative
- Trial name
- NCT03186274
- Testing
- Facilitated Group Session, CELA Session
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Magnetic Resonance Imaging Contrast Agents
Gadolinium-Based-Contrast-Agents (GBCA) Enhancement During MR Urography
Rationale: Dotarem provides superior enhancement characteristics compared to other GBCA in fMRU Specific Aims: Compare enhancement characteristics of Dotarem to other GBCAs in the kidneys used in fMRU Primary Objectives: Review…
- Trial name
- NCT03910114
- Testing
- Magnevist, Dotarem, Gadovist
- Where
- 2 sites in United States
- Volunteers
- 500 people
- Sponsor
- Vanderbilt University Medical Center
Acute Kidney Injury, Renal Injury
Pediatric Acute Kidney Injury (AKI) Retrospective, Real-Time and Repository Research
This proposal will incorporate statistical models developed by the investigators to predict risk for acute kidney injury into our electronic medical record system, enabling an alert to notify providers of the risk status.
- Conditions
- Acute Kidney Injury, Renal Injury, Kidney Disease
- Trial name
- PAR4 (NCT02660931)
- Testing
- AKI Risk Notification
- Where
- United States
- Volunteers
- 12,108 people
- Sponsor
- Vanderbilt University Medical Center
Narcotic Addiction
Auricular Acupuncture to Facilitate Outpatient Opioid Weaning
This study is to compare two groups undergoing opioid weaning as ordered by their referring physicians. One group will undergo the standard opioid weaning process and the other group will have the addition of the NADA Protocol to…
- Trial name
- NCT02882048
- Testing
- NADA Protocol, Medication management
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Vanderbilt University Medical Center
Gastrointestinal Disorders, Functional
Web-based Management of Pediatric Functional Abdominal Pain
Functional abdominal pain (FAP), a pediatric pain condition without significant organic pathology, is a precursor to chronic pain and high healthcare utilization in young adulthood.
- Trial name
- NCT02327377
- Testing
- Online Cognitive Behavior Therapy, Online Education
- Where
- United States
- Volunteers
- 344 people
- Sponsor
- Vanderbilt University Medical Center
Sickle Cell Anemia (HbSS, or HbSβ-thalassemia0)
Phase 2 Study of Montelukast for the Treatment of Sickle Cell Anemia
In this feasibility trial, the investigators will compare participants treated with montelukast and hydroxyurea to those treated with placebo and hydroxyurea for a total of 8 weeks.
- Trial name
- NCT01960413
- Testing
- Montelukast added to Hydroxyurea
- Where
- 2 sites in United States
- Volunteers
- 46 people
- Sponsor
- Vanderbilt University Medical Center
Autism Spectrum Disorder, Parents
Mindfulness Training and Parent-coaching Interventions for Autism Spectrum Disorder
Caregivers of children with autism spectrum disorder (ASD) report higher levels of depression and distress than caregivers of typically developing children as well as children with other developmental disabilities.
- Conditions
- Autism Spectrum Disorder, Parents, Stress
- Trial name
- NCT03889821
- Testing
- Parent-implemented Early Start Denver Model, Mindfulness Based Stress Reduction
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Vanderbilt University Medical Center
Obesity
Racial Differences in Vagal Control of Glucose Homeostasis
The investigators will test the hypothesis that acute central acetylcholinesterase inhibition will restore PNS activity and reduce oxidation in AAW compared to whites.
- Trial name
- RDVCGH (NCT02365285)
- Testing
- Galantamine, Intralipid, Heparin
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Human Papillomavirus Positive Oropharyngeal Squamous Cell Carcinoma, Oropharynx Cancer
New Modalities for Detection of Oropharyngeal Cancer
Background: The incidence of human papilloma virus-driven oropharyngeal cancer (HPV-OPC), a type of head and neck cancer, is rapidly increasing within the US. Currently, there are no screening methods for early detection.
- Conditions
- Human Papillomavirus Positive Oropharyngeal Squamous Cell Carcinoma, Oropharynx Cancer, Base of Tongue Carcinoma, Tonsil Cancer
- Trial name
- NCT03226613
- Testing
- Transcervical Oropharyngeal Ultrasound, Oral Rinse Collection, Blood Draw
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Vanderbilt University Medical Center
Type 1 Diabetes Mellitus
Check It! Positive Psychology Intervention to Improve Adherence in Adolescents With T1D
Problems with diabetes management in adolescents with type 1 diabetes are common - occurring at rates as high as 93% - and have serious health consequences, including poor blood sugar control and risk for later complications.
- Trial name
- NCT02746627
- Testing
- Positive Affect, Education
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Vanderbilt University Medical Center
Congestive Heart Failure
Study for Breathing Interventions in Congestive Heart Failure
Slow breathing may reduce stress. Adults with congestive heart failure have higher stress than the general population. This study will examine if using slow breathing is feasible among adults with heart failure.
- Trial name
- NCT03449121
- Testing
- Slow breathing techniques
- Sponsor
- Vanderbilt University Medical Center