Clinical trials: sponsored by Vanderbilt University Medical Center
HIV-1-infection, Aging, Premature
Mental Ability Challenge Study in Adults With and Without HIV
It is estimated that by 2016, nearly 50% of HIV-positive individuals in the US will be aged 50 or older, and up to 60% of those will experience some degree of cognitive impairment as they age.
- Conditions
- HIV-1-infection, Aging, Premature, Cognitive Impairment, Memory Impairment
- Trial name
- NCT03244488
- Testing
- Scopolamine Injectable Product, Mecamylamine Pill
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Colorectal Surgery, Quality Improvement
Enhanced Recovery After Surgery in Colorectal Surgery: A Large-Scale Quality Improvement Project
Multimodal perioperative care pathways have evolved into enhanced recovery after surgery (ERAS). ERAS pathways improve the quality of patient care, reduce morbidity, and shorten length of stay.
- Conditions
- Colorectal Surgery, Quality Improvement, Perioperative Care, ERAS
- Trial name
- ERAS (NCT03189550)
- Testing
- ERAS perioperative care, Standard perioperative care, Noninvasive hemodynamic monitoring
- Where
- United States
- Volunteers
- 664 people
- Sponsor
- Vanderbilt University Medical Center
Cesarean Delivery, Pain Management
Gabapentin in the Post-cesarean Pain Management of Buprenorphine Patient
The purpose of this study is to determine whether a perioperative course of gabapentin in parturients on buprenorphine maintenance would improve analgesia after elective cesarean delivery (CD).
- Trial name
- NCT03335436
- Testing
- Gabapentin
- Sponsor
- Vanderbilt University Medical Center
Spinal Fusion, Cervical Spine Degenerative Disease
Early Postoperative Home Exercise Program After Cervical Spine Surgery
The overall objective of this two-group randomized controlled trial is to gather preliminary evidence on the efficacy and safety of early postoperative exercise for improving disability, pain, and general physical health in…
- Trial name
- NCT02720172
- Testing
- Early Home Exercise Program, Usual Care
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Vanderbilt University Medical Center
Colonoscopy, Oxygenation
Comparison of Oxygenation and Ventilation With a Novel Nasal Mask Versus Standard of Care During Colonoscopy
Nasal continuous positive airway pressure (nCPAP) has been shown to effectively relieve upper airway obstruction in patients with OSA as it creates a pneumatic stent in the hypopharynx that reduces obstruction and allows for…
- Conditions
- Colonoscopy, Oxygenation, Ventilation
- Trial name
- NCT03139448
- Testing
- Oxygen via nasal cannula, Oxygen via SuperNO2VA nasal mask
- Where
- United States
- Volunteers
- 174 people
- Sponsor
- Vanderbilt University Medical Center
Metabolic Syndrome X
Diurnal Variation of Plasminogen Activator Inhibitor-1
To determine if nighttime administration of an aldosterone antagonist would effectively lower peak plasma Plasminogen Activator Inhibitor-1 (PAI-1) levels more effectively than morning administration.
- Trial name
- NCT00515021
- Testing
- Eplerenone (Morning), Eplerenone (Night-time)
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Vanderbilt University Medical Center
Tobacco Use in Childbirth, Smoking Cessation
Fish Oil to Reduce Tobacco Use iN Expectant Mothers Study
The purpose of this feasibility study is to obtain pilot data in preparation for an upcoming R01 submission. The goals of that submission will be to conduct a clinical trial of n-3 LCPUFAs for smoking cessation in pregnant women.
- Conditions
- Tobacco Use in Childbirth, Smoking Cessation, Pregnancy Related
- Trial name
- FORTUNE (NCT03077724)
- Testing
- Fish oil
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Postoperative Nausea and Vomiting, Pain, Postoperative
Guanfacine for PONV and Pain After Sinus Surgery
Postoperative nausea and vomiting (PONV) and pain are the most common causes of Post Anesthesia Care Unit (PACU) discharge delay, with untreated PONV occurring in 20-30% of post-surgical patients.
- Trial name
- NCT02882854
- Testing
- Guanfacine
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Vanderbilt University Medical Center
Healthy
The Effect of Acute Lysine Administration on α-aminoadipic Acid (Sub-study)
This sub-study aims to assess the effect and breakdown of lysine administration, specifically examining whether it leads to increased plasma 2-AAA in healthy humans.
- Trial name
- NCT03063476
- Testing
- C-13 labeled Lysine, Normal saline
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Metabolic Diseases, Diabetes Mellitus
Aldosterone and the Metabolic Syndrome
The purpose of this study is to determine the effects of mineralocorticoid receptor (MR) antagonism and renin inhibition on glucose metabolism in humans.
- Conditions
- Metabolic Diseases, Diabetes Mellitus, Endocrine System Diseases, Glucose Metabolism Disorders
- Trial name
- NCT01103245
- Testing
- Hydrochlorothiazide (HCTZ), Aliskiren 150 mg (ALI 150), Spironolactone (SPL 25)
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Vanderbilt University Medical Center
Spasticity, Muscle, Muscular Diseases
Validity and Inter-Rater Reliability of a Novel Bedside Referral Tool for Spasticity
The purpose of this study is to improve spasticity diagnosis through development of a simple physical examination guide for primary care providers to identify patients who would benefit from being referred to a movement disorders…
- Conditions
- Spasticity, Muscle, Muscular Diseases, Musculoskeletal Disease, Muscle Hypertonia
- Trial name
- NCT03209960
- Testing
- Bedside Referral Tool, Neurological Examination
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Spasticity, Muscle, Muscular Diseases
Using Telemedicine to Improve Spasticity Diagnosis Rates
The purpose of this study is to test the reliability of using telemedicine so a neurologist can remotely identify residents of a long-term care facility who should be referred to a neurologist for an in-person spasticity…
- Conditions
- Spasticity, Muscle, Muscular Diseases, Musculoskeletal Disease, Muscle Hypertonia
- Trial name
- NCT03211390
- Testing
- Neurological Examination, Teleneurological Examination
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Spasticity, Muscle, Muscular Diseases
Prevalence of Comorbid Spasticity and Urinary Incontinence in Residents of a Long-Term Care Facility
The purpose of this study is to improve spasticity diagnosis through exploration of potential new diagnostic markers for spasticity that can assist in diagnosis and referral.
- Conditions
- Spasticity, Muscle, Muscular Diseases, Musculoskeletal Disease, Muscle Hypertonia
- Trial name
- NCT03250988
- Testing
- Neurological Examination
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Cervical Radiculopathy
Cervical Interlaminar Versus Transforaminal Epidural Steroid Injection
compare cervical interlaminar epidural injection of betamethasone (9mg) and cervical transforaminal epidural injection of dexamethasone (15 mg) for cervical radicular pain
- Trial name
- NCT03165825
- Testing
- Transforaminal Epidural Steroid Injection with Dexamethasone, Interlaminar Epidural Steroid Injection with Betamethasone
- Sponsor
- Vanderbilt University Medical Center
Major Depressive Disorder
Depressed Mood Improvement Through Nicotine Dosing (Depressed MIND Study)
Late-life depression is characterized by both affective (mood) symptoms and cognitive deficits. There is currently no intervention that may provide consistent benefits to both mood and cognitive performance.
- Trial name
- NCT02816138
- Testing
- Nicotine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Vanderbilt University Medical Center
Obesity, Bariatric Surgery Candidate
Examination of Cognitive Function in Obesity and Following Weight Loss
Bariatric surgery is the most effective, long-term treatment for morbid obesity, and consistent with previous findings, individuals who lose significant weight after surgery also have improved cognition or "brain function".
- Conditions
- Obesity, Bariatric Surgery Candidate, Weight Loss
- Trial name
- NCT02994186
- Testing
- Bariatric Surgery, Medical Weight Loss Program
- Sponsor
- Vanderbilt University Medical Center
Respiratory Failure, Respiratory Failure With Hypoxia
Preventing Hypoxemia With Manual Ventilation During Endotracheal Intubation (PreVent) Trial
Complications are common during endotracheal intubation of critically ill adults. Manual ventilation between induction and intubation ("bag-valve-mask" ventilation) has been proposed as a means of preventing hypoxemia, the most…
- Conditions
- Respiratory Failure, Respiratory Failure With Hypoxia, Endotracheal Intubation
- Trial name
- PreVent (NCT03026322)
- Testing
- Manual Ventilation, No Manual Ventilation
- Where
- 5 sites in United States
- Volunteers
- 401 people
- Sponsor
- Vanderbilt University Medical Center
Asthma, Medical Informatics
A Reminder System for Paper-Based Asthma Guidelines in the Pediatric Emergency Department
The primary idea is that the use of a computerized reminder system to help with the guideline implementation will increase utilization and adherence of guideline-driven care, leading to improved patient outcomes.
- Trial name
- NCT00699439
- Testing
- Paper-based asthma flow diagram
- Where
- United States
- Volunteers
- 1,102 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Asthma
A Computerized Asthma Management System in the Pediatric Emergency Department
The primary goal of this study is that the combination of a computerized asthma reminder system with implementation of an guideline will increase utilization and adherence of guideline-driven care, leading to improved patient…
- Trial name
- NCT01070147
- Testing
- Computerized Asthma Management System
- Where
- United States
- Volunteers
- 1,631 people
- Sponsor
- Vanderbilt University Medical Center
Mastectomy, Nerve Block
Effect of Pectoralis Block on Analgesia After Simple Mastectomy
The pectoralis block, including pecs I and II block, is a novel technique first described in 2011 as an alternative to paravertebral blockade for analgesia following breast surgery.
- Conditions
- Mastectomy, Nerve Block, Analgesia, Postoperative
- Trial name
- NCT03143530
- Testing
- Pectoralis block, Normal saline injection, Ropivacaine Injection
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center