Clinical trials: sponsored by Vanderbilt University Medical Center
High Blood Pressure
The Effects of Renin Inhibition on Fibrinolytic Balance and Endothelial Function
Aliskiren (also called TekturnaTM) is a new drug for high blood pressure. Aliskiren works by blocking the actions of a substance called renin. Renin is a natural substance in the body that raises blood pressure.
- Trial name
- NCT03115853
- Testing
- Aliskiren 150 mg, HCTZ, Aliskiren 300 mg
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Vanderbilt University Medical Center
Asthma
Noninvasive Positive Airway Pressure in the Pediatric Emergency Department for the Treatment of Acute Asthma Exacerbations
Previous investigations and anecdotal experience have shown safety and utility of Noninvasive Positive Pressure Ventilation/Bilevel Positive Airway Pressure (NIPPV/BiPAP) for the treatment of asthma in children.
- Trial name
- RCT BiPAP (NCT01497691)
- Testing
- NIPPV (PALMtop PTV), Volumetric CO2 (NM3), USCOM
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center
Heart Failure
Prospective Randomized Evaluation of an Ultra Conservative Approach to Implantable Defibrillator (ICD) Programming in Patients With a Left Ventricular Assist Device (LVAD).
We propose to study a strategy empirically applied for the past 6 months at a high volume LVAD center (Vanderbilt Heart and Vascular Institute).
- Trial name
- NCT01977703
- Testing
- Ultra Conservative ICD Programming, Traditional ICD Programming
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Vanderbilt University Medical Center
Cerebrovascular Disorders
Cost Effectiveness of the EndoPhys Pressure Sensing Access System vs. Radial A-line for Intra-operative Blood Pressure Monitoring
This study aims to compare the time difference between radial arterial line placement and use of the EndoPhys sheath, as well as, assess the cost effectiveness of the EnoPhys sheath vs.
- Trial name
- NCT03239847
- Testing
- EndoPhys Sheath and Radial Arterial Line, EndoPhys Sheath
- Volunteers
- 40 people
- Sponsor
- Vanderbilt University Medical Center
Colorectal Cancer, Hereditary Non-polyposis Colon Cancer
Collecting Information From Patients and Family Members With Hereditary Colorectal Cancer Syndromes or Who Are at High Risk of Developing Colorectal Cancer
RATIONALE: Gathering medical and family history information from patients and family members may help doctors better understand hereditary colorectal cancer and hereditary polyposis syndrome and identify patients at high risk of…
- Conditions
- Colorectal Cancer, Hereditary Non-polyposis Colon Cancer, Precancerous Condition
- Trial name
- NCT00675636
- Testing
- study of socioeconomic and demographic variables, evaluation of cancer risk factors, study of high risk factors
- Where
- 3 sites in United States
- Volunteers
- 730 people
- Sponsor
- Vanderbilt University Medical Center
Congenital Heart Disease
Angiotensin Converting Enzyme Inhibitors During Cardiopulmonary Bypass in Infants and Children
The purpose of this study is to determine whether ACE inhibitors alter the fibrinolytic, inflammatory, and hemodynamic response to cardiopulmonary bypass in infants and children with congenital heart disease.
- Trial name
- NCT00848250
- Testing
- Angiotensin Converting Enzyme Inhibitor, No ACE Inhibitor
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Vanderbilt University Medical Center
End-stage Renal Disease
End-Stage Renal Disease Intra-dialysis Lifestyle Education Study
The purpose of this study is to compare the effects of intra-dialysis yoga to an educational program among patients with end-stage renal disease.
- Trial name
- END-IDLE (NCT02361268)
- Testing
- Intradialysis-yoga, Educational program
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- Vanderbilt University Medical Center
Intubation
Comparison of Two-hand Mask Ventilation Technique: Standard V-E Versus Reversal V-E Technique
This study hypothesizes that a novel reversal V-E ventilation technique will retain its high efficiency as that of standard V-E technique and will be easier to use.
- Trial name
- NCT03170037
- Testing
- Standard V-E ventilation technique, Reversal V-E ventilation technique
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Vanderbilt University Medical Center
Central Venous Catheterization, Ultrasonography
Bilateral Internal Jugular Veins Ultrasound Scanning Prior to CVC Placement
Central venous catheter placement is a common procedure in the intensive care unit and is a required skill for all residents working in the critical care setting.
- Conditions
- Central Venous Catheterization, Ultrasonography, Critical Care
- Trial name
- BIUS (NCT02741453)
- Testing
- Standard Practice, Bilateral IJ Ultrasound Scanning
- Where
- United States
- Volunteers
- 278 people
- Sponsor
- Vanderbilt University Medical Center
Allergic Rhinitis, Allergic Conjunctivitis
Olopatadine Eye Drops and Allergy Skin Testing
Use of olopatadine ophthalmic solution (eye drops) will decrease allergy skin test reactivity.
- Trial name
- NCT00775658
- Testing
- olopatadine
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Vanderbilt University Medical Center
Apnea
Comparison of Mask Ventilation Techniques in Patients Requiring General Anesthesia
This study compares the effectiveness of two kinds of two-handed facemask ventilation techniques (when breathing is supported with machines) at the time that general anesthesia is started.
- Trial name
- NCT02580526
- Testing
- V-E mask ventilation for one minute, C-E mask ventilation for one minute
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Vanderbilt University Medical Center
Prematurity
Effect of Colostrum on Mucosal Immunity in Very Low Birth Weight (VLBWs) Premature Infants
Background: Infection in preterm infants is a common, costly, and devastating problem frequently causing death or sequelae for survivors.
- Trial name
- NCT01776268
- Testing
- Oral priming
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Vanderbilt University Medical Center
Postoperative Pain
Pediatric Tonsillectomy Pain Reduction Study
Tonsillectomy is associated with a significant decrease quality of life in children secondary to pain, which is worsened with swallowing.
- Trial name
- NCT00678379
- Testing
- lidocaine (1%) + bupivacaine (0.5%), Normal saline, Lidocaine (1%) + Bupivacaine (0.5%) + Clonidine (25mcg)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Vanderbilt University Medical Center
GERD, Larynx Disease
Efficacy of Dx-pH Probe in Diagnosing Extra-esophageal Reflux Disease
The purpose of this study is to establish the clinical application of a new device that records pH changes in the hypopharynx. The investigators also aim to compare the consistency of distal esophageal pH with hypopharyngeal pH…
- Trial name
- ADHERE (NCT00388453)
- Testing
- Dx-pH Probe, Manometry
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Pseudohypoparathyroidism Type 1a, Albright Hereditary Osteodystrophy
Theophylline as a Treatment for Children With Pseudohypoparathyroidism Type 1a (Albright Hereditary Osteodystrophy)
This study will test an investigational drug, theophylline, in children with pseudohypoparathyroidism type 1a (PHP1a). This study involves a 3 day visit to the Vanderbilt Clinical Research Center.
- Trial name
- NCT02463409
- Testing
- Theophylline
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Vanderbilt University Medical Center
Dystrophic Epidermolysis Bullosa
Efficacy of Granulocyte Colony Stimulating Factor (GCSF) In Patients With Dystrophic Epidermolysis Bullosa
This is a feasibility study to see if Granulocyte Colony Stimulating Factor (GCSF) is effective as a treatment of Dystrophic Epidermolysis Bullosa (EB). Patients will receive one course of treatment with the study drug.
- Trial name
- NCT01538862
- Testing
- Granulocyte Colony Stimulating Factor (GCSF)
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Vanderbilt University Medical Center
Kidney Transplant
Mycophenolate Mofetil and Rapamycin as Secondary Intervention vs. Continuation of Calcineurin Inhibitors in Patients at Risk for Chronic Renal Allograft Failure
A study to determine the effect on renal function in renal transplant patients with biopsy proven Chronic allograft nephropathy (CAN) nephropathy who are switched from a Calcinerin inhibitor (CI) triple drug regimen to a…
- Trial name
- NCT00223678
- Testing
- Rapamycin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Vanderbilt University Medical Center
Catecholaminergic Polymorphic Ventricular Tachycardia
Flecainide for Catecholaminergic Polymorphic Ventricular Tachycardia
The purpose of this study is to test whether the addition of oral flecainide to standard therapy will reduce ventricular ectopy on exercise test compared to placebo plus standard therapy in patients with Catecholaminergic…
- Trial name
- NCT01117454
- Testing
- Flecainide Acetate, Beta blocker
- Where
- 10 sites in United States
- Volunteers
- 14 people
- Sponsor
- Vanderbilt University Medical Center
Photosensitive Epilepsy
Effect of Valproic Acid Concentration on Photic Response
We are trying to learn if small changes in the amount of a valproate in the blood (given through an IV) will change the way the brain reacts to flashing lights.
- Trial name
- NCT00609245
- Testing
- Valproic Acid
- Where
- 2 sites in United States
- Volunteers
- 13 people
- Sponsor
- Vanderbilt University Medical Center
Delirium, Respiratory Failure
How Your Patients' Non-REM Sleep Changes On Sedatives in the Intensive Care Units
The purpose of this study is to study the effect of two standard of care sedative medications on sleep stages and total sleep time.
- Trial name
- HYPNOS (NCT00826553)
- Testing
- Dexmedetomidine, GABA agonist
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Vanderbilt University Medical Center