Clinical trials: sponsored by Vanderbilt University Medical Center
Hepatocellular Carcinoma, Liver Disease
An Analysis of Urinary Proteases as Biomarkers for Hepatocellular Carcinoma-101423
Specific urine proteases or groups of these enzymes can be reliable biomarkers and an effective gauge of response to therapy in patients with hepatocellular carcinoma.
- Trial name
- NCT01316679
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Desaturation, Bradycardia
Validation of the NTX Wireless Patient Monitoring System
Reduction in time to detection of Clinically Significant events Reduction of time to Intervention during Clinically Significant events Reduction in the number of admissions to Intensive Care
- Conditions
- Desaturation, Bradycardia, Tachycardia, Hypertension
- Trial name
- TATRC (NCT00644644)
- Testing
- Rapid Response Team (NTX wireless monitoring system)
- Where
- United States
- Volunteers
- 1,303 people
- Sponsor
- Vanderbilt University Medical Center
Depression
Dynamic Measures of Neurochemistry in Mood Disorders
The purpose of this study is to understand changes in brain chemical signals when people take antidepressants called sertraline (Zoloft®) and bupropion (Wellbutrin SR, Zyban ®).
- Trial name
- NCT00178828
- Testing
- sertraline, bupropion
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Leukemia, Renal Toxicity
Kidney Dysfunction in Children and Young Adults Who Have Received Methotrexate for Acute Lymphoblastic Leukemia
RATIONALE: Gathering information about how often kidney dysfunction occurs in children and young adults receiving methotrexate for acute lymphoblastic leukemia may help doctors learn more about the disease and plan the best…
- Trial name
- NCT00993135
- Testing
- methotrexate, medical chart review, assessment of therapy complications
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Vanderbilt University Medical Center
Filariasis
Exhaled NO Testing in Filariasis
This study is looking at the difference in exhaled nitric oxide levels in patients with and without laboratory evidence of filariasis.
- Trial name
- NCT01628497
- Where
- Guyana
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Aortic Aneurysm, Abdominal
Inflammation and Risk Prediction in Patients With Abdominal Aortic Aneurysm
The purpose of this study is to better understand the role of inflammation in the pathophysiology of abdominal aortic aneurysm. In this study we hope to show better ways of predicting risk in this condition by using a combination…
- Trial name
- NCT00513773
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Vanderbilt University Medical Center
Neurocognitive Impairment, Delirium
Neurocognitive Functioning in Patients With Newly Diagnosed Upper Aerodigestive Tract Cancer Receiving Treatment at Henry-Joyce Cancer Clinic
RATIONALE: Gathering information about how often problems with neurocognitive functioning occur in patients with newly diagnosed upper aerodigestive tract cancers may help doctors learn more about the disease.
- Conditions
- Neurocognitive Impairment, Delirium, Esophageal Cancer, Head and Neck Cancer
- Trial name
- NCT00533884
- Testing
- Assessment of therapy complications, Neurocognitive assessment, Quality-of-life assessment
- Where
- 4 sites in United States
- Volunteers
- 86 people
- Sponsor
- Vanderbilt University Medical Center
Ischemia
Biomagnetic Characterization of Gastric Dysrhythmias:Study 2
The purpose of this study is to use the Squid magnetometer (Superconducting QUantum Interference Device) to help diagnose electrical and mechanical abnormalities of the stomach and intestines.
- Trial name
- SQUID (NCT00178984)
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Ischemia
Biomagnetic Signals of Intestinal Ischemia II
The lack of blood flow to the small intestine causes mesenteric ischemia. Using a Superconducting QUantum Interference Device (SQUID) which measures the magnetic field of the small intestine, we are hoping to identify…
- Trial name
- SQUID (NCT00179036)
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Cancer Survivors, Yoga
Yoga Intervention for Cancer Survivors
Impaired health related quality of life (HRQOL) including fatigue, problems with sleep and psychosocial well being (physical, emotional, and spiritual) have been noted in adult cancer survivors.
- Trial name
- NCT01228955
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Vanderbilt University Medical Center
HIV/AIDS
Multi-component HIV Intervention Packages for Chinese Men Who Have Sex With Men -Test, Link and Care (TLC)
1. The number of MSM who are tested for HIV in the 4 study clinics over 12 months will increase compared with historical data from the same 4 clinics over the past 12 months prior to the intervention. 2.
- Trial name
- MP3 (NCT01904877)
- Testing
- Enhancing HIV testing
- Volunteers
- 3,760 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Mastectomy, Postoperative Pain
The Use of an Acellular Dermal Matrix in a Two-Staged Breast Reconstruction
This study intends to compare postoperative outcomes of a tissue expander placement following a mastectomy with two different operative techniques.
- Conditions
- Mastectomy, Postoperative Pain, Complications
- Trial name
- NCT00616824
- Testing
- Dermamatrix to cover lateral aspect of tissue expander, Serratus anterior to cover lateral aspect of tissue expander
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Vanderbilt University Medical Center
Childhood Cancer
Childhood Cancer Survivors' Knowledge of Diagnosis,Treatment and Risk of Late Effects: Specialized Survivorship Clinic
This two-part research study will compare childhood cancer survivors receiving specialized follow-up care in the REACH for Survivorship clinic to patients receiving routine follow-up care.
- Trial name
- NCT01223872
- Testing
- interview, clinic visit and interview, interviews and clinic visit
- Where
- United States
- Volunteers
- 188 people
- Sponsor
- Vanderbilt University Medical Center
Normal Pressure Hydrocephalus
Prognostic Value of Transforming Growth Factor-Beta 1 in Normal Pressure Hydrocephalus
Correlation of cerebrospinal fluid levels of transforming growth factor beta-1 with functional improvements after insertion of ventriculoperitoneal shunt for normal pressure hydrocephalus
- Trial name
- NCT00600795
- Testing
- CSF collection
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Vanderbilt University Medical Center
GERD
Biology in Patients With Reflux Esophagitis
GERD is a common condition in the western world. In most cases, the diagnostic is established by good response to empiric proton pump inhibitor (PPI) therapy.
- Trial name
- BENCH (NCT01194323)
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Vanderbilt University Medical Center
Cardiac Diseases
The Use of Colloid Versus Crystalloid in Post-operative Pediatric Cardiac Patients for Fluid Resuscitation
The purpose of the study is to help determine if either crystalloid solution or colloid solution is more advantageous as a resuscitative fluid in post-operative pediatric cardiac patients.
- Trial name
- NCT00464126
- Testing
- 5% albumin, crystalloid
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Vanderbilt University Medical Center
Cancer, Chemotherapy
The Activity Intervention for Chemobrain
Cognitive dysfunction following chemotherapy is an adverse treatment effect that impacts the quality of life for many cancer survivors receiving this adjuvant therapy.
- Conditions
- Cancer, Chemotherapy, Cognitive Impairment
- Trial name
- TACTIC (NCT00495703)
- Testing
- Exercise, Usual Care
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Inflammatory Bowel Diseases, Crohn's Disease
Transition of Inflammatory Bowel Disease (IBD) Patients From Pediatric to Adult Gastroenterologist (GI)
The purpose of this study is to determine if the program that has been made to ease the transition of care for adolescent patients with IBD from pediatric gastroenterology to adult gastroenterology is effective to reduce the risk…
- Conditions
- Inflammatory Bowel Diseases, Crohn's Disease, Ulcerative Colitis
- Trial name
- NCT00360022
- Testing
- Joint visits
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- Vanderbilt University Medical Center
Crohns Disease, Fistula
Study to Look at Benefit of Surgical Drainage Before Beginning Medical Therapy for Crohns Perianal Fistulas
This study is looking at the advantage of establishing surgical drainage for Crohn's fistulas and abscesses prior to starting medical therapy.
- Conditions
- Crohns Disease, Fistula, Abscess
- Trial name
- NCT01145365
- Testing
- Exam under anesthesia (EUA)
- Where
- 3 sites in United States
- Volunteers
- 21 people
- Sponsor
- Vanderbilt University Medical Center
Evidence of Cardiovascular Morbidity
Biochemical and Radiological Indicators of Cardiovascular Morbidity in Children With Premature Pubarche
Children with premature pubarche will have radiological and radial artery tonometry evidence of cardiovascular morbidity at diagnosis when compared to matched controls.
- Trial name
- PP (NCT00581490)
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center