Clinical trials: sponsored by Vanderbilt University Medical Center
Evidence of Cardiovascular Morbidity
Biochemical and Radiological Indicators of Cardiovascular Morbidity in Children With Premature Pubarche
Children with premature pubarche will have radiological and radial artery tonometry evidence of cardiovascular morbidity at diagnosis when compared to matched controls.
- Trial name
- PP (NCT00581490)
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Heart Failure
Effectiveness of a Walking Program Modulating Cardioreparative Factors in Heart Failure
The incidence of heart failure grows as the population continues to age. Heart failure incidence approaches 10 per 1,000 persons after the age of 65.
- Trial name
- EPCCHFWalk (NCT00937443)
- Testing
- Physical Fitness, Walking Exercise Group
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Vanderbilt University Medical Center
Hypoglycemia, Hyperglycemia
Identification of Inpatients at Risk for Poor Glycemic Control
Both hypoglycemia and hyperglycemia can be detrimental to hospitalized patients. However, it is not clear which patients are more likely to develop significant problems with hypoglycemia or severe hyperglycemia in the hospital.
- Trial name
- NCT01043042
- Testing
- No interventions will be used in this study
- Where
- United States
- Volunteers
- 33,011 people
- Sponsor
- Vanderbilt University Medical Center
Normal Pressure Hydrocephalus
Prognostic Value of Transforming Growth Factor-Beta 1 in Normal Pressure Hydrocephalus
Correlation of cerebrospinal fluid levels of transforming growth factor beta-1 with functional improvements after insertion of ventriculoperitoneal shunt for normal pressure hydrocephalus
- Trial name
- NCT00600795
- Testing
- CSF collection
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Vanderbilt University Medical Center
Hyperlipidemia
Protein and Phospholipid Analysis of HDL in Patients With Very High Serum Levels of HDL-C
Coronary heart disease (CHD) is the single leading cause of death in the United States . Serum Cholesterol is known to have a direct impact on a number of human diseases through a variety of mechanisms.
- Trial name
- NCT00525083
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Vanderbilt University Medical Center
Mastectomy, Postoperative Pain
The Use of an Acellular Dermal Matrix in a Two-Staged Breast Reconstruction
This study intends to compare postoperative outcomes of a tissue expander placement following a mastectomy with two different operative techniques.
- Conditions
- Mastectomy, Postoperative Pain, Complications
- Trial name
- NCT00616824
- Testing
- Dermamatrix to cover lateral aspect of tissue expander, Serratus anterior to cover lateral aspect of tissue expander
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Vanderbilt University Medical Center
Arthralgia, Breast Cancer
Joint Pain and Medication Adherence in Postmenopausal Women Receiving Aromatase Inhibitors
RATIONALE: Gathering information over time about joint pain and stiffness from postmenopausal women with early-stage breast cancer who are receiving aromatase inhibitors may help doctors plan treatment and help patients live more…
- Trial name
- NCT00954564
- Testing
- aromatase inhibition therapy - OBSERVATIONAL ONLY, medical chart review, questionnaire administration
- Where
- 2 sites in United States
- Volunteers
- 351 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Trismus, Head and Neck Cancer
Feasibility Study of Dynasplint to Prevent Trismus in Head and Neck Cancer
The purpose of this study is to see if use of a device called the Jaw Dynasplint® System can be used during and immediately after cancer treatment.
- Trial name
- NCT01649583
- Testing
- Jaw Dynasplint System
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Vanderbilt University Medical Center
Ulcerative Colitis, Colon Cancer
Study of Effects of L-Arginine in Colitis and Colon Cancer
The purpose of this study is to look at the importance of L-Arginine in the digestive tract. L-Arginine is an amino acid and is important in making proteins within the cell.
- Trial name
- NCT01091558
- Where
- United States
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Osteoarthritis, Pain
Safety of Non-delayed Weight Bearing After Total Hip Replacement With Non-Cemented Fiber Metal Taper Stem
The purpose of this study is to determine if full weight bearing following total hip replacement can speed recovery when the hip replacement in the long bone of the leg is not cemented into the bone.
- Trial name
- NCT00179088
- Testing
- Patient may be able to put weight on the operated leg
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Larynx Disease, Gastroesophageal Reflux
Do Laryngeal Tissue Changes in Patients Suspected of Having Laryngopharyngeal Reflux Predict Response to Treatment?
The purpose of the study is to determine if tissue changes are predictor of clinical response to therapy. The hypothesis is that the patients who have laryngeal signs and symptoms related to acid reflux, will have ultrastructural…
- Trial name
- NCT00444145
- Testing
- Prevacid, Esophageal and Laryngeal Biopsies
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Vanderbilt University Medical Center
Screening Colonoscopies
Bowel Preparation Quality for Screening Colonoscopy
The study will consist of a prospective observational period performed in the GI Endoscopy Lab. The objective is to document the quality of bowel preps in patients undergoing a screening colonoscopy with and without an…
- Trial name
- NCT02690779
- Testing
- Educational intervention, Routine Care Instructions
- Where
- United States
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Metabolic Syndrome, Obesity
Study of Sildenafil Citrate on Insulin Resistance in African American
Obesity has a greater detrimental impact on the health of African American women than on any other racial or gender group. Nearly 80% of African American women are overweight or obese in the United States.
- Trial name
- NCT01334554
- Testing
- Sildenafil
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Vanderbilt University Medical Center
Hyperlipidemias
Elevated Serum HDL in Four Generations of a Nashville Family
The purpose of this study is to determine the genetic basis of one family's hereditary hyper-HDL-emia using multiple modalities such as linkage analysis and gene array.
- Trial name
- NCT00525109
- Testing
- No Intervention
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Obesity, Morbid
PET Imaging and Bariatric Surgery
The purpose of this study is to look at certain areas of the brain that are related to addictive behaviors, such as overeating. These areas are called 'dopamine type 2 receptors' (DRD2/3) and other studies have shown that obese…
- Trial name
- NCT00801827
- Testing
- F-18 (fallypride)
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Vanderbilt University Medical Center
Head and Neck Cancer
Germline Mutations in Patients With Head and Neck Cancer and a Family History of Cancer
RATIONALE: Studying gene mutations in samples of DNA from patients with head and neck cancer and a family history of cancer may help doctors learn more about the development of cancer in families.
- Trial name
- NCT00482872
- Testing
- gene expression analysis, mutation analysis, polymerase chain reaction
- Where
- 3 sites in United States
- Volunteers
- 400 people
- Sponsor
- Vanderbilt University Medical Center
Rhinosinusitis
SinuSurf vs. Saline Solution in Normal Subjects
Single-center, prospective, placebo controlled trial of tolerability and safety of low-concentration SinuSurf sinus irrigation solution in normal subjects. Forty (40) healthy subjects aged 18-65 will be enrolled in the study.
- Trial name
- SinuSurf (NCT02728505)
- Testing
- SinuSurf irrigation twice daily, NeilMed Sinus rinse irrigation twice daily
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Head and Neck Cancer
Study of Proteins in Head and Neck Cancer Cells
RATIONALE: Studying proteins in head and neck cancer cells in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00896948
- Testing
- Southern blotting, TdT-mediated dUTP nick end labeling assay, gene expression analysis
- Where
- 3 sites in United States
- Sponsor
- Vanderbilt University Medical Center
Head and Neck Cancer
Biomarkers in Patients With Head and Neck Cancer and in Healthy Volunteers
RATIONALE: Studying samples of blood, tissue, and saliva in the laboratory from patients with cancer and from healthy volunteers may help doctors identify and learn more about biomarkers related to cancer.
- Trial name
- NCT00899769
- Testing
- protein expression analysis, proteomic profiling, immunoenzyme technique
- Where
- 3 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Head and Neck Cancer
DNA Analysis of Tumor Tissue Samples From Patients With Human Papilloma Virus-Associated Cancer of the Oropharynx
RATIONALE: Studying samples of tumor tissue in the laboratory from patients with cancer may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00897988
- Testing
- gene expression analysis, mutation analysis, polyacrylamide gel electrophoresis
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Vanderbilt University Medical Center