Clinical trials: sponsored by Vanderbilt University Medical Center
Type 2 Diabetes
STrong Relationships to Improve DiabEtes Pilot
This is a pilot and feasibility study for a mobile phone-delivered intervention, called STRIDE (STrong Relationships to Improve DiabEtes), designed to provide support for adults with type 2 diabetes (improve glycemic management…
- Trial name
- STRIDE (NCT07210593)
- Testing
- FAMS, PEER
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Vanderbilt University Medical Center
Respiratory Failure, Mechanical Ventilation
Mode of Ventilation During Critical Illness at Multiple Centers
The goal of this clinical trial is to learn whether the choice of ventilator mode for patients on breathing machines in the intensive care unit affects their survival and recovery.
- Conditions
- Respiratory Failure, Mechanical Ventilation, Critical Illness
- Trial name
- MODEM (NCT07313956)
- Testing
- Volume control, Pressure control, Adaptive pressure control
- Where
- 4 sites in United States
- Volunteers
- 4,785 people
- Sponsor
- Vanderbilt University Medical Center
Type 2 Diabetes Mellitus (T2DM), Sarcopenia
HMB Plus Vitamin D to Preserve Muscle in Older Adults Starting Semaglutide
This randomized, double-blind, placebo-controlled trial will evaluate whether daily calcium beta-hydroxy-beta-methylbutyrate (calcium-HMB) plus vitamin D3 preserves muscle mass, physical function, and resting metabolism in adults…
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Sarcopenia, Obesity, Muscle Loss
- Trial name
- PRESERVE-HMB (NCT07760948)
- Testing
- Calcium-HMB Plus Vitamin D3
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Vanderbilt University Medical Center
Microtia, Dysbiosis
Microbiome Metabolites and Alcohol in HIV to Reduce CVD RCT
Among people living with HIV, heavy drinking increases the risk of heart disease and death. Studies suggest that alcohol changes the number and kind of bacteria in your gut and these changes increase the risk of heart disease and…
- Conditions
- Microtia, Dysbiosis, Alcohol Drinking, HIV Infections
- Trial name
- META HIV CVD (NCT05288790)
- Testing
- Probiotic
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Vanderbilt University Medical Center
Parkinson's Disease, Obsessive Compulsive Disorder
Physiological Brain Atlas Development
The NIH grant has funded the development of a physiological brain atlas registry that will allow us to significantly improve the data collectioin and use of physiological data into a normalized brain volume.
- Conditions
- Parkinson's Disease, Obsessive Compulsive Disorder, Dystonia, Essential Tremor
- Trial name
- Brain Atlas (NCT00575081)
- Testing
- Stereotactic brain procedures
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Vanderbilt University Medical Center
Achalasia
Botox or Botox With Esophageal Dilation in Patients With Achalasia
Achalasia is a rare esophageal motility disorder. Treatment of achalasia is aimed toward palliation of symptoms. These include botox injections to the lower esophageal sphincter (LES), pneumatic dilation, surgical myotomy, and…
- Trial name
- NCT03654066
- Testing
- Botulinum toxin type A, Endoscope balloon dilator, Patient reported outcomes
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Vanderbilt University Medical Center
Skin
Topical Carboxytherapy Paste Following Microneedling
Topical carboxytherapy refers to a gel paste that carries non-gaseous carbon dioxide (CO2). It is applied similarly to a face mask.
- Trial name
- NCT07431541
- Testing
- CO2 gel mask
- Volunteers
- healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Skin Cancer Excision Site, Basal Cell Carcinoma
Impact of Dysport on PMFF Donor Scar
The purpose of this research study is to investigate the effect of pre-operative injections of Dysport (Abobotulinumtoxin-A, commonly known as "Botox") on the cosmetic appearance of and overall satisfaction with study…
- Conditions
- Skin Cancer Excision Site, Basal Cell Carcinoma, Squamous Cell Carcinoma, Melanoma
- Trial name
- NCT07720726
- Testing
- Abobotulinumtoxin-A, Control- Saline injection
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Vanderbilt University Medical Center
Rupture of Anterior Cruciate Ligament
Multicenter Orthopaedics Outcomes Network for ACL Reconstructions
The purpose of this study is to determine the effect of modifiable risk factors on knee function, osteoarthritis, and re-rupture of the anterior cruciate ligament (ACL) following ACL reconstruction.
- Trial name
- NCT00463099
- Where
- 8 sites in United States
- Volunteers
- 3,294 people
- Sponsor
- Vanderbilt University Medical Center
Rupture of Anterior Cruciate Ligament
Multicenter ACL Revision Study (MARS)
The purpose of this study is to determine the effects of modifiable risk factors on patient-reported quality of life, physical activity levels, and risk of early osteoarthritis following revision anterior cruciate ligament (ACL)…
- Trial name
- MARS (NCT00625885)
- Where
- 49 sites in United States, Canada
- Volunteers
- 1,234 people
- Sponsor
- Vanderbilt University Medical Center
Cochlear Implant
Pediatric Image-Guided Cochlear Implant Programming
Cochlear implants are surgically implanted devices which restore the ability to hear to the hearing impaired. Recent literature has indicated that children receiving cochlear implants (CIs) often have dramatically improved speech…
- Trial name
- NCT03886168
- Testing
- Signal processing intervention of a biomedical device
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Vanderbilt University Medical Center
Duchenne Muscular Dystrophy (DMD)
Sodium/Glucose Cotransporter-2 Inhibitors (SGLT2i) Therapy in Duchenne Cardiomyopathy
This is a pharmacokinetic study (PK Study) to better understand empagliflozin dosing in pediatric Duchenne muscular dystrophy patients.
- Trial name
- CHERISH (NCT07172971)
- Testing
- SGLT-2 inhibitor, SGLT2 inhibitor
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Vanderbilt University Medical Center
ICU Delirium, Critical Illness
Exogenous Ketone Supplementation in ICU Delirium
Delirium is a common syndrome in intensive care unit (ICU) patients. Those experiencing delirium may suddenly feel confused, have trouble thinking clearly, struggle to pay attention, or see and hear things that are not real.
- Trial name
- KETONES-ICU (NCT07364162)
- Testing
- Ketone monoester
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Vanderbilt University Medical Center
Memory Disorders
Neural Basis of Human Working Memory
This ClinicalTrials.gov entry corresponds to the Neural Basis of Human Working Memory protocol approved under Vanderbilt University Medical Center IRB #251231.
- Trial name
- NCT07617506
- Testing
- Neurocognitive Tasks, Ripple Neuromed Summit System
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Vanderbilt University Medical Center
Obstructive Sleep Apnea
Muscle Stimulation During DISE
Drug-induced sleep endoscopy (DISE) is a widely used tool for assessing collapse patterns of the upper airway anatomy during sleep.
- Trial name
- NCT03589846
- Testing
- Grass S88 Muscle Stimulator
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Vanderbilt University Medical Center
Autism Spectrum Disorder
Addressing Disparities in Autism Spectrum Disorder Diagnosis Using a Direct-to-home Telemedicine Tool
The investigators propose to evaluate the use of a telemedicine tool, the TELE-ASD-PEDS (TAP), that is designed to assess for autism spectrum disorder (ASD) symptoms in toddlers.
- Trial name
- NCT05047224
- Testing
- Tele-assessment + in-person assessment, Tele-assessment only
- Where
- United States
- Volunteers
- 664 people
- Sponsor
- Vanderbilt University Medical Center
Pulmonary Arterial Hypertension
The MObile Health InterVEntion in Pulmonary Arterial Hypertension (MOVE PAH) Study
Patients with pulmonary arterial hypertension (PAH) have reduced health related quality of life (HRQOL) and impaired exercise capacity. Despite fourteen approved therapies, most patients die within ten years.
- Trial name
- MOVE PAH) (NCT05464095)
- Testing
- mHealth Intervention, Usual Care
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Vanderbilt University Medical Center
Post-Traumatic Stress Disorder, Acute Respiratory Failure
Effect of Ketamine and Etomidate During RSI on Long Term Outcomes
The RSI-LTO study collects long-term outcomes from the RSI trial (NCT05277896). One-third of adults who are intubated in the ED or ICU experience symptoms of posttraumatic stress disorder (PTSD).
- Trial name
- RSI-LTO (NCT06179485)
- Testing
- Ketamine, Etomidate
- Where
- 6 sites in United States
- Volunteers
- 1,756 people
- Sponsor
- Vanderbilt University Medical Center
Inflammatory Bowel Disease (IBD), Colonoscopy
Visualization of the Colon Through Use of the Magnetic Flexible Endoscope (MFE) in Participants With Inflammatory Bowel Disease (IBD)
In this study, the investigators will test the ability of the Magnetic Flexible Endoscope (MFE) to travel through the colon of people with Inflammatory Bowel Disease (IBD).
- Trial name
- NCT06989424
- Testing
- Magnetic Flexible Endoscope (MFE)
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Vanderbilt University Medical Center
Lumbar Spine Degenerative Changes, Lumbar Spine Surgery
Rehabilitation With Empowered STrategies to Optimize REcovery
The main goal of this clinical trial is to understand the benefits of remotely delivered Empowered Relief in patients undergoing lumbar spine surgery.
- Trial name
- RESTORE (NCT07406997)
- Testing
- Empowered Relief, Education
- Where
- 4 sites in United States
- Volunteers
- 100 people
- Sponsor
- Vanderbilt University Medical Center