Clinical trials: sponsored by Vanderbilt University Medical Center
Huntington Disease
Impact of Deutetrabenazine on Functional Speech and Gait Dynamics in Huntington Disease
Examine the effects of deutetrabenazine on functional speech and gait impairment
- Trial name
- NCT04713982
- Testing
- Deutetrabenazine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Vanderbilt University Medical Center
Retinopathy of Prematurity (ROP), ROP Examination
Point-of-Care Ophthalmic Diagnostic Imaging of Retinopathy of Prematurity
The goal of this proposal is to develop novel HH-SECTR technology for visualizing and quantifying diagnostic disease features in prematurely born infant retinopathy of prematurity (ROP) patients that lead to more informed…
- Trial name
- ROP Imaging (NCT06612541)
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Vanderbilt University Medical Center
Severe Obesity, Obesity
GLP-1 Receptor Agonists Post-Bariatric Surgery (GRABS) Pilot Trial
The goal of this pilot clinical trial is to determine the effectiveness of Tirzepatide in patients with persistent obesity (BMI \> 30) 12 months after bariatric surgery (Roux-en-Y Gastric Bypass).
- Conditions
- Severe Obesity, Obesity, BMI Greater Than 30
- Trial name
- GRABS-0 (NCT06162715)
- Testing
- Tirzepatide, Standard of Care post-gastric bypass
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Vanderbilt University Medical Center
Cochlear Implant
Image-guided Cochlear Implant Programming (IGCIP)
Cochlear implants are surgically implanted devices which restore the ability to hear to the hearing impaired. While remarkably successful, even in the best of performers restoration of hearing to levels of normal listeners is…
- Trial name
- NCT03306082
- Testing
- Image-Guided Cochlear Implant Programming
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Vanderbilt University Medical Center
Obesity
Effect of PDE5 Inhibition on Adipose Metabolism in Humans
This is a randomized, double-blinded, placebo-controlled study of the effects of PDE5 inhibition with tadalafil on adipose tissue in obese individuals.
- Trial name
- NCT04684589
- Testing
- Tadalafil 20 MG
- Where
- United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Rheumatoid Arthritis
Dietary Salt in Rheumatoid Arthritis
In this study investigators propose to address the following hypotheses: 1) Reduction in dietary sodium will decrease inflammation in patients with rheumatoid arthritis (RA).
- Trial name
- NCT03649178
- Testing
- salt
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Vanderbilt University Medical Center
Autism
Project VOICES: Vocal Optimization in Children Elevating the Spectrum
Thirty percent of children with autism barely talk or do not talk at all despite years of intervention. This study aims to address this important and long-standing challenge by developing a novel intervention to increase the…
- Trial name
- Project VOICES (NCT06875843)
- Testing
- Contingent responses, Contingent responses plus vocal elicitation strategies, Non-contingent control
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Vanderbilt University Medical Center
Bilateral Vocal Fold Paralysis (BVFP)
Functional Electrical Stimulation of the Bilaterally Paralyzed Human Larynx
The primary purpose of this project is to evaluate the safety of new treatment termed bilateral laryngeal pacing to improve treatment outcomes in patients with bilateral vocal fold paralysis (BVFP) (Aim 1).
- Trial name
- NCT04028674
- Testing
- Laryngeal Pacing Device
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Vanderbilt University Medical Center
Burn Injury
Clinical Assessment of Protopic® Ointment in Deep Partial-Thickness Burns
There is currently no standard treatment to prevent burn depth conversion in partial-thickness burns. Conversion into deeper wounds is associated with higher complications and morbidity.
- Trial name
- NCT05856994
- Testing
- Tacrolimus ointment
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Vanderbilt University Medical Center
Salt Sensitivity of Blood Pressure, High Blood Pressure
Effect of an Isolevuglandin Scavenger on Salt Sensitivity of Blood Pressure and Immune Cell Activation in Humans
Hypertension is the leading cause of preventable deaths globally, driven by complications such as myocardial infarction, stroke, heart failure, and kidney disease.
- Conditions
- Salt Sensitivity of Blood Pressure, High Blood Pressure, Inflammation, Renin-Angiotensin-Aldosterone System
- Trial name
- NCT07602166
- Testing
- 2-hydroxybenzylamine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Vanderbilt University Medical Center
Duchenne Muscular Dystrophy (DMD), Cardiomyopathy
Modeling Mortality in Duchenne Muscular Dystrophy Cardiomyopathy: Identification of Surrogate Outcome Measures for DMD Drug Trials
Dystrophin associated heart dysfunction is a leading cause of death in patients with Duchenne and Becker Muscular dystrophy (DMD/BMD) and Duchenne and Becker muscular dystrophy carriers (MDC); however, the evolution of heart…
- Conditions
- Duchenne Muscular Dystrophy (DMD), Cardiomyopathy, Becker Muscular Dystrophy, Carrier of Duchenne Muscular Dystrophy
- Trial name
- NCT07674758
- Where
- 9 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Vanderbilt University Medical Center
COPD, Asthma
A Pharmacist-Led Intervention to Increase Inhaler Access and Reduce Hospital Readmissions (PILLAR)
The goal of this study is to assess the impact of pharmacist-led benefits investigations and application of clinical practice guidelines on patient access to inhalers and time to hospital readmission or Emergency Department (ED)…
- Trial name
- PILLAR (NCT03927820)
- Testing
- Benefits investigation
- Where
- United States
- Volunteers
- 914 people
- Sponsor
- Vanderbilt University Medical Center
Complex Regional Pain Syndrome
Autonomic Dysfunction and Spinal Cord Stimulation in Complex Regional Pain Syndrome
To demonstrate that spinal cord stimulator has an effect on sympathetic function (the one that give us the fight and flight response).
- Trial name
- CRPS (NCT00780390)
- Testing
- Autonomic Function Assessment
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Vanderbilt University Medical Center
Vaccination Refusal
Improving Vaccinations for Young Children (IVY)
The IVY project focuses on improving combination 10 vaccine rates for Tennessee children through an educational and quality improvement intervention rolled out through a stepped-wedge cluster randomized trial.
- Trial name
- IVY (NCT04203277)
- Testing
- IVY
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
MASLD
A Study of Electronic Clinical Decision Support Tools for Steatotic Liver Disease
The overall objectives of this study are to determine the effectiveness of a participant-specific guided electronic decision support system on provider decision making for participants with metabolic-dysfunction associated…
- Trial name
- eMPOWER (NCT07382349)
- Testing
- eMPOWER Decision Aid
- Where
- United States
- Volunteers
- 7,200 people
- Sponsor
- Vanderbilt University Medical Center
Cirrhotic Cardiomyopathy
Prospective Investigation of Cirrhotic Cardiomyopathy in Humans
Cirrhotic Cardiomyopathy (CCM) is a recognized complication of cirrhosis, but understudied despite recent retrospective data suggesting it may be common, affecting one in three patients with decompensated cirrhosis, and…
- Trial name
- PITCH (NCT07658222)
- Where
- 2 sites in United States
- Volunteers
- 440 people
- Sponsor
- Vanderbilt University Medical Center
Post-acute COVID-19 Syndrome, Postural Tachycardia Syndrome (POTS)
Cardiovascular Autonomic and Immune Mechanism of Post COVID-19 Tachycardia Syndrome
The term post-acute COVID-19 syndrome or Long COVID is a disabling syndrome that persists beyond the 3-month convalescence period after COVID-19 infections.
- Conditions
- Post-acute COVID-19 Syndrome, Postural Tachycardia Syndrome (POTS), Long COVID, SARS CoV 2 Infection
- Trial name
- NCT05421208
- Testing
- Levels of inflammatory cytokine ( IL-6) in post-COVID-19 POTS and controls, Levels of inflammatory cytokine ( IL-6) in controls, Effect on inflammation after chronic PNS stimulation
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Obesity
Comparison of Body Composition Changes With Weight Loss Interventions
This study is being done to compare the effects of a newer class of weight loss medications to weight loss surgery on the body's muscle, metabolism, and side effects over time.
- Trial name
- REFORM (NCT07115069)
- Testing
- GLP-1 receptor agonist, Gastric Bypass Surgery (laparoscopic), Gastric Bypass Surgery (robotic)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Vanderbilt University Medical Center
Peripheral Arterial Disease
The Impact of Factor Xa Inhibition on Thrombosis, Platelet Activation, and Endothelial Function in Peripheral Artery Disease
The purpose of this study is to understand how the drug rivaroxaban improves symptoms associated with peripheral artery disease.
- Trial name
- NCT05009862
- Testing
- Rivaroxaban 2.5 Mg Oral Tablet, Aspirin 81Mg Ec Tab
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Vanderbilt University Medical Center
Back Pain Without Radiation, Low Back Pain
Parallel Versus Perpendicular Technique for Lumbar Medial Branch Radiofrequency Neurotomy
Low back pain is a leading cause of disability worldwide. The lumbar zygapophyseal joints (z-joints) are estimated to be the source of low back pain between 10% and 40% of the time.
- Conditions
- Back Pain Without Radiation, Low Back Pain, Lumbar Radiofrequency Neurotomy
- Trial name
- NCT03912519
- Testing
- Parallel placement of 16 gauge electrodes, Perpendicular placement with 22 gauge electrodes
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- Vanderbilt University Medical Center