Clinical trials: sponsored by Virginia Commonwealth University
Lymphoma, Acute Lymphoblastic Leukemia
Reduced IV Fluids to Improve Clearance of HDMTX in Children w/Lymphoma or Acute Lymphoblastic Leukemia
To determine whether a reduced volume hydration regimen will lead to a shorter time to methotrexate clearance when compared to a standard intravenous (IV) hydration regimen.
- Conditions
- Lymphoma, Acute Lymphoblastic Leukemia, Pediatric Cancer, Pediatric ALL
- Trial name
- NCT03964259
- Testing
- Intravenous fluids
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Virginia Commonwealth University
Glioma, Fear of Cancer
FearLess in Cognitively Intact Patients With Glioma
This study will assess the preliminary feasibility and acceptability of FearLess, a newly-developed psychological intervention for fear of cancer recurrence (FCR) among cognitively-intact patients with glioma.
- Trial name
- FearLess (NCT05604365)
- Testing
- FearLess Intervention
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Stress
Use of Stress Inoculation Training in Medical Education
The purpose of this research study is to test the feasibility and effectiveness of SIT in teaching medical students to perform in high-fidelity simulation settings similar to those they may experience in their practice.
- Trial name
- NCT04199221
- Testing
- Stress Innoculation Training (SIT), Extra attempt
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Energy Intake, Food Intake
The Acute Effect of Vaping on Food Intake
This study assesses the acute effects of a standardized 20-minute vaping episode compared to a non-vaping control condition on ad libitum food intake during a 30-minute buffet meal, occurring approximately 45 minutes after the…
- Conditions
- Energy Intake, Food Intake, E-Cig Use, Appetite
- Trial name
- NCT04219189
- Testing
- Vaping condition, Control condition
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Cryptogenic Sensory Peripheral Neuropathy in Metabolic Syndrome
Topiramate for Cryptogenic Sensory Peripheral Neuropathy in Metabolic Syndrome (CSPN)
The TopCSPN trial is a double blinded randomized placebo controlled study of oral topiramate as a potential disease modifying therapy for cryptogenic sensory peripheral neuropathy (CSPN).
- Trial name
- TopCSPN (NCT02878798)
- Testing
- topiramate
- Where
- 20 sites in United States
- Volunteers
- 132 people
- Sponsor
- Virginia Commonwealth University
Neuropathy, Peripheral Neuropathy
Study of Nicotine for Pain Associated With Chemotherapy-Induced Peripheral Neuropathy
Assess the efficacy of short-term nicotine transdermal patch administration for the treatment of chemotherapy-induced peripheral neuropathy (CIPN) in cancer stable patients or patients in remission.
- Conditions
- Neuropathy, Peripheral Neuropathy, Neuropathic Pain, Chemotherapy-induced Peripheral Neuropathy
- Trial name
- NCT04468230
- Testing
- Nicotine Transdermal Patch
- Where
- 2 sites in United States
- Volunteers
- 4 people
- Sponsor
- Virginia Commonwealth University
Lymphoid Leukemia, Myeloid Leukemia
Therapeutic Use of Intravenous Vitamin C in Allogeneic Stem Cell Transplant Recipients
This phase 2 trial studies the effect of intravenous (IV) vitamin C repletion after myeloablative allogeneic stem cell transplant.
- Conditions
- Lymphoid Leukemia, Myeloid Leukemia, Monocytic Leukemia, Myelodysplasia
- Trial name
- NCT03613727
- Testing
- Intravenous (IV) and oral Vitamin C
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Virginia Commonwealth University
Parkinson's Disease, Coping Skills
Expressive Writing for Individuals With Parkinson's Disease and Their Caregivers
This randomized, controlled trial (RCT) evaluates the benefits of expressive compared to neutral writing in individuals with Parkinson's Disease and their support persons.
- Trial name
- PDEWS (NCT02217735)
- Testing
- Writing Intervention
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Virginia Commonwealth University
Asthma
RVA Breathes: A Richmond City Collaboration to Reduce Pediatric Asthma Disparities
The goal of this study is to evaluate a sustainable, community-engaged program to reduce asthma disparities among 5 to 11-year-old children in Richmond, Virginia.
- Trial name
- NCT03297645
- Testing
- School, Asthma education, Home environmental remediation
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Virginia Commonwealth University
Neurocognitive Deficit, Mental Health Impairment
Intervention Effectiveness on the Neurocognitive Functioning of Children and Adolescents With Neurofibromatosis Type 1
Children with neurofibromatosis are more likely to have difficulties related to their psychological and neurocognitive functioning (e.g., more likely to have depression, have social difficulties, be diagnosed with ADHD).
- Conditions
- Neurocognitive Deficit, Mental Health Impairment, Neurofibromatosis 1
- Trial name
- OPTIMAL-SSI (NCT05377008)
- Testing
- OPTIMAL-SSI
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Virginia Commonwealth University
Alcoholic Hepatitis, Sepsis
Vitamin C Infusion for TReatment in Sepsis and Alcoholic Hepatitis
The purpose of this research study is to test the safety, tolerability, and effectiveness of Vitamin C (ascorbic acid) intravenous infusion when used to treat alcoholic hepatitis (inflammation of the liver from heavy alcohol use)…
- Trial name
- CITRIS-AH (NCT03829683)
- Testing
- Vitamin C, Dextrose 5% in water
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Virginia Commonwealth University
Premature
Feasibility Study of SPEEDI
The proposed feasibility study will evaluate the investigators ability to conduct a clinical trial of a novel intervention (SPEEDI) which addresses a striking gap in the literature.
- Trial name
- SPEEDI (NCT01889108)
- Testing
- SPEEDI
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Virginia Commonwealth University
Alcoholism
Rapid Determination Of The Clinical Utility Of Perampanel For The Treatment Of Alcohol Dependence
The purpose of this study is to determine whether perampanel alters the response to alcohol for heavy drinkers. It is hypothesized that perampanel will reduce the rewarding and reinforcing properties of alcohol in the laboratory…
- Trial name
- NCT02120365
- Testing
- Perampanel
- Where
- 4 sites in United States
- Volunteers
- 22 people
- Sponsor
- Virginia Commonwealth University
Caries
A Strategy to Prevent the Recurrence of Dental Disease in Children Receiving Dental Treatment With General Anesthesia
The purpose of this study is to evaluate the effectiveness of a preventive strategy in increasing return to follow up and recall appointments.
- Trial name
- NCT05212142
- Testing
- verbal education, verbal education, visual aids, and motivational interviewing
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Virginia Commonwealth University
Hiv, Transgenderism
Microeconomic Intervention to Reduce HIV Transmission in Economically Disadvantaged Transgender Women
The purpose of this research study is to learn more about the economic situations, discrimination experiences, and risk behaviors of transgender women.
- Trial name
- NCT04275310
- Testing
- Microeconomic Intervention
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Surgery
Netflix Streaming Services in the Operating Room During Total Knee Replacement - a Feasibility Study
The purpose of this research study is to test the safety, tolerability, and effectiveness of watching streamed videos through virtual reality (VR) goggles during surgery.
- Trial name
- NCT04469881
- Testing
- VR
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Virginia Commonwealth University
Diet, Food, and Nutrition
Salad Bars in the National School Lunch Program: Impact on Dietary Consumption Patterns in Elementary School Students
This project is a research study looking at what foods students choose and eat during school lunch and examines how salad bars impact what children eat.
- Trial name
- NCT05605483
- Testing
- Salad bar, Waitlisted control, Salad bar post-COVID
- Where
- United States
- Volunteers
- 6,269 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Alcohol Drinking, Alcohol Abuse
Screening and Management of Unhealthy Alcohol Use in Primary Care
Unhealthy alcohol use is the third leading preventable cause of death in the United States. Yet, primary care physicians do not, on average, screen for and address unhealthy alcohol use in their patient populations.
- Conditions
- Alcohol Drinking, Alcohol Abuse, Alcohol Use Disorder
- Trial name
- NCT04248023
- Testing
- Practice Facilitation
- Where
- 2 sites in United States
- Volunteers
- 13,680 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Xerostomia
Effects of an External Oral Irrigation Device on Patients With Dry Mouth
The purpose of this research study is to test the effectiveness of treating dry mouth through water rehydration using this extra oral water pump/irrigation device.
- Trial name
- NCT04901507
- Testing
- The Voutia System
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Virginia Commonwealth University
End Stage Liver DIsease
An Integrative Model for Palliative Care in End-Stage Liver Disease
The purpose of this research study is to understand the impact of palliative care in ESLD on quality of life, emergency room or hospital visits, and on care provider burden, and to work to develop the best way to provide…
- Trial name
- NCT05238779
- Testing
- Standard of care including palliative care
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Virginia Commonwealth University