Clinical trials: sponsored by Virginia Commonwealth University
Tetraplegia
Virtual Reality and Spinal Stimulation to Improve Arm Function
The main objective of our work is to develop and test the safety and feasibility of a home-based upper limb rehabilitation program for individuals with tetraplegia.
- Trial name
- NCT05065437
- Testing
- Active (Virtual reality and spinal stimulation)
- Where
- United States
- Sponsor
- Virginia Commonwealth University
Underage Alcohol Use, Smoking, Non-Tobacco Products
Culturally Enhancing a Motivational Interviewing Intervention For Latinx Adolescents
The purpose of this study is to compare two versions of an intervention focused on teaching 10-14-year-old Latina/o adolescent's skills that will decrease the likelihood that they will use tobacco, alcohol, and other drugs.
- Trial name
- NCT03947177
- Testing
- GMIT, GMIT+
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Diabetic Neuropathy, Painful
Theta Burst Brain Stimulation in Diabetic Neuropathy Patients With Neuropathic Pain: Investigating Neural Mechanisms
The purpose of the study is to determine the effects of a newer form of non-invasive brain stimulation (called transcranial magnetic stimulation or TMS) as a treatment in patients with painful diabetic neuropathy to examine its…
- Trial name
- NCT04988321
- Testing
- Prolonged continuous theta burst stimulation (pcTBS)
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Virginia Commonwealth University
Vaginal Bleeding
Tamoxifen Versus Estradiol for Unscheduled Bleeding in Etonogestrel Implant Users, a Randomized Pilot Trial
The purpose of this research study is to evaluate the ability of medicines called tamoxifen or estradiol to prevent annoying vaginal bleeding for arm implant users.
- Trial name
- NCT04933240
- Testing
- Tamoxifen Citrate 10Mg Tab, Estradiol
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Periodontitis Chronic Generalized Severe, Periodontitis Chronic Generalized Moderate
Scaling and Root Planning With Localized Delivery of Autogenous Growth Factors- Platelet Rich Fibrin (PRF)
The purpose of this research study is to find out about the effect of growth factors extracted from blood on improving healing of periodontal pockets (Gum pockets) after deep gum cleaning.
- Trial name
- NCT04978324
- Testing
- leukocyte platelet rich fibrin (L-PRF), Scaling and Root Planing
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Overweight and Obesity, Chronic Inflammation
The BMI Project (Body, Mind, Inflammation)
Obesity and chronic inflammation influence the development and progression of many types of cancer. These conditions share several of the same causes, including physical inactivity, poor nutrition, stress, and insufficient sleep.
- Trial name
- NCT04023318
- Testing
- Integrated Lifestyle Intervention
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Virginia Commonwealth University
Opioid Use Disorder
Virginia Opioid Overdose Treatment InitiatVE
This is a Phase 3b, open-label study in patients that present to the ED for an opioid OD and receive treatment with an opioid antagonist.
- Trial name
- VOTIVE (NCT03818399)
- Testing
- SUBLOCADE
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Virginia Commonwealth University
Spinal Cord Injuries
In-Home Adjustment of New Spinal Cord Injury Caregivers
To improve spinal cord injury (SCI) rehabilitation through stronger informal caregiving, the proposed study will modify and evaluate a telehealth Transition Assistance Program (TAP) for informal caregivers of individuals with SCI…
- Trial name
- NCT03244098
- Testing
- Transition Assistance Program
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Pain
Comparison of Physical Versus Visual Distraction in the Reduction of Pain During Local Anesthesia
The purpose of this study is to compare physical versus visual distractions to determine which technique reduces perceived pain better during local anesthesia injections.
- Trial name
- NCT04595721
- Testing
- Hidden object, Stress ball
- Sponsor
- Virginia Commonwealth University
Electronic Cigarette Use
The Impact of Vaping Ethanol in the Evaluation of Impairment
The purpose of this research study is to find out about ethanol-containing e-cigarettes impact ethanol breath tests, field sobriety tests, or other tests of sobriety. Ethanol is a common part of e-cigarette liquids.
- Trial name
- NCT03826303
- Testing
- E-cigarette liquid with ethanol, 1 puff, E-cigarette liquid without ethanol, 1 puff, E-cigarette liquid with ethanol, 10 puffs
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Cardiovascular Risk Factor, Lipemia
Postprandial Monocyte Maturation and Vascular Dysfunction Following High-Fat Meals - Study 1
The purpose of this research study is to examine the effect of high-fat meals on the health of blood vessels. In addition, the study will examine how exercise/fitness/physical activity impacts blood vessels after consumption of a…
- Trial name
- NCT03958734
- Testing
- High-fat meal
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Violence in Adolescence
Evaluating Outcomes for Youth Receiving Hospital-based Violence Prevention With and Without a Community-level Initiative
The purpose of this research study is to test if a hospital-based violence prevention strategy with a community-level initiative is effective for cross-cutting violence prevention in violently injured youth.
- Trial name
- NCT04192318
- Testing
- Bridging the Gap, Communities that Care (CTC), Treatment as usual
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Virginia Commonwealth University
Immunologic Desensitization
Desensitization and Cross-Desensitization During Oral Grass or Ragweed Pollen Immunotherapy
The purpose of this study is to determine if sublingual allergen immunotherapy tablets work by inducing a state of desensitization in mast cells and basophils.
- Trial name
- NCT02676765
- Testing
- allergen extract tablet
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Osteoarthritis, Knee
Postoperative Pain Control After Periarticular Injection During Total Knee Arthroplasty
This study will evaluate the use of a local injection around the knee (periarticular) during total knee replacement (TKR) surgery to see if it reduces postoperative pain levels.
- Trial name
- NCT02570503
- Testing
- Ropivacaine, Ketorolac, Clonidine
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Contrast-induced Acute Kidney Injury (CI-AKI)
Hemodynamic Effects Of Impella On Renal Circulation And Risk Of CA-AKI Among Patients Undergoing Protected PCI
Patients undergoing Percutaneous Coronary Intervention (PCI) are exposed to the risk of suffering from a damage to the kidneys which goes under the name of Contrast-Associated Acute Kidney Injury (CA-AKI), which is more common if…
- Trial name
- NCT04928118
- Testing
- Evaluate the blood flow and pressure into kidneys
- Sponsor
- Virginia Commonwealth University
Chronic Kidney Diseases, Sickle Cell Disease
Sickle Cell Uric Acid (SCUA) - Cohort Repository
The purpose of this research is to study the causes of Sickle Cell kidney disease, as well as to collect and store samples and information about people with Sickle Cell Disease.
- Trial name
- NCT04190888
- Testing
- No intervention
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Virginia Commonwealth University
Acute Kidney Injury, Coronary Artery Disease
A Zero Acute Kidney Injury Strategy for Percutaneous Coronary Intervention in Patients With ChronicKidney Disease
The purpose of this study is to compare the outcomes of Percutaneous Coronary Intervention (PCI) in patients with chronic kidney disease (CKD) using smaller doses of contrast dye that are validated as being at low risk of causing…
- Conditions
- Acute Kidney Injury, Coronary Artery Disease, Percutaneous Coronary Intervention
- Trial name
- Zero-AKI (NCT04928092)
- Testing
- Standard of care Ultra Low Contrast PCI
- Where
- United States
- Sponsor
- Virginia Commonwealth University
Cystic Fibrosis
Thermic Effect of Feeding in Cystic Fibrosis
The investigators propose to assess the contributions of the thermic effect of food intake (TEF), which is the amount of energy expended to digest food, to overall energy expenditure in Cystic Fibrosis (CF).
- Trial name
- NCT03931252
- Testing
- Boost VHC, Ensure High Protein
- Where
- United States
- Sponsor
- Virginia Commonwealth University
Alcohol Use Disorder
Understanding Genetic Risk for Alcohol Use Disorder
The purpose of this study is to evaluate an online educational tool that will help individuals better understand alcohol use disorder, risk factors, and genetic risk information and to better understand participant's beliefs…
- Trial name
- NCT05143073
- Testing
- Alcohol use disorder and strategies to reduce risk educational material, Complex polygenic risk scores, alcohol use disorder, and strategies to reduce risk educational material
- Where
- United States
- Volunteers
- 338 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Cerebral Palsy
Investigating the Effect of Stochastic Resonance Vibration on Gait and Balance and Upper Extremity Function in Children With Cerebral Palsy
The purpose of this research study is to determine the effects of wearable vibration devices for children with cerebral palsy and impaired arm function.
- Trial name
- NCT04388787
- Testing
- Stochastic resonance (SR) wraps
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Virginia Commonwealth University