Clinical trials: sponsored by Virginia Commonwealth University
Oral Hygiene, White Spot Lesion
Effects of Active Reminders and Motivational Techniques on Oral Hygiene and Gingival Health in Orthodontic Patients
This study will compare the use of text message reminders versus multiple in-person sessions of oral hygiene instructions and motivation on improving oral hygiene measurements.
- Conditions
- Oral Hygiene, White Spot Lesion, Gingivitis
- Trial name
- NCT03841825
- Testing
- Oral hygiene instructions
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Hypertension
Pilot for a Community Pharmacy Service Model: Impact of a Pharmacist Monitored Patient Blood Pressure Readings
This study is designed to explore whether routine measurement of blood pressure by community pharmacists can improve patient adherence to blood pressure medications.
- Trial name
- NCT03323840
- Testing
- Incentivized Care
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Virginia Commonwealth University
Rib Fractures
The Erector Spinae Plane Block and Its Effect on Respiratory Status and Pain Management in Rib Fracture Patients
The purpose of this research study is to identify the benefits of a type of nerve block, called an erector spinae plane block (ESP), in the treatment of patients with multiple rib fractures and uncontrolled pain despite receiving…
- Trial name
- NCT03805360
- Testing
- Ropivacaine, Normal Saline Flush, 0.9% Injectable Solution
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Virginia Commonwealth University
Electronic Cigarettes
Assessment of Two New Electronic Cigarettes in Cigarette Smokers
The purpose of this study is to determine differences in nicotine delivery, user behavior, subjective effects, and physiological effects, when cigarette smokers use an two new electronic cigarette devices (JUUL and IQOS) relative…
- Trial name
- NCT03435562
- Testing
- JUUL electronic cigarette, IQOS electronic cigarette, Own Brand cigarette
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Breast Cancer, Metastatic Breast Cancer
2nd Line Treatment With Pemetrexed and Sorafenib for Recurrent or Metastatic Triple Negative Breast Cancer
This phase 2 clinical trial will evaluate the efficacy of the combination of pemetrexed and sorafenib in patients with recurrent or metastatic Triple Negative Breast Cancer (TNBC).
- Conditions
- Breast Cancer, Metastatic Breast Cancer, Recurrent Breast Cancer
- Trial name
- NCT02624700
- Testing
- Experimental Arm A: Pemetrexed, Experimental Arm A: Sorafenib, Experimental Arm B: Pemetrexed
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Virginia Commonwealth University
Caries,Dental, Apical Periodontitis
Kovanaze Vs. Articaine in Achieving Pulpal Anesthesia of Maxillary Teeth - Endodontics
The primary goal of the study is to compare the success rates of pulpal anesthesia (defined as ability to complete the intended dental procedure without the need for rescue anesthesia) between Kovanaze nasal mist and Articaine…
- Trial name
- NCT04105985
- Testing
- Kovanaze Nasal Spray, Articaine Injection
- Sponsor
- Virginia Commonwealth University
Cocaine Use Disorder
Drug Interaction and Self Administration Studies of Compounds for Cocaine Use Disorder
The overall goal of this project is to develop initial human data on effects of novel compounds on safety (interactions with cocaine) and efficacy (subjective response to cocaine and self administration data) in non-treatment…
- Trial name
- NCT02537873
- Testing
- Lorcaserin, Cocaine Intravenous (IV)
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Virginia Commonwealth University
Cocaine-Related Disorders, Opioid-Related Disorders
Phase I Functional Magnetic Resonance Imaging (fMRI) Pharmacodynamic Studies of Compounds for Opioid Use Disorder and Cocaine Use Disorder
The purpose of Project 2 is to execute phase I functional magnetic resonance imaging (fMRI) studies to assess the effects of lorcaserin on brain target engagement (measured by fMRI brain activation and neural connectivity) in…
- Trial name
- NCT03143543
- Testing
- Group A Lorcaserin (10mg), Group A2 Lorcaserin (20 mg)
- Where
- United States
- Volunteers
- 171 people
- Sponsor
- Virginia Commonwealth University
Caregivers, Burnout
Eudaimonia and Sleep: Effects of a Mindfulness Intervention in Caregivers of People With Dementia
This research study seeks to understand how stress reduction training influences caregiver well-being, sleep, and physiological responses to stress. All participants are caregivers of persons with dementia.
- Conditions
- Caregivers, Burnout, Sleep
- Trial name
- CARING (NCT03857308)
- Testing
- Mindfulness Training, Reappraisal Training
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Chronic Rhinitis
The Effect of Oral Guaifenesin on Pediatric Chronic Rhinitis: A Pilot Study
This is a 14-day, randomized, placebo-controlled, parallel group, masked clinical trial of oral guaifenesin for the therapy of Chronic Rhinitis (CRS) in 36 children between the ages of 7 and 18 years.
- Trial name
- NCT01364467
- Testing
- Guaifenesin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Virginia Commonwealth University
Myeloma, Lymphoma
African American Cancer Clinical Trial Decisions: Testing Tailored Messages
The purpose of this study is to determine if the use of tailored health messages and/or involving physicians are effective in increasing African American (AA) patient activation in a clinical trial consultation.
- Conditions
- Myeloma, Lymphoma, Leukemia
- Trial name
- NCT02356549
- Testing
- EMR Tailoring, Survey Tailoring, Physician Involvement
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Virginia Commonwealth University
Kidney Transplant, Hepatitis C
Hepatitis C Virus Donor Positive Kidney Transplantation for Hepatitis C Virus Negative Recipients
The development of direct acting anti-virals (DAAs) for the treatment of Hepatitis C virus (HCV) has changed the landscape of HCV therapy dramatically in the last several years with reported sustained virologic response (SVR)…
- Trial name
- NCT03249194
- Testing
- Direct acting Anti-Viral Therapy using Epclusa or Zepatier
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Virginia Commonwealth University
Plastic Bronchitis
International Plastic Bronchitis Registry
The purpose of the international plastic bronchitis registry is to understand the natural course and long term health outcomes of subjects diagnosed with plastic bronchitis due to different types of casts.
- Trial name
- NCT01663948
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Virginia Commonwealth University
Obesity, Fatty Liver
Evaluation of Liver and Cardiometabolic Health Benefits on Low Carbohydrate Ketogenic Diet
To evaluate the impact of a Low Carbohydrate Ketogenic Diet (LCKD) weight loss program and compare to the standard of care program established for patients with Non-Alcoholic Fatty Liver Disease (NAFLD) on: (1) Liver fat and…
- Conditions
- Obesity, Fatty Liver, Ketogenic Dieting
- Trial name
- NCT03141008
- Testing
- Fibroscan changes with different diets
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Cavities of Teeth
An Evaluation of Protective Effects of OpalSeal™ Against Early Dental Decay in Orthodontic Patients
Fluoride is very effective in preventing dental decay (cavities) when applied in the form of a varnish on tooth surfaces. The purpose of this study is to verify if fluoride-releasing primer (OpalSeal) offers more protection…
- Trial name
- NCT03722264
- Testing
- OpalSeal, TransbondXT
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Virginia Commonwealth University
Leukemia
Effect of Prevention Education in Caries Formation in Pediatric Patients With Leukemia
This randomized pilot clinical trial studies how well preventive education works in decreasing caries formation in pediatric patients with leukemia.
- Trial name
- NCT03281746
- Testing
- Dental Procedure, Educational Intervention (prevention education), Interview
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Virginia Commonwealth University
Solid Tumor
Study of Regorafenib and Sildenafil for Advanced Solid Tumors
This is a phase 1 study of sildenafil in combination with regorafenib in patients with progressive advanced solid tumors. A modified 3+3 dose escalation design will be conducted for the dose escalation of the treatment…
- Trial name
- NCT02466802
- Testing
- Regorafenib, Sildenafil Citrate
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Virginia Commonwealth University
Stress Reduction
Stress Reduction Training for Emotion Regulation and Well-Being
This study will examine whether stress reduction training - which a growing body of research indicates has manifold benefits for behavior regulation, emotion regulation, and other salutary outcomes of relevance to this proposal …
- Trial name
- NCT03485807
- Testing
- Mindfulness Training (MT), Active Coping Training (CT)
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Sleep
The Impact of Physical (In)Activity on Sleep Quality
The proposed research will examine the role of physical activity (PA) on altering sleep quality (SQ) while systematically examining novel mechanisms that may drive changes in SQ.
- Trial name
- NCT03514953
- Testing
- Reduced Physical Activity
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Cancer
Feasibility of Delivering an Avatar Life-review Intervention to Support Patients With Active Cancer
The objective of the study is to determine the feasibility and acceptability of an integrated art and technology, storytelling, life review platform for patients with active cancer.
- Trial name
- NCT03996642
- Testing
- Avatar Life Review
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University