Clinical trials: sponsored by Virginia Commonwealth University
Mycosis Fungoides, Sézary Syndrome
TSEB and Brentuximab for Treatment of Mycosis Fungoides & Sezary Syndrome
The purpose of this study is to evaluate the cutaneous toxicity and treatment response associated with administering concurrent TSEB and brentuximab vedotin in patients with mycosis fungoides or Sézary Syndrome.
- Trial name
- NCT02822586
- Testing
- TSEB Therapy, Brentuximab vedotin
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Virginia Commonwealth University
Dyspareunia, Perineal Tear
Rapidly Absorbing Polyglactin 910 Versus Poliglecaprone 25 for Laceration Repair
To evaluate the rates of dyspareunia with rapidly absorbing polyglactin 910 compared to poliglecaprone 25 using a validated sexual function questionnaire.
- Conditions
- Dyspareunia, Perineal Tear, Sutured Laceration
- Trial name
- NCT03184077
- Testing
- Laceration Repair with Polyglactin 910, Laceration Repair with poliglecaprone 25
- Where
- United States
- Volunteers
- 318 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Breast Cancer, Gastrointestinal Cancer
Doxorubicin With or Without Sildenafil, With Analysis of Cardiac Markers
Sildenafil increases the therapeutic effect of doxorubicin used as treatment for cancers of solid tumors through both an increase in anti-tumor effects and protection from cardiac toxicity.
- Conditions
- Breast Cancer, Gastrointestinal Cancer, Genitourinary Cancer, Sarcoma
- Trial name
- NCT01375699
- Testing
- Doxorubicin, Sildenafil
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Virginia Commonwealth University
Liver Cancer
Sorafenib and Vorinostat in Treating Patients With Advanced Liver Cancer
This phase I trial is studying the side effects and best dose of vorinostat when given together with sorafenib tosylate in treating patients with advanced liver cancer.
- Trial name
- NCT01075113
- Testing
- sorafenib tosylate, vorinostat
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- Virginia Commonwealth University
Disordered Eating Behaviors
Piloting a Novel Intuitive Eating Intervention for College Women With Disordered Eating
The purpose of this research study is to pilot test a new intervention that helps young adult women learn adaptive eating and exercise strategies, increase their body acceptance, decrease unhealthy weight control behaviors and…
- Trial name
- NCT03612661
- Testing
- Group Intervention, Guided Self-Help
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Adhd
Improving Emotion Regulation in Adolescents With ADHD
The purpose of our study is to examine the impact of a program that provides emotion regulation skills for adolescents aged 11-16 with Attention-Deficit/Hyperactivity Disorder (ADHD) and poor emotion regulation.
- Trial name
- NCT03733548
- Testing
- RELAX
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Virginia Commonwealth University
Cerebral Palsy
Supervised Fitness Program for Adults With Cerebral Palsy
The purpose of this study is to compare the effectiveness of 2 community intervention approaches to maintain community mobility and walking speed in adults with cerebral palsy who have previously completed an 8 week course of…
- Trial name
- NCT03218774
- Testing
- Home Exercise Group, Fitness Center Group
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- Virginia Commonwealth University
Cocaine Dependence
An fMRI Study of SYN115 in Cocaine Dependent Subjects
The dopamine system is critical in modulation of reward and has been implicated in the initiation and maintenance of addiction (Volkow et al 2004).
- Trial name
- NCT00783276
- Testing
- SYN115
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Virginia Commonwealth University
Ventilator Associated Pneumonia, Nosocomial Infections in Children
Decreasing Antibiotic Use in Infants With Suspected Ventilator-associated Infection
This is a prospective study with three specific aims: (1) To convene a consensus conference to develop a guideline for antibiotic use in infants (age < 3 yrs) with suspected ventilator-associated infection; (2) To evaluate…
- Conditions
- Ventilator Associated Pneumonia, Nosocomial Infections in Children, Microbial Colonization
- Trial name
- VAIN2 (NCT03041207)
- Testing
- Development and implementation of an antibiotic guideline
- Where
- 23 sites in United States, Canada
- Volunteers
- 555 people
- Sponsor
- Virginia Commonwealth University
Pain, Postoperative, Pain, Chest
Pharmacokinetic Profile and Dermatomal Coverage of the Erector Spinae Plane Block
The goals of this study are as follows: 1. to confirm the safe dosing of ropivacaine for the erector spinae plane block 2. develop a pharmacokinetic profile of the erector spinae plane block, which will help demonstrate how…
- Trial name
- NCT03874806
- Testing
- Ropivacaine 0.25%-NaCl 0.9% Injectable Solution, Ropivacaine 0.2%-NaCl 0.9% Injectable Solution
- Where
- United States
- Sponsor
- Virginia Commonwealth University
Weight Loss, Breast Cancer Risk Factors
Addressing Modifiable Breast Cancer Risk Factors With Project CONECT
The objective of this protocol is to adapt and pilot test an existing lifestyle modification intervention for weight loss for women with overweight or obesity who have had a recent false positive mammography screen.
- Trial name
- NCT02871388
- Testing
- CONECT
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
HIV/AIDS
Developing and Examining Evidenced-Based HIV Testing Messages
The goals of this study are to: 1. Develop a HIV test message tailored for African American women. A generic non-tailored message will be developed as well for comparison.
- Trial name
- NCT03433053
- Testing
- HIV Testing Message Intervention, Control
- Where
- United States
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Adenocarcinoma of the Prostate, Stage I Prostate Cancer
Intensity-Modulated External Beam Radiation Therapy in Treating Patients With Prostate Cancer
RATIONALE: Radiation therapy uses high-energy x-rays and other types of radiation to kill tumor cells. Specialized radiation therapy, such as intensity-modulated radiation therapy, that delivers a high dose of radiation directly…
- Conditions
- Adenocarcinoma of the Prostate, Stage I Prostate Cancer, Stage II Prostate Cancer, Stage III Prostate Cancer
- Trial name
- NCT01117935
- Testing
- intensity modulated external beam radiation therapy
- Where
- 2 sites in United States
- Volunteers
- 55 people
- Sponsor
- Virginia Commonwealth University
Adult Brain Glioblastoma, Adult Giant Cell Glioblastoma
Dimethyl Fumarate, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme
This phase 1 trial studies the side effects and best dose of dimethyl fumarate when given together with temozolomide and radiation therapy(RT) in treating patients with newly diagnosed glioblastoma multiforme (GBM).
- Conditions
- Adult Brain Glioblastoma, Adult Giant Cell Glioblastoma, Adult Gliosarcoma
- Trial name
- NCT02337426
- Testing
- Dimethyl Fumarate, Temozolomide, Radiation Therapy
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Virginia Commonwealth University
Disorder of Vitamin C, Atrial Fibrillation
High Dose Vitamin C in Cardiac Surgery Patients
Coronary artery bypass grafting (CABG) is the most common procedure performed by cardiac surgeons. Post-operative atrial fibrillation (AF) is the most common adverse event following CABG, experienced in 20-50% of patients; the…
- Conditions
- Disorder of Vitamin C, Atrial Fibrillation, Complications Due to Coronary Artery Bypass Graft, Heart Valve Disease
- Trial name
- NCT02762331
- Testing
- Ascorbic Acid
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Virginia Commonwealth University
Empathy
Embodied Empathy; Virtual Reality and Experiencing Geriatrics
The Embodied Empathy pilot study proposes to use VR technology to create original narratives of real life patients from their own perspectives for medical students to embody.
- Trial name
- NCT03987269
- Testing
- Embodied Virtual Reality, Narrative Video
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Injuries, Patellofemoral Pain Syndrome
Effect of Strength and Coordination Training on Biomechanics and Injury in New Runners
The investigators hypothesize that new runners participating in an 8 week strength and coordination training program prior to beginning to run will 1) display different coordination patterns , and 2) experience fewer injuries…
- Conditions
- Injuries, Patellofemoral Pain Syndrome, Iliotibial Band Syndrome
- Trial name
- NCT03293121
- Testing
- Strength and Coordination Training, Walking
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Stress
Mindfulness Practices for Healthcare Professional Trainees
A newly developed intervention, Mindfulness Based Practices for Health Care Professionals in Training: Clinical Applications, will be piloted to determine the feasibility and accessibility within this population.
- Trial name
- NCT03403335
- Testing
- Mindfulness Based Practices for Health Care Professionals in Training
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Heart Failure, Systolic, Renal Disease, End Stage
Interleukin-1 Blockade for the Treatment of Heart Failure in Patients With Advanced Chronic Kidney Disease
Interleukin-1 blockade for the treatment of heart failure in patients with advanced chronic kidney disease (End-stage renal disease and Heart fAilure - Anakinra Remodeling Trial) is a Phase 2, single-arm trial designed to…
- Conditions
- Heart Failure, Systolic, Renal Disease, End Stage, Chronic Kidney Diseases
- Trial name
- E-HART (NCT03062176)
- Testing
- Anakinra
- Sponsor
- Virginia Commonwealth University
Nicotine Dependence
The Influence of Electronic (ECIG) Heater Resistance on ECIG Acute Effects
The purpose of this study is to measure the individual and combined influence of electronic cigarette (ECIG) heating element resistance and liquid nicotine concentration on ECIG acute effects.
- Trial name
- NCT03496116
- Testing
- ECIG Session
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University