Clinical trials: sponsored by Virginia Commonwealth University
Nontherapeutic
Randomized Controlled Trial Methods for Novel Tobacco Products Evaluation
The purpose of this study is to use Randomized Controlled Trial (RCT) methods to examine the influence of novel tobacco products on biomarkers of toxicant exposure and disease risk, reports of adverse events, and concurrent use…
- Trial name
- NCT02342795
- Testing
- e-cigarette, cigarette substitute
- Where
- 2 sites in United States
- Volunteers
- 520 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
High Intensity Interval Exercise (HIIE), Pain Perception
Acute Effects of High Intensity Interval Exercise on Executive Function
This study will examine the acute effects of high intensity interval ergometry on peripheral concentrations of lactate and hydrogen ions, as well as cognitive function.
- Conditions
- High Intensity Interval Exercise (HIIE), Pain Perception, Wisconsin Card Sorting Task
- Trial name
- NCT02270528
- Testing
- Exercise, Cognitive Task
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Metabolic Syndrome X, Insulin Resistance
Oral Contraceptives in the Metabolic Syndrome
Oral contraceptives (OCs) are the most widely used method of reversible birth control. However, the long-term cardiovascular safety of the widely used low-dose OCs (ethinyl-estradiol < 50 mcg) is still debated.
- Conditions
- Metabolic Syndrome X, Insulin Resistance, Obesity, Cardiovascular Diseases
- Trial name
- NCT00205504
- Testing
- Ortho Tri Cyclen
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Insulin Sensitivity, Cardiovascular Risk
Oral Contraceptives, Insulin Resistance and Cardiovascular Risk Profile in Pre-Menopausal Women
Birth control pills are the most commonly used method of birth control. The purpose of this research study is to examine whether birth control pills change heart disease risk and how the body handles blood sugar when given to…
- Conditions
- Insulin Sensitivity, Cardiovascular Risk, Perimenopausal Disorder
- Trial name
- NCT01475513
- Testing
- Ortho Cyclen®
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Heart Diseases
Multimodal Analgesia in Cardiac Surgery (Pilot Study)
The investigators objective is to assess the effectiveness of an opioid sparing multimodal approach for enhancing the recovery in Cardiac Surgical patients.
- Trial name
- NCT02734940
- Testing
- Lidocaine, Unrestricted Fentanyl, Ketamine
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Virginia Commonwealth University
Identify the Presence of a Marker of Ischemia/Hypoperfusion of the Brain Via Peripheral Blood, Ischemia/Hypoperfusion of Brain
Biomarkers of Ischemia: Xanthine, Hypoxanthine and Inosine Levels During Carotid Stenting Procedures
The purpose of the study is to determine if a new blood test can help the doctor determine if there is brain injury or ischemia. Ischemia occurs when not enough oxygen gets to the brain.
- Trial name
- NCT01639534
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Virginia Commonwealth University
Abortion, Second Trimester
24-hour Mifepristone and Buccal Versus Mifepristone and Vaginal Misoprostol for Cervical Preparation for D&E
This study aims to compare mifepristone and buccal misoprostol to mifepristone and vaginal misoprostol for cervical preparation for second trimester dilation and evacuation (D\&E).
- Trial name
- NCT03134183
- Testing
- Vaginal Misoprostol, Buccal Misoprostol
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Diabetes Mellitus, Type 2, Heart Failure, Systolic
SGLT2 Inhibition in Diabetes and Heart Failure
To determine the effects of SGLT2 inhibition with empagliflozin on cardio-respiratory fitness in patients with systolic heart failure.
- Trial name
- NCT02862067
- Testing
- Assessment of cardiorespiratory fitness
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Virginia Commonwealth University
Metastatic Brain Tumor, Cerebral Metastases
Impact of Cognitive Rehab and Physical Activity on Cognition in Patients With Metastatic Brain Tumors Undergoing RT
To determine the feasibility of processes and instruments with an overarching purpose to guide the design of a larger study. To determine the feasibility of individuals with metastatic brain tumor(s) to engage in physical…
- Trial name
- NCT03096431
- Testing
- Physical Activity, Cognitive rehabilitation
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Virginia Commonwealth University
Obesity
Pilot Study of Laparoscopic Gastric Plication in Adolescents With Severe Obesity
The proposed study aims to investigate the effects of laparoscopic gastric plication (LGP) on excess body weight, body mass index, and weight-related medical and psychological co-morbidities in obese adolescents.
- Trial name
- NCT01980758
- Testing
- Laparoscopic Gastric Plication
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Virginia Commonwealth University
Multiple Myeloma
Lenalidomide + Azacitidine for Adaptive Immunotherapy -> Auto SCT in Multiple Myeloma
RATIONALE: Lenalidomide may stimulate the immune system in different ways and stop cancer cells from growing. Drugs used in chemotherapy, such as azacitidine, work in different ways to stop the growth of cancer cells, either by…
- Trial name
- NCT01050790
- Testing
- Azacitidine
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Virginia Commonwealth University
Heart Failure With Normal Ejection Fraction
Interleukin-1 Blockade in HF With Preserved EF
Heart Failure with Preserved Ejection Fraction (HFpEF) is a common form of heart failure Standard treatment for heart failure, show less than ideal results in HFpEF Evidence of systemic inflammation is common in all forms of…
- Trial name
- D-HART2 (NCT02173548)
- Testing
- Anakinra
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Virginia Commonwealth University
Occupational Injuries
Effects of an OT Workstation Intervention on Knowledge, Self-efficacy, and Habit Formation
The study aims to determine whether a face to face ergonomic workstation intervention has any advantage over an online instructional training program for acquisition of knowledge, self-efficacy, and habit formation.
- Trial name
- NCT03174262
- Testing
- Ergonomic Computer Workstation Training
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Health Care Utilization, Primary Care Physician
Incentives for Primary Care Use in a Safety Net Setting
A randomized controlled trial (RCT) of incentives for an initial primary care visit within 6 months of enrollment in a health care coverage program.
- Conditions
- Health Care Utilization, Primary Care Physician, Uninsured
- Trial name
- NCT02922855
- Testing
- 0 dollars group, 50 dollars group, 25 dollars group
- Volunteers
- 1,228 people
- Sponsor
- Virginia Commonwealth University
Pregnancy
Centering Pregnancy Care + Yoga for Diverse Pregnant Women
This is a pilot longitudinal mixed-methods study of pregnant women (n=20) who participate in CPC+Y at the VCU Health System Nelson Clinic or the Virginia Department of Health Richmond Health District's prenatal clinic (RHD)…
- Trial name
- CPC+Y (NCT02873481)
- Testing
- Centering Pregnancy Care plus Yoga (CPC+Y)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Neuropathic Pain
The Role of N-acetyl-l-cysteine (NAC) as an Adjuvant to Opioid Treatment in Patients With Chronic Neuropathic Pain
This study will test whether treatment with N-acetyl-L-cysteine (NAC) is safe and decreases pain in patients with chronic neuropathic pain.
- Trial name
- NCT01840345
- Testing
- N-acetyl-l-cysteine
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Virginia Commonwealth University
Chronic Venous Insufficiency
Radiofrequency Ablation vs Laser Ablation of the Incompetent Greater Saphenous Vein
The aim of this study is to perform a randomized, prospective trial comparing the two current methods of treatment for chronic venous insufficiency, in an effort to evaluate complications and outcomes for each method, and…
- Trial name
- NCT02236338
- Testing
- Ablation of the Incompetent Greater Saphenous Vein, ClosureFAST radiofrequency catheter, EVLT 980nm diode laser system
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Virginia Commonwealth University
Nicotine Exposure, Nicotine Withdrawal Suppression
The Effect of Electronic Cigarette (ECIG) Liquid Vehicles on ECIG Acute Effects
This study examines the acute effects in ECIG users of the two primary vehicles in ECIG liquids, propylene glycol and vegetable glycerin.
- Trial name
- NCT02500615
- Testing
- ECIG liquid vehicles
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Cesarean Section, Obstetric Anesthesia
Dose and Response of Intrathecal Hydromorphone in Patients Undergoing Cesarean Section at Virginia Commonwealth University Health System
In the United States the incidence of cesarean deliveries have increased over the last several decades and is currently approximately 30% nationwide. The anesthesia and analgesia for elective c-sections vary between institutions.
- Trial name
- NCT02787928
- Testing
- Intrathecal hydromorphone
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Virginia Commonwealth University
Pregnancy Related
The Lullaby Project: A Musical Intervention for Pregnant Women
This study will evaluate the potential impact of a brief musical intervention, the Lullaby Project, in a sample of pregnant women. The study aims are: 1.
- Trial name
- NCT03207919
- Testing
- Lullaby Project
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Virginia Commonwealth University