Clinical trials: sponsored by Virginia Commonwealth University
ST Segment Elevation Acute Myocardial Infarction
Anakinra to Prevent Post-infarction Remodeling
Thousands of patients die daily from early and late complications of a heart attack (acute myocardial infarction, AMI). Patients surviving AMI remain at high risk of death from adverse cardiac remodeling (dysfunction and…
- Trial name
- VCU-ART (NCT00789724)
- Testing
- Anakinra
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Virginia Commonwealth University
Heart Failure
Pilot Study of the Safety and Efficacy of Anakinra (Recombinant Human Interleukin-1 Receptor Antagonist) in Heart Failure
This is an open-label, non-randomized, pilot-study to evaluate the effect of Interleukin-1 blockade on exercise capacity in patients with heart failure.
- Trial name
- NCT01300650
- Testing
- Anakinra
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Virginia Commonwealth University
Violence, Non-accidental
Violence Prevention Study for Youth Age 10-15
This study will evaluate the effectiveness of a hospital-community based violence prevention pilot study designed to increase protective factors and reduce negative risk factors associated with violence of children aged 10-15.
- Trial name
- NCT02393092
- Testing
- Brief Violence Awareness, Brief Violence Prevention, Emerging Leaders: East End curriculum
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- Virginia Commonwealth University
Healthy
Lorazepam, Diphenhydramine Hydrochloride, and Haloperidol Gel in Healthy Volunteers
RATIONALE: Lorazepam, diphenhydramine hydrochloride, and haloperidol gel, when absorbed into the skin, may be an effective treatment for nausea and vomiting.PURPOSE: This clinical trial studies lorazepam, diphenhydramine…
- Trial name
- NCT01204255
- Testing
- lorazepam, diphenhydramine hydrochloride, haloperidol
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Laryngeal Mask Airway, Tonsillectomy
Use of Laryngeal Mask Airway in Pediatric Adenotonsillectomy
The aim of the current study is to compare the use of laryngeal mask airway (LMA) and endotracheal tube (ETT) in pediatric adenotonsillectomy.
- Trial name
- NCT01141660
- Testing
- Endotracheal Tube, Laryngeal mask airway
- Where
- United States
- Volunteers
- 131 people
- Sponsor
- Virginia Commonwealth University
Pulmonary Hypertension
Pilot Study of the Safety and Efficacy of Anakinra (Recombinant Human Interleukin-1 Receptor Antagonist) in Pulmonary Hypertension
This is an open-label non-randomized, pilot study to evaluate the effect of Interleukin-1 blockade on exercise capacity in patients with pulmonary hypertension.
- Trial name
- NCT01479010
- Testing
- Anakinra 100 mg subcutaneously daily
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Virginia Commonwealth University
Traumatic Brain Injury, Acquired Brain Injury
Evaluation of a Skill-Building, Supportive, and Educational Intervention for Couples
1. To evaluate the efficacy of a structured outpatient couples intervention program (Therapeutic Couples Intervention, TCI) on couples' marital quality after acquired brain injury (ABI). 2.
- Trial name
- NCT01935609
- Testing
- Couples counseling
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Virginia Commonwealth University
Vestibular, Performance
VOR Suppression in Non-Gymnast Adults
The researchers hypothesize that there is a correlation between Vestibulo-ocular reflex (VOR) performance and innate athletic skill level.
- Trial name
- NCT03227718
- Testing
- VOR and coordination measurements
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Patellofemoral Pain Syndrome
Botox for Non-surgical Lateral Release in Patellofemoral Pain
The purpose of this study is to determine whether the use of botulinum toxin A injected into the lateral thigh muscle improves knee function and reduces knee pain secondary to patellofemoral syndrome.
- Trial name
- NCT00496964
- Testing
- Botulinum toxin A + exercise
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Virginia Commonwealth University
Prostate Cancer, Prostate Adenocarcinoma
MRI-Based Active Surveillance to Avoid the Risks of Serial Biopsies in Men With Low-Risk Prostate Ca
Phase II non-inferiority randomized trial of annual systematic biopsies versus mpMRI and targeted biopsies for men with low risk prostate cancer on active surveillance with any volume Gleason's Score 6, but no prior MRI imaging…
- Conditions
- Prostate Cancer, Prostate Adenocarcinoma, Multiparametric MRI, Gleason's Score 6
- Trial name
- NCT02564549
- Testing
- TRUS-guided biopsy, mpMRI with targeted biopsy
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Virginia Commonwealth University
Traumatic Brain Injury
A Culturally Sensitive Intervention for TBI Caregivers in Latin America
Traumatic brain injury (TBI) patients in Latin America experience high levels of disability and extremely poor functional outcomes, and their informal caregivers play a key role in their rehabilitation and care.
- Trial name
- NCT02207803
- Testing
- Transition Assistance Program
- Where
- 3 sites in Colombia, Mexico
- Volunteers
- 250 people
- Sponsor
- Virginia Commonwealth University
Ambulatory Surgery
REducing Anxiety in CHildren Undergoing Procedures
This is a small pilot, feasibility study designed as a quality improvement project. The purpose is to identify anxiety in children aged 4-12 years who will receive a sedated procedure and to see if the use of an iPad as a focused…
- Trial name
- REACH-UP! (NCT03054077)
- Testing
- iPad with downloaded games
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
PCOS
Pilot Study:Role of Dietary Fiber in PCOS Anovulation
The purpose of this study is to determine whether 6 months of fiber supplementation will improve ovulation in women with polycystic ovary syndrome (PCOS).
- Trial name
- NCT00703092
- Testing
- Fiber-Stat
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Cardiac Arrest, Reperfusion Injury
Intestinal Ischemia as a Stimulus for Systemic Inflammatory Response After Cardiac Arrest
Out-of-hospital cardiac arrest (CA) is a leading public health problem causing nearly one third of a million deaths annually in the US, accounting for half of all cardiovascular deaths and surpassing deaths from stroke, heart…
- Trial name
- TICA (NCT01944605)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Virginia Commonwealth University
Traumatic Brain Injury
Intervention to Promote Survivor Resilience and Adjustment: Efficacy Evaluation
1. To evaluate the short and longer-term efficacy of a structured outpatient intervention program (The Resilience and Adjustment Intervention, RAI) to improve survivors' resilience. 2.
- Trial name
- NCT01935583
- Testing
- Resilience/Adjustment Counseling
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- Virginia Commonwealth University
Pregnancy Related, Contraception
Effectiveness of Shortened Time Interval to Postpartum Visit in Improving Postpartum Attendance
Due to potential to improve family planning, clinicians are increasingly interested in shortening the time to postpartum visits, but lack an evidence base to change policy.There are no studies that have examined the effectiveness…
- Conditions
- Pregnancy Related, Contraception, Contraception Behavior, Contraception Use
- Trial name
- NCT03165838
- Testing
- Postpartum Visit 3-4 Weeks, Postpartum Visit 6-8 Weeks
- Volunteers
- 364 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Heart Failure
Implantable Cardioverter Defibrillator (ICD) Function During Ventricular Assist Device (VAD) Implantation
The purpose of this research study is to test the function of a subjects implantable cardioverter defibrillator (ICD) function throughout the duration of their heart surgery.
- Trial name
- NCT01576562
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Virginia Commonwealth University
Attention-Deficit/Hyperactivity Disorder (ADHD)
Efficacy of an Organizational Skills Intervention for Middle School Students With ADHD
Attention-Deficit/Hyperactivity Disorder (ADHD) is one of the most commonly diagnosed childhood disorders, with prevalence rates estimated at 8%.
- Trial name
- NCT02150668
- Testing
- Homework, Organization, and Planning Skills (HOPS) Intervention, Homework Support Intervention (HSI)
- Where
- United States
- Volunteers
- 260 people
- Sponsor
- Virginia Commonwealth University
Adenocarcinoma of the Prostate
High Dose-Rate Brachytherapy and/or Intensity Modulated External Beam Radiation Therapy for Prostate Cancer
The principal objective of this study is to demonstrate that patients can safely receive combined High Dose Rate brachytherapy and Intensity-Modulated Radiation Therapy without experiencing a treatment limiting toxicity.
- Trial name
- NCT00243321
- Testing
- high dose-rate brachytherapy, intensity-modulated radiation therapy
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Virginia Commonwealth University
Resistant Hypertension in Kidney Transplant Patients
The Management of Resistant Hypertension in Kidney Transplant Patients Using Chlorthalidone
Chlorthalidone might offer an effective, safe and inexpensive anti-hypertensive treatment for kidney transplant patients who have resistant hypertension on multi-drug therapy.
- Trial name
- NCT02030314
- Testing
- Chlorthalidone
- Where
- United States
- Sponsor
- Virginia Commonwealth University