Clinical trials: sponsored by Virginia Commonwealth University
PCOS
Insulin and Polycystic Ovary Syndrome
Increased insulin levels leads to increased secretion of D-chiro inositol(DCI) from the kidneys in women with PCOS, but not in normal women.
- Trial name
- NCT00683774
- Testing
- diazoxide
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Polycystic Ovary Syndrome
Pharmacogenetics of Metformin Action in PCOS
1. The polycystic ovary syndrome is the major cause of infertility in the United States. Metformin has been shown to increase frequency of ovulations in PCOS, and is used in clinical practice to treat infertility, but some women…
- Trial name
- NCT00703508
- Testing
- Metformin 500 mg tablet
- Where
- 2 sites in United States
- Volunteers
- 55 people
- Sponsor
- Virginia Commonwealth University
Low Back Pain
Trial of Scrambler Therapy or Sham Treatment for Low Back Pain
This pilot study will evaluate Scrambler therapy and Sham treatment on levels of low back pain, pain sensitivity and mRNA expression of pain sensitivity candidate genes.
- Trial name
- NCT01896687
- Testing
- Scrambler
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Virginia Commonwealth University
HIV
Pilot Study of Oral Probiotic Bacteria Supplementation to Reduce Chronic Immune Activation in HIV-infected Malian Women
The composition of the intestinal bacterial flora effects gut immunologic function and intestinal barrier integrity. HIV infection impairs gut immune and epithelial function resulting in an altered gut bacterial flora and…
- Trial name
- NCT02448238
- Testing
- VSL#3® probiotic
- Where
- Mali
- Volunteers
- 23 people
- Sponsor
- Virginia Commonwealth University
Substance Use
Motivational Interviewing Integrated With Social Network Counseling for Teens
The purpose of this research is to test the feasibility and efficacy of a brief (one session) preventative intervention using motivational interviewing integrated with social network counseling for substance use among adolescent…
- Trial name
- NCT01922947
- Testing
- Motivational Interviewing w/Social Network Counseling, Active Control Condition
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Virginia Commonwealth University
Non-alcoholic Fatty Liver Disease, NAFLD
Autonomic Dysfunction in Non-Alcoholic Fatty Liver Disease
There is a significant association between autonomic dysfunction and symptoms experienced by NAFLD patients mediated by increased systemic inflammation and insulin resistance, resulting in deteriorating quality of life of…
- Conditions
- Non-alcoholic Fatty Liver Disease, NAFLD, Fatty Liver, Nonalcoholic, Nonalcoholic Fatty Liver Disease
- Trial name
- AD-NAFLD (NCT02132780)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Virginia Commonwealth University
Pulmonary Arterial Hypertension
Pilot Study of the Safety and Efficacy of Carvedilol in Pulmonary Arterial Hypertension
The purpose of this study is to determine whether carvedilol treatment of patients with pulmonary arterial hypertension and associated right heart failure is safe and results in an improved function of the right heart.
- Trial name
- NCT00964678
- Testing
- Carvedilol
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Virginia Commonwealth University
Chemotherapeutic Agent Toxicity, Neurotoxicity
Electrical Stimulation Therapy Using the MC5-A Scrambler in Reducing Peripheral Neuropathy Caused by Chemotherapy
RATIONALE: Electronic stimulation using a MC5-A Scrambler may help relieve pain in patients who develop peripheral neuropathy while undergoing chemotherapy treatments for cancer.
- Conditions
- Chemotherapeutic Agent Toxicity, Neurotoxicity, Pain, Peripheral Neuropathy
- Trial name
- NCT00952848
- Testing
- questionnaire administration, Sensory Neuropathy Scale instrument, Quality of Life instrument
- Volunteers
- 18 people
- Sponsor
- Virginia Commonwealth University
Cocaine Dependence
Caffeine and Cocaine
This study is being done to find out if medicines that affect a neurotransmitter (chemical messenger) in the brain called adenosine improve behavioral problems that are related to drug abuse.
- Trial name
- NCT00733993
- Testing
- Caffeine 150 MG, Amphetamine, Caffeine 300 MG
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Fatty Liver, Cirrhosis
Development of a Breath Test for Monitoring Patients With Liver Disease
The purpose of this study is to determine the safety and efficacy of the Oridion Breath ID machine in monitoring liver metabolic functions.
- Trial name
- NCT00244569
- Testing
- 13C-Methacetin, Breath ID Machine
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Virginia Commonwealth University
Hepatitis C
Trial of Peg-interferon Plus Epoetin-alfa for Treatment of Chronic Hepatitis C Virus Infection
The purpose of this study is to determine if the use of epoetin-alpha will allow patients with chronic hepatitis C virus infection to be treated with higher doses of peginterferon-alpha-2b and ribavirin, thus increasing chances…
- Trial name
- NCT00248339
- Testing
- Peginterferon-alpha-2b (PEG-Intron), Ribavirin, Epoetin-alpha (Procrit)
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Virginia Commonwealth University
Hepatitis C, Cirrhosis
Peginterferon Alpha-2a Maintenance Therapy for Portal Hypertension in Patients With Hepatitis C
The primary purpose of this study is to determine if peginterferon alpha-2a maintenance therapy (90 mcg/week) will lower portal pressure in patients with hepatitis C virus infections and advanced fibrosis or cirrhosis.
- Conditions
- Hepatitis C, Cirrhosis, Fibrosis
- Trial name
- NCT00252642
- Testing
- Peginterferon Alpha-2a
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Virginia Commonwealth University
Dermatitis, Atopic
Histamine Pharmacogenetics in Children With Atopic Dermatitis
The primary goal of the study is to investigate the impact of a common genetic polymorphism in a histamine detoxification enzyme that may well have a common role in regulating the expression of atopic dermatitis (AD) and other…
- Trial name
- NCT00277433
- Testing
- Buccal Swab
- Where
- 7 sites in United States
- Volunteers
- 751 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Chronic Rejection
New Strategies for Non-invasive Detection of Chronic Allograft Nephropathy
The purpose of this study is to help researchers find out more about a condition called "Chronic Allograft Nephropathy" (CAN). CAN is a complication that sometimes occurs after kidney transplantation and affects the function of…
- Trial name
- NCT00283348
- Where
- United States
- Volunteers
- 121 people
- Sponsor
- Virginia Commonwealth University
TBI (Traumatic Brain Injury)
Pharmacological Intervention in Depression After Traumatic Brain Injury
The purpose of this study is to determine if treatment with venlafaxine reduces symptoms of depression in persons with traumatic brain injury.
- Trial name
- NCT00205491
- Testing
- Venlafaxine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Virginia Commonwealth University
Traumatic Brain Injury
Acute Cognitive and Neurobehavioral Intervention: Efficacy Evaluation
To learn more about behavior and everyday functioning after brain injury, and to learn if behavior and functioning gets better with more education about changes after brain injury.
- Trial name
- NCT00205569
- Testing
- First Steps Educational Curriculum
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- Virginia Commonwealth University
Pediatric Obesity
Evaluation of a Family-based Pediatric Obesity Program: TEENS+
Investigators propose to pilot an adolescent obesity intervention, TEENS+, to examine the feasibility of this dietary intervention strategy and preliminary effectiveness of two models of parental involvement within adolescent…
- Trial name
- NCT02262013
- Testing
- Parents as Coaches, Parent Weight Loss
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Heart Failure
Pilot Feasibility Study of the Safety and Efficacy of Anakinra in Heart Failure With Preserved Ejection Fraction
This will be a randomized, double-blind, crossover pilot study to measure the safety and feasibility of Interleukin-1 (IL-1) blockade with Anakinra in patients with stable heart failure with preserved ejection fraction.
- Trial name
- NCT01542502
- Testing
- Anakinra
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Virginia Commonwealth University
Gastrointestinal Bleeding
Safety Study of Octreotide Injection to Prevent GI Bleeding in Patients With Left Ventricular Assist Device (LVAD)
The investigators hypothesize that octreotide LAR (Long Acting Release) safely decreases GI bleeding in patients with a left ventricular assist device (LVAD).
- Trial name
- NCT01707225
- Testing
- Octreotide LAR Depot
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Virginia Commonwealth University
Parkinson's Disease, Levodopa
Erythromycin in Parkinson's Disease
Gastroparesis (slow stomach emptying) is a common feature of Parkinson's Disease. Levodopa (Sinemet), a common medication for Parkinson's Disease, can make gastroparesis worse.
- Trial name
- NCT02005029
- Testing
- Erythromycin
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Virginia Commonwealth University