Clinical trials: sponsored by Virginia Commonwealth University
Acute Myocardial Infarction, Heart Failure
Anakinra to Prevent Adverse Post-infarction Remodeling (2)
Acute myocardial infarction (AMI) remains a major cause of morbidity and mortality. Many patients die early during the course, and those who survive are at risk for dying late from adverse cardiac remodeling and heart failure.
- Trial name
- VCU-ART2 (NCT01175018)
- Testing
- Anakinra
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Virginia Commonwealth University
Alcohol Dependence
Study of Acamprosate to Prevent Alcohol Relapse in Criminal Justice Supervisees
The purpose of this study is to test how tolerable and effective acamprosate is when used to prevent alcohol relapse in criminal justice supervisees (those on probation, parole, or in drug court).
- Trial name
- NCT00249379
- Testing
- Acamprosate
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Virginia Commonwealth University
Heart Failure
Interleukin (IL)-1 Blockade in Acute Heart Failure (Anakinra ADHF)
Anakinra ADHF is a double-blind randomized clinical trial of anakinra, recombinant human interleukin-1 receptor blocker, or placebo in patients with acute decompensated heart failure with the aim to quench the acute inflammatory…
- Trial name
- NCT01936844
- Testing
- Anakinra (high dose), Anakinra (standard dose)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Virginia Commonwealth University
Non-small Cell Lung Cancer
Gated Intensity Modulated Radiation Therapy and Concurrent Chemotherapy for Inoperable NSCLC
Radiation therapy technology that allows increased radiation dose to the tumor while sparing healthy tissue will improve the balance between complications and cure.
- Trial name
- NCT00692380
- Testing
- Fractionated radiation therapy followed by chemotherapy
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Virginia Commonwealth University
Hemophilia A, Hemophilia B
Correlation Between Vitamin D Status and Bone Mineral Density in Patients With Hemophilia
Study will look at baseline Vitamin D levels, calcium, albumin, liver enzymes, testosterone, osteocalcin, urine N telopeptides, bone mineral density, nutritional assessment and physical activity assessment of boys with hemophilia…
- Conditions
- Hemophilia A, Hemophilia B, Vitamin D Deficiency
- Trial name
- NCT01090206
- Testing
- Vitamin D and calcium
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Virginia Commonwealth University
Acute Lymphocytic Leukemia, Acute Myeloid Leukemia
Belinostat and Bortezomib in Treating Patients With Relapsed or Refractory Acute Leukemia or Myelodysplastic Syndrome
RATIONALE: Belinostat and bortezomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Giving belinostat together with bortezomib may kill more cancer cells.
- Conditions
- Acute Lymphocytic Leukemia, Acute Myeloid Leukemia, Myelodysplastic Syndrome, Chronic Myelogenous Leukemia
- Trial name
- NCT01075425
- Testing
- bortezomib, belinostat, laboratory biomarker analysis
- Where
- 2 sites in United States
- Volunteers
- 41 people
- Sponsor
- Virginia Commonwealth University
Alcohol Withdrawal Syndrome
Treatment of Alcohol Withdrawal in Hospital Patients
The purpose of this study is to test how tolerable and effective lorazepam is when used to treat alcohol withdrawal in hospital patients at risk for alcohol withdrawal.
- Trial name
- NCT00249366
- Testing
- Lorazepam (drug), Lorazepam
- Where
- United States
- Volunteers
- 183 people
- Sponsor
- Virginia Commonwealth University
Blood Disease, Anemia, Sickle Cell
Pain in Sickle Cell Epidemiologic Study
To measure the variability in pain and response to pain in sickle cell disease, and to build multivariate models to explain both patients' pain and their response to pain, especially, utilization of health care.
- Trial name
- NCT00035763
- Sponsor
- Virginia Commonwealth University
Atrial Fibrillation
Recording for Potential AF Drivers and Patient Specific Atrial Anatomy & Atrial Electrogram Maps
The 64 pole basket catheter used for the mapping procedure will be defined "atypical" sites which sustain atrial fibrillation. The ablation through the driver will lead to more rapid ablation of the atrial fibrillation.
- Trial name
- CONFIRM (NCT01581437)
- Testing
- 64 pole basket catheter
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Virginia Commonwealth University
Cardiovascular Diseases, Heart Diseases
Longitudinal Twin Study - Cohort Study of Blood Pressure
To analyze the genetic and environmental contributions of juvenile hemodynamic determinants of blood pressure, including cardiac output and systemic vascular pressure, to adult cardiovascular risk.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension
- Trial name
- NCT00005161
- Sponsor
- Virginia Commonwealth University
Chronic Pancreatitis
Nerve Growth Factor in Chronic Pancreatitis
This study is to understand the role of nerve growth factor(NGF) and other cytokines in the pancreatic fluid of patients with chronic pancreatitis. Hypothesis: 1.
- Trial name
- NCT01255917
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Virginia Commonwealth University
Cardiovascular Diseases, Heart Diseases
Gender Differences in Familial Risk
To develop, test, and apply comprehensive mathematical models for the interaction of genetic and environmental effect on cardiovascular risk with gender differences.
- Trial name
- NCT00005355
- Sponsor
- Virginia Commonwealth University
Myelodysplastic Syndrome
5-Azacytidine Prior to Allogeneic Stem Cell Transplant in High Risk Myelodysplastic Syndrome
The purpose of this study is to examine the feasibility and efficacy of using the demethylating agent 5-Azacytidine prior to allogeneic stem cell transplantation in patients with high risk myelodysplastic syndrome (MDS).
- Trial name
- NCT00721214
- Testing
- 5-azacytidine
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Virginia Commonwealth University
Cardiovascular Diseases, Hypertension
Genetic Epidemiology--Development of Cardiovascular Risk
To determine how genetic and environmental factors influence the co-occurrence of obesity and hypertension during development and to identify cardiovascular risk factors in adolescence that will predict cardiovascular disease in…
- Conditions
- Cardiovascular Diseases, Hypertension, Obesity, Heart Diseases
- Trial name
- NCT00005512
- Sponsor
- Virginia Commonwealth University
Alcoholism, Respiration, Artificial
Pilot Study Evaluating Stress Response and Immune Function in Mechanically Ventilated Patients With Alcohol Use Disorders Treated With Propofol or Midazolam
The aim of this study is to evaluate the effects of the sedatives propofol and midazolam on stress response and immune function in critically ill patients with alcohol use disorders who are undergoing mechanical ventilation.
- Trial name
- NCT00871039
- Testing
- Propofol, Midazolam
- Where
- 2 sites in United States
- Sponsor
- Virginia Commonwealth University
Cardiovascular Diseases, Heart Diseases
Childhood Passive Smoking: Cohort Study of Cardiac Risk
To determine the effects of long-term exposure to passive smoking on the cardiovascular and oxygen transport systems in pre-adolescent twins.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Lung Diseases, Coronary Arteriosclerosis
- Trial name
- NCT00005242
- Sponsor
- Virginia Commonwealth University
Symptomatic Osseous Bone Lesions From Any Malignancy
Compassionate Same-Day Evaluation & Delivery of XRT for Bony Metastasis in Hospice Patients
This is a survey study to evaluate the feasibility and effectiveness of an affordable, $400 flat rate, same-day consultation, simulation, and delivery of a single fraction of palliative radiation therapy for patients with…
- Trial name
- NCT01760941
- Testing
- Radiation Therapy, Quality-of-Life Assessment, Survey Administration
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Virginia Commonwealth University
Obesity
Motivational Interviewing for Weight Loss With Young Adults
This study is a 2-arm randomized controlled trial to evaluate the feasibility, acceptability and preliminary efficacy of an MI-based program for weight loss in young adults.
- Trial name
- LiveWellRVA (NCT01899625)
- Testing
- Brief Behavioral Weight Loss (BWL), Motivation Enhanced BWL
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Virginia Commonwealth University
Basal Energy Expenditure, Spasticity
Energy Costs of Spasticity in Spinal Cord Injury: A Pilot Investigation
The purpose of this study is to determine if there is a relationship between spasticity and relative changes in Basal Energy Expenditure in persons with spinal cord injury.
- Trial name
- NCT00572845
- Testing
- Weaning of Antispasticity Medication
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Unspecified Adult Solid Tumor
Pemetrexed Disodium and Sorafenib Tosylate in Treating Patients With Advanced Solid Tumors
This phase I trial studies the side effects and best dose of giving pemetrexed disodium and sorafenib tosylate together in treating patients with advanced solid tumors.
- Trial name
- NCT01450384
- Testing
- sorafenib tosylate, pemetrexed disodium, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Virginia Commonwealth University