Clinical trials: sponsored by Virginia Commonwealth University
Shock, Hemorrhagic
Pre-Hospital Use of Plasma for Traumatic Hemorrhage
Type A Thawed Plasma (TP) will be compared in polytrauma patients who receive only Normal Saline (NS) (standard of care) before arrival at the hospital.
- Trial name
- PUPTH (NCT02303964)
- Testing
- Plasma, Normal saline
- Where
- United States
- Sponsor
- Virginia Commonwealth University
Acute Myocardial Infarction
Alpha-1 Anti-Trypsin (AAT) Treatment in Acute Myocardial Infarction
Acute myocardial infarction is characterized by an intense inflammatory response. The degree of the response influences clinical outcome, with 'more' inflammation promoting heart failure.
- Trial name
- VCU-Alpha1RT (NCT01936896)
- Testing
- Alpha 1-Antitrypsin
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Virginia Commonwealth University
Pediatric Obesity, Impact of Parent Intervention on Adolescent Weight Loss
Study of a Structured Parent Intervention on Adolescent Weight Loss Modification Program.
The study will enroll 110 overweight and obese adolescents ages 11-16 in a lifestyle modification program focusing on dietary modification and exercise.
- Trial name
- NCT02086851
- Testing
- Lifestyle Intervention, Parent Motivational Interviewing
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Cancer, Chronic Insomnia
CBT-I Intervention for Insomnia in Newly Diagnosed Cancer Patients
To determine the efficacy of a CBT-I intervention in improving sleep and other quality of life outcomes during cancer treatment.
- Trial name
- NCT02410564
- Testing
- cognitive behavioral therapy for insomnia (CBTI), Waitlist control condition
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Virginia Commonwealth University
Congestive Heart Failure, Cardiorenal Syndrome
Nesiritide and Renal Function After the Total Artificial Heart
The prevalence of renal dysfunction after implantation of the artificial heart is high. The infusion of exogenous B-type natriuretic peptide (BNP) after implantation of the total artificial heart (TAH) improves renal function in…
- Trial name
- NCT01836809
- Testing
- nesiritide
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Virginia Commonwealth University
Lung Cancer
4D Image-guided Adaptive Radiotherapy for Lung Cancer: Patient Image Acquisition
This clinical trial studies 4-dimensional (4-D) image-guided radiation therapy treatment planning in patients with stage I-IV non-small cell lung cancer.
- Trial name
- NCT01018147
- Testing
- 4-dimensional computed tomography
- Volunteers
- 22 people
- Sponsor
- Virginia Commonwealth University
Infection, Renal Dysfunction
Identification of Gene and Protein Markers of Kidney Injury in Aminoglycoside-treated Children
The purposes of this study are to identify potential gene and protein markers of aminoglycoside-induced kidney injury in infants, children and adolescents treated with aminoglycoside antibiotics.
- Trial name
- NCT00308906
- Testing
- aminoglycoside
- Where
- 2 sites in United States
- Volunteers
- 166 people
- Sponsor
- Virginia Commonwealth University
Cancer Survivors
Stress Management for Cancer Survivors
Determine the efficacy of a brief and inexpensive psychosocial intervention, (called expressive writing) in improving health outcomes for cancer survivors.
- Trial name
- NCT01888523
- Testing
- Expressive writing, Everyday experiences writing
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Virginia Commonwealth University
Obesity
Wellness Engagement Project, Petersburg
This study tests the feasibility of a health and wellness trial designed with community input. This 12-week program will be tested over a 24-week period using a delayed treatment control group.
- Trial name
- WE (NCT02652845)
- Testing
- Wellness Engagement Program
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Parkinson's Disease, Mild Cognitive Impairment
A Trial of Neurocognitive and Supportive Therapy Interventions for Individuals With Parkinson's Disease
This randomized, controlled trial (RCT) evaluates the benefits of memory and problem solving training compared to supportive therapy in individuals with Parkinson's Disease with Mild Cognitive Impairment (MCI) and their support…
- Trial name
- NCT01646333
- Testing
- Memory and Problem-Solving Intervention, Supportive Therapy
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Virginia Commonwealth University
Type 1 Diabetes
Prevention of Self-care Deterioration in Early Adolescents With Diabetes
Establish the efficacy of a brief, clinic-based prevention program of teamwork coping skills for youth and their parents during in a high risk period of early adolescence (11-14 yrs) when parental involvement and self-care…
- Trial name
- NCT00890331
- Testing
- TeamWork CS Sessions, Diabetes Education
- Where
- 2 sites in United States
- Volunteers
- 285 people
- Sponsor
- Virginia Commonwealth University
Parkinson's Disease, Mild Cognitive Impairment
Computer-based Cognitive Training for Individuals With Parkinson's Disease
Computer-Based Cognitive Training for Individuals with Parkinson's Disease" is a 3-arm randomized controlled trial (RCT) comparing Brain Fitness, InSight, and an active control (AC) training program to evaluate the feasibility of…
- Trial name
- NCT02225314
- Testing
- Brain Fitness, InSight, Active Control
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Virginia Commonwealth University
Shoulder Impingement Syndrome
Exercise and Manual Therapy for Shoulder Subacromial Impingement Syndrome
The purposes of this study are to: 1. determine if a rehabilitation program that consists of exercise and manual therapy reduces pain and improves quality of life in patients with shoulder subacromial impingement syndrome; 2.
- Trial name
- NCT00632996
- Testing
- Rehabilitation
- Where
- United States
- Volunteers
- 162 people
- Sponsor
- Virginia Commonwealth University
Smoking
Evaluation of a Computer-Delivered 5 A's Intervention for Smoking
This is a 2-group RCT in 380 tobacco-using medical patients that will compare a single session, computer-directed 5 A's intervention for smoking (experimental condition) to screening and resource provision (control condition).
- Trial name
- NCT01383278
- Testing
- Computer-directed 5 A's intervention for smoking, Screening and resource provision
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Virginia Commonwealth University
Depression, Traumatic Brain Injury
Exercise Training in Depressed Traumatic Brain Injury Survivors
The purpose of this study is to determine the feasibility of successfully delivering moderate intensity aerobic exercise training to depressed traumatic brain injury subjects between one and three years after injury.
- Trial name
- NCT01805479
- Testing
- aerobic exercise, stretching and flexibility program
- Where
- United States
- Sponsor
- Virginia Commonwealth University
Polycystic Ovary Syndrome, Insulin Resistance
Insulin Resistance Before and During Pregnancy in Women With Polycystic Ovary Syndrome
The polycystic ovary syndrome (PCOS) affects about 10% of reproductive-age women. Women with PCOS are at a higher risk of gestational diabetes, which may lead to more pregnancy complications.
- Conditions
- Polycystic Ovary Syndrome, Insulin Resistance, Insulin Sensitivity, Obesity
- Trial name
- NCT01475565
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Virginia Commonwealth University
Drug/Agent Toxicity by Tissue/Organ, Leukemia
High-Dose Cytarabine Plus Deoxycytidine in Treating With Acute Myelogenous Leukemia or Other Hematologic Malignancies
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Deoxycytidine may protect patients from the side effects of high-dose cytarabine.
- Conditions
- Drug/Agent Toxicity by Tissue/Organ, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00002818
- Testing
- cytarabine, deoxycytidine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Virginia Commonwealth University
Polycystic Ovary Syndrome (PCOS)
Blood Vessel Function in Adolescents and Women With Polycystic Ovary Syndrome
The purpose of this study is to determine if changes in blood vessel health lead to the menstrual irregularities that women with PCOS experience.
- Trial name
- NCT01615562
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Endocarditis
Retrospective Review of Management of Infective Endocarditis
This is an analysis of the outcomes of patients having undergone surgical intervention for infective endocarditis.
- Trial name
- NCT00579761
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Kidney Cancer, Melanoma (Skin)
Interleukin-2 Plus Bryostatin 1 in Treating Patients With Melanoma or Kidney Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Interleukin-2 may stimulate a person's white blood cells to kill tumor cells.
- Trial name
- NCT00006022
- Testing
- aldesleukin, bryostatin 1
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- Virginia Commonwealth University