Clinical trials: sponsored by Virginia Commonwealth University
Amyloidosis, Hereditary
Southeastern ATTR Amyloidosis Consortium: SEATTRAC Family Registry
The study design is a prospective registry including asymptomatic and symptomatic patients who carry a pathogenic TTR mutation. The study will enroll patients who meet the inclusion criteria and none of the exclusion criteria…
- Trial name
- NCT05974644
- Testing
- Registry
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Virginia Commonwealth University
Left Branch Bundle Block, RV - Right Ventricular Abnormality
Functional Outcomes in CondUction System Pacing and Right Ventricular Synchrony (FOCUS-Right)
The goal of this prospective single center clinical trial is to evaluate the safety and feasibility of performing simultaneous exercise stress cardiac magnetic resonance (CPET-CMR) and cardiopulmonary exercise testing in patients…
- Trial name
- FOCUS-Right (NCT06601322)
- Testing
- Pacemaker Interrogation and Electrocardiogram (ECG):, Cardiopulmonary Exercise Test (CPET) and Exercise Stress Cardiac Magnetic Resonance (ExeCMR, Continuous pacemaker telemetry (CPT)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Virginia Commonwealth University
Congenital Myotonic Dystrophy, Childhood Myotonic Dystrophy
Trial Readiness and Endpoint Assessment in Pediatric Myotonic Dystrophy Extension
This is a natural history study to improve the types of assessments and biological samples that will be used in clinical drug trials in both congenital myotonic dystrophy and childhood myotonic dystrophy.
- Conditions
- Congenital Myotonic Dystrophy, Childhood Myotonic Dystrophy, Myotonic Dystrophy
- Trial name
- TREAT-EXT (NCT06747884)
- Where
- 4 sites in United States, Brazil
- Volunteers
- 200 people
- Sponsor
- Virginia Commonwealth University
Tachyarrhythmia
Effectiveness of the Eko Digital Stethoscope in Capturing Infant ECGs
When a newborn is diagnosed with tachyarrhythmia, they are generally started on medical therapies, most commonly a beta-blocker, while being observed in an inpatient setting.
- Trial name
- NCT06382207
- Testing
- Eko Duo electronic stethoscope, CORE 500 electronic stethoscope
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- Virginia Commonwealth University
Kidney Transplant; Complications, Obesity
Feasibility Study for the Comprehensive Overweight/Obesity Management Pre-Kidney Transplant (COMPKT) Program
This project will be a single-arm feasibility study, with a treatment intervention that includes three interrelated components: (1) patient education using a proven weight loss curriculum, and (2) technology tools for making…
- Trial name
- NCT06688825
- Testing
- Education regarding Weight loss, Lifestyle tools for weight loss, Blood draw
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Virginia Commonwealth University
Substance Use Disorders
Enhancing Addiction Treatment Through Psychoeducation
Addiction is a brain disorder characterized by a broad range of both apparent and subtle cognitive impairments in attention, memory, executive functions, and decision-making.
- Trial name
- NCT07178158
- Testing
- Installing the Metacognium software app, Continue treatment as usual
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Virginia Commonwealth University
Type 1 Diabetes
Improving Transition Care for Adolescents and Young Adults With Type 1 Diabetes
The purpose of this research study is to evaluate a transition preparation program designed for adolescents and young adults (AYAs) with type 1 diabetes (T1D).
- Trial name
- SHIFT2 (NCT05639088)
- Testing
- Transition preparation program, Educational materials
- Where
- United States
- Volunteers
- 109 people
- Sponsor
- Virginia Commonwealth University
Eating Disorder Not Otherwise Specified
A Single-session Intervention Adaptation of the Habit Framework for the Prevention of Eating Disorders
The purpose of this proposal is to launch the first trial of a single-session intervention (SSI) specifically for the prevention of eating disorders (EDs).
- Trial name
- NCT06861608
- Testing
- Screening Questionnaire, Pre-Intervention Questionnaires (~10 minutes), SSI (Single-session intervention (~30 minutes) Active arm
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Virginia Commonwealth University
Mucosal Erosion, Gingival Recession
Patient-reported Outcomes of Donor Site Healing Using Different Palatal Protection Techniques
This study has been initiated to evaluate the question, "What is the best way to protect the palate after a gum graft is removed?" The overall objective is to determine if there is a difference in PROMs of donor site healing…
- Trial name
- NCT06892496
- Testing
- Visual Analog scale (VAS) questionnaire, Vacuum-formed retainer (VFR) technique, 3-D printed acrylic resin stent (3DS) technique
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Virginia Commonwealth University
Amputation
Assessing Ambulatory and Non-ambulatory Community Mobility in People With Lower Limb Amputation
Mobility is a fundamental aspect of daily life, enabling individuals to participate in social, occupational, and recreational activities.
- Trial name
- NCT07387744
- Testing
- Clinical Descriptive Measures related to amputation collected, GPS device education/distributed, activPAL device education/distributed
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Virginia Commonwealth University
Exotropia Intermittent
Using Dichoptic Therapy to Treat Intermittent Exotropia
Intermittent exotropia is difficult to treat. The mainstay of treatment involves surgery, and in one long-term study authors found that as many as 60% of IXT required at least one re-operation.Patching of the non-dominant eye has…
- Trial name
- NCT06529016
- Testing
- Luminopia, a virtual reality headset, Paper pre- survey, Paper Survey
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Virginia Commonwealth University
Kidney Transplant Rejection
Evaluating Urinary CXCL10 for Enhanced Detection of Acute Rejection in Kidney Transplant Patients With Low DD-CFDNA
Kidney transplant rejection remains a significant challenge to long-term graft survival. While histological biopsy continues to be the gold standard for diagnosing rejection, noninvasive biomarkers such as donor-derived cell-free…
- Trial name
- NCT07415876
- Testing
- Retrospective Cohort Enrollment, Prospective Cohort Enrollment
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Virginia Commonwealth University
Treatment Adherence
Impact of Food Assistance on Treatment Adherence and Clinical Outcomes in Food-Insecure Cancer Pts
Prospective cohort and descriptive study aimed at identifying cancer patients experiencing food insecurity at Virginia Commonwealth University (VCU) Massey Comprehensive Cancer Center.
- Trial name
- NCT07706192
- Testing
- Food Assistance Program, Standard of Care
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- Virginia Commonwealth University
Breast Cancer
Study to Evaluate the Feasibility of Twice Daily Use of Topical Azelaic Acid in Breast Cancer Patients Undergoing Radiation
This pilot study will evaluate the feasibility of at least twice daily use of azelaic acid in breast cancer patients undergoing radiation treatment.
- Trial name
- NCT06966388
- Testing
- Azelaic Acid
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Virginia Commonwealth University
Obesity
WE Project: 2.0 Grassroots Wellness Coaching (Phase 2)
African American adults that live in economically disadvantaged areas are at an increased risk for obesity and cardiometabolic disease.
- Trial name
- NCT06172582
- Testing
- 12-week lifestyle intervention
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Opioid Use Disorder, Opioid Use
Effects of Lemborexant on Insomnia and Its Relationship to Mood and Behavior on Opioid Use Disorder Subjects
The goal of this clinical trial is to learn about how certain medications used to treat insomnia (e.g., Lemborexant) impact sleep, mood, and behavior in men and women with Opioid Use Disorder who are taking prescribed…
- Conditions
- Opioid Use Disorder, Opioid Use, Insomnia, Orexin Antagonist
- Trial name
- NCT06981195
- Testing
- Lemborexant 10 MG
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Virginia Commonwealth University
Heart Failure, Heart Dysfunction
Treating Heart Dysfunction Related to Cancer Therapy With Sacubitril/Valsartan
To determine feasibility of recruitment and tolerability of treatment with sacubitril-valsartan among adult age survivors of cancer diagnosed at or before age 39 who have stage B heart failure.
- Trial name
- TREAT-HF (NCT05194111)
- Testing
- Sacubitril-valsartan, Valsartan, Carvedilol
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Virginia Commonwealth University
Neuromuscular Diseases, Neuromuscular Disorder
CIMR Neuromuscular Research Biobank
The purpose of this research repository is to collect, store, and share with other researchers any tissues that subjects with all types of neuromuscular disease are willing to donate.
- Conditions
- Neuromuscular Diseases, Neuromuscular Disorder, Neuromuscular Diseases in Children
- Trial name
- NRB-0001 (NCT05434572)
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Violence
A Hospital-based Intervention for Youth Injured Through Violence
The firearm violence epidemic is a major public health problem, especially for youth. Every day in the US, approximately 100 people fall casualty to firearms through forms of violence, such as homicide, suicide, and unintentional…
- Trial name
- NCT07475247
- Testing
- Elevate Virtual Reality (VR), Assessement completion
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- Virginia Commonwealth University
Perinatal Depression
"Mamma Mia" for Perinatal Health and Wellness
The purpose of this research study is to find out about ways to enhance well-being during pregnancy and the postpartum period (after the baby is born).
- Trial name
- NCT04300894
- Testing
- Mamma Mia, Mamma Mia Plus
- Where
- United States
- Volunteers
- 1,757 people
- Sponsor
- Virginia Commonwealth University