Clinical trials: sponsored by Virginia Commonwealth University
Neuropathic Pain
Vitamin D Supplementation on Reported Rates of Taxane-Induced Neuropathy
This is a two-arm randomized clinical trial in which 80 participants with Vitamin D deficiency and scheduled to begin taxane-based chemotherapy will be randomized to either: 1) prescribed vitamin D replacement or 2) standard of…
- Trial name
- NCT05259527
- Testing
- Ergocalciferol Capsules, Cholecalciferol Capsules
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Virginia Commonwealth University
Stroke
The Effect of SRS on Hemiplegia in Stroke Survivors
Strokes are one of the leading causes of long term disability and death in the United States. A stroke occurs when the blood supply to the brain is blocked, damaging parts of the brain.
- Trial name
- NCT06357247
- Testing
- Sensory Threshold, Nine Hole Peg Test, Semmes Weinstein Monofilament Assessment
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Virginia Commonwealth University
Advanced Solid Tumor, Ovarian Cancer
Niraparib and Neratinib in Advanced Solid Tumors With Expansion Cohort in Advanced Ovarian Cancer
To determine the recommended phase 2 dose (RP2D) of niraparib and neratinib in combination in patients with advanced solid tumors during Phase 1.
- Trial name
- iNNOVATE (NCT04502602)
- Testing
- Neratinib 160 mg, Neratinib 200 mg, Neratinib 240 mg
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Virginia Commonwealth University
Oral Cancer, Chatbot
Enhancing Oral Cancer Awareness
To evaluate the impact of AI-powered chatbot interactions versus traditional educational handouts on increasing participants' knowledge of oral cancer and its prevention
- Conditions
- Oral Cancer, Chatbot, Patient Education, Prevention
- Trial name
- NCT06682494
- Testing
- Traditional Education, AI-powered Chatbox
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Obesity, Adiposity
Redefining BMI: The Body, Mind, and Inflammation Trial
Emerging adulthood (18-25 years of age) is a critical developmental window to promote weight management and cardiometabolic health, particularly for emerging adult women.
- Trial name
- NCT06532747
- Testing
- Integrated Lifestyle Intervention (ILI), Monitoring with digital tools
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Virginia Commonwealth University
Heart Failure
Interleukin-1 Blockade in Acute Myocardial Infarction to Prevent Heart Failure
Patients who have a heart attack are at high risk for future development of heart failure ('weakening of the heart'). The researchers believe that the reaction of the heart muscle to injury (inflammation) during a heart attack…
- Trial name
- VA-ART4 (NCT05177822)
- Testing
- Anakinra
- Where
- 2 sites in United States
- Volunteers
- 84 people
- Sponsor
- Virginia Commonwealth University
Electronic Nicotine Delivery System Flavors
Potential Effects of Electronic Nicotine Delivery System Flavor Regulations on African American Menthol Smokers
This study aims to better understand how the availability of electronic nicotine delivery system (aka electronic cigarettes) flavors (e.g., menthol, tobacco) impacts tobacco use behaviors, toxicant exposure, and abuse liability…
- Trial name
- RVA Flavors (NCT05023096)
- Testing
- Tobacco product administration and assessment
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Postural Tachycardia Syndrome
Periaqueductal Gray-vagus Nerve Interface Malfunction Explain the Natural History With Its Numerous Co-morbidities?
This study is being conducted to see how people with Postural tachycardia syndrome (POTS) make sense of the things they see. The information may help doctors to learn more about how the different parts of people's brains…
- Trial name
- NCT05618054
- Testing
- Looming task
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Cancer Nos
Maladaptive Adipose Tissue Activity in Cancer
The purpose of this pilot research is to study brown adipose tissue, a type of fat that increases metabolism (burns energy) during exposure to cold, and how it may contribute to the weight loss observed in cancer.
- Trial name
- NCT03621124
- Testing
- Resting Energy Expenditure, Thermal Comfort Questionnaire
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Virginia Commonwealth University
Electronic Cigarette Use
Effects of Electronic Cigarette Flavors on Abuse Liability in Smokers (P3-Taste)
The purpose of this study is to determine if abuse liability indices will be impacted by varying flavors and e-cigarette (ECIG) nicotine delivery capability (i.e., nicotine flux) among current combustible cigarette users.
- Trial name
- NCT05971823
- Testing
- Tobacco product administration and assessment
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Nonalcoholic Steatohepatitis
Predicting Outcomes in Nonalcoholic Steatohepatitis With Advanced Fibrosis
Nonalcoholic Steatohepatitis (NASH) is a condition with increased amount of fat, inflammation and scarring in the liver. In compensated cirrhosis, the liver is coping with this damage and maintaining its important functions.
- Trial name
- NCT05720663
- Testing
- Standard of care
- Where
- 2 sites in United States
- Volunteers
- 240 people
- Sponsor
- Virginia Commonwealth University
Peripheral Vascular Diseases
Examining the Impact of Exercise Training on Vascular Dysfunction in Individuals With Mental Health Disorders - Study 3
The purpose of this research study is to examine the effect of various forms of exercise training on blood vessel function in healthy individuals as well as individuals with mental health disorders (posttraumatic stress disorder…
- Trial name
- NCT04916340
- Testing
- Muscular Strength Training Group, Muscular Fitness Training Group
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Stroke
Effectiveness of IVR Combined With Task-Specific Training on Hemiplegic Arm Function Following Stroke
The purpose of this research study is to understand the efficacy of using an immersive Virtual Reality (VR) environment, with task-specific training, to encourage arm movement following stroke.
- Trial name
- NCT05728866
- Testing
- VR immersive therapy
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Virginia Commonwealth University
Parkinson Disease
Optimizing Vibrational Therapy to Improve Gait and Balance in Parkinson's Disease
The purpose of this research study is to test the safety, tolerability, and the effect of vibration (delivered by an experimental device called PDVibe2) on freezing of gait (FOG) in persons with Parkinson's disease (PD).
- Trial name
- NCT03883217
- Testing
- Vibration Session, No vibration session
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Virginia Commonwealth University
Psychological
Psychobiological Responses Following Exercise and Brain Stimulation
Anxiety disorders are the most common mental health diagnosis in the US; 19.1% of U.S. adults (23.4% for females and 14.3% for males).
- Trial name
- NCT06874595
- Testing
- Cycling exercise at 65% of HRR for 20 minutes followed by HD-tDCS (exercise + HD-tDCS), No exercise followed by HD-tDCS (no exercise + HD-tDCS)., State Anxiety Inventory
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Motor Adaptation and Generalization, Posterior Parietal Cortex
Examining Lateralized Aspects of Motor Control Using Non-invasive Neural Stimulation
Motor adaptation and generalization are believed to occur via the integration of various forms of sensory feedback for a congruent representation of the body's position in space along with estimation of inertial properties of the…
- Conditions
- Motor Adaptation and Generalization, Posterior Parietal Cortex, Cerebellum
- Trial name
- NCT05947279
- Testing
- Comparing motor adaptation reaching performance
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Paroxysmal Atrial Fibrillation
EXercise Cardiac Magnetic Resonance Assessment of Left Atrial Mechanics Following Ablation
Longitudinal, observational cohort study to evaluate changes in left atrial (LA) reservoir function during exercise and overall exertional capacity in patients following catheter ablation for paroxysmal atrial fibrillation (AF).
- Trial name
- EXCLAMATORY (NCT06212791)
- Testing
- Self- Report Evaluation-Duke Activity Status Index, Self- Report Evaluation Atrial Fibrillation Effect on Quality of Life Questionnaire, Cardiopulmonary exercise test (CPET)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Virginia Commonwealth University
Dementia With Lewy Bodies, Parkinson Disease Dementia
Elucidating the Role of Cholinergic Degeneration in Cognitive Fluctuations in Lewy Body Dementia
The proposed study aims to address the critical gaps in understanding the mechanisms of CF (Cognitive Fluctuations) by leveraging recently emerged molecular biomarkers, advanced neuroimaging techniques to assess measures of…
- Conditions
- Dementia With Lewy Bodies, Parkinson Disease Dementia, Healthy Controls
- Trial name
- NCT07284290
- Testing
- Syn-One skin biopsy, Multi modal MRI, Assessment of dynamic EEG features over 48-hour periods across all study aims
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Prostate Cancer, Supportive Care
Behavioral Exercise Training to Reduce Cardiovascular Disease Risk
To test the preliminary effectiveness of a home-based exercise training (ET) intervention to improve exercise capacity (VO2 peak \& 6-minute walk distance [6MWD]) among prostate cancer (PC) patients compared to controls receiving…
- Trial name
- EXTRA-PC (NCT06237179)
- Testing
- Exercise Training Intervention, Healthy Living Education
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Virginia Commonwealth University
Limb Girdle Muscular Dystrophy, Muscular Dystrophies
Defining Clinical Endpoints in Limb Girdle Muscular Dystrophy (LGMD)
Limb Girdle Muscular Dystrophy comprise a group of disorders made up of over 30 mutations which share a common phenotype of progressive weakness of the shoulder and hip girdle muscles.
- Trial name
- GRASP-01-001 (NCT03981289)
- Where
- 10 sites in United States, United Kingdom
- Volunteers
- 116 people
- Sponsor
- Virginia Commonwealth University