Clinical trials: sponsored by Virginia Commonwealth University
LGMD1B, LGMD1C
Long-Term Development of Muscular Dystrophy Outcome Assessments
This is a 24-month, observational study of up to 1000 participants with Limb Girdle Muscular Dystrophy (LGMD), Myotonic Dystrophy Type 2 (DM2), and late onset Pompe disease (LOPD).
- Conditions
- LGMD1B, LGMD1C, LGMD1D, LGMD1E
- Trial name
- GRASP-01-005 (NCT05989620)
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Virginia Commonwealth University
Peripheral Vascular Diseases
Examining the Impact of Exercise Training on Vascular Dysfunction in Individuals With Mental Health Disorders - Study 2
The purpose of this research study is to examine the effect of various forms of exercise training on blood vessel function in healthy individuals as well as individuals with mental health disorders (posttraumatic stress disorder…
- Trial name
- NCT04922762
- Testing
- Moderate Intensity, Normal Volume Exercise Training, High Intensity, Normal Volume Exercise Training, Moderate Intensity, High Volume Exercise Training
- Where
- United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Hydration, Dental Caries
Healthy Hydration Pilot in Elementary Schools
This study will pilot a school-based stakeholder-informed hydration intervention and examine its feasibility and preliminary efficacy.
- Conditions
- Hydration, Dental Caries, Body Mass Index
- Trial name
- NCT06132763
- Testing
- Hydration Intervention, Control - Assessments Only
- Where
- United States
- Volunteers
- 563 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Prostate Cancer
Behavioral Exercise TRaining for Men Undergoing Androgen Depr Therapy for Prostate Ca
To refine a remote behavioral exercise training intervention for testing in a larger randomized trial.
- Trial name
- BETR-PC (NCT06250751)
- Testing
- Behavioral Exercise Training (BET) intervention
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Virginia Commonwealth University
Human Immunodeficiency Virus
Antiretroviral Improvement Among Medicaid Enrollees
This study will evaluate whether a new program will affect how often human immunodeficiency virus (HIV) antiretroviral therapy (ART) prescriptions are filled and whether the program improves the health of people living with HIV.
- Trial name
- AIMS (NCT05477485)
- Testing
- Experimental: AIMS program - patient, No Intervention/Usual care
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Virginia Commonwealth University
Brain Tumor, Brain Metastases
CALM: Managing Distress in Malignant Brain Cancer
The purpose of this study is to test an empirically supported psychotherapeutic intervention, Managing Cancer and Living Meaningfully (CALM), compared to treatment as usual (TAU) in those with malignant brain cancer diagnoses.
- Conditions
- Brain Tumor, Brain Metastases, Brain Cancer, Metastatic Lung Cancer
- Trial name
- NCT06180460
- Testing
- CALM, Treatment as usual
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Virginia Commonwealth University
Endometrial Cancer, Mismatch Repair-Proficient
Study of Lenvatinib w/ Pembro in Black Participants w/Mismatch Repair-Prof Recurrent Endometrial Cancer
Determine the efficacy of the combination of lenvatinib and pembrolizumab in Black participants
- Conditions
- Endometrial Cancer, Mismatch Repair-Proficient, Recurrent Endometrial Cancer
- Trial name
- NCT05263492
- Testing
- Lenvatinib, Pembrolizumab
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Virginia Commonwealth University
Primary Brain Tumor, Glioblastoma
CBT-I in Primary Brain Tumor Patients: Phase IIc Randomized Feasibility Pilot Trial
This study seeks to investigate an evidence-based, manualized, behavioral health intervention, Cognitive Behavioral Therapy for Insomnia (CBT-I), in individuals with primary brain tumors (PBT) and insomnia.
- Conditions
- Primary Brain Tumor, Glioblastoma, Astrocytoma, Oligodendroglioma
- Trial name
- CBT-I in PBT (NCT06439420)
- Testing
- Cognitive Behavioral Therapy for Insomnia
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Virginia Commonwealth University
Cirrhosis
Health IT Generated PROs to Improve Outcomes in Cirrhosis
SPECIFIC AIM 1: To evaluate in a multi-center, randomized trial the effectiveness of PROs elicited using PatientBuddy and EncephalApp on the prevention of avoidable 30 day readmissions in patients with cirrhosis and their…
- Trial name
- HEROIC (NCT03564626)
- Testing
- Health-IT +/- Scheduled Follow Up
- Where
- 3 sites in United States
- Volunteers
- 232 people
- Sponsor
- Virginia Commonwealth University
Imbalance of Constituents of Food Intake
An Intervention Targeting Fruit and Vegetable Intake Among Rural Youth
The investigators implemented a theory-based randomized controlled trial in ten rural Virginia middle schools in 2008-2010 and assessed the impact on health behaviors including fruit/vegetable intake as a primary outcome.
- Trial name
- NCT01412697
- Testing
- Fruit and vegetable intake in rural youth
- Where
- United States
- Volunteers
- 1,119 people
- Sponsor
- Virginia Commonwealth University
Cirrhosis
Patient Buddy App for the Prevention of Avoidable Readmission in Cirrhosis
To use the PatientBuddy App to reduce 30-day avoidable readmissions in cirrhotic patients using a patient and caregiver perspective.
- Trial name
- NCT02534805
- Where
- United States
- Volunteers
- 232 people
- Sponsor
- Virginia Commonwealth University
Heart Failure With Preserved Ejection Fraction
Sleep Extension to Improve Sleep Efficiency and QoL in HF With Preserved Ejection Fraction: the SLEEP-HF Pilot Study
Nearly one-third of US adults have poor sleep quality. Sleep quality refers to sleep efficiency, sleep latency, sleep duration, wake after sleep onset, and movement during the night.
- Trial name
- NCT06567925
- Testing
- Customized Sleep Coaching, Sleep Hygiene Training
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Virginia Commonwealth University
Cesarean Section
Determination of Core Body Temperature in Parturient Warmed With Upper or Underbody Forced Air Cover (Bair Hugger)
This study is intended to calculate the core body temperature in patients who are having a Cesarean Section (C/S) and are kept warm with an Upper Body Forced Air Warming device (Bair Hugger) or underbody forced air warmer.
- Trial name
- NCT05314075
- Testing
- Upper Body Forced Air Warming device, Under Body Forced Air Warming device
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Virginia Commonwealth University
Parkinson Disease
SCH: Context-aware Freezing of Gait Mitigation in Real-world Setting
People with Parkinson's disease (PD) may experience a walking problem called freezing of gait (FoG) that can interfere with the person's ability to conduct daily activities.
- Trial name
- NCT04746846
- Testing
- UG motion sensor with PDVibe3
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Virginia Commonwealth University
Colorectal Cancer, CRC
Engaging Black Men in Colorectal Cancer Screening
To determine the unmet needs, attitudes, barriers and facilitators of African American (AA)/ Black men use of colorectal cancer screening and describe how community leaders such as barbers may act as Community Champions to…
- Conditions
- Colorectal Cancer, CRC, Behavior
- Trial name
- SUCCEED (NCT05980182)
- Testing
- mHealth Application
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Survivorship
Anti-Inflammatory Lifestyle Intervention for Emerging Adult Cancer Survivors
To test the feasibility and acceptability of AILI and associated research procedures among emerging adult cancer survivors (EACS, N=16) age 18-29.
- Trial name
- HEAL (NCT06442397)
- Testing
- Anti-Inflammatory Lifestyle Intervention
- Sponsor
- Virginia Commonwealth University
COVID-19, Organ Transplant
Immune Registry for Organ Transplantation From COVID Positive Donors.
The purpose of this study is to collect data generated by standard clinical practice to determine the short term and long term clinical outcomes of recipients of solid organ transplantation from COVID-19 infected donors and…
- Trial name
- NCT05595837
- Testing
- Standard organ transplant
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Duchenne Muscular Dystrophy
Assessment of Neurodevelopmental Needs in Duchenne Muscular Dystrophy
Duchenne Muscular Dystrophy is a genetic disease that causes progressive muscle weakness. There is now substantial evidence that boys with this disease do not demonstrate age-related gains in their cognitive skills.
- Trial name
- NCT05280730
- Testing
- No intervention
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Virginia Commonwealth University
Cardiac Sarcoidosis
Interleukin-1 Blockade for Treatment of Cardiac Sarcoidosis
Sarcoidosis is a heterogeneous disorder of unknown etiology whose signature lesions are granulomatous inflammatory infiltrates in involved tissues. Tissue commonly affected are lungs, skin, eyes, lymph nodes and the heart.
- Trial name
- MAGiC-ART (NCT04017936)
- Testing
- Anakinra
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- Virginia Commonwealth University
Heart Failure, Systolic, Inflammation
Interleukin-1 Blockade In Recently Decompensated Heart Failure - 2
REDHART2 is a randomized, double-blinded, placebo-controlled trial to determine the effects of Anakinra on peak aerobic exercise capacity measured with a cardiopulmonary test after 24 weeks in patients with recently decompensated…
- Trial name
- REDHART2 (NCT03797001)
- Testing
- Anakinra
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Virginia Commonwealth University