Clinical trials: open to volunteers, sponsored by Virginia Commonwealth University
Kidney Transplant Recipient
Biomarker-Guided Mycophenolate Mofetil Elimination in Low-Risk Older Adult Kidney Transplant Recipients
Most kidney transplant recipients take a combination of anti-rejection medicines for the rest of their life. One of these is called mycophenolate mofetil (MMF), also known by the brand name CellCept.
- Trial name
- OPTIMA-KT (NCT07806136)
- Testing
- Tacrolimus (Kidney transplant maintenance immunosuppression), Mycophenoate Mofetil, Prednisone (SOC arm)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Virginia Commonwealth University
Obesity, Morbid
Bariatric Surgery Registry
Periodic analyses of our extensive database with regards to different surgical procedures for severe obesity and different obesity co-morbidities will be of benefit to our severely obese patients as well as to others world-wide.
- Trial name
- NCT01055054
- Where
- United States
- Volunteers
- 8,000 people
- Sponsor
- Virginia Commonwealth University
Acute Myeloid Leukemia
Oral Azacitidine in Transplant-Eligible Patients With Acute Myeloid Leukemia (AML) Suffering From Health-Inequality
Test feasibility of an oral maintenance strategy for transplant eligible AML patients in first CR who are medically underserved or have a disadvantage in the CDC SDOH domains
- Trial name
- REMAIN1 (NCT06370000)
- Testing
- Oral Azacitidine
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Virginia Commonwealth University
Amyloidosis, Hereditary
Southeastern ATTR Amyloidosis Consortium: SEATTRAC Family Registry
The study design is a prospective registry including asymptomatic and symptomatic patients who carry a pathogenic TTR mutation. The study will enroll patients who meet the inclusion criteria and none of the exclusion criteria…
- Trial name
- NCT05974644
- Testing
- Registry
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Virginia Commonwealth University
Dementia
Prescribing Trends and Associated Outcomes of Antiepileptic Drugs in US Nursing Homes Surrounding the COVID-19 Pandemic
Since the "National Partnership to Improve Dementia Care" debuted in 2012, almost all long-stay psychoactive prescribing has been graded by CMS, which has correlated to decreased use.
- Trial name
- NCT06095284
- Testing
- Pre-Extraction Phase, Extraction Phase, Post-Extraction Phase
- Where
- United States
- Volunteers
- 22,500,000 people
- Sponsor
- Virginia Commonwealth University
Congenital Myotonic Dystrophy, CDM
DMCRN-02-001: Assessing Pediatric Endpoints in DM1
The overall goal of the study is to establish valid clinical endpoint assessments for children with congenital myotonic dystrophy type 1 and develop biomarkers for the condition.
- Trial name
- ASPIRE-DM1 (NCT05224778)
- Where
- 5 sites in United States, Italy
- Volunteers
- 50 people
- Sponsor
- Virginia Commonwealth University
Myotonic Dystrophy 1, DM1
Estab Biomarkers and Clinical Endpoints in Myotonic Dystrophy Type 1 (END-DM1)
Building on previous work of the Myotonic Dystrophy Clinical Research Network (DMCRN), the present study seeks to overcome insufficient data on natural history; lack of reliable biomarkers; and incomplete characterization and…
- Trial name
- NCT03981575
- Where
- 17 sites in United States, Canada and 5 more
- Volunteers
- 700 people
- Sponsor
- Virginia Commonwealth University
Androgen Deprivation Therapy, Prostate Cancer
Autonomic and Renal Contributions to Hypertension With ADT
This study plans to learn more about contributors to high blood pressure in men who undergo androgen deprivation therapy (ADT) to treat prostate cancer.
- Conditions
- Androgen Deprivation Therapy, Prostate Cancer, Hypertension, Autonomic Dysfunction
- Trial name
- ARCH (NCT07848828)
- Testing
- Gonadotropin Releasing Hormone Agonists (GNRH), Androgen receptor (AR) inhibitor
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Symptoms and Signs, Cancer
Heuristic Tool To Improve Symptom Self-Management in Adolescents and Young Adults With Cancer
Determine the effects of the Computerized Symptom Assessment Tool (C-SCAT) versus usual care on the primary outcomes of self-efficacy for symptom management and symptom self-management behaviors
- Conditions
- Symptoms and Signs, Cancer, Childhood Cancer
- Trial name
- NCT05958316
- Testing
- Computerized Symptom Capture Tool (C-SCAT) Intervention, Usual Care Control
- Where
- 5 sites in United States
- Volunteers
- 126 people
- Sponsor
- Virginia Commonwealth University
Tetraplegia/Tetraparesis
Transspinal Stimulation With and Without Blood Flow Restricted Exercise Via Telehealth in Persons With Tetraplegia
The purpose of the current study is to evaluate whether a home-based, telehealth-supported intervention combining Blood Flow Restricted Exercise (BES) and Transspinal Stimulation (TS) will improve motor and functional abilities…
- Trial name
- SCIMS Main (NCT05423600)
- Testing
- BES + TS
- Where
- 3 sites in United States
- Volunteers
- 44 people
- Sponsor
- Virginia Commonwealth University
Breast Cancer
Single FrAction Interstitial BreaSt BracHytherApy
This phase 2, single arm prospective study has been designed to determine the safety of delivering accelerated partial breast irradiation (APBI) with a multicatheter interstitial implant in a single fraction over 1 day.
- Trial name
- SASHA (NCT07654257)
- Testing
- Partial Breast Irradiation
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- Virginia Commonwealth University
Young Adult-Mediated Intervention to Increase Colorectal Cancer Screening
Young Adult-Mediated Intervention to Increase Colorectal Cancer Screening
This study will garner preliminary data to develop a young adult-mediated intervention whereby a younger family member encourages their older family member to get colorectal cancer (CRC) screening.
- Trial name
- NCT05936931
- Testing
- Changes in CRC screening awareness and intentions
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Breast Cancer, Supportive Care in Cancer
EMBRACE (EMPA in BReast Cancer for Activity and Cardiac ProtEction)
The primary objective of this pilot study is to evaluate the feasibility and acceptability of a clinical trial protocol investigating 10 mg/day empagliflozin in breast cancer patients receiving anthracycline-based chemotherapy.
- Trial name
- EMBRACE (NCT07883512)
- Testing
- Empagliflozin
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Virginia Commonwealth University
DM1, Myotonic Dystrophy
Establishing Biomarkers and Clinical Endpoints in Myotonic Dystrophy Type 1 (END-DM1) Extension
Myotonic Dystrophy type 1 (DM1) is an autosomal dominant multisystemic disorder that causes progressive disability and shortened life expectancy.
- Conditions
- DM1, Myotonic Dystrophy, Myotonic Dystrophy 1, Myotonic Dystrophy Type 1
- Trial name
- END-EXT (NCT07700225)
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Virginia Commonwealth University
Violence
A Virtual Reality Brief Violence Intervention: Preventing Gun Violence Among Violently Injured Adults
The overall aim of the proposed project is to develop and evaluate the effectiveness of Brief Violence Intervention-Virtual Reality (BVI-VR) for reducing firearm-related violence, re-injury, and mortality among victims of…
- Trial name
- NCT06239285
- Testing
- Brief Violence Intervention VR (BVI-VR), Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- Virginia Commonwealth University
Violence, Exposure to Violent Event
Evaluation of Violence Prevention Strategies to Prevent and Reduce Community Levels of Youth Violence
The goal of this research study is to implement and evaluate a comprehensive community-level approach, Healthy Communities for Youth, that includes both a selective hospital-based prevention strategy, Emerging Leaders, and…
- Conditions
- Violence, Exposure to Violent Event, Adolescent Behavior
- Trial name
- NCT06176300
- Testing
- PAR - the SEED Method, PAR-Youth Voices, Emerging Leaders hospital-based intervention
- Where
- United States
- Volunteers
- 3,390 people
- Sponsor
- Virginia Commonwealth University
POTS - Postural Orthostatic Tachycardia Syndrome
Does a Periaqueductal Gray-vagus Nerve Interface Malfunction Explain the Nat hx With Its Numerous Co-morbidities?
Postural tachycardia syndrome (POTS) is a common and disabling disorder among adolescents. No epidemiologic data exist to support the often cited 0.5 to 2% prevalence.
- Trial name
- NCT06616363
- Testing
- Questionnaires to be competed, Provide list of medication and lifetime events, Use phone App to record new life events
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Cocaine Use Disorder
Open-label Feasibility Trial of HD-tDCS During Cognitive Behavioral Therapy for Cocaine Use Disorder
Cocaine Use Disorder (CocUD) is a significant public health issue with increasing cocaine-related overdose mortality. Effective treatments for CocUD are highly needed.
- Trial name
- NCT07829263
- Testing
- High Definition Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Virginia Commonwealth University
Brain Tumor
C-SMART vs BE Well for Patients With Brain Tumors
The goal of this clinical trial is to learn about the acceptability and feasibility of Cognitive Strategies, Mindfulness, and Rehabilitation Therapy (C-SMART) and Brain health Education and Wellness (BE Well) in adults with brain…
- Trial name
- NCT07224503
- Testing
- C-SMART, BE Well
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Virginia Commonwealth University
Peripheral Vascular Diseases
Examining the Impact of Exercise Training on Vascular Dysfunction in Individuals With Mental Health Disorders - Study 1
The purpose of this research study is to examine the role oxidants, substances produced in the blood that can damage blood vessel function, may play in blood vessel function in healthy individuals as well as individuals with…
- Trial name
- NCT04916327
- Testing
- Antioxidant
- Where
- United States
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University