Clinical trials: sponsored by Yale University
Cutaneous Sarcoidosis, Granuloma Annulare
Open-label Trial of Tofacitinib in Cutaneous Sarcoidosis and Granuloma Annulare
To investigate the ability of tofacitinib, a Janus kinase (JAK) inhibitor, to treat patients with cutaneous sarcoidosis and granuloma annulare during 6 months of therapy.
- Trial name
- NCT03910543
- Testing
- Tofacitinib 5 mg twice daily
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Yale University
Addiction, Substance Abuse Drug Chronic
Stage III Community-based Efficacy Trial for Mothering From the Inside Out
This is a Stage III community-based randomized clinical efficacy trial testing Mothering from the Inside Out (MIO), the first evidence-based parenting intervention designed to be delivered by addiction counselors in addiction…
- Conditions
- Addiction, Substance Abuse Drug Chronic, Child Neglect, Child Neglect Emotional
- Trial name
- NCT02955199
- Testing
- Mothering From the Inside Out (MIO), Parent Education
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- Yale University
Alcohol Drinking
Does Guanfacine Attenuate Stress-Induced Drinking?
Evaluating the effect of guanfacine on alcohol consumption. The investigators hypothesize that guanfacine versus placebo will decrease the amount of alcohol consumption (mls consumed) during the 2-hour self-administration period…
- Trial name
- NCT02164422
- Testing
- Guanfacine 3mg/day, Guanfacine 1.5mg/day
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Yale University
Atrial Fibrillation, Atrial Fibrillation, Persistent
Ivabradine for Rate Control in Permanent Atrial Fibrillation
Ivabradine may be useful as a rate controlling agent in atrial fibrillation without negative effects on hemodynamics and inotropy.
- Trial name
- NCT03987204
- Testing
- Ivabradine
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Yale University
E-Cig Use, Vaping
A Virtual Reality Videogame for E-cigarette Prevention in Teens
The use of the Invite Only VR, with the aim to prevent the initiation of e-cigarette use in teens by increasing their knowledge, decreasing their intentions to use e-cigarettes, influencing their harm perceptions and attitudes…
- Trial name
- NCT04054765
- Testing
- videogame, treatment as usual
- Where
- United States
- Volunteers
- 287 people, healthy volunteers welcome
- Sponsor
- Yale University
CTCL
A Study of ABT-199 (Venetoclax) for Cutaneous T Cell Lymphoma (CTCL)
The objective of this study are to evaluate the safety and tolerability of ABT-199 (venetoclax) in patients with advanced Cutaneous T cell lymphoma (CTCL).
- Trial name
- NCT04171791
- Testing
- ABT-199 (venetoclax)
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Yale University
Quality of Life, Cultural Competence
Mindful Kala: Virtual Bharatanatyam Wellness Program for Students
In the current study, the researchers propose to develop and pilot test a Bharatanatyam (i.e. Indian classical dance) program called Mindful Kala with the hopes of decreasing stress and increasing psychosocial well-being…
- Conditions
- Quality of Life, Cultural Competence, Stress
- Trial name
- NCT04745364
- Testing
- A 4-week Bharatanatyam course from the organization Mindful Kala
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Yale University
Opiate Dependence
Drug Counseling and Abstinent-Contingent Take-Home Buprenorphine in Malaysia
A randomized clinical trial evaluating whether Behavioral Drug and HIV Risk Reduction Counseling (BDRC), abstinence-contingent take-home buprenorphine (ACB), or the combination of the two improve efficacy and cost-effectiveness…
- Trial name
- NCT00539123
- Testing
- behavioral drug and HIV risk reduction counseling (BDRC), abstinence-contingent buprenorphine (ACB)
- Where
- 2 sites in United States, Malaysia
- Volunteers
- 234 people
- Sponsor
- Yale University
Pain
Opioid and Pain Cognition
The proposed research will provide foundational research to develop this low-burden behavioral intervention that can potentially improve outcomes of OUD.
- Trial name
- opioid (NCT04132609)
- Testing
- Cognitive bias modification, Standard attentional bias
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Yale University
Cognitive Function, Depression in Old Age
Computer Presented and Physical Exercises to Maintain Cognitive Function and Emotional Health in Older Adults
The aim of this study is to investigate and compare how 18-weeks of computer-based brain training and physical exercise together can improve physical performance, cognitive function and mood in older adults in a cross-over design…
- Trial name
- NCT04404621
- Testing
- Physical exercise (PE) training and computer-based brain (CBB)
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Yale University
C.Surgical Procedure; Cardiac, Cardiac Dysrhythmia
Bridge Occlusion Balloon in Lead Extraction Procedure
To evaluate the use of an occlusion balloon (Bridge™ Occlusion Balloon, Spectranetics) within the Superior Vena Cava in lead extraction patients.
- Conditions
- C.Surgical Procedure; Cardiac, Cardiac Dysrhythmia, Disorder of Pacing Function
- Trial name
- NCT02714153
- Testing
- Bridge Balloon
- Where
- 7 sites in United States
- Volunteers
- 23 people
- Sponsor
- Yale University
Pediatric Obesity
Does Mindfulness Enhance BMI in Obese Adolescents Enrolled in the Bright Bodies Weight Management Program?
Participants will be randomized to an evidence-based healthy lifestyle program alone or a healthy lifestyle program with mindfulness meditation added.
- Trial name
- NCT03611660
- Testing
- Traditional Healthy Lifestyle Program, Mindfulness Meditation Instruction
- Where
- 2 sites in United States
- Volunteers
- 42 people
- Sponsor
- Yale University
COVID-19
Validation of a Rapid Quantitative Test for Loss of Smell in COVID-19 Subjects
The purpose of this study is to evaluate the performance of a non-invasive olfactory device as a rapid indicator of COVID-19 in positive subjects.
- Trial name
- NCT04431908
- Testing
- olfactory device
- Where
- United States
- Volunteers
- 1,320 people
- Sponsor
- Yale University
Prostate Cancer
Nutrition and Prostate Cancer
The purpose of this study is to assess the efficacy of Fermented Soy vs. placebo in 72 adults with localized prostate cancer prior to radical prostatectomy.
- Trial name
- NCT03532308
- Testing
- Fermented Soy
- Where
- 3 sites in United States
- Volunteers
- 19 people
- Sponsor
- Yale University
Nutrition
Pilot: Feasibility of Intermittent Enteral Feeding in Ventilated MICU Patients
Specific Aims: Aim 1: Evaluate the feasibility of intermittent feeding in intensive care unit patients who are mechanically ventilated.
- Trial name
- NCT04164108
- Testing
- Intermittent Enteral Nutrition Protocol
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- Yale University
Social Anxiety Disorder, Performance Anxiety
Acute Anxiolytic Effects of Riluzole on Subjects With Social Anxiety Disorder
The goal of the current proposal is to examine if sublingual riluzole can reduce anxiety in people with social anxiety disorder during a public speaking task.
- Trial name
- NCT03017508
- Testing
- BHV-0223
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Yale University
Mental Health Wellness 1
The Momba Mobile Application-based Community
The investigators' mobile application-based community, termed Momba, will provide a bi-directional flow of information on maternal and infant mental health to traditionally underrepresented groups of mothers and their infants.
- Trial name
- MOMBA (NCT01816945)
- Testing
- MOMBA web-based application
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Yale University
Clinical High Risk for Psychosis
Randomized Controlled Trial of Aspirin vs Placebo in the Treatment of Pre-psychosis
The primary objective of this study is to determine whether aspirin is effective in alleviating symptoms of the clinical high risk (CHR) syndrome for psychosis.
- Trial name
- NCT02047539
- Testing
- Aspirin
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Yale University
Pediatric Obesity
Improving Pediatric Obesity Practice Using Prompts
This study compares the effectiveness of electronic health record (EHR)-based tools to support the management of pediatric obesity in primary care.
- Trial name
- iPOP-UP (NCT03648242)
- Testing
- Interruptive Clinical Decision Support
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Yale University
COVID-19
Respiratory Supports and COVID-19 Mortality
Critically ill COVID-19 patients have a relatively high mortality rate (~30%). Most critically ill COVID-19 patients require respiratory supports.
- Trial name
- NCT04832061
- Testing
- Respiratory supports
- Where
- United States
- Volunteers
- 2,300 people
- Sponsor
- Yale University