Clinical trials: sponsored by Yonsei University
Non-small Cell Lung Cancer (NSCLC)
An Open-label, Multicenter, Phase II Study of LDK378 in Patients With Non-small Cell Lung Cancer Harboring ROS1 Rearrangement
ROS1 is a receptor tyrosine kinase with constitutive kinase activity. ROS1 was previously discovered in cell lines where ROS1 fused with other proteins to act as a driver oncogene.
- Trial name
- NCT01964157
- Testing
- LDK378
- Where
- South Korea
- Volunteers
- 32 people
- Sponsor
- Yonsei University
Diffuse Large B-cell Lymphoma
A Study of Polatuzumab Vedotin and Glofitamab in Patients With Relapsed or Refractory Diffuse Large B-Cell Lymphoma Within 12 Months After R-CHOP
Patients with diffuse large B-cell lymphoma (DLBCL) who are primary refractory to first-line R-CHOP therapy or relapse within 12 months after R-CHOP have a poor prognosis and limited treatment options.
- Trial name
- NCT07702851
- Testing
- Polatuzumab vedotin, Glofitamab
- Volunteers
- 47 people
- Sponsor
- Yonsei University
Severe Aortic Stenosis or Severe Aortic Regurgitation
Prognostic Value of Soluble Urokinase-type Plasminogen Activator Receptor in Valvular Heart Disease
This study investigates the association between level of suPAR and valvular heart disease in patients who have severe aortic stenosis or severe aortic regurgitation using commercially available suPARnostic standard enzyme-linked…
- Trial name
- NCT04571372
- Where
- South Korea
- Volunteers
- 222 people
- Sponsor
- Yonsei University
Chronic Obstructive Pulmonary Disease
Evaluation of the Effectiveness, Safety, and Cost of a Smart Hospital System for Patients With Chronic Obstructive Pulmonary Disease
This study aims to analyze the effectiveness/safety/cost of the Smart Homespital system that provides a service that allows patients with Chronic Obstructive Pulmonary Disease to easily access and use biosignals generated using…
- Trial name
- NCT06601777
- Testing
- Immediate application of the Smart Homespital system, Delayed application of the Smart Homespital system after 3 months
- Where
- South Korea
- Volunteers
- 196 people
- Sponsor
- Yonsei University
Diabetes Mellitus, Hypoglycemia
Perioperative Hypoglycemia in Diabetic Patients Undergoing Vitrectomy: a Masked CGM Prospective Observational Study
Patients with diabetes are at increased risk of perioperative glycemic disturbances due to preoperative fasting, the surgical stress response, and the use of insulin or oral hypoglycemic agents.
- Trial name
- NCT07696910
- Testing
- Masked continuous glucose monitoring (FreeStyle Libre 2®)
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Patients With Locally Advanced or Metastatic But Resectable Clear Cell Renal Cell Carcinoma
A Phase 2 Multicenter Single-Arm Clinical Trial of Zanzalintinib and Pembrolizumab in Subjects With Resectable Clear Cell Renal Cell Carcinoma
This is a multicenter, single-arm, phase 2 clinical trial designed to evaluate the clinical efficacy of combination therapy with zanzalintinib and pembrolizumab in patients with locally advanced intermediate- to high-risk…
- Trial name
- NCT07691476
- Testing
- Zanzalintinib and Pembrolizumab
- Volunteers
- 48 people
- Sponsor
- Yonsei University
Radiation Exposure
Comparison of Operator Radiation Exposure During Percutaneous Coronary Intervention Between Left Distal and Right Conventional Radial Access
This study aims to compare the operator's radiation exposure between left distal radial access (LDRA) and right transradial access (RTRA) in patients undergoing percutaneous coronary intervention (PCI).
- Trial name
- DOSE-PCI (NCT07579169)
- Testing
- Radial Artery Puncture Method for Coronary Angiography and Intervention
- Where
- 4 sites in Japan, South Korea
- Volunteers
- 748 people
- Sponsor
- Yonsei University
Non-small Cell Lung Cancer
Neoadjuvant Lazertinib With or Without Chemotherapy for Patients With EGFR-mutated Resectable Non-small Cell Lung Cancer
In the randomized, multicenter Phase II clinical trial, we aim to evaluate the efficacy and safety of Lazertinib monotherapy or the combination of Lazertinib and cytotoxic chemotherapy as neoadjuvant therapy in patients with…
- Trial name
- NeoLazer (NCT06268210)
- Testing
- Lazertinib+Pemetrexed+Carboplatin, Lazertinib
- Where
- South Korea
- Volunteers
- 160 people
- Sponsor
- Yonsei University
Dyslipidemias, Atherosclerotic Cardiovascular Disease
Effects of Pitavastatin or Combination of Pitavastatin and Ezetimibe on Glucose Metabolism Compared to AtoRvastatin in atheroscLerotic Cardiovascular Disease Patients With Metabolic Syndrome: The EZ-PEARL Randomized Trial
The purpose of this study was to investigate the effect of pitavastatin or pitavastatin and ezetimibe combination therapy on glucose metabolism compared to atorvastatin in patients with atherosclerotic cardiovascular disease with…
- Trial name
- NCT05705804
- Testing
- Pitavastatin, Pitavastatin plus Ezetemibe, Atorvastatin
- Where
- South Korea
- Volunteers
- 250 people
- Sponsor
- Yonsei University
Stomach Neoplasms, Pain
A Phase IV Randomized Trial of Maxigesic® Versus Standard Analgesia After Radical Gastrectomy
Background: Radical gastrectomy causes moderate-to-severe pain during the first 48 hours after surgery. Opioids are effective but carry adverse effects and risks of prolonged use, so ERAS-based care recommends multimodal…
- Conditions
- Stomach Neoplasms, Pain, Postoperative
- Trial name
- NCT07687394
- Testing
- Acetaminophen (Newaminophen Premix), Maxigesic IV (acetaminophen/ibuprofen)
- Volunteers
- 160 people
- Sponsor
- Yonsei University
Interstitial Lung Disease
Evaluation of the Effectiveness, Safety, and Cost of a Smart Home-based Hospital System for Patients With Interstitial Lung Disease: Prospective Multicenter Randomized Controlled Trial
This study aims to analyze the effectiveness/safety/cost of the Smart Homespital system that provides a service that allows patients with interstitial lung disease to easily access and use biosignals generated using biosignal…
- Trial name
- NCT06601790
- Testing
- Immediate application of the Smart Homespital system, Delayed application of the Smart Homespital system after 3 months
- Where
- South Korea
- Volunteers
- 83 people
- Sponsor
- Yonsei University
Atrial Fibrillation Patients With Intermediate Stroke Risk
The Efficacy and Safety of Non-vItamiN K antaGonist oraL Anticoagulants for intermEdiate Stroke Risk in Patients With Atrial Fibrillation (SINGLE-AF)
Atrial fibrillation (AF) increases the risk of stroke, and oral anticoagulation is strongly recommended for patients at high thromboembolic risk.
- Trial name
- NCT04437654
- Testing
- Anticoagulation group(DOAC group)
- Where
- South Korea
- Volunteers
- 1,803 people
- Sponsor
- Yonsei University
Spontaneous Intracranial Hypotension
ONSD Changes and Treatment Response After Epidural Blood Patch in Spontaneous Intracranial Hypotension
"This is a prospective observational study investigating changes in optic nerve sheath diameter (ONSD) and its association with clinical improvement following epidural blood patch (EBP) in patients with spontaneous intracranial…
- Trial name
- NCT07085260
- Where
- South Korea
- Volunteers
- 23 people
- Sponsor
- Yonsei University
Atrial Fibrillation/Flutter in Patients With High Risk of Stroke
A Clinical Trial to Evaluate the Detection of Atrial Fibrillation for an One Day Versus More Than or Equal to Eight Days Using MEMO Patch PLUS in Individuals Aged ≥ 75 Years, or Those at High Risk of Stroke
The purpose of this study is to evaluate the benefits in the atrial fibrillation detection rate of the continuous ECG monitoring group for more than 8 days by contrasting with one-day ECG monitoring using MEMO Patch PLUS in 1000…
- Trial name
- MEMO-DAF8 (NCT05355948)
- Testing
- MEMO Patch PLUS for 1 day, MEMO Patch PLUS for More than 8-days
- Where
- South Korea
- Volunteers
- 1,000 people
- Sponsor
- Yonsei University
Adult, Laryngeal Masks, Remimazolam, Remifentanil
The Appropriate Remifentanil Dose for Optimal Insertion of Laryngeal Mask Airway in Adult Patients During Induction of General Anesthesia Using Remimazolam.
The laryngeal mask airway (LMA) is an airway maintenance device that is easy to insert and has the advantage of causing less sore throat and autonomic nervous system stimulation.
- Trial name
- NCT06289829
- Testing
- remifentanil of the assigned dose, Ambu Auragain for airway management
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Yonsei University
Severe Aortic Stenosis
Aspirin vs Clopidogrel After TAVR
Currently, the optimal antithrombotic therapy after transcatheter aortic valve replacement (TAVR) remains still unknown., The purpose of the study is to compare aspirin versus clopidogrel monoantiplatelet therapy for preventive…
- Trial name
- NCT05493657
- Testing
- Aspirin single antiplatelet therapy, Clopidogrel single antiplatelet therapy
- Where
- South Korea
- Volunteers
- 270 people
- Sponsor
- Yonsei University
Adult Patients Aged 19-64, Scheduled for Elective Arthroscopic Knee Surgery
Effect of Nociception Level Monitoring During Remimazolam-based Total Intravenous Anesthesia on Intraoperative Opioid Requirements and Postoperative Pain
This study aims to investigate whether the use of nociception monitoring during general anesthesia with remimazolam-based total intravenous anesthesia has an effect on intraoperative opioid requirements and postoperative pain.
- Trial name
- NCT05615441
- Testing
- Analgesia Nociception Index monitor, Standard monitoring
- Where
- South Korea
- Volunteers
- 54 people
- Sponsor
- Yonsei University
Renal Insufficiency, Atherosclerosis
Moderate-Intensity Statin Plus Ezetimibe in CKD and ASCVD
The ULTRA-CKD trial is a prospective, randomized, open-label, multicenter trial designed to compare the efficacy and safety of moderate-intensity statin plus ezetimibe combination therapy versus high-intensity statin monotherapy…
- Conditions
- Renal Insufficiency, Atherosclerosis, Dyslipidemia, Hypercholesterolemia
- Trial name
- NCT07524101
- Testing
- Moderate-intensity statin and ezetimibe combination therapy, High-intensity statin monotherapy
- Where
- South Korea
- Volunteers
- 1,952 people
- Sponsor
- Yonsei University
Head and Neck Squamous Cell Carcinoma
HPV 16-positive and/or HPV 18-positive Recurrent and/or For Patients With Metastatic Head and Neck Cancer to Evaluate GX-188E DNA Vaccination, GX-I7 and Nivolumab Combination Therapy
This study is to explore the efficacy and safety of GX-188E DNA vaccination, GX-I7, and nivolumab combination therapy in HPV 16-positive and/or HPV-18 positive R/M HNSCC patients. The objective of this study is as follows.
- Trial name
- TRINITY (NCT05280457)
- Testing
- nivolumab-GX-188E-GX-I7
- Where
- South Korea
- Volunteers
- 21 people
- Sponsor
- Yonsei University
Head and Neck Squamous Cell Carcinoma (HNSCC)
A Study for Identification of Immune Determinants for Response to Nivolumab in Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma
A study for identification of immune determinants for response to Nivolumab in Recurrent /Metastatic HNSCC(Head and neck squamous cell carcinoma) patients.
- Trial name
- NCT04603248
- Testing
- Nivolumab
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Yonsei University