Clinical trials: sponsored by Yonsei University
Neoplasms of Bone and Articular Cartilage With Unspecified Anatomical Site
EVERolimus and LenvAtinib Versus Everolimus for Bone Sarcoma
Those studies demonstrate strong rationale to combine a multikinase inhibitor targeting VEGFR, PDGFR with mTOR inhibitor. Moreover, another multi-targeted TKI, lenvatinib monotherapy showed promising activity in osteosarcoma.
- Trial name
- NCT07619950
- Testing
- Everolimus and Lenvatinib, Everolimus
- Volunteers
- 94 people
- Sponsor
- Yonsei University
Cardiovascular Disease
Effect of Intensive LDL-cholesterol Targeting for Elderly Patients With Cardiovascular Disease: I-OLD Trial
Although there have been studies regarding intensive lowering of low-density lipoprotein (LDL)-cholesterol with high intensity statins in patients with cardiovascular disease, elderly patients were either excluded or accounted…
- Trial name
- NCT05361421
- Testing
- Intensive targeting group, Conventional therapy group
- Where
- South Korea
- Volunteers
- 1,200 people
- Sponsor
- Yonsei University
Head and Neck Squamous Cell Carcinoma
Trial of Neoadjuvant Therapy With Paclitaxel and Carboplatin in Operable Locally Advanced Head and Neck Cancer Patients
Objective: Primary objective: To evaluate the major pathologic response (mPR) of locally advanced head and neck cancer after paclitaxel and carboplatin-induction chemotherapy followed by surgery.
- Trial name
- NEOS (NCT05294900)
- Testing
- paclitaxel/carboplatin
- Where
- South Korea
- Volunteers
- 79 people
- Sponsor
- Yonsei University
Ischemic Heart Diease, Non-ischemic Heart Disease
Exercise Echocardiography Registry for Ischemic and Non-Ischemic Heart Disease
Exercise echocardiography is a widely used non-invasive test that evaluates cardiac structure and function during physical stress.
- Trial name
- Exercise-Echo (NCT07367893)
- Where
- South Korea
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Prostate Cancer
Ultra-hypofractionated Carbon-ion Therapy for Prostate Cancer
This is a single-arm, exploratory phase I clinical trial evaluating the safety and efficacy of ultra-hypofractionated carbon ion radiotherapy (CIRT) in 6 fractions compared to the conventional 12-fraction regimen in patients with…
- Trial name
- NCT07495293
- Testing
- ultra-hypofractionated carbon ion therapy
- Volunteers
- 20 people
- Sponsor
- Yonsei University
Potentially Resectable Stage II/IIIa NSCLC
Concurrent Neoadjuvant Chemoradiotherapy Plus Durvalumab (MEDI4736) in Resectable Stage III NSCLC
Combination treatment of Durvalumab with chemoradiotherapy is ongoing for head/neck cancer, renal cell carcinoma, melanoma, and non-small cell lung cancer (NCT02318771) and pancreatic cancer (NCT02305186).Combining Durvalumab…
- Trial name
- NCT03694236
- Testing
- durvalumab
- Where
- South Korea
- Volunteers
- 39 people
- Sponsor
- Yonsei University
Alcohol Drinking, High-Risk Drinking Patterns
Clinical Effectiveness of a Motivational Interviewing-Based Conversational Mobile Application for High-Risk Drinkers
This study aims to evaluate and compare the degree of alcohol reduction between high-risk drinkers who use a motivational interviewing-based conversational agent (chatbot) application for four weeks and those in the control group…
- Trial name
- NCT07238998
- Testing
- Motivational Interviewing-Based Conversational Agent (Mobile Chatbot), No Intervention (Waitlist Control)
- Where
- South Korea
- Volunteers
- 220 people
- Sponsor
- Yonsei University
Atrial Fibrillation
Effect of Enavogliflozin on Recurrence of Atrial Fibrillation After Catheter Ablation
Objective: The purpose of this study is to determine if there is a difference in the recurrence rate of atrial fibrillation (AF) between a group of patients with AF and heart failure undergoing catheter ablation who are…
- Trial name
- ENAVO-AF (NCT06528262)
- Testing
- Enavogliflozin
- Where
- South Korea
- Volunteers
- 390 people
- Sponsor
- Yonsei University
Arthroplasty, Replacement
sACB vs cACB in TKA
This study compares the analgesic efficacy of single-dose adductor canal block (sACB) versus continuous-dose adductor canal block (cACB) for postoperative pain management in total knee replacement patients.
- Conditions
- Arthroplasty, Replacement, Knee
- Trial name
- NCT07581886
- Testing
- Continuous ACB, Single-shot ACB
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Ovarian Neoplasms, Endometrial Neoplasms
A Three-arm Randomized Phase II Study of Dostarlimab Alone or With Bevacizumab Versus Nonplatinum Chemotherapy in Recurrent Gynecological Clear Cell Carcinoma: DOVE (APGOT-OV7/ ENGOT-ov80 Study)
Multicenter, randomized, open-label, phase II clinical study comparing Dostarlimab +/- Bevacizumab with standard chemotherapy in patients with gynecological clear cell carcinoma.
- Conditions
- Ovarian Neoplasms, Endometrial Neoplasms, Uterine Cervical Neoplasms, Vulvar Cancer
- Trial name
- DOVE (NCT06023862)
- Testing
- Dostarlimab, Bevacizumab, Doxorubicin
- Where
- 27 sites in Australia, Hong Kong and 5 more
- Volunteers
- 198 people
- Sponsor
- Yonsei University
Medical Education, Interprofessional Relations
Simulation-Based Interprofessional Education for Operating Room Teams
This single-center, prospective, single-arm pilot study will evaluate a simulation-based interprofessional education program for early-career operating room team members at Yongin Severance Hospital.
- Conditions
- Medical Education, Interprofessional Relations, Patient Safety, Teamwork
- Trial name
- Surgical IPE (NCT07570134)
- Testing
- Simulation-Based Interprofessional Education
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Atrial Fibrillation (AF), Heart Failure
LBBAP vs. CS Pacing for CRT in Permanent Atrial Fibrillation and Heart Failure (SYNC-AF)
This is a prospective, multicenter, randomized controlled trial comparing Left Bundle Branch Area Pacing (LBBAP)-based cardiac resynchronization therapy (CRT) with conventional coronary sinus (CS) lead-based CRT in patients with…
- Conditions
- Atrial Fibrillation (AF), Heart Failure, Cardiomyopathies
- Trial name
- SYNC-AF (NCT07560891)
- Testing
- Left Bundle Branch Area Pacing (LBBAP) for CRT, Coronary Sinus (CS) Lead-Based Biventricular CRT
- Volunteers
- 44 people
- Sponsor
- Yonsei University
Sarcoma
A Study of Durvalumab in Combination With Doxorubicin for Advanced Soft Tissue Sarcoma
The yearly incidence of soft-tissue sarcomas (STS) in the USA is roughly 11,280 cases, and metastatic STS have a median overall survival of about 12 months.
- Trial name
- NCT03802071
- Testing
- Durvalumab+doxorubicin cobination
- Where
- South Korea
- Volunteers
- 44 people
- Sponsor
- Yonsei University
Sarcoma,Soft Tissue
Pemetrexed, Cisplatin With Soft Tissue Sarcoma
Soft tissue sarcoma (STS) is rare malignancy of mesodermal origin, representing less than 1% of all malignant neoplasms. They are a group of diseases encompassing diverse histological subtypes with very different biomorphologies…
- Trial name
- ALBATROSS (NCT04605770)
- Testing
- pemetrexed+cisplatin
- Where
- South Korea
- Volunteers
- 164 people
- Sponsor
- Yonsei University
Rare Cancer
Registry Study on Rare Cancers in Korea
This study aims to determine the participation rate of patients with registered rare cancers in clinical research.
- Trial name
- rarecancer (NCT06746766)
- Where
- South Korea
- Volunteers
- 500 people
- Sponsor
- Yonsei University
Radiotherapy, Patient Education
Comparison of Patient Understanding and Anxiety According to the Delivery Method of Educational Videos
This study aims to evaluate whether a generative artificial intelligence (AI)-based educational video is more effective than a conventional video in improving patient understanding and reducing anxiety before radiation therapy.
- Trial name
- NCT07550686
- Testing
- AI-based educational video, Conventional educational video (PPT + narration)
- Where
- South Korea
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Coronary Artery Disease, Optical Coherence Tomography
Efficacy and Safety of Zotarolimus-eluting Stent Overexpansion With OCT
Investigators aimed to evaluate efficacy and safety of expansion capacity of zotarolimus-eluting Stent assessed by optical coherence tomography (OCT) in vivo study.
- Conditions
- Coronary Artery Disease, Optical Coherence Tomography, Stent
- Trial name
- ONYSOVER (NCT05340361)
- Testing
- Optical coherence tomography-guided percutaneous coronary intervention, Optical coherence tomography-guided Onyx family stent expansion
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Yonsei University
Safety, Efficacy
Safety and Efficacy of Distal Radial Access (SAFE-BOX)
A Prospective Registry to assess the Safety and Efficacy of Distal Radial Approach
- Trial name
- NCT05776550
- Where
- South Korea
- Volunteers
- 3,600 people
- Sponsor
- Yonsei University
Chronic Coronary Syndrome
Effect of ZaStaprazan on Platelet Reactivity of Clopidogrel After PercuTaneous CoronAry InteRvention
The purpose of this study is to evaluate the clinical utility of zastaprazan compared to proton pump inhibitors (PPIs) in patients receiving dual antiplatelet therapy (DAPT) including clopidogrel after percutaneous coronary…
- Trial name
- EZ-STAR (NCT07471867)
- Testing
- Zastaprazan, Rabeprazole
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Yonsei University
Neoplasms of Connective and Soft Tissue With an Unspecified Anatomical Site
Gemcitabine and Docetaxel With or Without Bevacizumab (Onbevzi) for Soft Tissue Sarcoma
Arm1- bevacizumab (Onbevzi) at a dose of 15 mg/kg administered as a 30-minute intravenous infusion on Day 1 of each 21-day cycle, followed by intravenous infusion of gemcitabine and docetaxel in sequence.
- Trial name
- NCT07547592
- Testing
- Bev + Gem + Doc, Gem + Doc
- Volunteers
- 92 people
- Sponsor
- Yonsei University