Clinical trials: sponsored by Yonsei University
Obstructive Sleep Apnea
A Comparison of Surgical Outcome Following Drug-induced Sleep Endoscopic Diagnosis Using Propofol or Dexmedetomidine for Sedation : A Prospective Randomized Trial
Obstructive sleep apnea is a common disease, associated with cardiovascular disease, cerebrovascular disease, and many other medical conditions. Therefore the precise diagnosis and treatment are important.
- Trial name
- NCT01895348
- Testing
- Propofol, propofol-remifentanil, Dexmedetomidine-remifentanil
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Yonsei University
NSCLC (Non-Small Cell Lung Cancer)
An Open-label Phase Ib/II Study of BAY 1000394 (Roniciclib) in Combination With Docetaxel in Second- or Third-line Treatment of Patients With Advanced Non-small Cell Lung Cancer (NSCLC)
This study part will be conducted in an open-label, non-randomized, Phase I conventional 3+3 dose-escalating design to define the safety, tolerability, pharmacokinetics, and MTD of BAY 1000394 (Roniciclib) given in a 3 days on /…
- Trial name
- NCT02522910
- Testing
- BAY 1000394 (Roniciclib) in combination with docetaxel
- Sponsor
- Yonsei University
Coronary Artery Disease
Impact of IntraVascular UltraSound Guidance on Outcomes of Xience Prime Stents in Long Lesions (IVUS-XPL Study)
This study is designed as a prospective, randomized, multi-center trial to demonstrate an inequality between IVUS-guided versus angiography-guided implantation of everolimus-eluting stents(EES) at long lesions(> 28 mm) in…
- Trial name
- NCT01308281
- Testing
- PCI with IVUS guidance, PCI without IVUS guidance
- Where
- South Korea
- Volunteers
- 1,079 people
- Sponsor
- Yonsei University
All-comer, Percutaneous Coronary Intervention
Comparison of Biodegradable Stents: Orsiro and BioMatrix
The use of a biodegradable polymer has the potential to reduce the sustained inflammatory response of the arterial wall, facilitating re-endothelialization and minimizing the risk of thrombus formation and late restenosis.
- Trial name
- NCT02084901
- Testing
- Drug-eluting biodegradable stent Orsiro implantation, Drug-eluting biodegradable stent BioMatrix or BioMatrix Flex implantation
- Where
- South Korea
- Volunteers
- 12 people
- Sponsor
- Yonsei University
Coronary Artery Disease
A Comparison of Optical Coherence Tomography Guidance and Angiography-only Guidance for Percutaneous Coronary Intervention With Bioresorbable Vascular Scaffold
It is well-known that non-optimal stent implantation associated with under-expansion or incomplete strut apposition during percutaneous coronary intervention (PCI) leads to a higher incidence of restenosis and stent thrombosis.
- Trial name
- NCT02466282
- Testing
- Angiography-guided PCI with bioresorbable vascular scaffold, optical coherence tomography-guided PCI with bioresorbable vascular scaffold
- Where
- South Korea
- Volunteers
- 13 people
- Sponsor
- Yonsei University
Coronary Artery Disease, Stenosis
Clinical Usefulness of Fractional Flow Reserve Measurement for Significant Stenosis in Proximal Coronary Artery
Fractional flow reserve (FFR) is a pressure-wire-based index that is used during coronary angiography to assess the potential of a coronary stenosis to induce myocardial ischemia.
- Trial name
- NCT02475291
- Where
- South Korea
- Volunteers
- 26 people
- Sponsor
- Yonsei University
Multi-vessel Diseases, Angina
Serial EValuation of multiplE Coronary Artery Diseases by an Optical Coherence Tomography; Assessment of the Changes of de Novo Lesions and Comparisons of Neointimal Coverage Between Xience Prime® Versus Cypher SelectTM Stents; SEVEN-Xience Study
This study is a prospective open-labeled, randomized study to compare the neointimal coverage at 3 months and 12 months and its serial changes between 3 months and 12 months according to the implanted DES and evaluate the serial…
- Trial name
- NCT01856374
- Testing
- Sirolimus-eluting stent (Cypher SelectTM, Cordis, Miami, FL), Everolimus-eluting stent(Xience Prime®, Abbott Vascular, Santa Claea, CA), Pravastatin 20mg
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Yonsei University
Coronary Bifurcation Lesions
PCI With AXXESS Biolimus A9 Eluting Bifurcation Stent in Treating Coronary Artery Bifurcation Disease
1. To compare the safety and efficacy of AXXESS stent with conventional DES in patients with coronary artery bifurcation disease 2.
- Trial name
- NCT02384629
- Testing
- OCT-guided PCI with AXXESS stent, OCT-guided PCI with conventional DES (Biomatrix flex stent), Angio-guided PCI with AXXESS stent
- Sponsor
- Yonsei University
Stable Angina or Acute Coronary Syndrome Considered for Percutaneous Coronary Intervention With Dyslipidemia or Hypertension
Neointimal Coverage After Implantation of Biolimus Eluting Stent With Biodegradable Polymer: Optical Coherence Tomographic Assessment According to the Treatment of Dyslipidemia and Hypertension and the Types of Implanted Drug-eluting Stents
There has been little research on neointimal coverage and malapposition after BES implantation using OCT in human coronary artery. Furthermore, specific drug may possibly influence the vascular healing after stent implantation.
- Trial name
- NCT01502904
- Testing
- Sirolimus-eluting stent, Biolimus-eluting stents, pravastatin 20mg/day after DES implantation
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Yonsei University
Coronary Artery Disease
COmparison and Modification in Neointimal Pattern Assessed by Optical Coherence Tomography With High Versus Moderate Efficacy Statin Treatment After Drug Eluting Stent Implantation: COMPASS Trial
This study is a prospective randomized trial to evaluate and compare the quantitative and qualitative characteristics of neointimal formation between high and low efficacy statin treatment after drug eluting stent (DES)…
- Trial name
- NCT02155530
- Testing
- Atorvastatin 40mg, pravastatin 20 mg
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Yonsei University
Chronic Hepatitis B
Study on Treatment of Pegylated Interferon Alfa 2a(Pegasys®) in the Korean Chronic Hepatitis B(CHB) Adults
Patients will receive Peginterferon alfa-2a according to the standard medical practice but the observation period is 12 weeks
- Trial name
- NCT02822547
- Testing
- Peginterferon alfa-2a
- Where
- South Korea
- Volunteers
- 253 people
- Sponsor
- Yonsei University
Chronic Cough Caused by Gastroesophageal Reflux
Efficacy of Proton Pump Inhibitor for Chronic Cough Caused by Gastroesophageal Reflux; Double-blind, Placebo-controlled, Randomized Clinical Trial
Efficacy of proton pump inhibitor for chronic cough caused by gastroesophageal reflux; double-blind, placebo-controlled, randomized clinical trial
- Trial name
- NCT01888549
- Testing
- High-dose PPI, standard PPI
- Where
- South Korea
- Volunteers
- 48 people
- Sponsor
- Yonsei University
Video-assisted Thoracoscopic Surgery, Chronic Obstructive Pulmonary Disease
Effects of Iloprost on Pulmonary Hemodynamics and Oxygenation in Patients of Chronic Obstructive Pulmonary Disease During One-lung Ventilation
The inhaled Iloprost, approved for pulmonary hypertension, caused increase in oxygenation, and increase exercise tolerance in ARDS or chronic obstructive pulmonary disease.
- Trial name
- NCT02490657
- Testing
- Inhaled iloprost, normal saline (Saline 0.9%)
- Where
- South Korea
- Volunteers
- 44 people
- Sponsor
- Yonsei University
Pulmonary Complications
Effect of Perioperative Lung Protective Strategies on the Occurrence of Postoperative Pulmonary Complications in Patients Undergoing Lumbar Spinal Surgery in the Prone Position
Postoperative pulmonary complications are main cause of overall perioperative morbidity and mortality in the patients following general anesthesia.
- Trial name
- NCT02373475
- Testing
- Conventional ventilation, Protective lung ventilation
- Where
- South Korea
- Volunteers
- 78 people
- Sponsor
- Yonsei University
LDL-cholesterol Level 130-159mg/dL
The Effectiveness of Plant Stanols as Ester on Change in Blood Cholesterol Level
The purpose of randomized, double-blind, placebo-controlled study was to determine whether yoghurt drink containing 2g plant stanols (3.4g as plant stanol esters) is effective in the control of blood cholesterol level in subjects…
- Trial name
- NCT02779673
- Testing
- Yoghurt drink containing plant stanol as esters, Yoghurt drink without plant stanol as esters
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Healthy
Measurements of Corneal Biomechanical Properties Using a Dynamic Scheimpflug Analyzer for Normal Adults in South Korea
The human cornea is affected by the magnitude and velocity of both internal and external forces because the cornea has both static and dynamic resistance components.
- Trial name
- NCT02627170
- Testing
- dynamic Scheimpflug analyzer (corneal visualization Scheimpflug technology [Corvis ST], OCULUS, Wetzlar, Germany)
- Where
- South Korea
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Apical Thrombus Formation, Acute Myocardial Infarction
Implication of Left veNtricle Vortex Flow Guided aNticOagulation Therapy for preVenting Apical Thrombus Formation In Patients With Acute myOcardial infarctioN: Multicenter Prospective Randomized Clinical Trial; INNOVATION Study
Implication of left veNtricle vortex flow guided aNticOagulation therapy for preVenting Apical Thrombus formation In patients with acute myOcardial infarctioN: Multicenter Prospective Randomized Clinical Trial; INNOVATION study
- Trial name
- NCT01869998
- Where
- South Korea
- Volunteers
- 111 people
- Sponsor
- Yonsei University
Peripheral Circulation During On-pump Cardiac Surgery
Assessment of Skin Perfusion Pressure as an Indicator of Tissue Oxygenation in Cardiac Surgery Patients Undergoing Cardiopulmonary Bypass
This study is aim to evaluate usefulness of the perioperative monitoring of skin perfusion pressure as an indicator of perpheral perfusion in patients undergoing on-pump cardiac surgery.
- Trial name
- NCT02329392
- Where
- South Korea
- Volunteers
- 72 people
- Sponsor
- Yonsei University
Healthy Subjects
Impact of an 8-week Linoleic Acid Intake in Soy Oil on Lp-PLA2 Activity in Healthy Adults
Self-reported healthy participants (n=150) aged 30-65 years with 18.5 kg/m^2 ≤ BMI < 30 kg/m^2 were randomly assigned into three groups: a low linoleic acid (LA, 18:2n-6) group (n=50) replaced 10 mL soy oil with one apple; a…
- Trial name
- NCT02753907
- Testing
- Low LA, High LA
- Where
- South Korea
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Type 2 Diabetes, Impaired Glucose Intolerance
G-CREDIT (Gangnam-Cohort for Risk Evaluation of Diabetes and Impaired Glucose Tolerance)
The prevalence of type 2 diabetes has consistently increased and type 2 diabetes can cause many types of vascular complications. Diabetes develops due to glucose intolerance.
- Trial name
- NCT02726256
- Volunteers
- 500 people
- Sponsor
- Yonsei University