Clinical trials: sponsored by Zhejiang Cancer Hospital
Pancreatic Cancer Non-resectable
Establishment of a Predictive Model for Immunotherapy Response in Pancreatic Cancer
This project aims to establish a single-center, prospective, observational clinical cohort for pancreatic cancer immunotherapy. It plans to enroll 100 patients with advanced pancreatic cancer, collecting tumor tissue sections…
- Trial name
- NCT07271823
- Testing
- Sample Collection
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Zhejiang Cancer Hospital
Barium Meal Examination
Real-Time Dynamic Imaging Study of Normal Pharyngolaryngeal Structures During Barium Swallow (GLAM-III)
The integrity and functional stability of pharyngolaryngeal anatomical structures are critical for airway management, and the dynamic changes of key structures (e.g., pyriform sinus, cricoid cartilage lamina) during swallowing…
- Trial name
- GLAM-III (NCT07264322)
- Where
- China
- Volunteers
- 3 people
- Sponsor
- Zhejiang Cancer Hospital
The Impact of American Ginseng on the Metabolomics of Urine and Plasma in Healthy Individuals
LCMS-Based Metabolic Analysis Explores the Effect of American Ginseng on Urine and Plasma in Healthy Individuals
Researchers will use LCMS Metabolic Analysis to Explore the Effect of American Ginseng on Urine and Plasma in Healthy Individuals Participants will: Take 3 grams of American Ginseng powder every day for 14 days Collect the…
- Trial name
- NCT07252362
- Testing
- American Gginseng
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Zhejiang Cancer Hospital
Supraglottic Airway Device
An in Vivo CT Imaging Study of GMA-Tulip, I-gel, and LMA Supreme (GLAM-II)
Laryngeal masks are core devices for supraglottic airway management, and the accuracy of their anatomical position directly impacts ventilation safety and the incidence of complications.
- Trial name
- GLAM-II (NCT07196696)
- Testing
- GMA-Tulip, I-gel, LMA-Supreme insertion
- Where
- 2 sites in China
- Volunteers
- 9 people
- Sponsor
- Zhejiang Cancer Hospital
Non-Resectable Pancreas Carcinoma
Firstline Sequential AG and mFOLFOX Combined With Serplulimab and Bevacizumab Versus AG Chemotherapy Alone in Advanced Pancreatic Cancer
A randomized, multicenter, Phase III trial evaluating the efficacy and safety of first-line Sequential AG-mFOLFOX chemotherapy combined with Serplulimab and Bevacizumab versus AG chemotherapy alone in advanced pancreatic cancer.
- Trial name
- NCT07235930
- Testing
- Sequential AG and mFOLFOX in Combination With Serplulimab and Bevacizumab, AG chemotherapy
- Where
- China
- Volunteers
- 292 people
- Sponsor
- Zhejiang Cancer Hospital
Breast Cancer Females
A Real-world Study on the Compliance of OFS-assisted Endocrine Therapy for Hormone Receptor-positive(HR+) Premenopausal Breast Cancer
The goal of this observational study is to observe the long-term prognosis of patients with early HR-positive premenopausal breast cancer.
- Trial name
- NCT07180914
- Volunteers
- 300 people
- Sponsor
- Zhejiang Cancer Hospital
Radiation-induced Lung Injury
Study on Safety and Efficacy of UCB-MNCs for Radiation-induced Lung Injury
This study aims to evaluate the safety and efficacy of the umbilical cord blood mononuclear cells (UCB-MNCs) therapy for radiation-induced lung injuryr (RILI) by observing factors related to the therapeutic effect and adverse…
- Trial name
- NCT07177456
- Testing
- UCB-MNCs
- Volunteers
- 10 people
- Sponsor
- Zhejiang Cancer Hospital
Chronic Radiation Induced Intestinal Injury, Chronic Radiation Enteritis
Study on Safety and Efficacy of UCB-MNCs for Chronic Radiation Enteritis
This study aims to evaluate the safety and efficacy of the umbilical cord blood mononuclear cells (UCB-MNCs) therapy for chronic radiation enteritis (CRE) by observing factors related to the therapeutic effect and adverse…
- Trial name
- NCT07175207
- Testing
- UCB-MNCs
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Zhejiang Cancer Hospital
Anxiety State, Esketamine
Effect of Esketamine on Anxiety State in Patients Undergoing Abdominal Tumor Surgery
To evaluate whether esketamine can relieve anxiety in patients undergoing abdominal tumor surgery.
- Trial name
- NCT06530706
- Testing
- Esketamine, normal saline
- Where
- China
- Volunteers
- 185 people
- Sponsor
- Zhejiang Cancer Hospital
Esophageal Squamous Cell Carcinoma
Neoadjuvant ChemoRadiotherapy Followed by Immunotherapy and Surgery for Resectable Esophageal Squamous Cell Carcinoma（CRIS-2 Trial）
Based on our previous single-arm Phase Ib study (CRIS trial, NCT06303583), we observed that neoadjuvant chemoradiotherapy followed by immunotherapy (nCRIT) significantly increased the pathological complete response (pCR) rate…
- Trial name
- NCT06509568
- Testing
- Neoadjuvant chemoradiotherapy followed by immunotherapy, Neoadjuvant chemoimmunotherapy
- Where
- China
- Volunteers
- 92 people
- Sponsor
- Zhejiang Cancer Hospital
Locally Advanced Rectal Cancer
Irinotecan Liposomes in Total Neoadjuvant Therapy in Locally Advanced Rectal Cancer
This study enrolled patients with locally advanced rectal cancer. The experimental group received irinotecan liposomes combined with standard total neoadjuvant therapy (TNT), while the control group received standard TNT.
- Trial name
- CinClare-2 (NCT07074353)
- Testing
- NALIRI, LCRT, FOLFOX
- Where
- China
- Volunteers
- 360 people
- Sponsor
- Zhejiang Cancer Hospital
Gastric Cancer
Clinical Evaluation of GRAPE Model for Gastric Cancer Screening
A Prospective Study Evaluating the Performance of the GRAPE Model in Gastric Cancer Screening and Its Detection Rates Across Different Disease Stages
- Trial name
- NCT07067983
- Testing
- Results following systematic screening
- Where
- China
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Zhejiang Cancer Hospital
Liver Cancer
Postoperative Analgesia With Liposomal Bupivacaine Versus Standard Bupivacaine Combined With Dexamethasone
Liposomal bupivacaine is a novel long-acting local anesthetic approved by the FDA for postoperative analgesia because of its ability to significantly prolong the analgesic effect for up to 72 hours.
- Trial name
- NCT06173466
- Testing
- Liposomal bupivacaine, Bupivacaine Hydrochloride combined with dexamethasone
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Zhejiang Cancer Hospital
Cervical Cancer Stage IVA, Cervical Cancer Metastatic
a Single Arm, Phase II Multicenter Clinical Trial to Evaluate the Efficacy and Safety of the Combination Therapy of Iparomlimab and Tuvonralima b and Chemotherapy ± Bevacizumab Induction Therapy Followed by Concurrent Chemoradiotherapy in Patients With Advanced Cervical Cancer .
This study is a single arm, phase II multicenter clinical trial to evaluate the efficacy and safety of the combination therapy of Iparomlimab and Tuvonralimab(QL1706) and chemotherapy ± bevacizumab induction therapy followed by…
- Trial name
- NCT07035808
- Testing
- 2 cycles of combined drug induction therapy: every 3 weeks for 2 cycles; After ,synchronous radiotherapy and chemotherapy combined immunotherapy
- Volunteers
- 46 people
- Sponsor
- Zhejiang Cancer Hospital
Breast Cancer
Pyrotinib Combined With Dalpiciclib Combined With Letrozole in ER-positive and HER2-positive Advanced Breast Cancer
This is a a multicenter Phase II clinical study investigating efficacy of pyrotinib combined with dalpiciclib combined with letrozole in ER-positive and HER2-positive advanced breast cancer patients. The sample size is 63.
- Trial name
- NCT07014410
- Testing
- pyrotinib dalpiciclib letrozole
- Where
- China
- Volunteers
- 63 people
- Sponsor
- Zhejiang Cancer Hospital
Gastric Cancer, Tongue Images
Development of Novel Gastric Cancer Screening and Diagnosis Technologies Using Tongue Imaging and Study of Tongue Image Changes Mechanisms
In this study, the investigators will prospectively recruit 100,000 individuals, including gastric cancer patients who have not undergone any anti-tumor treatment and non-gastric cancer participants.
- Conditions
- Gastric Cancer, Tongue Images, Diagnosis
- Trial name
- NCT06078930
- Testing
- Tongue imaging, tougue coating, saliva, gastric juice, and feces
- Where
- China
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Zhejiang Cancer Hospital
Hepatocellular Carcinoma (HCC)
Hepatic Arterial Infusion Chemotherapy and Immunotherapy for Hepatocellular Carcinoma
Dear Sir/Madam, We would like to invite you to participate in this clinical research, which has been approved by the Medical Ethics Committee of Zhejiang Cancer Hospital.
- Trial name
- HAICI (NCT06741020)
- Testing
- Adebrelimab, Oxaliplatin, Fluorouracil,Leucovorin
- Where
- 2 sites in China
- Volunteers
- 10 people
- Sponsor
- Zhejiang Cancer Hospital
Locally Advanced Inoperable Esophageal Squamous Cell Carcinoma
Sequential Tegafur-gimeracil-oteracil Potassium Capsule (s-1) and Serplulimab Following Concurrent Chemoradiotherapy for Esophageal Squamous Cell Carcinoma
This Phase II trial evaluates the efficacy and safety of Serplulimab combined with S1 chemotherapy in patients with inoperable, locally advanced esophageal squamous cell carcinoma after concurrent chemoradiation.
- Trial name
- Stars (NCT06422858)
- Testing
- Serplulimab, Tegafur-gimeracil-oteracil potassium capsule(S1), Radiotherapy
- Where
- China
- Volunteers
- 37 people
- Sponsor
- Zhejiang Cancer Hospital
BTK Inhibitors, Follicular Lymphoma
Zanubrutinib Plus GCVP (Obinutuzumab, Cyclophosphamide, Vindesine, Prednisolone) in Previously Untreated Follicular Lymphoma
Previously untreated patients with follicular lymphoma are treated with the ZGCVP regimen (zanubrutinib, obinutuzumab, cyclophosphamide, vindesine, prednisolone) for 6 cycles.
- Conditions
- BTK Inhibitors, Follicular Lymphoma, Immunochemotherapy
- Trial name
- NCT06918015
- Testing
- ZGCVP
- Where
- China
- Volunteers
- 58 people
- Sponsor
- Zhejiang Cancer Hospital
Liver Tumor; Surgery, 3D Printing
SH-LPS System in Preoperative Planning for Liver Resection
Effective preoperative planning and real-time intraoperative guidance are crucial for performing accurate liver resections. To address this need, the researchers have designed advanced 3D-printed liver models using a self-healing…
- Conditions
- Liver Tumor; Surgery, 3D Printing, Preoperative Planning
- Trial name
- NCT06911086
- Testing
- 3D printed models, CT or MRI image
- Volunteers
- 100 people
- Sponsor
- Zhejiang Cancer Hospital