Clinical trials: sponsored by Zhejiang Cancer Hospital
Gastric Cancer, CT Images
DLCS for Predicting Neoadjuvant Chemotherapy Response
The early noninvasive screening of patients suitable for neoadjuvant chemotherapy (NCT) is essential for personalized treatment in locally advanced gastric cancer (LAGC).
- Conditions
- Gastric Cancer, CT Images, Deep Learning, Neoadjuvant Chemotherapy
- Trial name
- NCT05617469
- Testing
- develop and visualized a radio-clinical signatures from pretreatment oversampled CT images
- Where
- China
- Volunteers
- 1,100 people
- Sponsor
- Zhejiang Cancer Hospital
Unresectable Gastric Cancer
A Retrospective Study of Immunotherapy in Conversion Therapy of Unresectable Gastric Cancer
This study was an observational, non-interventional, multicenter retrospective study to evaluate the feasibility and safety of sintilimab combined with chemotherapy (SOX or PS) in the clinical practice of unresectable locally…
- Trial name
- NCT05385809
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Zhejiang Cancer Hospital
Postoperative Delirium
Whether Opioids Are Factor That Induced POD?
The purpose of this study was to investigate whether perioperative use of low doses of opioids could reduce postoperative delirium .
- Trial name
- POD (NCT05596071)
- Testing
- Sufentanil Citrate, Ropivacaine 0.75% Injectable Solution, Epidural catheter
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Zhejiang Cancer Hospital
Endobronchial Metastases, Bronchoesophageal Fistula
Clinical Application Value of Remazolam Combined With Sugammadex Sodium in Anesthesia for Endotracheal Surgery Under Bronchoscopy
This study is a prospective, randomized, controlled trial. In this study, 30 patients who underwent endotracheal tumor resection under rigid bronchoscope or stent placement for acquired tracheoesophageal fistula were selected as…
- Conditions
- Endobronchial Metastases, Bronchoesophageal Fistula, General Anesthetic Drug Adverse Reaction
- Trial name
- NCT05468671
- Testing
- Remimazolam, Propofol, Rocuronium
- Where
- China
- Volunteers
- 34 people
- Sponsor
- Zhejiang Cancer Hospital
Bladder Cancer
Oncolytic Adenovirus Combined With PD-1 Inhibitor in Patients With Non-muscle-invasive Bladder Cancer
H101 is an E1B55KD deleted oncolytic adenovirus, which is the first and only adenovirus to be approved by China State Food and Drug Administration in 2005 for treating head and neck cancer.
- Trial name
- NCT05564897
- Testing
- H101, Camrelizumab
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Zhejiang Cancer Hospital
Gastrointestinal Cancer
A Single-Arm Phase II Exploratory Clinical Study of Pemigatinib in the Treatment of Advanced Gastrointestinal Cancer (Excluding Biliary Tract Cancer) Patients With FGFR Alterations Who Have Failed Standard Therapy
This study is a prospective single-arm phase II clinical study. Advanced Gastrointestinal cancer (excluding Biliary Tract Cancer) patients with FGFR 1-3 alterations who have failed standard therapy will be enrolled in this study…
- Trial name
- NCT05559775
- Testing
- Pemigatinib Pill
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Zhejiang Cancer Hospital
Metastatic Breast Cancer in the Liver
Dynamic Contrast-enhanced MRI Combined With IVIM-DWI for Early Prediction of Chemosensitivity in Liver MBC
The purpose of this study is to further use DCE-MRI and ivim-dwi to predict the chemotherapy sensitivity of liver metastasis of breast cancer at an early stage, and to predict the treatment response of tumor at an early stage by…
- Trial name
- DreaminLMBC (NCT05550090)
- Testing
- Chemotherapy
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Zhejiang Cancer Hospital
SCLC,Extensive Stage
TRT for ES-SCLC After First Line Treatment With Immune Checkpoint Inhibitors
To Evaluate the Safety and Efficacy of Thoracic Radiotherapy for?ES-SCLC After First Line Treatment with Immune Checkpoint Inhibitors.
- Trial name
- NCT05544149
- Testing
- Thoracic radiotherapy
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Zhejiang Cancer Hospital
Locally Advanced Gastric Cancer
Tirelizumab in Combination With Chemoradiation in Patients With Unresectable Gastric Cancer or Gastroesophageal Junction Adenocarcinoma
To evaluate the efficacy and safety of chemoradiotherapy combined with tirelizumab in the treatment of initial unresectable locally advanced gastric cancer or gastroesophageal junction cancer.
- Trial name
- NCT05528367
- Testing
- Nab-PTX,S-1,Tirelizumab, Chemoradiation
- Where
- China
- Volunteers
- 33 people
- Sponsor
- Zhejiang Cancer Hospital
Nasopharyngeal Carcinoma
Radiotherapy Combined With Endostatin and Capecitabine for NPC
Radiotherapy combined with recombinant human endostatin and capecitabine for patients with nasopharyngeal carcinoma (NPC) resistant to induction chemotherapy.
- Trial name
- NCT05514275
- Testing
- Endostatin and Capecitabine
- Where
- 7 sites in China
- Volunteers
- 41 people
- Sponsor
- Zhejiang Cancer Hospital
Esophageal Squamous Cell Carcinoma
Watch and Wait for NeoAdjuvant Concurrent Radiochemotherapy Combined With Camrelizumab in Patients With Resectable ESCC
To observe the 1-year disease-free survival rate （1-year PFS） of patients with resectable esophageal squamous cell carcinoma who received neoadjuvant chemoradiotherapy combined with camrelizumab and achieved clinical complete…
- Trial name
- WATCHER (NCT05507411)
- Testing
- Neoadjuvant Radiotherapy, Neoadjuvant Chemotherapy, Immunotherapy
- Where
- 3 sites in China
- Volunteers
- 100 people
- Sponsor
- Zhejiang Cancer Hospital
Hepatocellular Carcinoma, Desflurane Adverse Reaction
Effect of Propofol and Desflurane on Nucleic Acid of Liver Circulating Tumor
To investigate the effects of perioperative anesthetic drugs propofol and desflurane on circulating tumor nucleic acids (CK7, ELF3, EGFR and EphB4 mRNA) in the blood of patients with liver cancer, so as to provide scientific…
- Conditions
- Hepatocellular Carcinoma, Desflurane Adverse Reaction, Propofol Adverse Reaction, Circulating Tumor Cells
- Trial name
- NCT05502458
- Testing
- Desflurane, Propofol
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Zhejiang Cancer Hospital
Histologically Confirmed Breast Cancer ,Diagnosis of Bone Metastasis
Effect of Zoledronic Acid Treatment on Bone-related Events in Breast Cancer Patients With Bone Metastases: a Prospective, Multicenter, Real-world Study
non-intervention、real world study； Effect of timing and regular treatment of zoledronic acid on the incidence of SREs in breast cancer patients
- Trial name
- NCT05480189
- Testing
- Non-intervention
- Volunteers
- 1,000 people
- Sponsor
- Zhejiang Cancer Hospital
Homologous Recombination Deficiency, Triple Negative Breast Cancer
Phase II Study of Niraparib in Metastatic TNBC Patients With Homologous Recombination Deficiency
The incidence of homologous recombination deficiency in metastatic triple negative breast cancer was 52%-59%，PARP plays a key role in sensing DNA damage and converting it into intracellular signals that activate the base excision…
- Trial name
- NCT05461690
- Testing
- Niraparib
- Volunteers
- 50 people
- Sponsor
- Zhejiang Cancer Hospital
Cervical Cancer
A Clinical Study to Explore the Efficacy and Safety of Tislelizumab in Combination With Bevacizumab and Chemotherapy in Patients With Persistent, Recurrent, or Metastatic Cervical Cancer
Efficacy and safety of Tislelizumab combined with Bevacizumab and chemotherapy in patients with persistent, recurrent or metastatic cervical cancer.
- Trial name
- NCT05247619
- Testing
- Tislelizumab / Bevacizumab/Paclitaxel/Cisplatin/Carboplatin
- Where
- China
- Volunteers
- 49 people
- Sponsor
- Zhejiang Cancer Hospital
Liver Surgery
Anterior Quadratus Lumborum Block at the Lateral Supra-arcuate Ligament for Analgesia After Open Liver Surgery
This is a prospective, randomized, controlled, noninferiority trial for evaluating the efficacy of ultrasound-guided anterior quadratus lumborum block at the lateral supra-arcuate ligament versus thoracic epidural analgesia after…
- Trial name
- NCT04668391
- Testing
- Ultrasound-guided anterior quadratus lumborum block at the lateral supra-arcuate ligament, Thoracic epidural analgesia
- Where
- China
- Volunteers
- 74 people
- Sponsor
- Zhejiang Cancer Hospital
Uterine Cervical Neoplasms
The Role of Clean Intermittent Catheterization in Patients Undergoing Radiotherapy After Radical Hysterectomy for Cervical Cancer
Through a prospective, randomized and controlled research design method, this study implemented intermittent catheterization for patients with urinary dysfunction after postoperative radiotherapy of cervical cancer, formulated a…
- Trial name
- NCT05410444
- Testing
- Clean Intermittent Catheterization, Indwelling catheterization
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Zhejiang Cancer Hospital
Early Gastric Cancer
Early Detection of Gastric Cancer Using Plasma Cell-free DNA Fragmentomics
The purpose of this study is to enable non-invasive early detection of gastric cancer in high-risk populations through the establishment of a multimodal machine learning model using plasma cell-free DNA fragmentomics.
- Trial name
- NCT05269056
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Zhejiang Cancer Hospital
NSCLC Stage IV
SBRT for Oligoprogressive NSCLC After First Line Treatment With Immune Checkpoint Inhibitors
The treatment modality with immunotherapy has been the first-line standard treatment for advanced NSCLC. But more than 2/3 patients still develop acquired drug resistance within 5 years of immunotherapy, and more than 1/2…
- Trial name
- NCT05387044
- Testing
- SBRT
- Where
- China
- Volunteers
- 28 people
- Sponsor
- Zhejiang Cancer Hospital
Stage IV Esophagus Squamous Cell Carcinoma
Phase II Clinical Study of Camrelizumab Combined With Chemotherapy or Anlotinib in Advanced Esophageal Squamous Cell Cancer
To observe and evaluate the efficacy and safety of camrelizumab combined with chemotherapy or anlotinib in patients with advanced esophageal squamous cell carcinoma previously Treated With First-line Immunotherapy
- Trial name
- NCT05322499
- Testing
- Camrelizumab, Irinotecan, Paclitaxel
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Zhejiang Cancer Hospital