Clinical trials: sponsored by Zhejiang University
Bipolar Disorder (BD)
Research on the Efficacy and Safety of Targeted Suprachiasmatic Nucleus Electrical Stimulation for Improving Metabolic Disorders in Patients With Stable Bipolar Disorder Comorbid With Obesity
This study aims to stabilize the patients with bipolar disorder (BD) comorbid with obesity in the stable phase by using temporal interference stimulation (TIS ) intervention.
- Trial name
- NCT07589647
- Testing
- Temporal Interference Stimulation
- Where
- China
- Volunteers
- 70 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Cirrhosis, Liver, Hypertension, Portal
Prophylactic Antibiotics in Endoscopic Secondary Prevention of Gastroesophageal Variceal Bleeding
Whether prophylactic antibiotics should be administered in the endoscopic secondary prevention of GVB or not is unclear. In this non-inferiority trial, we are aimed to evaluate whether prophylactic antibiotics are essential in…
- Conditions
- Cirrhosis, Liver, Hypertension, Portal, Variceal Hemorrhage
- Trial name
- NCT06437964
- Testing
- No use of prophylactic antibiotics, Prophylactic Antibiotics
- Where
- China
- Volunteers
- 226 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Prostate Cancer (Post Prostatectomy), Perioperative Anesthetic
Effects of Rectal Indomethacin Suppository on Postoperative CRBD in Patients Undergoing LRP
The postoperative incidence of catheter-related bladder discomfort (CRBD) ranges from 47% to 95%. It increases postoperative pain and agitation, thus requiring early intervention.
- Conditions
- Prostate Cancer (Post Prostatectomy), Perioperative Anesthetic, Catheter-related Bladder Discomfort (CRBD)
- Trial name
- NCT07607990
- Testing
- Indomethacin suppository
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Zhejiang University
Major Depressive Disorder
The Efficacy and Safety of Task-state-based Temporal Interference Stimulation (TI) in the Treatment of Patients With Depression
This study intends to investigate the intervention efficacy of temporal interference stimulation (TI) on mood symptoms in depressed patients, as well as to explore the neuroimaging mechanisms of TI improvement in depressed…
- Trial name
- NCT06826469
- Testing
- Temporal Interference Stimulation
- Where
- China
- Volunteers
- 43 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Hepatocellular Carcinoma
Early-stage Detection of Liver Cancer by Proteins in Peripheral Blood
By collecting blood samples from liver cancer patients and healthy individuals, and comparing the blood protein profiles of the two, the biomarkers for early diagnosis and tissue traceability were identified to accurately…
- Trial name
- NCT06544083
- Testing
- Proteomics
- Where
- China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Heat Stroke
Application of an Early In-Hospital Temperature Management Protocol for Heat Stroke Patients
Heat stroke is a life-threatening clinical syndrome characterized by an imbalance between heat production and heat dissipation in the body, resulting from exposure to hot and humid environments and/or strenuous exercise.
- Trial name
- NCT06537557
- Testing
- the early in-hospital temperature management protocol for heat stroke patients
- Where
- 7 sites in China
- Volunteers
- 188 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Central Serous Chorioretinopathy
the Study of the Association Between the Gut Microbiota and Central Serous Chorioretinopathy
To investigate the potential association between gut microbiota and central serous chorioretinopathy (CSC), clinical observations have indicated that patients with CSC frequently present with chronic gastrointestinal symptoms.
- Trial name
- NCT06527326
- Testing
- Live Combined Bifidobacterium
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Bipolar Disorder
Efficacy and Safety of Task-activated rTMS in Improving Cognitive Function in Patients With Bipolar Disorder
1. To clarify the efficacy and safety of task-based repetitive transcranial magnetic stimulation (rTMS) on cognitive function in patients with stable bipolar disorder. 2.
- Trial name
- NCT06782763
- Testing
- Repetitive transcranial magnetic stimulation device
- Where
- China
- Volunteers
- 82 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Bipolar Disorder
Neuronavigation rTMS to Improve Depressive Episodes of Bipolar Disorder in Adolescent
The purpose of this study is to explore a new stimulation target and protocol for the treatment of depressive episode in adolescents with bipolar disorder through the repetitive transcranial magnetic stimulation(rTMS) under…
- Trial name
- NCT05929183
- Testing
- Repetitive Transcranial magnetic stimulation
- Where
- China
- Volunteers
- 40 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Heat Stroke
Non-inferiority Study of the Effect of Non-cooling Blanket on Body Temperature in Patients With Heat Stroke
The goal of this clinical trial is to test the cooling effect of cooling blanket in patients with heat stroke. The main questions it aims to answer are: the cooling rate of cooling blanket in patients with heat stroke the…
- Trial name
- NCT05923931
- Testing
- cooling blanket, non-cooling blanket
- Where
- 7 sites in China
- Volunteers
- 126 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Bipolar Depression
Task-State-Based Temporal Interference Stimulation (TI) to Improve Depression in Patients With Bipolar Disorder
The purpose of this study is to investigate the efficacy and safety of temporal interference stimulation (TI) in improving depressive episodes of bipolar disorder, to analyze the therapeutic principle of TI in bipolar disorder…
- Trial name
- NCT06516991
- Testing
- Temporal Interference Stimulation
- Where
- China
- Volunteers
- 36 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Prenatal Diagnosis, Fetal Diseases
Utility of Whole Genome Sequencing in Fetuses With Abnormal Ultrasound Findings
The goal of this observational study is to learn if whole-genome sequencing (WGS) can help find the genetic cause in fetuses with structural abnormalities that remain unexplained after standard genetic testing (such as…
- Trial name
- NCT07606989
- Where
- 4 sites in China
- Volunteers
- 1,000 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
CIN 2/3, Cervical Cancer (Early Detection)
Peripheral Blood CyTOF Immune Model for Cervical Lesion Detection in HPV16/18+ Women
This prospective, multicenter cohort study will recruit eligible HPV16/18-positive women from three tertiary hospitals in China.
- Trial name
- NCT07606677
- Volunteers
- 1,465 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Biliary Tract Cancer, Colorectal Carcinoma
CDH17 CAR-T Therapy in Advanced Malignant Solid Tumors
The investigational product used in this study, UCLH801 cells, is a CAR-T cell therapy specifically targeting CDH17. The proposed indication includes CDH17-positive advanced solid tumors, such as but not limited to colorectal…
- Conditions
- Biliary Tract Cancer, Colorectal Carcinoma, Gastric Cancer, Metastatic, Pancreatic Adenocarcinoma (Ductal Adenocarcinoma)
- Trial name
- NCT06937567
- Testing
- CDH17 CAR-T, FAST LACO-Stim CDH17 CAR-T
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Zhejiang University
Castration-Resistant Prostate Cancer (CRPC)
A Clinical Study Evaluating the Safety and Efficacy of Local Injection of ACT#001 Chimeric Antigen Receptor T Cells in the Treatment of Castration-Resistant Prostate Cancer
An exploratory clinical study evaluating the safety and efficacy of ACT#001 chimeric antigen receptor T-cell (CAR-T cell) local injection in the treatment of castration-resistant prostate cancer.
- Trial name
- NCT07240857
- Testing
- Intraprostatic or localized lesion injection of ACT#001-PSMA CAR-T cells under transrectal ultrasound (TRUS) guidance
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Zhejiang University
Vitiligo
Efficacy and Safety of Ruxolitinib Cream in Chinese Children Aged 2-11 Years With Non-segmental Vitiligo
The goal of this clinical trial is to evaluate the efficacy and safety of Ruxolitinib Phosphate Cream in treating non-segmental vitiligo in children aged 2 to 11 years under real-world conditions.
- Trial name
- NCT07595939
- Testing
- Ruxolitinib 1.5% Cream BID
- Where
- China
- Volunteers
- 20 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Perioperative Anxiety, Major Abdominal Surgery
Effect of taVNS on Perioperative Anxiety in Major Abdominal Surgery
It is reported that over 50% of patients undergoing major abdominal surgery experience perioperative anxiety, which often triggers a vicious cycle of "anxiety-pain-gastrointestinal dysfunction" and significantly hinders…
- Trial name
- taVNS-MASAnx (NCT07495163)
- Testing
- transauricular auricular vagus nerve stimulation
- Where
- 4 sites in China
- Volunteers
- 282 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Insomnia Disorder, Sleep Initiation and Maintenance Disorders
Inulin-Spirulina Co-intervention for Insomnia Disorder
The goal of this clinical trial is to learn if inulin and spirulina, used alone or in combination, can improve insomnia disorder in adults aged 18 to 60 years with chronic insomnia disorder.
- Trial name
- NCT07537192
- Testing
- Inulin, Spirulina, Maltodextrin
- Volunteers
- 180 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Congenital Heart Disease, Physical Inactivity
Exergame-Based Physical Activity Promotion for Children and Adolescents With Congenital Heart Disease
The goal of this clinical trial is to learn whether a Nintendo Switch-based exergame physical activity program can help children and adolescents with congenital heart disease increase their physical activity.
- Trial name
- ExPACE-CHD (NCT07593118)
- Testing
- Nintendo Switch-Based Exergame Physical Activity Promotion Intervention
- Where
- China
- Volunteers
- 13 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Solid Tumor Leptomeningeal Metastasis
A Prospective Single Arm Phase II Exploratory Study on the Combination of Whole Brain Radiotherapy, Thiotepa Intrathecal Injection and Systemic Treatment of Primary Diseases in the Treatment of Solid Tumor Leptomeningeal Metastasis
The goal of this prospective, single-arm exploratory clinical study is to explore the safty and efficacy of whole-brain radiotherapy combined with Thiotepa intrathecal injection combined with systemic therapy for the primary…
- Trial name
- NCT06376292
- Testing
- Intrathecal Injection of Thiotepa+Radiation+Systemic Treatment of Primary Diseases
- Where
- China
- Volunteers
- 58 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
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