Clinical trials: sponsored by Zhejiang University
Periodontis, Aggressive Periodontitis
Single-cell and Spatial Transcriptomic Profiling of Gingival Tissues in Aggressive and Chronic Periodontitis: Deciphering Cellular Heterogeneity and Inflammatory Microenvironment Features
The goal of this observational study is to investigate cellular heterogeneity and inflammatory microenvironment features in gingival tissues from patients with aggressive periodontitis compared to chronic periodontitis and…
- Trial name
- NCT07487272
- Where
- China
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Overweight and Obese Adults
RWS of of Liraglutide Alone and in Combination With Orlistat for Weight Loss in Overweight/Obese Patients.
To evaluate the differences in weight loss between liraglutide monotherapy and combined with orlistat in overweight/obese patients.
- Trial name
- NCT07301437
- Testing
- liraglutide monotherapy, liraglutide combined with orlistat
- Volunteers
- 120 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Inflamatory Bowel Disease, Inflamatory Bowel Disease (Crohn's and Ulcerative Colitis)
A Prospective Observational Study on the Efficacy and Safety of Guselkumab in the Treatment of Crohn's Disease Patients Previously Treated With Ustekinumab
This is a prospective, single-center, observational study aimed at evaluating the efficacy and safety of guselkumab in patients with moderate to severe Crohn's disease (CD) who have previously failed or were intolerant to…
- Trial name
- NCT07487480
- Testing
- Observation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Inflamatory Bowel Disease
A Prospective Cohort Study Evaluating the Efficacy and Safety of Guselkumab (GUS) With JAK Inhibitors in Patients With Difficult-To-Treat Inflammatory Bowel Disease (IBD)
Patients with refractory inflammatory bowel disease (IBD) show inadequate response to conventional biologics and small molecule drugs, with persistently active disease that severely impacts quality of life and long-term…
- Trial name
- NCT07487311
- Testing
- guselkumab (GUS), JAK inhibitors (such as upadacitinib/tofacitinib)
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Music Therapy
Nurse-Led Staged Art Therapy Effects on Psychological Distress and Pregnancy Outcomes in AIH: RCT
Music therapy is a comprehensive therapy that integrates musicology, psychology and medicine. It is an application and development outside the field of traditional art appreciation and aesthetics .
- Trial name
- NCT07356830
- Testing
- music therapy
- Where
- China
- Volunteers
- 254 people, healthy volunteers welcome
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia
HEM-SURVIVE: Structuralized Follow-up for Childhood Hematological Malignancy Survivors
This study aims to construct a structuralized follow-up model for survivors of childhood hematological malignancies in China. Using a multicenter prospective cohort design, it will identify the burden and risk factors of late…
- Conditions
- Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Lymphoma, Leukemia
- Trial name
- NCT07483749
- Where
- 3 sites in China
- Volunteers
- 400 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Lymphoma Patients With High-risk of Central Nervous System Relapse
ASCT With TEAM Conditioning for Lymphoma With High Risk of CNS Relapse
In the era of novel therapeutic agents, high-dose conditioning chemotherapy combined with autologous hematopoietic stem cell transplantation (auto-HSCT) remains an important and feasible consolidation strategy for non-Hodgkin…
- Trial name
- NCT07481669
- Testing
- TEAM regimen (thiotepa, etoposide, cytarabine and melphalan)
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Uterine Fibroids (Leiomyoma), Ovarian Tumors
TEAS Combined With Triple Antiemetic Drugs to Prevent PONV in High-Risk Patients
The goal of this clinical trial is to evaluate the effects of transcutaneous electrical acupoint stimulation (TEAS) combined with triple antiemetics for postoperative nausea and vomiting (PONV) in high-risk patients.
- Conditions
- Uterine Fibroids (Leiomyoma), Ovarian Tumors, Gallstones
- Trial name
- NCT07480785
- Testing
- transcutaneous electrical acupoint stimulation, triple antiemetic drugs
- Where
- China
- Volunteers
- 780 people
- Sponsor
- Zhejiang University
Postoperative Delirium (POD), Prostate Cancer
A Phase II Clinical Two-Stage Study of Transcranial Magnetic Stimulation in Preventing Postoperative Delirium in Elderly Patients After Urological Surgery
Cases were included based on the inclusion and exclusion criteria, and induction, maintenance, and recovery were conducted in accordance with the standard protocol for general anesthesia.
- Conditions
- Postoperative Delirium (POD), Prostate Cancer, Kidney Tumor
- Trial name
- NCT07480044
- Testing
- Transcranial Magnetic Stimulation Device
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Zhejiang University
Refractory/Recurrent Peripheral T-cell Lymphoma
Exploratory Study of Umbilical Cord Blood-Derived CAR-NK Cell Therapy Targeting TRBC1/2 for Relapsed/Refractory T-Cell Lymphoma
This study aims to evaluate the safety and efficacy of Umbilical Cord Blood-Derived CAR-NK Cell Therapy Targeting TRBC1/2 (TRBC1/2 CAR-NK cells) in patients with refractory or relapsed peripheral T-cell lymphoma (PTCL).
- Trial name
- NCT07164560
- Testing
- Anti-TRBC1 CAR-T cells
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Venentoclax, Myeloid Malignancies
Fludarabine Plus Melphalan Versus Addition of Venetoclax to Fludarabine/Melphalan Conditioning Regimen for Allogeneic Hematopoietic Stem Cell Transplantation in AML/MDS Patients Aged > 50 Years: a Multicenter, Randomized, Phase 3 Trial
Allogeneic Hematopoietic Cell Transplantation (Allo-HCT) serves as a curative treatment modality for the vast majority of patients with hematological malignancies.
- Conditions
- Venentoclax, Myeloid Malignancies, Conditioning, ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION
- Trial name
- NCT07396480
- Testing
- Venetoclax in combination with fludarabine and melphalan, Fludarabine and Melphalan
- Where
- 18 sites in China
- Volunteers
- 186 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Esophageal and Gastric Varices
Study on Portal Vein Pressure Gradient Measurement Under Endoscopic Ultrasound Guidance for Gastric Fundal Varices
This study aimed to evaluate the feasibility and safety of direct gastric variceal pressure measurement in patients with large spontaneous portosystemic shunts, and to determine whether the gastric variceal pressure gradient…
- Trial name
- NCT07478770
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Tumor
T Cell Receptor Gene-Engineered and Dominant Negative TGF-β Receptor T Cell Therapy Targeting KRAS Mutations in the Treatment of Subjects With Advanced Solid Tumor
An open label, dose-escalation clinical study to evaluate the safety, anti-tumor activity and pharmacokinetics/pharmacodynamic (PK/PD) of NW-301VT in subjects with advanced solid tumor.
- Trial name
- NCT07474168
- Testing
- NW-301VT
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Zhejiang University
Hydatidiform Mole, Gestational Trophoblastic Neoplasia
Study of Different Therapeutic Strategies in Hydatidiform Mole With Lung Nodule
The purpose of present study is to provide clinical evidences for the appropriate management of molar pregnancy with lung nodule. The hydatidiform mole patients with lung nodule ≥1.0cm will be randomized into 2 groups: A.
- Trial name
- NCT03785574
- Testing
- Follow up, chemotherapy
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Ankle Ligament Injury，Chronic Ankle Instability，Ankle Arthroscopy
Preop US-Guided Nerve Blocks for Pain & Recovery After Ankle Arthroscopy
This randomized, double-blind controlled trial investigates the effectiveness and potential trade-offs of preoperative ultrasound-guided popliteal sciatic and saphenous nerve blocks in patients undergoing ankle arthroscopy, a…
- Trial name
- NCT07470021
- Testing
- Ultrasound-guided popliteal sciatic and saphenous nerve block
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Social Anxiety Disorder (SAD)
Intermittent Theta Burst Stimulation of the Prefrontal Cortex in Social Anxiety Disorder
This study aims to investigate the therapeutic effects of intermittent theta burst stimulation on social anxiety disorder and to track physiological changes in the brain using electroencephalography (EEG).
- Trial name
- NCT07466277
- Testing
- Active Intermittent Theta-Burst Stimulation (iTBS)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Lung Cancer, Pulmonary Nodule
Video Double-Lumen Tube for Secondary Pulmonary Resection
During thoracic surgery, double-lumen endotracheal intubation with one-lung ventilation is routinely performed to optimize surgical exposure, facilitate operative manipulation, and prevent iatrogenic lung injury.
- Trial name
- NCT07467005
- Testing
- Video Double-Lumen Tube Group, Conventional Double-Lumen Tube Group
- Where
- 3 sites in China
- Volunteers
- 500 people
- Sponsor
- Zhejiang University
EEG Data Analysis, Orthopedic Surgery
Characteristic Electroencephalogram of General Anesthesia
Patients were enrolled according to predefined inclusion and exclusion criteria. Following surgical admission, standard monitoring was initiated, including continuous assessment of heart rate, blood pressure, electrocardiogram…
- Trial name
- NCT07468162
- Testing
- After the use of sedative drugs, the changes in the electroencephalogram (EEG) spectrum were observed with an EEG monitor
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Atrial Fibrillation Recurrence
Atrial Fibrillation Recurrence Prediction
We aimed to develop an dual-branch deep learning network that integrates feature representations extracted from medical texts using large language models, with structured data features derived from perioperative records of AF…
- Trial name
- NCT06977516
- Where
- 5 sites in China
- Volunteers
- 2,508 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Subarachnoid Haemorrhagic Stroke
Beta-sitosterol for Subarachnoid Hemorrhage: Mechanistic Analysis of Recovery and Therapy
Subarachnoid Hemorrhage (SAH), a devastating form of stroke, is associated with high mortality and disability rates due to complex secondary brain injuries-including neuroinflammation, oxidative stress, and blood-brain barrier…
- Trial name
- B-SMART (NCT07457333)
- Testing
- Supplementation of β -sitosterol, Standard medical treatment
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
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