Clinical trials: sponsored by Zhejiang University
Lung Cancer
A Hierarchical Multi-modal AI Framework for Pathological and Genetic Subtyping of Lung Cancer Based on PET/CT Imaging
PET/CT imaging and clinical information (age, gender, smoking history, family history of cancer, history of present illness, and several tumor biomarkers, etc.) were used to establish a hierarchical multi-modal AI framework for…
- Trial name
- NCT07463300
- Testing
- PET imaging analysis, data mining, and AI model developing
- Where
- 9 sites in China
- Volunteers
- 5,500 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Gastric Cancer Stage, Esophageal Cancer
Development and Validation of a Risk Prediction Model for Gastric Retention in Patients Undergoing Sedated Gastroscopy
Gastric retention not only compromises the quality of endoscopic examination but also significantly increases the risk of reflux and aspiration in sedated patients.
- Conditions
- Gastric Cancer Stage, Esophageal Cancer, Gastroparesis
- Trial name
- NCT07104214
- Where
- 3 sites in China
- Volunteers
- 5,000 people
- Sponsor
- Zhejiang University
Hypoxemia, Esophageal Cancer
Combination of COMBO Endoscopy Oropharyngeal Airway and HFNC Oxygenation in Sedated Gastrointestinal Endoscopy for Morbidly Obese Patients
Hypoxaemia during sedated gastrointestinal endoscopy exceeds 40 % in morbidly obese (BMI ≥ 35 kg m-²) patients. High-flow nasal cannula alone often fails because of persistent airway collapse.
- Conditions
- Hypoxemia, Esophageal Cancer, Morbidly Obese Patients, Gastric Cancer
- Trial name
- NCT07175155
- Testing
- COMBO Endoscopy Oropharyngeal Airway with High-Flow Nasal Cannula Oxygenation, High-Flow Nasal Cannula Oxygenation
- Where
- 5 sites in China
- Volunteers
- 410 people
- Sponsor
- Zhejiang University
Aphasia, Dysarthria
Chinese-Specific Speech Imagery Coding Using High-Density ECoG
The goal of this study is to investigate whether high-density electrocorticography (ECoG) signals recorded from the surface of the brain can be used to decode neural representations of Mandarin Chinese speech features, including…
- Conditions
- Aphasia, Dysarthria, ALS, Speech and Language Disorder
- Trial name
- NCT07460037
- Testing
- Intraoperative high-density ECoG recording, Permanent high-density ECoG implantation
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Ankle Sprain, Ankle (Ligaments); Instability (Old Injury)
Comparison of Anesthetic Techniques for Early Recovery After Ankle Arthroscopy
Ankle arthroscopy is increasingly performed as a day-case procedure, making rapid recovery and efficient discharge critical. Anesthetic technique substantially influences postoperative recovery, yet high-quality evidence…
- Conditions
- Ankle Sprain, Ankle (Ligaments); Instability (Old Injury), Pain Management, ERAS
- Trial name
- NCT07460310
- Testing
- Total intravenous anesthesia combined with peripheral nerve block (TIVA + PNB) group, General anesthesia combined with peripheral nerve block (GA + PNB) group, Spinal anesthesia
- Volunteers
- 200 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Childhood Acute Lymphoblastic Leukemia
NUDT15/TPMT Multi-gene Guided 6-MP Dosing in Childhood ALL Maintenance Therapy
This is a prospective, single-center clinical study to evaluate the safety and efficacy of a personalized 6-mercaptopurine (6-MP) dosing strategy guided by NUDT15 and TPMT genotypes in children with Acute Lymphoblastic Leukemia…
- Trial name
- NCT07462299
- Testing
- NUDT15/TPMT genotype-guided 6-MP dosing
- Where
- China
- Volunteers
- 110 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Soft Tissue Sarcoma (Excluding GIST)
Liposomal Irinotecan in Combination With Temozolomide and Bevacizumab in Patients With Advanced STS
The study is expected to include 24 patients with metastatic or surgically unresectable relapsed/refractory soft tissue sarcoma confirmed by histological evidence, who have received at least one line of systemic treatment…
- Trial name
- NCT07457775
- Testing
- Irinotecan Hydrochloride Liposome Injection(II) combined with temozolomide and bevacizuma
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Allergic Rhinitis Due to House Dust Mite
The Efficacy of Specific Immunotherapy Guided by Component-Resolved Diagnosis for Dust Mite Allergens in Chinese Pediatric Patients With Rhinitis and/or Asthma
This study is a Study to Understand How to Better Match Allergy Shots to a Child's Unique Mite Allergy Profile 1. Why is this study being done? For many children, tiny house dust mites are a major cause of persistent allergies…
- Trial name
- NCT07452380
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Myocardial Infarction
Development and Validation of a Multimodal Artificial Intelligence Model for Early Prediction of Acute Myocardial Infarction
Acute myocardial infarction (AMI) remains a leading cause of mortality worldwide. Although early revascularization has markedly improved short-term outcomes, the incidence of major adverse cardiovascular events after the index…
- Trial name
- NCT07457320
- Testing
- Percutaneous coronary intervention
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Head and Neck Cancer Squamous Cell Carcinoma
A Study Testing Emactinib Sulfate With Chemotherapy and Immunotherapy Before Surgery for Advanced Head and Neck Cancer
The goal of this clinical trial is to evaluate the efficacy and safety of a novel combination therapy for locally advanced head and neck squamous cell carcinoma (HNSCC).
- Trial name
- NCT07457346
- Testing
- cisplatin+ nab-paclitaxel +adebrelimab + imaxitinib
- Where
- China
- Volunteers
- 76 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
TNBC, Triple Negative Breast Cancer
Neoadjuvant Toripalimab Plus SBRT for Chemo-Resistant Triple-Negative Breast Cancer
The goal of this clinical trial is to test whether a "rescue" strategy can turn chemotherapy-resistant triple-negative breast cancer (TNBC) into a curable state.
- Trial name
- NEOTRIO-2 (NCT07457359)
- Testing
- SBRT, Toripalimab (anti-PD-1 antibody), Chemotherapy switch
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Effectiveness
A Study on the Efficacy and Safety of Telitacicept in the Treatment of Children Ocular Myasthenia Gravis
Under conventional treatment regimens, pediatric ocular myasthenia gravis (OMG) is prone to relapse and is associated with corticosteroid-related adverse effects, indicating an unmet clinical need.
- Trial name
- NCT07298928
- Testing
- Telitacicept
- Where
- 3 sites in China
- Volunteers
- 30 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Abdominal Diseases
Rapid Abdominal Diagnosis With AI & Radiology
This study aims to develop an AI-assisted diagnostic system for abdominal contrast-enhanced CT images using data from multiple inpatient centers.
- Trial name
- RADAR (NCT07040358)
- Where
- China
- Volunteers
- 2,000,000 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Migraine
Multicenter, Double-blind, and Randomized Controlled Trial of Ultra-Distal TENS Device for Migraine Treatment
Multicenter, double-blind, and randomized controlled trial of Ultra-Distal Transcutaneous Electrical Nerve Stimulation (TENS) Device for Migraine treatment.
- Trial name
- NCT07451158
- Testing
- Trail of Ultral-distal Transcutaneous Electrical Nerve Stimulation, Fake Stimulus
- Where
- China
- Volunteers
- 206 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Digital Eye Strain, Computer Vision Syndrome
Effect of Yellow Light AG Mobile Phone Screen on Dry Eye and Asthenopia.
This study aimed to evaluate the protective effects of yellow-light etching anti-glare (AG) screen on Digital Eye Strain (DES) induced by prolonged video display terminal (VDT) use under dim environment, Based on the proved…
- Conditions
- Digital Eye Strain, Computer Vision Syndrome, Dry Eye, Asthenopia
- Trial name
- NCT07340359
- Testing
- reading 2h on smartphone
- Where
- China
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
pMMR, MSS
Serplulimab Combined With CAPEOX + Celecoxib as Neoadjuvant Treatment for Locally Advanced Rectal Cancer
Colorectal cancer of Mismatch Repair-proficient (pMMR)/ Microsatellite Stability (MSS) accounts for approximately 85% of all colorectal cancer patients, which might be insensitive to immunotherapy.
- Conditions
- pMMR, MSS, MSI-L, Locally Advanced Rectal Carcinoma
- Trial name
- NCT05731726
- Testing
- Serplulimab, Capecitabine, Oxaliplatin
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Zhejiang University
Non Small Cell Lung Cancer
18F-FDG PET/CT Radiomics Models for Precision Diagnosis and Prognosis in NSCLC
This multicenter retrospective study aims to investigate the value of 18F-FDG PET/CT radiomics features in the preoperative precision staging, pathological typing, gene mutation status prediction, and prognostic risk…
- Trial name
- PET-Rad-NSCLC (NCT07449858)
- Where
- 4 sites in China
- Volunteers
- 500 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Head and Neck Cancer, Radiotherapy
Iparomlimab and Tuvonralimab Plus Hypofractionated Radiotherapy and Chemotherapy for HAHNSCC
Head and neck squamous cell carcinoma (HNSCC) is often diagnosed at a locally advanced stage, where cisplatin-based chemoradiotherapy is standard but still results in high recurrence rates.
- Conditions
- Head and Neck Cancer, Radiotherapy, Anti-PD-1/CTLA-4 Antibody
- Trial name
- NCT07447570
- Testing
- Iparomlimab and Tuvonralimab injection, Hypofractionated Radiotherapy, Chemotherapy
- Where
- China
- Volunteers
- 27 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Breast, Breast Cancer
Clinical Translation Research on a Multi-omics Breast Cancer Distant Metastasis Prediction Model Empowered by Artificial Intelligence
Breast cancer is one of the most common malignancies in women worldwide, and distant metastasis is the main cause of poor prognosis and death.
- Conditions
- Breast, Breast Cancer, Pathology
- Trial name
- COMPASS-BC (NCT07252986)
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Hysterectomy
Clinical Application and Efficacy of a Self-Locking Uterine Manipulator Stand in Hysterectomy
The primary goal of this clinical trial is to evaluate whether a Universal Self-Locking Uterine Manipulator Stand can reduce the level of fatigue experienced by clinicians during total hysterectomy.The key question it aims to…
- Trial name
- NCT07445880
- Testing
- a Universal Self-Locking Uterine Manipulator Stand
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
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