Clinical trials: sponsored by Zhejiang University
Liver Diseases, Gallbladder Diseases
Research on Construction and Verification of Multimodal Medical Imaging Large Model
With the accumulation of multimodal clinical data such as medical imaging and electronic health records (EHRs), efficient utilization of multi-source information to achieve precise diagnosis and intelligent decision-making has…
- Conditions
- Liver Diseases, Gallbladder Diseases, Pancreatic Diseases, Artificial Intelligence (AI)
- Trial name
- NCT07445152
- Volunteers
- 2,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Hematopoietic Stem Cell Transplantation, Thrombocytopenia
Comparison of Etamsylate Versus Placebo to Prevent Bleeding in HSCT
This study employs a prospective, randomized, double-blind, placebo-controlled design. It aims to compare the efficacy of etamsylate versus placebo in preventing bleeding complications in patients with thrombocytopenia following…
- Trial name
- NCT07442513
- Testing
- etamsylate
- Where
- China
- Volunteers
- 404 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
CD - Crohn's Disease, Stricture; Bowel
Guselkumab Vs Ustekinumab in Stricturing Crohn's Disease
This study intends to select patients with confirmed moderate-to-severe Crohn's disease (CD) and obstructive symptoms of intestinal stenosis, who have clear evidence of lumen stenosis caused by the disease itself through…
- Conditions
- CD - Crohn's Disease, Stricture; Bowel, IBD - Inflammatory Bowel Disease
- Trial name
- NCT07444060
- Testing
- Guselkumab (GUS), Ustekinumab (UST)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Autism Spectrum Disorder (ASD), Autism
Xenon Therapy for Children With Autism Spectrum Disorder
This study aims to evaluate the efficacy and safety of inhaled xenon for the treatment of children with autism spectrum disorder (ASD).
- Trial name
- ASD; Xe (NCT07435103)
- Testing
- Xenon
- Where
- China
- Volunteers
- 72 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Marginal Zone Lymphoma
Optimize Study - Orelabrutinib Combined With BR/G in Untreated Marginal Zone Lymphoma (MZL)
This is a multi-center, prospective cohort study. The main purpose of Cohort A is to evaluate the efficacy and safety of Orelabrutinib combined with BR (bendamustine and rituximab) for previously untreated young patients with…
- Trial name
- NCT06504940
- Testing
- Orelabrutinib combined with bendamustine and rituximab, Orelabrutinib combined with obinutuzumab
- Where
- China
- Volunteers
- 69 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Acute Myeloid Leukemia, Pediatric Acute Myeloid Leukemia
Selinexor Combined With Induction Chemotherapy for Children With NUP98-positive AML
This is a prospective, single-arm, open-label clinical study to evaluate the efficacy and safety of Selinexor combined with a standardized induction chemotherapy regimen (ZJCH-AML) for children with NUP98-fusion positive Acute…
- Conditions
- Acute Myeloid Leukemia, Pediatric Acute Myeloid Leukemia, NUP98 Fusion-positive Acute Myeloid Leukemia
- Trial name
- NCT07437170
- Testing
- Selinexor, ZJCH-AML Standardized Chemotherapy
- Where
- China
- Volunteers
- 10 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Fabry Disease
Evaluate the Safety and Preliminary Efficacy of EXG110 in Subjects With Fabry Disease
Objective: To explore the safety and tolerability of different doses of EXG110 with Fabre disease
- Trial name
- NCT06539624
- Testing
- EXG110 injection
- Where
- 2 sites in China
- Volunteers
- 12 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Osteomyelitis (Refractory)
Prospective, Randomized, Multicenter Clinical Trial of Bisphosphonates Combined With Vancomycin for the Treatment of Cierny-Mader Type I and III Osteomyelitis
A Multicenter, Prospective, Randomized Controlled Trial to Evaluate the Efficacy and Safety of Bisphosphonates Combined with Vancomycin in the Treatment of Refractory Osteomyelitis
- Trial name
- NCT07435051
- Testing
- Bisphosphonates Combined with Vancomycin, Vancomycin
- Where
- China
- Volunteers
- 280 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Crohn Disease, Stricture; Bowel
Efficacy of Ustekinumab Therapy in Patients With Symptomatic Stricturing Crohn's Disease
This study intends to select patients with confirmed moderate-to-severe Crohn's disease (CD) and obstructive symptoms of intestinal stenosis, who have clear evidence of lumen stenosis caused by the disease itself through…
- Conditions
- Crohn Disease, Stricture; Bowel, Intestinal Stricture
- Trial name
- NCT05387031
- Testing
- Ustekinumab
- Where
- 8 sites in China
- Volunteers
- 239 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Pediatric Sever Pneumonia
A Multicenter Clinical Study on the Optimization of Timing and Efficacy Evaluation of Bronchoscopic Intervention in Pediatric Severe Pneumonia
1. Main objectives: ① To determine the optimal timing for bronchoscopic lung lavage in treating severe pneumonia in children, providing evidence-based guidance for the standardized clinical implementation of this technique.
- Trial name
- NCT07437183
- Testing
- Bronchoalveolar lavage
- Volunteers
- 3,168 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Colorectal Cancer
Everolimus in CDK12-Deficient Metastatic Colorectal Cancer (EVER-RECODE)
This is a prospective, open-label, multicenter, single-arm Phase Ib/II study evaluating the safety and preliminary efficacy of everolimus in patients with CDK12-deficient refractory metastatic colorectal cancer.
- Trial name
- EVER-RECODE (NCT07435584)
- Testing
- Everolimus (Afinitor) tablets
- Volunteers
- 38 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
B-Cell Acute Lymphoblastic Leukemia
Clinical Study of SYNCAR-100 in the Treatment of Relapsed/Refractory Acute B-Lymphoblastic Leukemia
The purpose of this study is to assess the safety, tolerability, and preliminary efficacy of SYNCAR-100 in patients with CD19-positive relapsed or refractory B-cell acute lymphoblastic leukemia (R/R B-ALL).
- Trial name
- NCT07429461
- Testing
- SYNCAR-100 Injection
- Where
- China
- Volunteers
- 16 people
- Sponsor
- Zhejiang University
Pulmonary Infection, Pulmonary Nodule
Remimazolam for Bronchoscopy in High-Risk Patients
Bronchoscopy is currently widely used for the diagnosis and treatment of various respiratory diseases. However, the operation of bronchoscopy is irritating, causes a strong stress response, and shares the airway with the patient…
- Conditions
- Pulmonary Infection, Pulmonary Nodule, Phthisis, Endotracheal Tumour
- Trial name
- NCT07395596
- Testing
- propofol and alfentanil, remimazolam combined with propofol and alfentanil
- Where
- 2 sites in China
- Volunteers
- 360 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Pulmonary Infection, Pulmonary Nodule
COMBO Endoscopy Oropharyngeal Airway in Sedated Fiberoptic Bronchoscopy for Patients: A Simon Two-Stage Trial
Hypoxia represents the prevailing adverse occurrence during the sedation of patients undergoing fiberoptic bronchoscopy with propofol.
- Conditions
- Pulmonary Infection, Pulmonary Nodule, Endotracheal Tumour, Bronchiectasis
- Trial name
- NCT07063290
- Testing
- the COMBO Endoscopy Oropharyngeal Airway
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Zhejiang University
Post-Stroke Cognitive Impairment
Key Technical Research on the Treatment of Post-stroke Cognitive Impairment With Brain Electric Field Therapy Based on Acupoint Regulation
This clinical study investigates whether electroacupuncture can improve thinking and memory in people with cognitive problems after a stroke (Post-Stroke Cognitive Impairment, or PSCI).
- Trial name
- NCT07423715
- Testing
- True Electroacupuncture
- Volunteers
- 110 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Post-stroke Depression
Intervention Study of Virtual Reality-Based Mindfulness-Based Cognitive Therapy (VR-MBCT) Combined With Adaptive tDCS Modulation for Post-Stroke Depression
This study investigates whether combining virtual reality mindfulness-based cognitive therapy (VR-MBCT) with transcranial direct current stimulation (tDCS) can effectively treat depression occurring after a stroke (post-stroke…
- Trial name
- NCT07422740
- Testing
- Virtual Reality Mindfulness-Based Cognitive Therapy (Active VR-MBCT), Active transcranial Direct Current Stimulation (Active tDCS)
- Volunteers
- 120 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Crohn's Diseases, Crohn's Disease in Pediatric Patient
The Efficacy and Safety of Infliximab Combination With Azathioprine in Crohn's Disease in Children
The goal of this clinical trial is to investigate whether there are significant differences in the efficacy of infliximab monotherapy and combined azathioprine therapy in treating pediatric Crohn's disease, as well as whether…
- Trial name
- NCT07424040
- Testing
- Infliximab combined with azathioprine therapy, Infliximab monotherapy
- Where
- 4 sites in China
- Volunteers
- 154 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Inflamatory Bowel Disease, Crohn Disease (CD)
Safety and Efficiency of the Universal CNK-UT009 in Difficult-to-treat Inflammatory Bowel Disease Patients
Inflammatory bowel disease patients who failed from at least two types of biologics or suffered refractory after at least twice surgery are defiened as difficult-to-treat IBD.
- Conditions
- Inflamatory Bowel Disease, Crohn Disease (CD), Ulcerative Colitis (UC)
- Trial name
- NCT07416383
- Testing
- injection of CNK-UT009
- Volunteers
- 40 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Solid Tumor
Clinical Trial of WBC100 on Advanced Solid Tumor
This is a phase I clinical study of WBC100 in patients with advanced solid tumor.
- Trial name
- NCT05100251
- Testing
- WBC100 QOD, WBC100 QD, WBC100 BID
- Where
- China
- Volunteers
- 68 people
- Sponsor
- Zhejiang University
B-ALL
Evaluate the Safety, Efficacy and Pharmacokinetics of ThisCART19A in Patients With R/R B-ALL
This is an open label, phase I study to assess the safety, efficacy and pharmacokinetics of ThisCART19A in patients with relapsed and refractory acute B-cell leukemia
- Trial name
- NCT05350787
- Testing
- ThisCART19A
- Where
- 2 sites in China
- Volunteers
- 10 people
- Sponsor
- Zhejiang University
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