Clinical trials: sponsored by Zhejiang University
Tendinopathy
Effect of PRP vs Corticosteroid in Rotator Cuff Tendinopathy Subtypes in Arthroscopic Repair
Prospective, multicenter, randomized, single-blinded, parallel group，placebo-controlled，three-group establishment of specific treatment regimen for subtypes of tendinopathy
- Trial name
- NCT05603468
- Testing
- platelet rich plasma, Corticosteroid, Normal saline
- Where
- China
- Volunteers
- 387 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Metastatic Colorectal Cancer (CRC)
A Clinical Study on the Treatment of Metastatic Colorectal Cancer at the Second-line or Beyond.
A single-arm, open-label clinical study of irinotecan liposome combined with capecitabine, bevacizumab and camrelizumab as second-line or above treatment for patients with metastatic colorectal cancer, aiming to evaluate the…
- Trial name
- NCT07395063
- Testing
- Irinotecan liposome combined with capecitabine, bevacizumab and camrelizumab
- Volunteers
- 68 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Coronary Artery Disease, CT Angiography
Further Lipid-Lowering With PCSK9 Inhibitors for Cardiovascular Outcomes in High-Risk Coronary Plaques Assessed by CT Angiography
The primary objective was to evaluate the effect of PCSK9 inhibitors in addition to the background lipid-modifying therapy (LMT), compared with standard LMT in terms of clinical outcomes in patients with coronary CT angiography…
- Conditions
- Coronary Artery Disease, CT Angiography, PCSK9, Cardiovascular Events
- Trial name
- FLAVOUR IV (NCT06863545)
- Testing
- PCSK9 inhibitors and background lipid-modifying therapy, Standard lipid-modifying therapy
- Where
- 6 sites in China, South Korea
- Volunteers
- 3,596 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Biliary Atresia
Kasai Portoenterostomy Timing and Outcomes in Biliary Atresia
What is this study about? This study aims to find out the best timing for a major surgery called Kasai portoenterostomy (Kasai surgery) in infants with a liver disease called biliary atresia.
- Trial name
- NCT07328204
- Testing
- Kasai portoenterostomy
- Where
- China
- Volunteers
- 200 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Portal Pressure Gradient (PPG) Measurement Guided by Endoscopic Ultrasound (EUS), Left Lateral Decubitus
Left Lateral Position and Supine Position in EUS-PPG Measurement
The consistency of EUS-PPG measurements between left lateral decubitus and supine positions is unclear. In this prospective comparative study, we are aimed to evaluate the correlation between EUS-PPG measured in supine position…
- Trial name
- NCT06994039
- Testing
- EUS-lePPG
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Hypoxia, Pulmonary Nodule
The Efficacy and Safety of the Supraglottic Oxygenation Via Nasotracheal Intubation for Deep Sedation Fiberoptic Bronchoscopy
Bronchoscopy is now widely used for the diagnosis and treatment of various respiratory diseases. However, the procedure is highly stimulating and provokes a strong stress response; because the airway is shared, patients are prone…
- Conditions
- Hypoxia, Pulmonary Nodule, Pulmonary Infection
- Trial name
- NCT07389083
- Testing
- wire-reinforced tracheal tube
- Where
- China
- Volunteers
- 50 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Myelofibrosis
18F-FAPI PET/MRI Imaging in Myelofibrosis: a Prospective Observational Study.
This study intends to use a prospective, observational, self-controlled, multi-center study design to evaluate the feasibility and diagnostic efficacy of 18F-FDG PET/CT and 18F-FAPI PET/MRI imaging for the evaluation of systemic…
- Trial name
- NCT06164561
- Where
- China
- Volunteers
- 57 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Supraglottic Airway Devices Position
New-Generation GMA Laryngeal Mask Airway Versus Conventional Inflatable Laryngeal Mask Airway
This study aims to compare the new-generation GMA laryngeal mask airway (LMA) with the traditional inflatable LMA in patients undergoing elective surgery under general anesthesia.
- Trial name
- NCT07177586
- Testing
- GMA Laryngeal Mask Airway, Inflatable Laryngeal Mask Airway
- Where
- China
- Volunteers
- 1,384 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Acute Myeloid Leukemia, FLT3 Internal Tandem Duplication Positive
Gilteritinib Plus VA Followed By Consolidation Chemotherapy in Newly Diagnosed FLT3-ITD+ AML
This clinical trial aims to evaluate whether molecular MRD-guided chemotherapy can effectively treat FLT3-ITD mutated AML and potentially replace allogeneic hematopoietic stem cell transplantation.
- Conditions
- Acute Myeloid Leukemia, FLT3 Internal Tandem Duplication Positive, Intermediate Risk Acute Myeloid Leukemia, Fit Patients
- Trial name
- GANCE (NCT07259707)
- Testing
- GVA + HDAC Consolidation & Gilteritinib Maintenance
- Where
- China
- Volunteers
- 25 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Intensive Chemotherapy Unfit, Newly Diagnosed Acute Myeloid Leukemia (AML)
Alternating Regimen of VA and Low-dose CHA in the Treatment of Unfit Newly Diagnosed AML
This phase II trial tests how well VA alternating with low-dose CHA works in treating unfit patients with newly diagnosed acute myeloid leukemia (AML).
- Conditions
- Intensive Chemotherapy Unfit, Newly Diagnosed Acute Myeloid Leukemia (AML), Age ≥60
- Trial name
- CHANCE (NCT07172204)
- Testing
- Alternately treated with VA/low CHA regimen
- Where
- 5 sites in China
- Volunteers
- 25 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Acute Myeloid Leukemia, Adult
Cladribine Plus Homoharringtonine and Cytarabine Regimen (CHA) for de Novo Acute Myeloid Leukemia
The goal of this clinical trial is to evaluate the response and safety of Cladribine plus Homoharringtonine and Cytarabine regimen (CHA) protocol in de novo acute myeloid leukemia with age <60y.
- Trial name
- CHA (NCT05906914)
- Testing
- cladribine + homoharringtonine + cytarabine
- Where
- China
- Volunteers
- 65 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Systemic Lupus Erythematosus, CAR-T Cell Therapy
Study of Therapeutic Efficacy of Anti-CD19 CAR-T Cells in Refractory Systemic Lupus Erythematosus
This is an investigator-initiated trial aimed at assessing the safety of anti-CD19 CAR-T cells in the treatment of refractory systemic lupus erythematosus.
- Trial name
- NCT06222853
- Testing
- anti-CD19-CAR-T cells
- Where
- China
- Volunteers
- 22 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Paediatric B Cell-related Autoimmune Diseases, Autoimmune Diseases
Exploratory Clinical Study of Second-generation CD19/BCMA Chimeric Antigen Receptor NK Cell Injection in Treating Paediatric B Cell-related Autoimmune Diseases
Evaluating the efficacy and safety of anti-CD19/BCMA CAR-NK Cells in Paediatric B cell-related autoimmune diseases
- Conditions
- Paediatric B Cell-related Autoimmune Diseases, Autoimmune Diseases, CAR
- Trial name
- NCT07283315
- Testing
- anti-CD19/BCMA CAR NK cells (KN5601-K)
- Where
- China
- Volunteers
- 12 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Autoimmune Diseases, Systemic Lupus Erthematosus (SLE)
CAR T-cell Therapy Targeting CD19 and BCMA in Patients With B Cell Mediated Autoimmune Disease
CAR T-cell Therapy Targeting CD19 and BCMA in Patients With B cell mediated autoimmune disease.
- Conditions
- Autoimmune Diseases, Systemic Lupus Erthematosus (SLE), Multi-Drug Resistant Nephrotic Syndrome, IgA Nephropathy (IgAN)
- Trial name
- NCT07305116
- Testing
- UCAR T-cell
- Where
- China
- Volunteers
- 15 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Inflammatory Bowel Disease (IBD), CD - Crohn's Disease
Prophylactic Dexamethasone Before Infliximab in Moderate-to-Severe IBD
This comparative observational cohort clinical study aims to investigate the necessity of premedication for allergy prevention prior to infliximab injection, and is designed to evaluate whether non-routine administration of…
- Conditions
- Inflammatory Bowel Disease (IBD), CD - Crohn's Disease, UC - Ulcerative Colitis
- Trial name
- PA (NCT07385131)
- Testing
- Dexamethasone (IV)
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
HR Positive/HER2 Low Breast Cancer
Neoadjuvant Therapy Combined With Trastuzumab Rezetecan and Toripalimab for HR+/HER2-low Breast Cancer (NEOTORCH-BREAST 08)
This study is a prospective, multi-cohort, multicenter, open-label exploratory clinical trial. The primary study objective is to evaluate the pathologic complete response (PCR) of treatment of HR+/HER2-low breast cancer with…
- Trial name
- NCT07383818
- Testing
- Neoadjuvant therapy combined with Trastuzumab Rezetecan and Toripalimab, Neoadjuvant Chemotherapy in Combination with Toripalimab, Neoadjuvant Chemotherapy
- Where
- 5 sites in China
- Volunteers
- 111 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Crohn Disease
Specific Dietary Pattern for Crohn's Disease Patients Following Surgery
Over the past 10 years, there are a large number of dietary treatments related to the CD, such as specific carbohydrate diet, low Fermentable Oligo-, Di-, Mono-saccharides And Polyols (FODMAP) diet, and allergen-free foods.
- Trial name
- NCT05502965
- Testing
- dietary pattern, EEN
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Cardiogenic Shock, Cardiogenic Shock Post Myocardial Infarction
Safety and Efficacy of FAP iCDC in Acute Myocardial Infarction With Cardiogenic Shock
To study the safety and efficacy of fibroblast activation protein (FAP)-targeted allogeneic immunosuppressive chimeric antigen receptor-dendritic cell (CAR-DC) in the treatment of acute myocardial infarction with cardiogenic…
- Conditions
- Cardiogenic Shock, Cardiogenic Shock Post Myocardial Infarction, STEMI - ST Elevation Myocardial Infarction
- Trial name
- NCT07380659
- Testing
- FAP allogeneic immunosuppressive CAR-DC
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Coronary Artery Disease, Myocardial Ischaemia
Coronary CT-Derived FFR-Guided Strategy Versus Medical Therapy
The overall purpose of ACCURATE II trial is to compare the clinical outcomes of CT-derived FFR guided strategy versus medical therapy in patients with chronic coronary syndrome.
- Trial name
- ACCURATE II (NCT05824520)
- Testing
- ITS plus OMT, OMT
- Where
- China
- Volunteers
- 1,066 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Sepsis-Induced Myocardial Dysfunction
Investigating the Clinical Benefits and Underlying Mechanisms of Danhong Injection in Modulating Mitochondrial Homeostasis Against Sepsis-Associated Myocardial Dysfunction
This study aims to evaluate the clinical efficacy of Danhong injection in patients with septic myocardial injury through a prospective randomized controlled trial.
- Trial name
- NCT07375862
- Testing
- Danhong injection, Saline
- Volunteers
- 140 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
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