Clinical trials: sponsored by Zhejiang University
IgAVN, IgA Vasculitis
Telitacicept in the Treatment of Pediatric IgA Vasculitis-Associated Nephritis
To further evaluate the efficacy and safety of Telitacicept in the treatment of pediatric IgA vasculitis nephritis (IgAVN) within real-world settings, this study employs a multicenter, retrospective and prospective observational…
- Trial name
- NCT07354503
- Testing
- Collect clinical data from the patients., This study exclusively prospectively collected clinical data from the patients and did not involve any therapeutic interventions
- Volunteers
- 300 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
HER2-positive Early Breast Cancer
Neoadjuvant Trastuzumab-rezetecan Plus Pertuzumab or Nab-Paclitaxel, Carboplatin, Trastuzumab, and Pyrotinib After Suboptimal Response to Neoadjuvant Dual HER2-Targeted Therapy Combined With Chemotherapy in HER2-Positive Early Breast Cancer
This prospective, response-guided phase II study investigates individualized neoadjuvant treatment strategies for patients with human epidermal growth factor receptor 2 (HER2)-positive early breast cancer.
- Trial name
- TAYLOR (NCT07340398)
- Testing
- Nab paclitaxel, Carboplatin, Trastuzumab
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Glaucoma
Efficacy and Safety of iStent in Reducing Intraocular Pressure in Open-angle Glaucoma
To evaluate the efficacy and safety of istent inject W in reducing intraocular pressure in Chinese adult patients with open-angle glaucoma complicated with cataract.
- Trial name
- NCT07354009
- Testing
- PHACO+PC-IOL+iStent, PHACO+PC-IOL
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Hepatocellular Carcinoma
A Study to Evaluate Safety and Efficacy of Armored CAR-T Cell Injection C-CAR031 in Advanced Hepatocellular Carcinoma
A study that aimed to assess the safety and anti-tumor activity of CCAR031 injection in unresectable HCC patients.
- Trial name
- NCT05155189
- Testing
- C-CAR031, Lenvatinib, Regorafenib (BAY 73-4506)
- Where
- 2 sites in China
- Volunteers
- 72 people
- Sponsor
- Zhejiang University
Postoperative Pain
Pharmacokinetic Evaluation of Anrikefon Injection in the Geriatric Population With the Management of Acute Pain Following Abdominal Laparoscopy
This study used a single-center, single-arm, pharmacokinetic ( PK ) study design. Thirty subjects who met the inclusion criteria were stratified according to age, including 15 in each age group of 65-74 years old and ≥ 75 years…
- Trial name
- PAGAP1 (NCT07353983)
- Testing
- Inject Anrikefon Injection
- Volunteers
- 30 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Liver Cirrhosis, Polyps of Colon
Effect of HFNC on Incidence of Hypoxia During Sedated Gastrointestinal Endoscopy in Critical Patients
High flow nasal cannula oxygenation (HFNC) offers high flow and concentration oxygen delivery, providing excellent non-respiratory oxygenation. As a relatively new oxygen delivery method, it has gained widespread use.
- Conditions
- Liver Cirrhosis, Polyps of Colon, Gastrointestinal Dysfunction
- Trial name
- NCT07252102
- Testing
- High-flow nasal catheter oxygen, regular nasal catheter oxygen
- Where
- 3 sites in China
- Volunteers
- 450 people
- Sponsor
- Zhejiang University
Childhood-onset Systemic Lupus Erythematosus
Immune Profiling of Refractory cSLE Exposed to CD3×CD19 BiTE
This prospective observational study aims to characterize the peripheral immune landscape of pediatric patients with childhood-onset systemic lupus erythematosus ( cSLE) who are receiving CD3×CD19 bispecific T-cell engager (BiTE)…
- Trial name
- BiTE-cSLE-IP (NCT07352332)
- Where
- China
- Volunteers
- 6 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Neonatal Hyperbilirubinemia
Modified Diagnosis and Treatment of Neonatal Hemolysis With ETCOc in sNH
The goal of this clinical trial is to learn if modified diagnosis and treatment (MDT) of neonatal hemolysis (a common cause to newborn jaundice) incorporated with ETCOc measurement (a non-invasive measurement of exhaled gas)…
- Trial name
- MDTinsNH (NCT06832800)
- Testing
- MDT, control (current management)
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Alzheimer Disease, Biomarker in Early Diagnosis
miR-342-5p/AnkG Pathway in Early AD Synaptic Dysfunction
Alzheimer's disease is the most common memory loss disease among the elderly. This disease affects the patient's memory, language, attention, and behavioral abilities.
- Trial name
- NCT07353502
- Testing
- Collect peripheral blood, and if the patient consents, also collect cerebrospinal fluid.
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
TNBC - Triple-Negative Breast Cancer
Neoadjuvant Chemotherapy Combined With Sintilimab and Bevacizumab for TNBC (NEOTORCH-BREAST07)
This study is a prospective, single arm, multi-center phase II clinical trial. The primary study objective is to evaluate the pathologic complete response（PCR） of treatment of TNBC breast cancer with neoadjuvant chemotherapy…
- Trial name
- NCT07351487
- Testing
- Neoadjuvant chemotherapy combined with Sintilimab and Bevacizumab
- Where
- 2 sites in China
- Volunteers
- 37 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Parkinson Disease
Efficacy and Safety of TJ0113 Capsule in Patients With Parkinson's Disease
A randomized, double-blind, placebo parallel-controlled Phase II clinical trial to evaluate the efficacy and safety of TJ0113 capsule in patients with early-stage Parkinson's disease
- Trial name
- NCT06596005
- Testing
- TJ0113 200mg, TJ0113 400mg
- Where
- China
- Volunteers
- 149 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Chronic Ankle Instability, Ankle Ligament Injury
Dilute Epinephrine vs Tourniquet for Visualization in Ankle Arthroscopy: A RCT
This multicenter, prospective randomized controlled trial investigates the effect of dilute epinephrine irrigation versus tourniquet use on visual field clarity (VFC) during ankle arthroscopy.
- Conditions
- Chronic Ankle Instability, Ankle Ligament Injury, Ankle Arthroscopy
- Trial name
- NCT07349407
- Testing
- Epinephrine group, Tourniquet group
- Volunteers
- 88 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Neonatal Hyperbilirubinemia
Investigation Into the Dynamic Variations of End-Tidal Carbon Monoxide Concentration (ETCOc) in Neonates Utilizing Non-Dispersive Infrared Spectroscopy and Its Implications for Jaundice Management
The objective of this study is to ascertain the diagnostic threshold of end-tidal carbon monoxide (ETCOc, adjusted for ambient CO levels) within the first three days postpartum, stratified by neonatal age at birth.
- Trial name
- ETCO (NCT07346976)
- Testing
- Erythrocyte Life Span Tester
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Peritoneal Metastasis, CRC (Colorectal Cancer)
A Prospective, Safety, and Efficacy Clinical Trial of Pressurized Intraperitoneal Aerosol Therapy for Peritoneal Metastasis of Colorectal Cancer
For colorectal cancer with peritoneal metastasis, the current first-line standard treatment offers very limited benefits and short survival.
- Trial name
- NCT07349043
- Testing
- Mitomycin-PIPAC, Raltitrexed-PIPAC
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Myelofibrosis
Clinical Trail to Evaluate the Effect of Long-term Treatment With Gecacitinib on Myelofibrosis and Gene Mutation Levels
This study was an observational study, and about 40 patients with intermediate and high risk myelofibrosis who had participated in any previous clinical study of Gecacitinib hydrochloride and were still receiving Gecacitinib…
- Trial name
- NCT07342712
- Where
- China
- Volunteers
- 40 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Hemodynamics, Transcatheter Aortic Valve Replacement
Efficacy and Safety of Ciprofol for General Anaesthesia in Patients Undergoing Transcatheter Aortic Valve Replacement
Aortic valve stenosis is the most common debilitating valvular heart lesion in old patients. Transcatheter aortic valve replacement (TAVR) is an emergent technique for high-risk patients with aortic stenosis.
- Conditions
- Hemodynamics, Transcatheter Aortic Valve Replacement, General Anesthesia, Post-induction Hypotension
- Trial name
- NCT05881291
- Testing
- ciprofol, propofol
- Where
- China
- Volunteers
- 124 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Hepotacellular Carcinoma, Cholangiocarcinoma
Hepatobiliary and Pancreatic Tumor Biobank
This study aims to establish a hepatobiliary and pancreatic tumor biobank at the Second Affiliated Hospital of Zhejiang University School of Medicine.
- Conditions
- Hepotacellular Carcinoma, Cholangiocarcinoma, Pancreatic Cancer
- Trial name
- NCT07344116
- Testing
- No Interventions
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Consciousness Disorders
Micro-expressions in Patients With Prolonged Disorders of Consciousness
The goal of this observational study is to learn about the microexpressions in patients with prolonged disorders of consciousness.
- Trial name
- NCT06088628
- Testing
- Facial expression; Electroencephalogram; MRI
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
TNBC, Triple Negative Breast Cancer
Neoadjuvant Chemotherapy Combined With Toripalimab for TNBC (NEOTORCH-BREAST02)
This study is a prospective, single arm, multi-center phase II clinical trial. The primary study objective is to evaluate the pathologic complete response（PCR） of Adjuvant treatment of TNBC breast cancer with Toripalimab combined…
- Trial name
- NCT06682195
- Testing
- Neoadjuvant chemotherapy combined with Toripalimab
- Where
- 13 sites in China
- Volunteers
- 35 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Coronary Artery Calcification, Calcific Coronary Arteriosclerosis
ClinicAL outComes of IntraVascular Lithotripsy Combined With Conventional Lesion Preparation in Patients With Moderate to Severe Coronary Artery Calcification
The goal of this clinical trial is to investigate whether the clinical outcomes of combined application of intravascular lithotripsy (IVL) following routine preconditioning are superior to those of routine preconditioning alone…
- Trial name
- CALC-IVL (NCT07340294)
- Testing
- Intensive Preconditioning Group, Routine preconditioning strategy
- Where
- 4 sites in China
- Volunteers
- 1,096 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
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