Clinical trials: sponsored by Zhejiang University
Pediatric Urolithiasis, Extracorporeal Shock Wave Lithotripsy
Optical Motion Capture-Assisted Ultrasound for Pediatric ESWL
The incidence of pediatric urinary system stones has shown an upward trend in recent years, and Extracorporeal Shock Wave Lithotripsy (ESWL) has become one of the most important minimally invasive treatments for pediatric upper…
- Conditions
- Pediatric Urolithiasis, Extracorporeal Shock Wave Lithotripsy, Optical Motion Capture, Ultrasound Localization
- Trial name
- NCT07299032
- Testing
- ESWL with Optical Motion Capture-Assisted Ultrasound Localization, ESWL with Conventional Ultrasound Localization
- Where
- China
- Volunteers
- 80 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Fecal Microbiota Transplantation (FMT), Gastrointestinal Neoplasms
A Real-World Study of Fecal Transplants for Cancer Therapy Side Effects
The goal of this clinical trial is to learn if fecal microbiota transplantation can treat in Gastrointestinal cancer patients with chemotherapy / targeted gastrointestinal symptoms.
- Conditions
- Fecal Microbiota Transplantation (FMT), Gastrointestinal Neoplasms, Antineoplastic Agents, Drug-related Side Effects and Adverse Reactions
- Trial name
- NCT07319364
- Testing
- Fecal microbiota transplantation (FMT)
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Multiple Myeloma
Ixazomib Plus Low-dose Lenalidomide Versus Ixazomib Alone for Maintenance Treatment of High Risk Multiple Myeloma
Ixazomib combined with low-dose lenalidomide(10mg) vs Ixazomib alone as maintenance regimen in patients with high-risk multiple myeloma after induction and consolidation of VRD-based regimen.
- Trial name
- NCT05722405
- Testing
- Ixazomib plus low-dose lenalidomide, Ixazomib
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Anemia, Cardiac Surgery
Mediation Analysis in Cardiac Surgery
This study investigates the mediating role of intraoperative allogeneic red blood cell transfusion in the relationship between preoperative anaemia and postoperative complications in patients undergoing cardiac surgery.
- Conditions
- Anemia, Cardiac Surgery, Transfusion, Mediation
- Trial name
- MACS (NCT07092683)
- Testing
- anemia, nonanemia
- Where
- China
- Volunteers
- 13,683 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Adhesive Capsulitis
Conservative Treatment of Early Adhesive Capsulitis
A prospective, multicentre, randomized controlled study comparing the efficacy of conservative treatment for early adhesive capsulitis
- Trial name
- NCT06041282
- Testing
- manipulation under anesthesia, supervised home rehabilitation
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Metabolic Syndrome
Intensive Lifestyle Intervention for Remission of Metabolic Syndrome
This is a randomized, prospective clinical trial investigating metabolic syndrome in overweight or obese Chinese individuals. The study aims to evaluate the efficacy of a structured intensive lifestyle intervention program in…
- Trial name
- INSLIMS (NCT04116905)
- Testing
- Intensive Lifestyle Intervention, Conventional Treatment
- Where
- China
- Volunteers
- 68 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Breast Adenocarcinoma
Assessing Combined SBRT in Breast Cancer Non-Responders to Neoadjuvant Chemotherapy
The goal of this clinical trial is to assess whether the addition of preoperative stereotactic body radiation therapy (SBRT) can improve pathological complete response (pCR) rates and safety in breast cancer patients who do not…
- Trial name
- NCT06596018
- Testing
- SBRT, Chemotherapy
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Intraoperative Hypotension, Ciprofol
Effect of Ciprofol on Intraoperative Hypotension in Elderly Patients Receiving Renin-angiotensin System Inhibitors
The prevention of intraoperative hypotension could reduce postoperative organ injury and mortality, particularly in elderly patients receiving long-term renin-angiotensin system inhibitors.
- Conditions
- Intraoperative Hypotension, Ciprofol, Renin-angiotensin System Inhibitors
- Trial name
- NCT06952608
- Testing
- Ciprofol group, Propofol group
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Brain Stem Hematoma
Stereotactic Aspiration of Brain Stem Hematoma
This clinical study is a high-level evidence-based medical research project designed to compare the efficacy differences between stereotactic aspiration and conservative treatment in patients with brainstem hemorrhage.
- Trial name
- SABSH (NCT07300501)
- Testing
- stereotactic aspiration surgery
- Where
- 11 sites in China
- Volunteers
- 300 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Neuroendocrine Tumors
18F-AlF-NOTA-Octreotide PET in Neuroendocrine Neoplasms
The study aims to elucidate how 18F-Octreotide PET/CT or PET-MR can assist in accurate localization, treatment planning, prognostic predictions, and the selection of PRRT efficacy in neuroendocrine tumors.
- Trial name
- NCT07102056
- Testing
- 18F-AlF-NOTA-Octreotide PET-CT or PET-MR
- Volunteers
- 152 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Glioma, High Grade
A Phase I Clinical Trial of a mRNA Vaccine for Recurrent or Progressive High-grade Glioma
This clinical trial is designed to evaluate the safety and efficacy of a universal mRNA vaccine targeting a panel of glioma-associated mutations in patients with recurrent or progressive high-grade glioma.
- Trial name
- NCT07306299
- Testing
- Glioma-related multi-target mRNA vaccines
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Systemic Sclerosis (SSc), ANCA Associated Vasculitis (AAV)
Anti-CD19 IL-10/IL15 CAR-NK Cells in Refractory/Relapsed Autoimmune Diseases
This study is a single-center, open-label, single-arm, dose-escalation trial. The aim of this study is to investigate the safety and efficacy of Anti-CD19 IL-10/IL15 CAR-NK cells in patients with refractory/relapsed autoimmune…
- Conditions
- Systemic Sclerosis (SSc), ANCA Associated Vasculitis (AAV), Idiopathic Inflammatory Myopathy (IIM), Sjogren's Syndrome
- Trial name
- NCT06614270
- Testing
- Anti-CD19 IL-10/IL15 CAR-NK
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
TCM Constitution Theory
Research on an Intelligent Health Recommendation System for Chronic Disease Comorbidity Integrating TCM
1. Construct a Traditional Chinese Medicine (TCM) constitution database, clarify the distribution patterns of TCM constitution in populations with comorbid "three-high" conditions (hypertension, hyperlipidemia, and hyperglycemia)…
- Trial name
- NCT07308366
- Testing
- Multimodal AI Models
- Volunteers
- 195 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Non-targeted Metabolomics
Mechanism of Umbilical Moxibustion in the Treatment of IBS-b
Evaluate the therapeutic efficacy of umbilical moxibustion therapy for IBS. Compare and analyze the differences in gut microbiota composition and diversity between the umbilical moxibustion group and the control group based on…
- Trial name
- NCT07308262
- Testing
- Umbilical moxibustion
- Volunteers
- 60 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Brain Network Functional Connectivity
Brain Network fMRI Analysis in Proprioceptive Training for Chronic Low Back Pain
Through longitudinal analysis of dynamic changes in DMN functional connectivity before and after sensory training intervention, combined with pain behavioral and functional improvement indicators, this study systematically…
- Trial name
- NCT07308249
- Testing
- Multimodal Imaging Evaluation
- Volunteers
- 40 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Non-neoplastic and Non-infectious Diseases
Development & Preliminary Validation of a Community Health Education Program
This study analyzes the needs of patients regarding the content and form of home-based health education through interviews, and constructs a health education program tailored to these needs.
- Trial name
- NCT07301398
- Testing
- The use and guidance of the mini-program
- Volunteers
- 92 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Living Donor Liver Transplantation Recipients, Deceased Donor Liver Transplantation Recipients
Longitudinal Follow-up and Health-Related Outcomes in Liver Transplant Recipients and Living Donors
This prospective cohort study aims to identify risk factors for postoperative adverse events in liver transplant recipients and living donors.
- Conditions
- Living Donor Liver Transplantation Recipients, Deceased Donor Liver Transplantation Recipients, Living Liver Donor
- Trial name
- NCT07301853
- Testing
- liver transplantation, Living Donor Hepatectomy
- Where
- China
- Volunteers
- 9,999 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Prostate
Is it Feasible to Use Data Obtained Through a Three-Dimensional Reconstructed Image to Assist in Prostate Targeted Biopsy?
Objectives:There are numerous auxiliary methods to improve the accuracy of pathology results regarding prostate biopsy. However, there is no consensus on how to achieve precise targeted biopsy.
- Trial name
- NCT07296510
- Testing
- Prostate biopsy
- Where
- China
- Volunteers
- 436 people
- Sponsor
- Zhejiang University
Colorectal Cancer Metastatic
Clinical Study of Second-line Treatment in Advanced Colorectal Cancer With Chemotherapy With Bevacizumab or Cetuximab
Guidelines recommend FOLFIRI in combination with bevacizumab or cetuximab as a treatment option for advanced second-line colorectal cancer, and this study explores the efficacy and safety of a clinical study of liposomal…
- Trial name
- NCT06540326
- Testing
- irinotecan liposome (II), fluorouracil, cetuximab
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Adults With Simple Obesity
Semaglutide and Tirzepatide for Genetic Aging Delay in Adults With Obesity
This study is a prospective, randomized, open-label clinical trial enrolling 66 adults with simple obesity who have not used weight-loss medications for at least 3 months.
- Trial name
- NCT07293325
- Testing
- Semaglutide, Tirzepatide, Metformin
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
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