Clinical trials: sponsored by Zhejiang University
Hypoxia, Esophageal Cancer
COMBO Endoscopy Oropharyngeal Airway Reduces Hypoxia During Sedated Gastrointestinal Endoscopy in Obese Patients: A Multicenter, Randomized, Controlled Clinical Trial
Hypoxia represents the prevailing adverse occurrence during the sedation of patients undergoing gastrointestinal endoscopy with propofol. This is particularly true for obese patients, who have a higher incidence of hypoxia.
- Conditions
- Hypoxia, Esophageal Cancer, Gastric Cancer
- Trial name
- NCT06796764
- Testing
- the COMBO Endoscopy Oropharyngeal Airway Group, Regular Nasal Cannula
- Where
- 3 sites in China
- Volunteers
- 580 people
- Sponsor
- Zhejiang University
Breast Cancer
Dragon Boat Race Versus Family Unsupervised Training to Improve the Physical Function and Quality of Life in Breast Cancer Patients
Investigators plans to conduct a randomized, open, single center clinical study of Dragon Boat Race versus family unsupervised training to improve the physical function and quality of life in breast cancer patients to compare the…
- Trial name
- NCT07162298
- Testing
- Dragon Boat Training, Home-based Unsupervised Training
- Where
- China
- Volunteers
- 72 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Diffuse Large B-Cell Lymphoma, Relapsed Non-Hodgkin Lymphoma
Homoharringtonine, BCL-2 Inhibitor, Rituximab, and Prednisone in Relapsed/Refractory Diffuse Large B-Cell Lymphoma
Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma in China and worldwide. Although standard immunochemotherapy with Rituximab, Cyclophosphamide, Doxorubicin Hydrochloride, Vincristine…
- Conditions
- Diffuse Large B-Cell Lymphoma, Relapsed Non-Hodgkin Lymphoma, Refractory Non-Hodgkin Lymphoma
- Trial name
- NCT07159906
- Testing
- Homoharringtonine, BCL-2 inhibitor, CD20 Antibody
- Where
- China
- Volunteers
- 62 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Urologic Injuries, Urology
The Clinical Research of Traditional Chinese Medicine Compound Formulas
To observe the efficacy and safety of Shenkangling, a traditional Chinese medicine decoction, for renal ischemia-reperfusion injury, and to provide evidence-based medical evidence and ideas for clinical therapeutic use.
- Trial name
- NCT07153731
- Testing
- Shenkangling
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Rectal Cancer
Pucotenlimab Plus Radiotherapy and Chemotherapy for Neoadjuvant Treatment of Locally Advanced Rectal Cance(PUCRT)
Colorectal cancer is a common gastrointestinal tumor, with rising incidence in China. Rectal cancer accounts for nearly half of new cases, and many patients are diagnosed at a locally advanced stage.
- Trial name
- PUCRT (NCT06770270)
- Testing
- Pucotenlimab
- Where
- China
- Volunteers
- 68 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Alzheimer Disease, Mild Cognitive Impairment (MCI)
Prospective Cohort Study of Patients With Early Alzheimer's Disease Treated With Lecanemab
As the population increases and aging intensifies, cognitive disorders represented by Alzheimer's disease (AD) not only pose a severe threat to public health but also bring significant social and economic burdens.
- Trial name
- NCT06741553
- Testing
- Lecanemab 10 mg/kg
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Current Status of Analgesia and Sedation Cognition and Implementation
Emergency Room Analgesia and Sedation Survey-2
Part 1: Assessment of Healthcare Providers' Knowledge on Analgesia and Sedation in Emergency Resuscitation Rooms Across China This study aims to evaluate the understanding of healthcare providers in emergency resuscitation rooms…
- Trial name
- EASY-2 (NCT07152457)
- Testing
- No intervention
- Volunteers
- 13,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Central Retinal Artery Occlusion
Microneedle Intra-Arterial Injection for Retinal Artery Occlusion
This prospective interventional study evaluates the efficacy and safety of direct intra-arterial microneedle injection combined with pars plana vitrectomy for acute retinal artery occlusion (including central retinal artery…
- Trial name
- NCT07151755
- Testing
- Vitrectomy + Direct Intra-Arterial Microneedle Thrombolysis + Standard Care, Standard Clinical Care Only
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Alzheimer Disease (AD), Alzheimer Dementia
Therapeutic Efficacy of Monoclonal Antibody Drugs for Alzheimer's Disease Based on PET Research
Preliminary clinical trial results indicate that Aβ-targeting monoclonal antibody drugs can delay disease progression more effectively.
- Conditions
- Alzheimer Disease (AD), Alzheimer Dementia, Mild Cognitive Impairment (MCI)
- Trial name
- NCT07152418
- Testing
- Lecanemab 10 mg/kg, Conventional anti-dementia treatment group
- Volunteers
- 120 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Cognitive Impairment, Diet Interventions
The Resistant Starch Intervention for Cognitive Enhancement
The investigation will explore the potential effects of resistant starch The Resistant Starch Intervention for Cognitive Enhancement study aimed to evaluate the effect of high-resistant starch diet intervention in slowing…
- Conditions
- Cognitive Impairment, Diet Interventions, Cognitive Decline, Genetic Risk Factors
- Trial name
- NCT07152483
- Testing
- High resistant starch staple foods, Regular starch staple foods
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Multi-Drug Resistant Nephrotic Syndrome, CAR-T Cell Therapy
Study of Therapeutic Efficacy of CAR-T Cell Therapy in Patients With MDR-SRNS
This is an investigator-initiated trial aimed at assessing the safety and efficacy of anti-BCMA/CD70 CAR-T cells in the treatment of patients with Multi-drug resistant SRNS
- Trial name
- NCT06553898
- Testing
- anti-BCMA/CD70 CAR-T cells
- Where
- China
- Volunteers
- 18 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Pregnancy Complications
Study on the Effect of Combined Estrogen and Progestogen Therapy on Endometrial Repair After Induced Abortion
Induced abortion is a common method to terminate pregnancy, but during the operation, it is necessary to dilate the cervix and aspirate the uterine cavity.
- Trial name
- NCT06546397
- Testing
- 17β-estradiol/dydrogesterone tablets
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
taVNS, Gastrointestinal Tumor Surgery
taVNS Reduces Postoperative Pain and Complications in Patients With Gastric and Intestinal Tumors
Postoperative acute pain control in patients with gastrointestinal tumors is not satisfactory, and surgical complications including gastrointestinal dysfunction, gastrointestinal fistula, abdominal and gastrointestinal…
- Conditions
- taVNS, Gastrointestinal Tumor Surgery, Visual Analogue Scale, Complications
- Trial name
- taVNS (NCT06763913)
- Testing
- taVNS
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Acute Myeloid Leukemia
Donor Derived CD117 CAR-T Cells in the Treatment of R/R Acute Myeloid Leukemia
A Clinical Study on the Safety and Effectiveness of Donor Derived CD117 CAR-T Cell in the treatment of Relapsed/Refractory Acute Myeloid Leukemia
- Trial name
- NCT07144020
- Testing
- CD117 CAR T-cells
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Zhejiang University
Idiopathic Epiretinal Membranes
Clinical Evaluation of With or Without Internal Limiting Membrane Peeling for Idiopathic Epiretinal Membrane Surgery: A Randomized Controlled Trial
Idiopathic epiretinal membrane (ERM) is an age-related degenerative retinal condition. One of the primary treatment approaches is vitrectomy combined with epiretinal membrane peeling.
- Trial name
- NCT07142785
- Testing
- Epiretinal membrane peeling, Epiretinal membrane peeling combined with internal limiting membrane peeling
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Esophageal Squamous Cell Carcinoma (ESCC)
A Study of Trifluridine/Tipiracil Combined With Anlotinib as Second-line Treatment for Recurrent and Metastatic Esophageal Squamous Cell Carcinoma
Esophageal squamous cell carcinoma (ESCC) is one of the malignant tumors with a high incidence worldwide, especially remaining persistently high in Asian regions.
- Trial name
- NCT07142421
- Testing
- Combination therapy (COMB)
- Where
- China
- Volunteers
- 35 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Periodontitis
Effect of Photodynamic Therapy on Soft Tissue Healing After Tooth Extraction at Sites of Periodontal Infection
Main Purpose: To evaluate the effect of photodynamic therapy on soft tissue healing after tooth extraction at periodontal infection site, and to compare the effect on pain degree and bone tissue remodeling after tooth extraction.
- Trial name
- NCT05664087
- Testing
- Dental diode laser device Paiwei™（Zhengzhou Gata biotechnology Co.,Ltd.,China） which was 650-670nm with a power of 160mw-220mw.
- Where
- China
- Volunteers
- 38 people
- Sponsor
- The Dental Hospital of Zhejiang University School of Medicine
Diffuse Large B-Cell Lymphoma (DLBCL)
Orelabrutinib Combined With Pola-R-CHP Regimen for the Treatment of Untreated Non-GCB Diffuse Large B-Cell Lymphoma
Assess the preliminary efficacy and safety of orelabrutinib in combination with the Pola-R-CHP regimen for the treatment of treatment-naive Non-GCB diffuse large B-cell lymphoma.
- Trial name
- NCT07078500
- Testing
- orelabrutinib combined with the Pola-R-CHP regimen
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Edentulous Alveolar Ridge
The Impact of the Adequacy of Keratinized Mucosa on Peri-implant Tissue Health and Patient-reported Outcomes
This study aims to conduct a cross-sectional study to compare the differences in clinical indices, patient-reported outcomes, and levels of inflammatory factors in peri-implant gingival crevicular fluid between sites with…
- Trial name
- NCT07124416
- Testing
- No intervention
- Where
- China
- Volunteers
- 150 people
- Sponsor
- The Dental Hospital of Zhejiang University School of Medicine
Refractory/Recurrent Central Nervous System Lymphoma
Cord Blood-derived CAR-NK Cells Targeting CD19 for Refractory/Relapsed Central Nervous System Lymphoma
This study is designed to evaluate the safety and efficacy of cord blood-derived CAR-NK019 in the treatment of refractory/relapsed central nervous system lymphoma.
- Trial name
- NCT06827782
- Testing
- anti-CD19 CAR-NK cells
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
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