Clinical trials: sponsored by Zhejiang University
Advanced Hepatocellular Carcinoma (HCC)
Personalized Tumor Neoantigen mRNA Therapy for Advanced Hepatocellular Carcinoma
This study is to evaluate the feasibility and safety of personalized tumor neoantigen mRNA therapy iNeo-Vac-R01 combined with PD-1 monoclonal antibody, anti-VEGFR monoclonal antibody and TACE regimen for the treatment of patients…
- Trial name
- NCT06995105
- Testing
- TACE, Sintilimab combined with Bevacizumab, individualized anti-tumor new antigen iNeo-Vac-R01 injection
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Zhejiang University
Colorectal Cancer Metastatic, Colorectal Cancer Recurrent
Trifluridine/Tipiracil Plus Regorafenib vs Trifluridine/Tipiracil Plus Bevacizumab for Refractory Metastatic Colorectal Cancer
The goal of this clinical trial is to demonstrate the non-inferiority of trifluridine/tipiracil + regorafenib vs trifluridine/tipiracil + bevacizumab in terms of progression free survival in patients with refractory metastatic…
- Trial name
- REGTAS-2 (NCT06992648)
- Testing
- Trifluridine/Tipiracil + Regorafenib, Trifluridine/tipiracil + bevacizumab
- Where
- China
- Volunteers
- 302 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Systemic Lupus Erythematosus
Anti-CD19 CAR-NK Cells in Refractory/Relapsed Systemic Lupus Erythematosus
This study is a single-center, open-label, single-arm trial. The aim of this study is to investigate the safety and efficacy of anti-CD19 CAR-NK cells in patients with refractory/relapsed systemic lupus erythematosus.
- Trial name
- NCT06421701
- Testing
- anti-CD19 CAR-NK cells
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Accommodation
The Changes Under Different Accommodation of Anterior Eye and 3D Crystal Reconstruction.
Accommodation is defined as a dynamic change in the overall refractive power of the eye during near fixation. Despite extensive investigations, the exact nature of human accommodation remains controversial.
- Trial name
- NCT06704503
- Where
- 2 sites in China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Headache Disorders, Primary, Headache Disorders, Secondary
International Headache Registry Study
In the International Headache and Vertigo Registration Study, patients aged 4-99 years with headache (primary headache and secondary headache such as migraine and tension type headache), vertigo (vertigo diseases such as…
- Conditions
- Headache Disorders, Primary, Headache Disorders, Secondary, Migraine, Tension-Type Headache
- Trial name
- IHRS (NCT05418218)
- Where
- China
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Hemangioma Liver
Efficacy Evaluation of Propranolol Treatment of Hepatic Hemangioma
Hepatic hemangioma is one of the most common benign tumor of the liver. Although the overall prognosis is good, active interventions are still needed in high-risk patients.
- Trial name
- NCT03633747
- Testing
- Propranolol Hydrochloride
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Lens Diseases
Study on the Application of Intraoperative Optical Coherence Tomography Technique in the Diagnosis and Treatment of Lens Diseases
Accurately assessing and dealing with anterior segment changes in the eyes of patients with lens diseases can better guide the operation details during surgery and make reasonable plans for possible intraoperative and…
- Trial name
- NCT06687356
- Testing
- Surgery with Intraoperative Optical Coherence Tomography application, Conventional surgery
- Where
- 2 sites in China
- Volunteers
- 600 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
B7-H3-positive Advanced Malignant Solid Tumors Advanced Primary Peritoneal Tumors or Secondary Abdominal Metastatic Malignant Solid Tumors
MT027 in Patients With Advanced Peritoneal Malignancies or Abdominal Metastatic Solid Tumors
This is an open-label, single-arm phase I dose-escalation study designed to evaluate the safety, tolerability, pharmacokinetic profile, and preliminary efficacy of MT027 in patients with advanced primary peritoneal malignancies…
- Trial name
- NCT06912152
- Testing
- MT027 CAR-T cells
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Zhejiang University
Hypoxia, Esophageal Cancer
COMBO Endoscopy Oropharyngeal Airway in Sedated Gastrointestinal Endoscopy for Obese Patients
Hypoxia represents the prevailing adverse occurrence during the sedation of patients undergoing gastrointestinal endoscopy with propofol. This is particularly true for obese patients, who have a higher incidence of hypoxia.
- Conditions
- Hypoxia, Esophageal Cancer, Colon Cancer, Gastric Cancer
- Trial name
- NCT06804876
- Testing
- the COMBO Endoscopy Oropharyngeal Airway
- Where
- China
- Volunteers
- 107 people
- Sponsor
- Zhejiang University
HR+/HER2- Breast Cancer
Neoadjuvant Chemotherapy in Combination With Toripalimab for HR+/HER2- Breast Cancer : a Randomized, Open-label, Parallel-controlled, Multi-center Phase III Study (NEOTORCH-BREAST04)
Our center plans to conduct a randomized, open-label, parallel-controlled, multi-center phase III study to evaluate the efficacy and safety of neoadjuvant chemotherapy combined with Toripalimab for HR+/HER2- breast cancer.
- Trial name
- NCT06977893
- Testing
- Neoadjuvant Chemotherapy in Combination with Toripalimab, Neoadjuvant Chemotherapy
- Where
- 13 sites in China
- Volunteers
- 194 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Fragility Fractures
Application and Effect of "Internet + Nursing" in Hip Fragility Fracture Patients Based on Fracture Liaison Service
Fragility fractures, also known as osteoporotic fractures, are fractures that occur as a result of low-energy trauma or minor impact.
- Trial name
- NCT06975254
- Testing
- On the basis of routine nursing, the "Internet + nursing program" based on the FLS model is implemented
- Where
- China
- Volunteers
- 94 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Hypofibrinogenemia
A Point-of-care Electrochemical-based Device for Rapid Detection of Fibrinogen on Type A Aortic Dissection Surgery
This study compares the results of the existing fibrinogen concentration monitoring technology to the Electrochemical-based device, a point-of-care and rapid method,using a small amount of extra blood obtained in Type A Aortic…
- Trial name
- NCT06434389
- Testing
- the Electrochemical-based device
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Cataract
Multifunctional Cataract Surgery Assistive Instruments Used in Cataract Surgery
In order to better cope with complex situations of cataract surgery, we designed and improved a new set of multi-functional cataract surgery auxiliary devices, including ophthalmic surgery auxiliary hooks, eye retractor hooks and…
- Trial name
- NCT06182605
- Testing
- multifunctional instruments, traditional instruments
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Migraine Disorders, Headache Disorders
Idebenone for the Preventive Treatment of Migraine
Idebenone improves energy metabolism similarly to Coenzyme Q10, which is effective in migraine prophylaxis. The investigators compare idebenone (90 mg/day, 270 mg/day) and placebo in 180 migraine patients in a double-blind…
- Trial name
- NCT04151472
- Testing
- 90mg Idebenone, 270mg Idebenone
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Colorectal Cancer With Liver Metastasis
A Prospective Multicenter Study: Ivosimab + Chemotherapy as Neoadjuvant for Resectable pMMR/MSS CRC Liver Mets
The population receiving ivosimab combined with chemotherapy for neoadjuvant treatment of colorectal cancer liver metastasis.
- Trial name
- NCT06972498
- Testing
- Patients will receive ivosimab combined with the XELOX/FOLFOX regimen, followed by radical surgery 4-6 weeks after the last dose; adjuvant chemotherapy will continue for 3 months postoperatively.
- Volunteers
- 35 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Non-Small Cell Lung Cancer
Clinical Study of Combined EphA2-targeted CAR-DC and CAR-T Cell Therapy for Non-small Cell Lung Cancer
This is an open-label, single-arm clinical study designed to evaluate the safety and preliminary efficacy of EphA2-targeted CAR-DC combined with CAR-T cell therapy in patients with non-small cell lung cancer.
- Trial name
- NCT06972576
- Testing
- EphA2-targeted CAR-T Cells, EphA2-targeted CAR-DCs
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Vestibular Migraine, Adults 18 Years and Older (no Other Exclusion Criteria)
A Clinical Trial of Rimegepant for Vestibular Migraine Evaluation: Pre-experiment
Vestibular migraine (VM) is one of the most common vestibular disorders, affecting 1.0% to 2.7% of the general population1, 7% of patients with definite migranous vertigo in dizziness clinics2, as well as 10.3% of VM patients in…
- Trial name
- NCT06748664
- Testing
- Rimegepant
- Volunteers
- 240 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Mastitis Chronic, Idiopathic Granulomatous Mastitis
Baricitinib in Idiopathic Granulomatous Mastitis
This study will explore the mechanism of targeted drug in treatment of idiopathic granulomatous mastitis, and clarify the clinical classification and corresponding markers.
- Trial name
- B-IGM (NCT05852171)
- Testing
- Baricitinib
- Where
- China
- Volunteers
- 20 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Intracerebral Hemorrhage
Reduction of Edema With a Specialized Cocktail for Ultra-early Management in Intracerebral Hemorrhage
Intracerebral hemorrhage (ICH) is a severe stroke subtype with high mortality and disability rates, often worsened by perihematomal edema (PHE), which increases intracranial pressure and leads to poor outcomes.
- Trial name
- NCT06863558
- Testing
- PPA Intervention
- Volunteers
- 58 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Breast, Mammaplasty
Options on the Breast Reconstruction Timing and Method After Removal of Polyacrylamide Hydrogel
Since polyacrylamide hydrogel (PAAG) was used in cosmetic surgery in 1997, about 30 million women have received PAAG injection for breast augmentation.
- Conditions
- Breast, Mammaplasty, Breast Reconstruction
- Trial name
- NCT04715802
- Testing
- Immediate breast reconstruction with implant, delayed breast reconstruction with implant, delayed breast reconstruction with autologous fat transplantation
- Where
- China
- Volunteers
- 240 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
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