Clinical trials: sponsored by Zhejiang University
Liver Carcinoma
Radiofrequency-responsive Layered Double Hydroxides for Enhanced Arterial Embolization and Thermal Immunotherapy in Hepatocellular Carcinoma
Liver cancer is one of the most common malignant tumors and the third leading cause of cancer-related deaths globally. Recent epidemiological studies show that in China, liver cancer ranks fourth in incidence and second in…
- Trial name
- NCT06966986
- Where
- China
- Volunteers
- 130 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Acute Acquired Comitant Esotropia
Efficacy of Botulinum Toxin Type A for Acute Acquired Comitant Esotropia: An Age-Stratified Two-Year Follow-Up Study
The goal of this clinical trial is to assess and compare the efficacy of two-year follow-up botulinum toxin type A （BTXA) in the treatment of acute acquired comitant esotropia (AACE) across five age groups: ≤6 years, >6 to ≤12…
- Trial name
- NCT06966999
- Testing
- Botulinum Toxin Type A Injection [Botox]
- Where
- China
- Volunteers
- 276 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Metastatic Pancreatic Cancer
Multimodal Managements for Metastatic Pancreatic Cancer.
Pancreatic ductal adenocarcinoma (PDAC) remains a challenging malignancy, with over 300,000 patients diagnosed annually worldwide.
- Trial name
- NCT06967233
- Testing
- Multimodal treatment
- Where
- China
- Volunteers
- 360 people
- Sponsor
- Zhejiang University
Pancreatic Adenocarcinoma Resectable, Neoadjuvant Chemotherapy
Sequential Use of AG and mFOLFIRINOX as Neoadjuvant Chemotherapy for Resectable Pancreatic Cancer
The prognosis of pancreatic cancer is extremely poor. Current guidelines recommend Nab-paclitaxel, Gemcitabine and modified Folfirinox as the first-line chemotherapeutic regimen.
- Trial name
- NCT03750669
- Testing
- AG regimen, mFolfirinox
- Where
- China
- Volunteers
- 324 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Alzheimer Disease
Effects of Repetitive Transcranial Magnetic Stimulation in Patients With Alzheimer's Disease
Previous studies have shown that repetitive transcranial magnetic stimulation (rTMS) can improve cognitive function in Alzheimer's disease (AD), but studies on the improvement of sleep disorders in AD are limited.
- Trial name
- NCT06385106
- Testing
- Real repetitive transcranial magnetic stimulation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Malocclusion
Comparing of the Clinical Outcome of Periodontal Accelerated Osteogenic Orthodontics With Horizontal or Vertical Releasing Incisions
The study aims to compare the effect of periodontal accelerated osteogenic orthodontics (PAOO) with horizontal or vertical releasing incisions on operation time, healing, adverse effects, and effectiveness of bone augmentation.
- Trial name
- NCT05441683
- Testing
- horizontal extending incision, vertical releasing incision
- Where
- China
- Volunteers
- 22 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Non Small Cell Lung Cancer (Stage III)
The Efficacy and Safety of Sintilimab Plus Chemotherapy in Surgical Conversion for Patients With Unresectable Stage IIIB-IIIC NSCLC: A Prospective, Single-Arm, Phase II Study
This study aimed to evaluate the conversion rate to curative-intent treatment in patients with unresectable stage IIIB-IIIC non-small cell lung cancer (NSCLC) following induction therapy with PD-1 blockade combined with…
- Trial name
- NCT06962189
- Testing
- chemoimmunothrapy
- Volunteers
- 39 people
- Sponsor
- Zhejiang University
Pancreatic Cancer, Resected, Diarrhea
Clinical Study on Fecal Microbiota Transplantation for Diarrhea After Total Pancreatectomy
By 2030, pancreatic cancer is projected to become the second leading cause of cancer-related deaths, with a 5-year survival rate below 10%.
- Trial name
- FMT-TP (NCT06960122)
- Testing
- Fecal Microbiota Transplant (FMT), Standard Therapy
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Health
Effects of Coffee Consumption on Health Among Adults
The purpose of this study is to research the changes of typical thermal processing food intervention on health outcome, metabolites, and gut microbiota, in order to explore the molecular mechanism of interaction between maillard…
- Trial name
- NCT03817944
- Testing
- Warm Water, Caffeinated Coffee, Decaffeinated Coffee
- Where
- China
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Zhejiang University
Advanced Intrahepatic Cholangiocarcinoma
Personalized Tumor Neoantigen mRNA Therapy for Advanced Intrahepatic Cholangiocarcinoma
The main purpose of this study is to evaluate the feasibility and safety of personalized tumor neoantigen mRNA therapy iNeo-Vac-R01 combined with PD-1 monoclonal antibody and standard chemotherapy regimen for the treatment of…
- Trial name
- NCT06956716
- Testing
- individualized anti-tumor new antigen iNeo-Vac-R01 injection, Gemcitabine + cisplatin (GP), Sintilimab injection
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Zhejiang University
Systemic Lupus Erythematosus
UCAR T-cell Therapy Targeting CD19/BCMA in Patients With r/r Systemic Lupus Erythematosus
This is an open label, single-site, dose-escalation study in up to 18 participants with relapsed or refractory Systemic lupus erythematosus.
- Trial name
- NCT06920433
- Testing
- UCAR T-cell group
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Zhejiang University
Prostate Cancer
IONM During Radical Prostatectomy
At present, the preferred treatment for patients with prostate cancer is still radical prostatectomy. Postoperative patients often face some complications, the most common complications include urinary incontinence and erectile…
- Trial name
- NCT06950216
- Testing
- IONM
- Volunteers
- 40 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Colorectal Neoplasia
Exploratory Clinical Study of Claudin18.2-Targeted CAR-DC and CAR-T Therapy in Advanced Colorectal Cancer
This is an open-label, single-arm clinical study designed to evaluate the safety and preliminary efficacy of Claudin18.2-targeted CAR-DC combined with CAR-T cell therapy in patients with advanced colorectal cancer.
- Trial name
- NCT06946615
- Testing
- Claudin18.2-targeted CAR-T Cells, Claudin18.2-targeted CAR-DCs
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Gestational Diabetes Mellitus (GDM)
Preventive Effect of Probiotics in GDM
Gut microbiota is instrumental in the microbial and metabolic network of pregnant women, and is potentially related with gestational diabetes.
- Trial name
- NCT06938464
- Testing
- Probiotics
- Where
- China
- Volunteers
- 334 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
CAR T Cell Therapy, Systemic Lupus Erythematosus
Study of BCMA/CD70 CAR-T Therapy for Refractory cSLE
This is an investigator-initiated trial aimed at assessing the safety and efficacy of anti-BCMA/CD70 CAR-T cells in the treatment of refractory systemic lupus erythematosus.
- Conditions
- CAR T Cell Therapy, Systemic Lupus Erythematosus, BCMA
- Trial name
- NCT06934447
- Testing
- anti-BCMA/CD70-CAR-T cells
- Where
- China
- Volunteers
- 18 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Cancer Diagnosis, Liver Cancer, Adult
Raman Spectroscopy-Based Deep Learning Model for Early Pan-Cancer Early Diagnosis
The goal of this observational study is to explore whether a Raman-based, deep learning-assisted approach can be used to develop an effective method for early pan-cancer screening.
- Conditions
- Cancer Diagnosis, Liver Cancer, Adult, Cancer Screening, Colorectal Cancer (CRC)
- Trial name
- NCT06822413
- Testing
- No Interventions
- Where
- 4 sites in China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Locally Advanced Thymoma
Neoadjuvant Radiotherapy for Locally Advanced Unresectable Thymoma
The goal of this prospective, randomized, controlled phase II clinical study is to evaluate the efficacy and safety of neoadjuvant radiotherapy in patients with locally advanced unresectable thymoma.
- Trial name
- NCT06924619
- Testing
- neoadjuvant radiotherapy, cisplatin
- Where
- China
- Volunteers
- 178 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
COPD, Interstitial Pneumonia
Perioperative Risk Factors Related to the Prognosis of Lung Transplantation: A Retrospective Study
This study analyzes patients who underwent lung transplantation at the First Affiliated Hospital of Zhejiang University from 2017 to 2024, focusing on anesthesia's impact on post-op results.
- Conditions
- COPD, Interstitial Pneumonia, Bronchiectasis, Respiratory Failure
- Trial name
- NCT06922916
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Zhejiang University
Glioblastoma
Enhanced Adjuvant Therapy for Newly Diagnosed GBM With Partial Surgical Resection or Short-term Progression
This study is a prospective Bayesian adaptive randomized phase II clinical trial of enhanced adjuvant therapy for newly diagnosed glioblastoma with partial surgical resection or short-term progression.
- Trial name
- NCT06936046
- Testing
- Dual antibody A, Dual antibody B, Modified Stupp
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Ischemic Stroke
Reduction of Edema With a Specialized Cocktail for Ultra-early Management in Ischemic Stroke
Large ischemic stroke is a severe subtype of acute ischemic stroke (AIS), often leading to malignant cerebral edema, elevated intracranial pressure, and poor functional outcomes.
- Trial name
- NCT06863571
- Testing
- PPA Intervention
- Where
- China
- Volunteers
- 68 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
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