Clinical trials: sponsored by Zhejiang University
Myasthenia Gravis
UCAR T-cell Therapy Targeting CD19/BCMA in Patients With r/r Myasthenia Gravis
This is an open label, single-site, dose-escalation study in up to 18 participants with relapsed or refractory Myasthenia gravis.
- Trial name
- NCT06933563
- Testing
- UCAR T-cell group
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Zhejiang University
Gestational Diabetes Mellitus in Pregnancy
D-chiro Inositol in Prevention of Gestational Diabetes Mellitus in China
Inositol is a type of food additives, which plays an important role in insulin signal pathway and is related to insulin sensitivity.
- Trial name
- NCT04801485
- Testing
- D-chiro inositol
- Where
- China
- Volunteers
- 291 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Liver Transplant, Hepatocellular Carcinoma
Efficacy and Safety of Liver Transplantation for Hepatocellular Carcinoma With Bile Duct Tumor Thrombus: a Single-arm, Multicenter, Prospective Study (HCC-BDTT in LT)
The prognosis for patients diagnosed with hepatocellular carcinoma with bile duct tumor thrombus (BDTT-HCC) remains notably grim, as there are presently no universally accepted treatment guidelines in place to address this…
- Conditions
- Liver Transplant, Hepatocellular Carcinoma, Bile Duct Tumor Thrombus
- Trial name
- NCT06928415
- Volunteers
- 130 people
- Sponsor
- Zhejiang University
Bone Tumor, Acute Normovolemic Hemodilution
A Substudy of the Effect of Acute Normovolemic Hemodilution in Bone Tumor Surgery
The prevention of perioperative anemia has the potential to reduce complications, hospital stays, and long-term prognosis in patients undergoing bone tumor surgery.
- Conditions
- Bone Tumor, Acute Normovolemic Hemodilution, Goal-Directed Fluid Therapy
- Trial name
- NCT06881498
- Testing
- acute normovolemic hemodilution
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Colorectal Polyps
Application of Changyanning Granule in Endoscopic Resection of Colorectal Polyps
This study aims to evaluate the efficacy of Chanyanning granules in patients undergoing endoscopic resection of colorectal polyps with a basal diameter of 5-30 mm.
- Trial name
- NCT06927258
- Testing
- changyanning granules
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Treatment-related Gastrointestinal Toxicity (Including Diarrhea, Constipation, Nausea, and Vomiting), Extrapulmonary Neuroendocrine Neoplasms
Fecal Microbiota Transplantation for Preventing Gastrointestinal Symptoms in Extrapulmonary Neuroendocrine Neoplasms: A Real-World Study
Existing studies have demonstrated that patients with different types of tumors exhibit significant increases in Enterobacter and Staphylococcus genera, along with marked decreases in Lactobacillus, Bacteroides, Bifidobacterium…
- Trial name
- FMT-NENs (NCT06924645)
- Testing
- Fecal Microbiota Transplant (FMT), Standard Therapy
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Gitelman Syndrome, CPPD - Calcium Pyrophosphate Deposition Disease
The Osteoarticular Manifestations in Patients With Gitelman Syndrome
Patients with clinically and genetically confirmed Gitelman Syndrome are screened for CPPD, and the clinical and radiographic manifestations are collected and analyzed.
- Trial name
- CPPD and more (NCT06922370)
- Testing
- conventional radiograph or computed tomography
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Relapsed / Refractory Autoimmune Hemolytic Anemia
UCAR T-cell Therapy Targeting CD19/BCMA in Patients With r/r Autoimmune Hemolytic Anemia
This is an open label, single-site, dose-escalation study in up to 18 participants with relapsed or refractory Autoimmune hemolytic anemia.
- Trial name
- NCT06920446
- Testing
- UCAR T-cell group
- Volunteers
- 18 people
- Sponsor
- Zhejiang University
Pain, Postoperative, Nerve Block
Application of Celiac Plexus Block in Postoperative Analgesia of Whipple Surgery
This subject intends to explore the value of intraoperative celiac plexus block in postoperative acute pain management and its promoting effect on patients' rapid recovery during Whipple surgery through a randomized controlled…
- Trial name
- NCT05205720
- Testing
- Celiac plexus block, Ropivacaine
- Where
- China
- Volunteers
- 78 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Colonoscopy
The Study on the Effect of Different Administration Methods of Simethicone in Reducing Bubbles During Bowel Preparation
To find the simplest and most effective method of intestinal preparation for dimethicone administration.
- Trial name
- NCT06919120
- Testing
- Simethicone is mixed into the final packet of compound polyethylene glycol electrolyte powder, Take simethicone separately
- Where
- China
- Volunteers
- 3 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Type 2 Diabetes
Sequences of Aerobic and Resistance Exercise and Cardio-metabolic Functions in T2D
Aerobic exercise and resistance exercise are two types of exercise commonly used in physical conditioning. Compared to aerobic exercise, a combination of aerobic and resistance exercise has been linked to a greater reduction in…
- Trial name
- ARRA (NCT06145542)
- Testing
- AR group: aerobic training before resistance training, RA group: resistance exercise before aerobic exercise
- Where
- China
- Volunteers
- 56 people
- Sponsor
- Zhejiang University
Major Depression Disorder
Efficacy and Safety of Toludesvenlafaxine Hydrochloride Sustained-release Tablets Versus Venlafaxine Hydrochloride Sustained-release Tablets in Patients With Major Depression Disorder
The purpose of this study is to evaluate efficacy and safety of toludesvenlafaxine hydrochloride sustained-release tablets in the treatment of major depression disorder compared to venlafaxine hydrochloride sustained-release…
- Trial name
- NCT06278038
- Testing
- Toludesvenlafaxine hydrochloride sustained-release tablets, Venlafaxine hydrochloride sustained-release tablets
- Where
- China
- Volunteers
- 84 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Endometrial Cancer Stage I, Endometrial Cancer Stage II
PROfiling Based Endometrial Cancer Adjuvant Therapy
This is a prospective, multicenter, randomized phase III trial among women with endometrioid adenocarcinoma with high-intermediate and intermediate risk features to investigate the role of integrated genomic-pathologic…
- Trial name
- PROBEAT (NCT05179447)
- Testing
- Vaginal brachytherapy, External beam radiotherapy, Observation
- Where
- 10 sites in China
- Volunteers
- 590 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
ADHD, Immune System
Immunoprofilling of Peripheral Blood Mononuclear Cells in Children With Attention Deficit/Hyperactivity Disorder
The goal of this observational study is to learn about The immune cell landscape of peripheral blood mononuclear cells in children with ADHD compared to typically developing controls.
- Conditions
- ADHD, Immune System, Clinical Syndrome
- Trial name
- NCT06109337
- Testing
- drow blood
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Autoimmune Gastritis
Exploratory Study on the Efficacy of Betaine Hydrochloride in Treating Autoimmune Gastritis
Autoimmune gastritis (AIG) is a chronic autoimmune disorder characterized by parietal cell destruction and oxyntic mucosal atrophy, leading to achlorhydria and intrinsic factor deficiency.
- Trial name
- NCT06881511
- Testing
- No intervention (Control Group), Oral betaine hydrochloride (2 capsules, 3 times daily)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Benign Gallbladder Disease
Single-Incision Laparoscopic Cholecystectomy with Inflexible Laparoscopic Instruments and Laparoscopy: a Single-Center Experience
Since being introduced by Mühe in 1985, laparoscopic cholecystectomy (LC) has garnered global acceptance and defined as gold standard treatment for benign gallbladder diseases (BGDs).
- Trial name
- NCT06708390
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Vascular Cognitive Impairment No Dementia
Language Intervention Training for Cognitive Protection in High-risk Cardio-Cerebrovascular Elderly Population
The global population is aging rapidly, with the number of elderly people with dementia projected to rise sharply, posing significant challenges to quality of life and societal burden.Frequent language switching, such as in…
- Trial name
- NCT06898931
- Testing
- Dialect Interpreting Training
- Volunteers
- 80 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Asherman Syndrome
Establishment and Application of Endometrial 3D-organoid in Endometrial Injury Repair
Normal endometrial repair occurs without scar formation; however, in some women, these normal repair mechanisms are aberrant, resulting in intrauterine adhesion (IUA) formation.
- Trial name
- NCT05521932
- Testing
- endometrium collected
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Verruca Plantaris
A Randomized Controlled Trial to Evaluate the Effectiveness of Bleomycin and Cryotherapy in Treating Plantar Warts.
To evaluate the efficacy of bleomycin and cryopreservation in the treatment of plantar verruca by dermoscopy and explore the influencing factors.
- Trial name
- NCT06718192
- Testing
- Bleomycin injection, Cryotherapy
- Where
- China
- Volunteers
- 70 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Pancreatic Cancer Resectable
Personalized Tumor Neoantigen MRNA Therapy Adjuvant Treatment for Postoperative Pancreatic Cancer.
This study is a single-center, open-label clinical study to evaluate the feasibility and safety of personalized tumor neoantigen mRNA therapy (iNeo-Vac-R01) in combination with PD-1 antibody and standard chemotherapy regimen as…
- Trial name
- NCT06888674
- Testing
- individualized anti-tumor new antigen iNeo-Vac-R01 injection, Gemcitabine + Capecitabine, Sintilimab injection
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Zhejiang University
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