Clinical trials: sponsored by Zhejiang University
Cerebral Infarction Recovery, Rehabilitation Treatment
The Application of Kinesio Taping Technique in the Early Upper Limb Functional Activities Induction of Hemiplegic Patients After Stroke
1. To observe the inducing and promoting effect of kinesio taping technique on the recovery of upper limb function in early-stage stroke patients. 2.
- Conditions
- Cerebral Infarction Recovery, Rehabilitation Treatment, Upper Extremity Motor Function, Emg Biofeedback
- Trial name
- NCT06834750
- Testing
- Experimental Group
- Where
- China
- Volunteers
- 120 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Pancreatic Cancer Metastatic, Pancreatic Cancer Non-resectable
Personalized Tumor Neoantigen MRNA Therapy for Advanced Pancreatic Cancer.
This study is a single-arm phase I/II clinical study to evaluate the effectiveness of evaluate the feasibility and safety of personalized tumor neoantigen mRNA therapy (iNeo-Vac-R01) in combination with PD-1 antibody and standard…
- Trial name
- NCT06888648
- Testing
- individualized anti-tumor new antigen iNeo-Vac-R01 injection, mFOLFIRINOX Treatment Regimen, Sintilimab injection
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Zhejiang University
Probiotic Combination Have the Potential to Improve Alcohol and Acetaldehyde in the Body After Drinking, The Potential of the Probiotics Combination Tablet on Alcohol Metabolism
Intervention Study on Probiotic Combination Tableted Candy Hangover
Study Design Type: Randomized, blinded, placebo-controlled, crossover trial Participants: 40 volunteers, divided into two groups (n=20) Grouping Method: Minimization randomization based on age and BMI matching Intervention…
- Trial name
- NCT06883760
- Testing
- Probiotic tablet candy group
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Zhejiang University
Portal Hypertension
Clinical Study on the Selection of Endoscopic Varicose Disconnection Strategy Based on Natural Portal Shunt with Portal Hypertension
Research content: This trial follows the randomized controlled study protocol to study the varicose vein elimination rate, amount of tissue glue used, rebleeding rate, complications, mortality, length of hospital stay, treatment…
- Trial name
- NCT06883071
- Testing
- Endoscopic ultrasound (EUS)-guided spring plug combined with ECI, Titanium clip plus EUS-guided spring plug placement for flow limiting combined with ECI
- Volunteers
- 32 people
- Sponsor
- Zhejiang University
Treatment Resistant Depression (TRD)
Comparison of Different Acceleration Modes of Transcranial Magnetic Stimulation
To compare the efficacy and safety of 6 times a day, 10 times a day acceleration mode and sham stimulation intervention for TRD, and to explore the antidepressant mechanism of accelerated mode, so as to provide a more simple and…
- Trial name
- NCT06881030
- Testing
- Noninvasive transcranial magnetic stimulation was administered six times daily, Noninvasive transcranial magnetic stimulation was administered 10 times daily
- Volunteers
- 45 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Treatment Resistant Depression, Visual Perceptual Weakness
Positron Emission Tomography in Transcranial Magnetic Stimulation Intervention for Treatment-resistant Depression
Major depressive disorder (MDD) exhibit reduced visual motor perception, which affects prognosis. Metabolic substance changes and abnormal neural activity in the middle temporal visual area (MT) mediate this perceptual…
- Trial name
- NCT06044324
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- China
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
HELICOBACTER PYLORI INFECTIONS
Low-Dose Amoxicillin Dual-Therapy Combined with Licorice and Lotus Root Powder Helicobacter Pylori Treatment
In recent years, the increasing prevalence of Helicobacter pylori (H. pylori, Hp) resistance has led to a gradual decline in the eradication rate of Hp.
- Trial name
- NCT06881524
- Testing
- First-line licorice and lotus root powder combined with low-dose amoxicillin, First line high-dose amoxicillin, Rescue licorice and lotus root powder combined with low-dose amoxicillin
- Volunteers
- 374 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Gastric-type Endocervical Adenocarcinoma, Cervical Cancer
Comparative Study of Adjuvant Therapy for Postoperative Cervical Gastric-type Adenocarcinoma
Background: Gastric-type endocervical adenocarcinoma (G-EAC) is a new classification of cervical mucinous carcinoma. G-EAC is a unique human papillomavirus unrelated adenocarcinoma that can be distinguished from typical…
- Trial name
- NCT06870565
- Testing
- paclitaxel and platinum, platinum
- Volunteers
- 238 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Persistent Atrial Fibrillation
Study on the Ablation of Persistent Atrial Fibrillation Using Pulsed Electric Fields Under Different Surgical Procedures
Atrial fibrillation (AF) is one of the most common arrhythmias in clinical practice, and there are more than 20 million AF patients in my country.
- Trial name
- NCT06671197
- Testing
- Pulmonary vein isolation, Pulmonary vein isolation+posterior left atrial wall line+superior vena cava isolation
- Where
- China
- Volunteers
- 436 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Premature Ovarian Insufficiency
The Study of Human Chorionic Gonadotropin (HCG) Activating the Dormant Follicles .
This project aims to activate dormant follicles in patients with premature ovarian insufficiency by injecting human chorionic gonadotropin (hCG) to explore the feasibility of a treatment plan that stimulates the growth of dormant…
- Trial name
- NCT06754332
- Testing
- human chorionic gonadotropin
- Volunteers
- 60 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Ventricular Septal Defect
Immune Heterogeneity Before and After Cardiopulmonary Bypass in Children
The goal of this observational study is to learn about functional heterogeneity of immune cells before and after cardiopulmonary bypass (CPB) in children with congenital heart disease (CHD).
- Trial name
- NCT06214182
- Where
- China
- Volunteers
- 3 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Erectile Dysfunction
Evaluation of Tadalafil Combined With LIPUS for Treating Erectile Dysfunction
This study aims to evaluate the clinical efficacy and histological changes of tadalafil combined with low-intensity pulsed ultrasound (LIPUS) in patients with erectile dysfunction (ED) through a randomized controlled trial.
- Trial name
- NCT06543628
- Testing
- Tadalafil 5mg, LIPUS (Low Intensity Pulsed Ultrasound)
- Where
- China
- Volunteers
- 114 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Premature Ovarian Insufficiency
Exploratory Clinical Study on the Efficacy and Safety of Lactobacillus Johnsonii in the Treatment of Patients with Premature Ovarian Insufficiency
The goal of this clinical trial is to explore the effectiveness and safety of Lactobacillus johnsonii in improving ovarian function and perimenopausal symptoms in patients with premature ovarian insufficiency (POI).
- Trial name
- NCT06866990
- Testing
- Lactobacillus johnsonii
- Volunteers
- 60 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Solitary Plasmacytoma
SBRT Plus Lenalidomide for Solitary Plasmacytoma: Phase II Trial
Solitary Plasmacytoma (SP) is a rare malignant plasma cell tumor, including Solitary Bone Plasmacytoma (SBP) and Solitary Extramedullary Plasmacytoma (SEP). Radiotherapy is the preferred treatment for SP.
- Trial name
- NCT06863584
- Testing
- Lenalidomide (Revlimid), SBRT
- Where
- China
- Volunteers
- 41 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
NSCLC (Non-small Cell Lung Cancer)
Phase II Clinical Study of Befotertinib in EGFR Non-classical Mutant NSCLC
This is a prospective, multi-cohort, single-arm Phase II clinical trial evaluating the efficacy and safety of befotertinib, a third-generation EGFR tyrosine kinase inhibitor (TKI), in patients with advanced or metastatic…
- Trial name
- NCT06863506
- Testing
- befotertinib
- Where
- China
- Volunteers
- 78 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Type 2 Diabetes
Efficacy and Safety Comparison of Cofrogliptin Add-on Versus Metformin Dose-escalation in Type 2 Diabetes Patients Inadequately Controlled With SGLT-2 Inhibitors Plus Low-Dose Metformin:A Multicenter, Open-Label Trial
The aim of this study is to evaluate the change in glycated hemoglobin (HbA1c) levels of adding cofrogliptin compared to escalation of metformin dose after 24 weeks in type 2 diabetes patients who have failed to achieve adequate…
- Trial name
- NCT06863532
- Testing
- Cofrogliptin+SGLT2i+Metformin, Metformin dose escalation
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Esophageal and Gastric Varices
Evaluation of Endoscopic Treatment Effect Based on HVPG
This study aims to evaluate the endoscopic treatment effect and related influencing factors of patients with esophageal and gastric varices based on HVPG.
- Trial name
- NCT06863519
- Testing
- Endoscopic treatment
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Leukemia, Lymphocytic, Acute
Effectiveness and Safety of InO±DLI for Relapsed B-ALL/LBL After Allo-HSCT
B cell acute lymphoblastic leukemia (B-ALL)/Lymphoblastic lymphoma (LBL) is a hematological malignancy caused by malignant transformation and clonal expansion of B-lineage precursor cells.
- Trial name
- ZJU-HSCT-INO (NCT06861348)
- Testing
- Inotuzumab Ozogamicin±Donor Lymphocyte Infusion
- Where
- China
- Volunteers
- 23 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Thrombosis, Acute Ischemic Stroke (AIS)
Intravenous Thrombolytic Therapy for Acute Ischemic Stroke Patients with Low NIHSS and Non-disabling Deficits
Minor stroke is considered an acute ischemic stroke (AIS) that has a National Institute of Health Stroke Scale (NIHSS) score ≤ 5 points.
- Trial name
- ALLOW (NCT06115070)
- Testing
- Intravenous thrombolysis (alteplase and other guideline-recommended thrombolytic agents)
- Where
- China
- Volunteers
- 390 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Cataract
Clinical Evaluation of Extended Depth-of-focus Intraocular Lens in Refractive Cataract Surgery: a Randomized Controlled Trial
The goal of this clinical trial is to compare the clinical outcomes of two extended depth-of-focus intraocular lens after cataract surgery. The randomized controlled trail will enroll 90 participants.
- Trial name
- NCT06658119
- Testing
- cataract surgery
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
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