Clinical trials: sponsored by Zhejiang University
Dry Eye, Asthenopia
Dry Eye and Asthenopia Treatment Effect Evaluation.
Asthenopia is a group of syndroms in which the human eye can see more than its visual function can bear due to various causes, resulting in visual disorders, eye discomfort or systemic symptoms after the use of the eyes, and thus…
- Trial name
- NCT06763822
- Testing
- close eyes, cold compress
- Where
- China
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
REM Sleep Behavior Disorder, Parkinson Disease
A Study of Efficacy and Safety of Idebenone Vs. Placebo in Prodromal Parkinson Disease
To investigate whether 24 months of idebenone may reduce the progression from Prodromal Parkinson disease (PPD) to Parkinson disease (PD).
- Trial name
- SEASEiPPD (NCT04152655)
- Testing
- Idebenone
- Where
- China
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Acute Myeloid Leukemia
A Clinical Study to Explore the Safety and Efficacy of CD33 CAR-T Cell in Relapsed/Refractory Acute Myeloid Leukemia
A Clinical Study on the Safety and Effectiveness of targeting CD33 CAR-T Cell in the treatment of Relapsed/Refractory Acute Myeloid Leukemia
- Trial name
- NCT06762132
- Testing
- CD33 CAR T-cells
- Where
- China
- Volunteers
- 27 people
- Sponsor
- Zhejiang University
Organoids, Breast Cancer
Organoids Based Drug Sensitivity in Neoadjuvant Chemotherapy of Breast Cancer
Breast cancer is the most common malignancy in women worldwide. Patients with breast cancer are often diagnosed at later stages and have a strong desire for breast conservation, necessitating neoadjuvant chemotherapy.
- Conditions
- Organoids, Breast Cancer, Neoadjuvant Chemotherapy
- Trial name
- ONAC (NCT06155305)
- Testing
- Biopsy
- Where
- China
- Volunteers
- 58 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Cholecystectomy, Laparoscopic
Single Incision Laparoscopic Cholecystectomy Compared with Conventional Laparoscopic Cholecystectomy, a Randomized Controlled Clinical Study
Laparoscopic cholecystectomy has been accepted and is nowadays considered as the gold standard treatment of gallstones disease. Conventional laparoscopic cholecystectomy (CLC) was defined as three or four port surgery carried out…
- Trial name
- NCT05728463
- Testing
- Laparoscopic cholecystectomy
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Autoimmune Diseases
A Study of CAR-T Cells in Subjects with Autoimmune Diseases
The purpose of this study is to assess the safety and efficacy of CAR-T cell therapy in Subjects with autoimmune diseases.
- Trial name
- NCT06762119
- Testing
- CAR-T cell
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Zhejiang University
Breast Cancer Metastatic, Hydrothorax
Drug Sensitivity of Hydrothorax and Ascite Organoids from Breast Cancer
Malignant hydrothorax and ascitic fluid in advanced breast cancer often arise from metastasis to the lungs, pleura, or liver. Patients with this condition experience rapid disease progression and multidrug resistance, facing…
- Conditions
- Breast Cancer Metastatic, Hydrothorax, Ascites, Organoids
- Trial name
- NCT06658080
- Testing
- organoid drug test
- Where
- 3 sites in China
- Volunteers
- 90 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
REM Sleep Behavior Disorder, Parkinson Disease
Efficacy and Safety of Rasagiline in Prodromal Parkinson's Disease
To investigate whether a year of rasagiline may reduce the progression from idiopathic REM sleep behavior disorder (RBD) to Parkinson's disease (PD).
- Conditions
- REM Sleep Behavior Disorder, Parkinson Disease, Synucleinopathies
- Trial name
- NCT05611372
- Testing
- Rasagiline
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Obese Subjects
Construction of an in Vitro Intestinal Microbial Ecological Simulation System for Obese People
About 2.6 billion people ( about 40 % of the world 's population ) are affected by overweight or obesity. The prevalence of overweight and obesity in Chinese adults has exceeded 50 %, and the prevalence is still on the rise.The…
- Trial name
- NCT06621186
- Testing
- No intervention measures
- Where
- China
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Metastatic Pancreatic Carcinoma
Metronomic Capecitabine with Camrelizumab and Apatinib Mesylate for Treatment of Advanced Pancreatic Cancer
This study is a multicenter, single-arm, phase II exploratory study, aims to evaluate the efficacy and safety of metronomic capecitabine with camrelizumab and apatinib mesylate in advanced pancreatic cancer after the failure of…
- Trial name
- NCT06759090
- Testing
- Metronomic capecitabine, Camrelizumab, Apatinib Mesylate Tablets
- Where
- China
- Volunteers
- 43 people
- Sponsor
- Zhejiang University
Soft Tissue Sarcoma, Stereotactic Body Radiotherapy
Safety and Efficacy of Preoperative SBRT and Radical Surgery for Soft Tissue Sarcoma of Extremities
Currently, the effectiveness and safety of preoperative hypo-fractionated radiotherapy in treating extremity soft tissue sarcomas remain inconclusive, warranting further investigation.
- Conditions
- Soft Tissue Sarcoma, Stereotactic Body Radiotherapy, Surgery
- Trial name
- NCT06760221
- Testing
- stereotactic body raiotherapy
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Colorectal Surgery, Postoperative Pulmonary Complications (PPCs)
Dorsal Vetilation and PPCs in Colorectal Cancer Surgery Patients
Postoperative pulmonary complications (PPCs) are common in patients after major abdominal surgery. It has been shown that 5-40% of patients occur PPCs after major surgery, and the mid to high PPC rate is observed after…
- Trial name
- NCT06662799
- Where
- China
- Volunteers
- 92 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Cataract
Clinical Application Comparison of Two Femtosecond Laser Systems
The goal of this clinical trial is to compare the perioperative parameters of femtosecond laser-assisted cataract surgery (FLACS) using two laser systems.
- Trial name
- NCT06754358
- Testing
- LenSx, Z8
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Malignant Tumors, Solid Tumor Malignancy
Clinical Application of 99mTc-FDPH46 SPECT/CT Imaging in Malignant Solid Tumor: a Prospective Exploratory Study
The goal of this observational study aims to preliminarily evaluate the diagnostic efficacy of 99mTc-FDPH46 SPECT/CT in malignant solid tumors (compared to the pathological gold standard).
- Trial name
- 99mTc；FAPI；mCi (NCT06753513)
- Testing
- 99mTc-FDPH46 SPECT/CT Imaging
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Zhejiang University
Precursor B-Cell Acute Lymphoblastic Leukemia
Venetoclax Combined With Olverembatinib and Predinisone in Treating Ph+ B-ALL
Precursor B cell acute lymphoblastic leukemia (B-ALL) is an aggressive type of leukemia, with high relapse rate and poor long term survival in adults.
- Trial name
- NCT06754267
- Testing
- Venetoclax, Olverembatinib, Predinisone
- Where
- China
- Volunteers
- 36 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Acute Graft-versus-Host Disease
Universal CNK-UT Therapy for Refractory aGVHD
This is a single arm, open-label, multi-center, pilot studies (Investigator Initiated Trial, IIT) to evaluate the safety, tolerability, efficacy, pharmacokinetics and pharmacodynamics of universal T-cells engineered with chimeric…
- Trial name
- CNK-UT (NCT06750133)
- Testing
- Chimeric Natural Killer Receptor Universal T-cells (CNK-UT)
- Where
- 2 sites in China
- Volunteers
- 23 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Small Cell Lung Cancer Extensive Stage
Liposomal Irinotecan and Apatinib in ES-SCLC
The purpose of this study is to observe the efficacy and safety of liposomal irinotecan combined with apatinib in the treatment of extensive stage small cell lung cancer progressed from first-line regimen.
- Trial name
- LIAES (NCT06749691)
- Testing
- Liposomal Irinotecan and Apatinib
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Pancreatic Cancer Non-resectable
Endoscopic Ultrasound (EUS) Intratumoral Injection of CAR-NK Cells in the Treatment of Advanced Pancreatic Cancer
This is a single-center, single-arm, open-label, dose-escalation clinical study to evaluate the safety and anti-tumor efficacy of intratumoral NKG2D CAR-NK cell injection guided by endoscopic ultrasound in the treatment of…
- Trial name
- NCT06478459
- Testing
- CAR-NK
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Zhejiang University
Pancreatic Cancer Non-resectable
A Trail of Second-line Chemotherapy Sequential NKG2D CAR-NK Cell Therapy for Pancreatic Cancer
This is a single-center, single-arm, open-label, dose-escalation clinical study to evaluate the safety and anti-tumor efficacy of second-line systemic chemotherapy sequential NKG2D CAR-NK cell therapy for pancreatic cancer
- Trial name
- NCT06503497
- Testing
- chemotherapy sequential CAR-NK cell infusion
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Zhejiang University
Osteoarthritis of the Hip or Knee, Joint Arthroplasty
Effects of Vitamin D Supplementation on Postoperative Rehabilitation in Hip and Knee Osteoarthritis Patients
The goal of this clinical trial is to learn if vitamin D supplementation affects postoperative rehabilitation in osteoarthritis patients who underwent joint arthroplasty.
- Trial name
- NCT06747559
- Testing
- Vitamin D
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
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