Clinical trials: sponsored by Zhejiang University
Acute Myeloid Leukemia
Mitoxantrone Hydrochloride Liposome in Combination With Cytarabine and Venetoclax Regimen in Newly Diagnosed Elderly AML
This is a phase 2 study to evaluate the efficacy and safety of mitoxantrone hydrochloride liposome in combination with cytarabine and venetoclax (MAV) regimen in newly diagnosed elderly AML.
- Trial name
- NCT06621199
- Testing
- Mitoxantrone hydrochloride liposome, Cytarabine, Venetoclax
- Where
- China
- Volunteers
- 42 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Spine Degeneration
Unscheduled Hospital Readmission After Crenel Lateral Interbody Fusion
The goal of this observational study is to learn about the readmission related to Crenel Lateral Interbody Fusion (CLIF). The main question it aims to answer is: What are the risk factors for readmission after CLIF surgery?
- Trial name
- NCT06614296
- Testing
- Crenel Lateral Interbody Fusion, Crenel lateral interbody fusion plus second stage surgery
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Varicose Veins
Varicose Vein in Patients Under the Age of 40
Varicose veins are a result of valvular insufficiency and presented with twisted, enlarged veins. They not only cause cosmetic concerns but also lead to limb edema, skin pigmentation/lipodermatosclerosis, and even venous ulcers.
- Trial name
- NCT05410912
- Testing
- Great saphenous vein stripping and ambulatory phlebectomy
- Where
- China
- Volunteers
- 168 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Vascular Diseases, Stent Complication
Eluvia DES for the Patients with Femoropopliteal Artery Lesions.
This study is a multicenter, prospective, observational study, aiming to enroll 400 patients with peripheral arterial disease in the femoral-popliteal segment implanted with Eluvia stent. Each patient was followed up for 2 years.
- Trial name
- NCT05522218
- Testing
- Eluvia drug eluting stent
- Where
- China
- Volunteers
- 400 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Atrial Fibrillation (AF), Ischemic Stroke
Prediction of Stroke Risk in Patients with Atrial Fibrillation Based on Chest CT Images
This study aims to create and assess a deep learning framework for extracting left atrial appendage features in atrial fibrillation patients and combining them with clinical data to predict ischemic stroke risk.
- Trial name
- NCT06611995
- Testing
- observational study
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Ulcerative Colitis
The Efficacy and Safety of Combining Probiotic VSL#3 With Vedolizumab for the Treatment of Moderate Ulcerative Colitis
An imbalance in the gut microbiota and mucosal immune dysfunction leading to intestinal inflammation are central to the pathogenesis of ulcerative colitis (UC).
- Trial name
- NCT06609447
- Testing
- VSL#3, Vedolizumab
- Where
- 12 sites in China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Heat Stroke
Early Body Temperature Targets and Relationship With Prognosis in Patients With Heat Stroke
The goal of this observational study is to explore the optimal target body temperature in first 24 hours and the relationship between body temperature and adverse outcomes of heat stroke.
- Trial name
- NCT05921682
- Testing
- observation
- Where
- 6 sites in China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Pancreatic Cancer
SBRT and Anti-programmed Cell Death Protein 1(Anti-PD-1) in Late Stage or Recurrent Pancreatic Cancer Patients
When gemcitabine based chemo and fluorouracil based chemo regimes are failed in late-stage or recurrent pancreatic cancer patients, there is no alternative options. Anti-PD-1 antibody has became a promising anti-cancer drug.
- Trial name
- CISPD-2 (NCT03716596)
- Testing
- SBRT, anti-PD-1 antibody
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Periodontitis
the Clinical Effect of Nd: YAG Laser Assisted Periodontal Initial Therapy in Patients With Moderate to Severe Periodontitis
The goal of this clinical trial is to learn if Neodymium-Doped Yttrium Aluminum Garnet（Nd: YAG） Laser-assisted non-surgical periodontal treatment is effective in treating stage II/III periodontitis.
- Trial name
- NCT06587334
- Testing
- SRP, Nd: YAG Laser Assisted SRP
- Where
- China
- Volunteers
- 22 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Intracranial Infections
Intraventricular Administration of Intracranial Infections Caused by （Carbapenem-resistant Gram-negative Bacilli）CRGNB
This clinical trial aims to compare two methods of administering polymyxin B for treating severe brain infections caused by carbapenem-resistant Gram-negative bacteria (CRGNB).
- Trial name
- NCT06595979
- Testing
- Polymyxin B
- Where
- 3 sites in China
- Volunteers
- 222 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Liver Cancer
Clinical Application of Quantitative Major Imaging Features of CEUS LI-RADS
Liver cancer (LC) is the sixth most common malignant tumor and the third cause of cancer mortality in the world. According to the 2018 United States Association for the Study of Liver Diseases guidelines for the diagnosis and…
- Trial name
- NCT06590948
- Testing
- contrast-enhanced ultrasound
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Postoperative Complications After Lung Transplantation
The Effect of Perioperative Factors on Postoperative Outcomes After Lung Transplantation
1. Evaluate the influence of perioperative factors on postoperative outcomes in patients undergoing lung transplantation patients. 2.
- Trial name
- NCT06603350
- Testing
- No intenvention
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Helicobacter Pylori Infection
The Efficacy of Quadruple Therapy Containing Sodium Bicarbonate as the Primary Treatment for Helicobacter Pylori Infection
The goal of this clinical trial is to learn the efficacy of sodium bicarbonate-containing quadruple therapy as the primary treatment for Helicobacter pylori infection.
- Trial name
- NCT06591494
- Testing
- Classic quadruple therapy, Quadruple therapy with sodium bicarbonate instead of bismuth, Quadruple therapy with sodium bicarbonate instead of clarithromycin
- Volunteers
- 855 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Liver Transplantation, Sarcopenia
Perioperative Rehabilitation Therapy in Patients Undergoing Liver Transplantation
Patients undergoing liver transplantation frequently experience a reduction in skeletal muscle mass, malnutrition, and decreased levels of physical activity.
- Trial name
- NCT06591507
- Testing
- BCAA Nutritional Intervention, Muscle Rehabilitation Training, Standard Nutritional Therapy
- Volunteers
- 750 people
- Sponsor
- Zhejiang University
Moderate Aortic Valve Stenosis, Moderate Aortic Valve Regurgitation
Prospective Observational Cohort Study of Moderate Aortic Valve Disease
The objective of this research is to evaluate and predict the progression of moderate aortic stenosis and regurgitation from clinical characterization, biological, echocardiographic, and computed tomography (CT) et. al.
- Conditions
- Moderate Aortic Valve Stenosis, Moderate Aortic Valve Regurgitation, Aortic Valve Disease
- Trial name
- NCT06595992
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Breast Cancer, Measurable Residual Disease
Exploratory Research on Constructing a Computational Biological Model Based on NGS for MRD After Breast Cancer Surgery
This study will include 80 subjects after radical breast cancer resection, collect blood samples of the above subjects, observe and quantify the characteristic changes of cfDNA in the blood of breast cancer subjects after…
- Trial name
- NCT06595966
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Chronic Pelvic Pain, Endometriosis
Research on the Impact of Chronic Pelvic Pain on Endometriosis
Chronic pelvic pain (CPP) is a common disease with multiple systems and multiple causes. In recent years, the incidence rate of CPP in women has gradually increased.
- Trial name
- NCT06584760
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Sadness
Psychophysiological Effects of Birdsongs VS Music
The main goal of this study is to learn the psychophysiological effects of birdsongs on sadness. The main questions it aims to answer are: 1. Can birdsongs alleviate sadness in a short term? 2.
- Trial name
- NCT06581445
- Testing
- Birdsongs, Music
- Where
- China
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Zhejiang University
IgA Nephropathy
Effect of Finerenone in IgA Nephropathy
The aim of this trial is to conduct a randomized, multicenter, placebo-controlled, double-blind clinical trial to determine the safety and efficacy of Finerenone in reducing proteinuria and protecting renal function in patients…
- Trial name
- FIGHT (NCT06580288)
- Testing
- Finerenone
- Volunteers
- 120 people
- Sponsor
- Zhejiang University
Metastatic Non-Small Cell Lung Cancer, NSCLC Stage IV
Stereotactic Body Radiotherapy for Oligo-Progression Metastatic Non-Small Cell Lung Cancer
The goal of this clinical trial is to learn if Stereotactic Body Radiotherapy (SBRT) can treat the oligo-progressive metastatic non-small cell lung cancer (NSCLC) after first-line chemotherapy.
- Conditions
- Metastatic Non-Small Cell Lung Cancer, NSCLC Stage IV, OligoProgressive Metastatic Disease
- Trial name
- OPPRESS (NCT06523673)
- Testing
- Stereotactic Body Radiotherapy, second-line systemic therapy
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
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