Clinical trials: sponsored by Zhejiang University
Colorectal Cancer, Adenomatous Polyps
Exploratory Study of a Novel Based rbcDNA Liquid Biopsy Technique for Colorectal Cancer Early Detection
Exploration of a novel rbcDNA liquid biopsy technique for early detection of colorectal cancer is a promising development in the field of disease diagnosis and screening.
- Conditions
- Colorectal Cancer, Adenomatous Polyps, Adenoma, Advanced Adenoma
- Trial name
- NCT05875584
- Testing
- rbcDNA test
- Where
- China
- Volunteers
- 598 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Alopecia Areata, Janus Kinase Inhibitors
Efficacy and Safety of JAK Inhibitors in Patients With AA: RWE Study
The introduction of Janus Kinase inhibitors (JAKi) seems to revolutionize the field of alopecia areata (AA) therapeutics. However, the ideal JAKi is not yet settled and the real-world data are still missing.
- Trial name
- NCT06573593
- Testing
- Tofacitinib, Baricitinib, Ruxolitinib
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Age-Related Macular Degeneration, Diabetic Macular Edema
Evaluation of Therapeutic Efficacy of Faricimab for Clinical AMD, DME, and RVO Patients
The goal of this clinical trial is to learn if drug Faricimab works to treat nAMD, DME or RVO in adults. It will also learn about the safety of drug Faricimab.
- Conditions
- Age-Related Macular Degeneration, Diabetic Macular Edema, Retinal Vein Occlusion
- Trial name
- NCT06572553
- Testing
- Faricimab
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Rhinitis, Allergic, Asthma
Allergic Rhinitis With/Without Asthma: Pre- and Post-Qipian Analysis
Allergic rhinitis and asthma are common respiratory diseases. Qipian® is a Chinese medicine made from three types of bacteria, used to treat these conditions.
- Trial name
- NCT06573164
- Testing
- Bacillus clausii tablets（Qipian®）, conventional medication
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Nephrotic Syndrome in Children, Telitacicept
Study of the Telitacicept in Pediatric Patients With Frequently Relapsing or Steroid Dependent Nephrotic Syndrome
The main objective is to evaluate the effectiveness of telitacicept in pediatric patients with frequently relapsing or steroid dependent nephrotic syndrome within the 52-week follow-up.
- Trial name
- STERN (NCT06125405)
- Testing
- Telitacicept
- Where
- China
- Volunteers
- 20 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Stroke
A Study on the Effectiveness Evaluation in Stroke Patients Using Lower Limb Assistive Walking Devices
The main purpose of this clinical trial is to evaluate the effectiveness and safety of the MI-R1 walking machine in lower limb motor function training for stroke patients. The main question is to answer: 1.
- Trial name
- NCT06564480
- Testing
- MI-R1 lower limb walking machine assisted training device, Walking rehabilitation training under the guidance of therapists
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Postpartum Depression
Effects of Epidural Labor Analgesia With Esketamine on the Incidence of Postpartum Depression in Parturients
Postpartum depression is a common psychological abnormality during the puerperium, which seriously affects maternal and neonatal health.
- Trial name
- NCT05826327
- Testing
- Esketamine, Sufentanil
- Where
- China
- Volunteers
- 364 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Postoperative Pain, Analgesia
Application of Anterior Quadratus Lumborum Block at the Lateral Supra-arcuate Ligament Under Laparoscopic Direct Vision in Laparoscopic Renal Surgery
Evaluation of the effectiveness of Anterior Quadratus Lumborum Block at the lateral supra-arcuate ligament under laparoscopic direct vision compared to local infiltration anesthesia for postoperative analgesia after laparoscopic…
- Conditions
- Postoperative Pain, Analgesia, Quadratus Lumborum Block, Laparoscopic Renal Surgery
- Trial name
- NCT06550869
- Testing
- Anterior Quadratus Lumborum Block at the lateral supra-arcuate ligament under laparoscopic direct vision, Local infiltration anesthesia
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Functional Dysphonia
A Trial of Transcranial Magnetic Stimulation in the Treatment of Functional Dyspepsia
The goal of this clinical trial is to learn if theta burst stimulation (TBS), a form of Transcranial Magnetic Stimulation (TMS), can treat functional dyspepsia (FD) and compare its effectiveness against conventional drug…
- Trial name
- NCT06559748
- Testing
- transcranial magnetic thetaburst stimulation （TBS）
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Pituitary Tumor
Surgical and Pharmacological Efficacy of Knosp Grade 0-2 Prolactinoma
The investigators carried out a multi-center comparative study, involving hospitals including the Second Affiliated Hospital of Zhejiang University School of Medicine, Peking Union Medical College Hospital, West China Hospital…
- Trial name
- NCT06556186
- Testing
- Transnasal transsphenoidal pituitary lesion resection under neuroendoscopy, Bromocriptin 2.5mg, 2-3 times a day
- Volunteers
- 600 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Refractory or Relapsed Diffuse Large B Cell Lymphoma
A Study of Zanubrutinib in Combination With Polatuzumab Vedotin, Bendamustine and Rituximab in the Treatment of Relapsed/Refractory Diffuse Large B-cell Lymphoma
This is a prospective, multicenter, single-arm, open phase II study to explore the efficacy and safety of Zanubrutinib in combination with Polatuzumab Vedotin, bendamustine, and rituximab (Polo-ZBR) in subjects with…
- Trial name
- NCT06554600
- Testing
- Zanubrutinib, Polatuzumab Vedotin, Bendamustine
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Precursor B-Cell Lymphoblastic Leukemia
Blinatumomab Plus Venetoclax Sequenced With Inotuzumab Ozogamicin in Treating B-ALL
Precursor B cell acute lymphoblastic leukemia (B-ALL) is an aggressive type of leukemia, with high relapse rate and poor long term survival in adults.
- Trial name
- NCT06554626
- Testing
- Dexamethasone, Blinatumomab, Venetoclax
- Where
- China
- Volunteers
- 20 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
PCNSL
A Study of Pomadomide in Combination With Rituximab and Methotrexate for Newly-diagnosed Primary Central Nervous System Lymphoma
This is a prospective, multicenter, single-arm, open Phase Ib/II clinical study to explore the safety and efficacy of pomadomide in combination with rituximab and methotrexate (RPM) in newly diagnosed primary central nervous…
- Trial name
- NCT06554561
- Testing
- Pomalidomide, Rituximab, Methotrexate
- Where
- China
- Volunteers
- 43 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Ocular Surface Disease
Clinical Application Research of Scleral Lenses in Ocular Surface Diseases
To evaluate the therapeutic efficacy of scleral lenses in patients with irregular corneal astigmatism stemming from ocular surface diseases (OSD), focusing on visual acuity improvement, comfort, and overall satisfaction.
- Trial name
- NCT06555367
- Testing
- scleral lenses
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Stroke, Intracerebral Hemorrhage
Clinical Outcomes Following Primary Intracerebral Hemorrhage
The investigators design an observational multi-center cohort study to provide contemporary information on the prevalence, characteristics, risk stratification，cost-effective ,treatments and prognosis of Chinese hospitalized…
- Trial name
- COPI (NCT06548737)
- Where
- China
- Volunteers
- 25,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Postoperative Analgesia, Quality of Recovery
Effect of SNB on the QoR in Patients Undergoing Supratentorial Tumor Resection
Patients with Supratentorial tumor undergoing craniotomy have a higher risk of postoperative pain, which will affect their postoperative quality of recovery (QoR).
- Conditions
- Postoperative Analgesia, Quality of Recovery, Supratentorial Tumor, Craniotomy
- Trial name
- NCT06157359
- Testing
- scalp nerve block
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Critically Ill Patients
the Multi-modal Evaluation of Agitation in Critically Ill Patients Based on Remote Video-Ultra-sensitive Detection Wave
The goal of this observational study is to learn about the effectiveness of the multi-modal evaluation for agitation behavior in critically ill patients based on remote video-Ultra-sensitive detection wave.
- Trial name
- NCT06543602
- Testing
- multi-model monitoring and alert
- Where
- 2 sites in China
- Volunteers
- 580 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Gingival Recession, Inadequately Attached Gingiva
Efficacy of Collagen Sponge on Palatal Wound Healing
The aim of this study is to compare the efficacy of collagen sponge and gelatin sponge on the palatal wound healing and postoperative pain following gingival graft harvesting.
- Trial name
- NCT05287763
- Testing
- Palatal soft tissue graft harvesting
- Where
- China
- Volunteers
- 32 people
- Sponsor
- The Dental Hospital of Zhejiang University School of Medicine
Periodontitis
Efficacy of Collagen Sponge Versus Collagen Membrane on Ridge Preservation of Periodontally Compromised Teeth
The study aims to evaluate the efficacy of ridge preservation with collagen sponge or collagen membrane in combination with collagenated bovine bone mineral in extraction sockets of periodontally diseased teeth.
- Trial name
- NCT05188196
- Testing
- alveolar ridge preservation
- Where
- China
- Volunteers
- 36 people
- Sponsor
- The Dental Hospital of Zhejiang University School of Medicine
Acute Coronary Syndrome, Percutaneous Coronary Intervention
Sequential MonotherApy of TicagrElor and Clopidogrel After Coronary Intervention
The MATE study is a randomized, multicenter, open-label, investigator-initiated clinical trial aimed to evaluate efficacy and safety of sequential monotherapy of ticagrelor and clopidogrel in patients with acute coronary syndrome…
- Trial name
- MATE (NCT04937699)
- Testing
- Standard-DAPT of Ticagrelor plus aspirin, Sequential monotherapy of Ticagrelor and clopidogrel
- Where
- China
- Volunteers
- 2,690 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
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