Clinical trials: sponsored by Zhejiang University
Multiple Myeloma, Minimal Residual Disease
Primary Multiple Myeloma Who Achieved MRD Negativity After Induction Therapy, ASCT or Not
The goal of this observational study is to compare the efficacy and safety of autologous hematopoietic stem-cell transplantation (ASCT) versus non ASCT regimens in primary multiple myeloma patients achieved MRD negativity after…
- Trial name
- NCT06463717
- Testing
- Transplant, Autologous, Chemotherapy drug
- Where
- China
- Volunteers
- 210 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Overweight and Obesity
Lifestyle Intervention for Patients With Impaired Glucose Regulation
Impaired glucose regulation (IGR) is closely related to overweight/obesity. By studying different dietary patterns (energy-limited diet vs.
- Trial name
- NCT04469400
- Testing
- Low fat diet intensive intervention, Low-Carbon Water Diet Intensive Intervention
- Where
- 8 sites in China
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Atopic Dermatitis
Efficacy and Safety of Dupilumab in Combination With Tofacitinib in Moderate to Severe Adult AD Patients
Atopic dermatitis (AD) is a common chronic inflammatory skin disease characterized by intense pruritus and sleep disturbances. The clinical manifestations of AD are varied, with the most basic features being dry skin, chronic…
- Trial name
- NCT06465732
- Testing
- Dupilumab, Tofacitinib
- Volunteers
- 220 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
To Compare the Efficacy and Safety of Hybrid ESD and ESD in the Treatment of Colorectal LST
Endoscopic Therapy for Laterally Spreading Tumors (LSTs)
This study will retrospectively include LST patients who were admitted to 6 medical centers (The Second Affiliated Hospital, College of Medicine, Zhejiang University; The Affiliated Jinhua Hospital, Zhejiang University School of…
- Trial name
- LST (NCT06464874)
- Testing
- Conventional ESD, Hybrid ESD
- Where
- China
- Volunteers
- 890 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Hypoxemia, Sedation Complication
Position Intervention to Reduce Hypoxemia in Sedation Patients
Hypoxemia was defined as an SpO2 of < 90% for any duration. Failure to treat promptly can lead to hypoxemia, which may increase the risks of arrhythmia, nausea and vomiting, and cognitive dysfunction.
- Conditions
- Hypoxemia, Sedation Complication, Emergencies, Airway Remodeling
- Trial name
- NCT06459167
- Testing
- The position adopted when patients undergoing procedure or surgery
- Where
- China
- Volunteers
- 1,752 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Hyperfibrinolysis
A Novel Viscoelastic Test Based on Ultrasonic Guided Wave for Identifying Hyperfibrinolysis Rapidly
This study compares the results of the existing fibrinolysis monitoring technology to the Ultrasound-based viscoelastic hemostasis analysis, a new method, using small amount of extra blood obtained during routine blood draws in…
- Trial name
- NCT06374953
- Testing
- Ultrasound-based viscoelastic hemostasis analysis
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Finerenone, IgA Nephropathy
Study of the Clinical Efficacy and Safety of Finerenone for the Treatment of IGA Nephropathy
IgA nephropathy accounts for about 45 per cent of primary glomerular diseases in China and about 26 per cent of renal biopsies in patients with chronic failure.According to current guideline recommendations, there are limited…
- Conditions
- Finerenone, IgA Nephropathy, Proteinuria, Safety Issues
- Trial name
- NCT06460987
- Testing
- Finerenone, RAS inhibitor, Immune Suppressant
- Where
- China
- Volunteers
- 245 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Nephropathy
Clinical Trial of Anti-PLA2R-IgG Detection Kit (Time-resolved Fluorescence Immunoassay)
Conduct comparative experimental studies on clinical serum samples using assessment reagents and approved products, and evaluate the equivalence between assessment reagents and comparison reagents.
- Trial name
- NCT06456801
- Where
- China
- Volunteers
- 219 people
- Sponsor
- Zhejiang University
Middle and Lower Face and Submental Region Skin Laxity
The Efficacy of Microfocused Ultrasound Technique in the Treatment of Facial Skin Laxity
This is a prospective study of 20 Chinese patients with lower facial laxity treated by High Intense focused ultrasound (HIFU). Response will be assessed via paired comparison of pretreatment and posttreatment photographs by two…
- Trial name
- NCT06449911
- Testing
- HIFU
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Dental Implantation, Dental Implants
The Application of Root Analogy Implant in Immediate Implantation
The current clinical implant techniques used include immediate implantation, early implantation, and delayed implantation. With the acceleration of the current pace of life, immediate implantation is increasingly favored by…
- Conditions
- Dental Implantation, Dental Implants, Osseointegration
- Trial name
- RAI (NCT06449391)
- Testing
- RAI
- Where
- China
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- The Dental Hospital of Zhejiang University School of Medicine
Safety Issues, Feasibility
A Pilot Study of Deep Cervical Lymphatic-venous Anastomosis in the Treatment of Alzheimer's Disease
Alzheimer's disease (AD) is the most prevalent form of dementia, affecting 3-4% of the population over a lifetime. It's characterized by abnormal Amyloid-beta (Aβ) and tau protein expression and accumulation in the central…
- Conditions
- Safety Issues, Feasibility, Therapeutic Value
- Trial name
- NCT06448442
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Non Small Cell Lung Cancer, Perioperative Complication
Efficacy and Safety of Modified Si Jun Zi Tang in Perioperative NSCLC Treatment
Chemotherapy combined with immunotherapy is the current standard perioperative treatment for non-small cell lung cancer (NSCLC). However, this regimen has multiple side effects and shows variable efficacy among individuals.
- Trial name
- MSJZT-NSCLC (NCT06445881)
- Testing
- Modified Si Jun Zi Tang
- Where
- China
- Volunteers
- 60 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Subarachnoid Hemorrhage, Lymphatic System Disorder
Radiological Changes of Glymphatic-meningeal Lymphatic Drainage System After Subarachnoid Hemorrhage
Subarachnoid hemorrhage (SAH) is a common and extremely critical disease in neurosurgery. The mortality rate within 30 days of the onset of SAH is as high as 50%, and about 15% of SAH patients die without reaching the hospital.
- Conditions
- Subarachnoid Hemorrhage, Lymphatic System Disorder, Meningeal Lymphatic Vessels
- Trial name
- NCT06444438
- Testing
- subarachnoid hemorrhage
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Disorder of Consciousness
HD-tDCS Combined With Circadian Rhythm Reconstruction and Micro Expression Changes on Consciousness Recovery in Patients With Chronic Disturbance of Consciousness
The circadian rhythm characteristics of sleep cycle and neuroendocrine in patients with chronic disorder of consciousness show different degrees of disorder, and the relationship between this disorder and consciousness level is…
- Trial name
- HD-tDCS (NCT05285124)
- Testing
- Melatonin, HD-tDCS
- Where
- China
- Volunteers
- 90 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Dermatomyositis
3T Therapy in the Treatment of MDA5-positive Dermatomyositis
The goal of this clinical trial is to learn if a combination of tacrolimus, tafocitinib and thalidomide (3T therapy) works to treat severe MDA5 positive dermatomyositis in adults.
- Trial name
- NCT06438679
- Testing
- Tofacitinib 5 MG
- Where
- China
- Volunteers
- 133 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Narrative Medicine, Case-based Learning
Exploring the Application of Narrative Medicine Combined With Case-Based Learning in the Standardized Training of General Practice Residents
This was a prospective, longitudinal, single-center nonrandomized controlled study. A total of 36 first- and second-year general practice residents of Zhejiang University School of Medicine were voluntarily enrolled in the…
- Trial name
- NCT06436963
- Testing
- narrative medicine training combined with CBL training, CBL training
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Relapsed/Refractory Acute Myeloid Leukaemia, Myeloid Malignancy
Mitoxantrone Hydrochloride Liposome Injection, Cytarabine Combined With Venetoclax in the Treatment of R/R AML
The goal of this study is to evaluate the efficacy and safety of a combination regimen of mitoxantrone hydrochloride liposome injection, cytarabine and venetoclax (MAV) in the treatment of relapsed or refractory (R/R) AML.
- Trial name
- NCT06434662
- Testing
- mitoxantrone hydrochloride liposome, Cytarabine, Venetoclax
- Where
- China
- Volunteers
- 34 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Hepatocellular Carcinoma, Transcatheter Arterial Chemoembolization
Postoperative TACE(Transhepatic Arterial Chemotherapy And Embolization) for Patients With Hepatocellular Carcinoma
1. Hepatocellular carcinoma (HCC) is the most common primary malignancy of liver, representing the third leading cause of cancer-related death worldwide. 2.
- Trial name
- NCT02109146
- Testing
- Prophylactic Transcatheter Arterial Chemoembolization, Observation
- Where
- China
- Volunteers
- 332 people
- Sponsor
- Zhejiang University
Airway Remodeling, Radiography in Otolaryngology
Effect of Lateral Positions on the Shape of Upper Airway
The severity and frequency of respiratory events is increased in the supine body posture compared with the lateral position in emergency, difficult airway patients.
- Conditions
- Airway Remodeling, Radiography in Otolaryngology, Position, Patency
- Trial name
- NCT06236971
- Testing
- MRI scanning first at supine position and then turn into lateral position
- Where
- China
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Burnout
Investigation on Burnout of Physicians
This study proposes to analyze the burnout, emotional states, and sleep conditions of internal medicine doctors at the Second Affiliated Hospital of Zhejiang University School of Medicine through a questionnaire survey.
- Trial name
- NCT06418581
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
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