Clinical trials: sponsored by Zhejiang University
Acute Lymphoblastic Leukemia,B-Cell, Non-hodgkin Lymphoma,B Cell
CD19-BAFF CAR-T Cells Therapy for Patients With Relapsed / Refractory B-cell ALL and B-cell NHL
Clinical Trial for the safety and efficacy of CD19-BAFF CAR-T cells therapy for refractory/relapsed B-cell acute lymphoblastic leukemia and B-cell non-Hodgkin lymphoma.
- Trial name
- NCT06346912
- Testing
- CD19-BAFF Targeted CAR T-cells
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Zhejiang University
Immune Checkpoint Inhibitors, Liver Injury
A Clinical Study on the Analysis of Risk Factors for the Occurrence of PD-1/PD-L1 Inhibitor-associated Liver Injury in Lung Cancer Patients
The goal of this observational study is to investigate the risk factors of PD-1/PD-L1 inhibitor-associated liver injury, to construct a prediction model for the occurrence of liver injury.
- Trial name
- NCT06402981
- Testing
- High risk prediction model for liver injury
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Zhejiang University
Locally Advanced Gastric Carcinoma
Research on Intelligent Screening and Decision-making for Neoadjuvant Therapy in Locally Advanced Gastric Cancer Based on Multi-omics Integration
In this study, investigators utilize a radiopathomics integrated Artificial Intelligence (AI) supportive system to predict tumor response to neoadjuvant chemoradiotherapy (nCRT) before its administration for patients with locally…
- Trial name
- NCT06396143
- Where
- 4 sites in China
- Volunteers
- 120 people
- Sponsor
- Zhejiang University
Metastatic Tumor, Advanced Solid Tumor
A Clinical Study of Anti-CD70 UCAR-T in Relapsed or Refractory Solid Tumors
This is a single-center, single-arm ，open-label ，dose escalation and dose extension study. In this study we plan to evaluate the safety and efficacy of CD70-targeting UCAR-T cells in the treatment of CD70-positive refractory or…
- Conditions
- Metastatic Tumor, Advanced Solid Tumor, Renal Cell Carcinoma, Ovarian Cancer
- Trial name
- NCT06383507
- Testing
- CHT101
- Volunteers
- 18 people
- Sponsor
- Zhejiang University
EGF-R Positive Non-Small Cell Lung Cancer
The Feasibility of Dynamic Liquid Biopsy Monitoring During Neoadjuvant Treatment for EGFR-mutated NSCLC
This study aimed to assess the value of dynamic ctDNA monitoring in guiding the development of personalized neoadjuvant treatment strategies for EGFR-mutated NSCLC patients.
- Trial name
- NCT06287593
- Testing
- ctDNA monitoring
- Volunteers
- 300 people
- Sponsor
- Zhejiang University
AML, Adult
Natural Killer(NK) Cell Therapy Targeting CLL1 or CD33 in Acute Myeloid Leukemia
This is a phase 1, first-in-human (FIH), open-label, multicohort study to evaluate the safety, tolerability and preliminary efficacy of CLL1 or CD33 target Chimeric antigen receptor (CAR) -induced pluripotent stem cells derived…
- Trial name
- NCT06367673
- Testing
- iPSC-NK cells
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Zhejiang University
Zhejiang University
Split or Whole Liver Transplantation? A Multicenter Retrospective Cohort Study of Patients With Benign and Malignant Liver Disease
The primary objective of this study was to assess the safety and feasibility of split liver transplantation(SLT) for adult hepatocellular carcinoma (HCC) patients, while comparing the prognostic disparities between adult SLT and…
- Trial name
- NCT06359496
- Testing
- No intervention factor
- Where
- China
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Zhejiang University
Autoimmune Diseases
CD19-BAFF CAR-T Cells Therapy for Patients With Autoimmune Diseases
Clinical Trial for the safety and efficacy of CD19-BAFF CAR-T cells therapy for Autoimmune Diseases.
- Trial name
- NCT06279923
- Testing
- CD19-BAFF Targeted CAR T-cells
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Zhejiang University
Liver Diseases, Surgery
A Study to Evaluate Safety and Feasibility of Robotic Liver Resection
The robotic surgery system, the most advanced technology in minimally invasive surgery, overcame some shortcomings of laparoscopic surgery and improved the flexibility and precision of liver resection.
- Trial name
- NCT06353672
- Testing
- Robotic liver resection
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Zhejiang University
Dementia, Stroke
MIND Diet to Improve Cognitive Function in Mild Stroke Patients (MINDICOMS) II
A 6-month pilot randomized controlled trial designed to test the effect of the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diet + usual medical care versus usual medical care on cognitive change and several…
- Conditions
- Dementia, Stroke, Cognitive Change, Cerebrovascular; Disorder, Thrombotic
- Trial name
- NCT06331247
- Testing
- General dietary advice, Localized MIND diet intervention, Routine medical care
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Zhejiang University
Cirrhosis, Acute Variceal Haemorrhage
The Association Between Albumin Administration and Short-term Rebleeding Risk in Cirrhosis Patients With Acute Variceal Hemorrhage and Stable Hemodynamics
The impact of albumin administration in cirrhotics with acute variceal hemorrhage (AVH) is controversial. We aim to investigate the short-term rebleeding risk associated with albumin administration in a retrospective study of…
- Trial name
- NCT06348004
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Zhejiang University
Liver Transplantation, Hepatocellular Carcinoma
Assessment of AFP and PIVKA-II as Prognostic Indicators in Liver Transplantation for Hepatocellular Carcinoma
As key biomarkers in HCC, AFP and PIVKA-II reflects biological features of tumor and has been widely applied for clinical diagnosis.
- Conditions
- Liver Transplantation, Hepatocellular Carcinoma, Alpha-Fetoprotein, Protein Induced by Vitamin K Absence or Antagonist-II
- Trial name
- NCT06331260
- Volunteers
- 600 people
- Sponsor
- Zhejiang University
Liver Transplantation, No-touch Technique
Impact of "No-touch" Technique on the Outcome of Liver Transplantation for Hepatocellular Carcinoma
The "no-touch" technique has been one of the most important principles of oncological surgery and aimed to prevent seeding and tumor cell dissemination.
- Conditions
- Liver Transplantation, No-touch Technique, Hepatocellular Carcinoma
- Trial name
- NCT06331273
- Testing
- Liver transplantation with "No-touch" technique
- Volunteers
- 800 people
- Sponsor
- Zhejiang University
Dementia, Cognitive Change
MIND Diet to Improve Cognitive Function in Mild Stroke Patients
A 6-month pilot randomized controlled trial designed to test the effect of the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diet + usual medical care versus usual medical care on the rate of cognitive change…
- Conditions
- Dementia, Cognitive Change, Stroke, Cerebral Infarction
- Trial name
- MINDICOMS (NCT05921084)
- Testing
- MIND diet intervention, General dietary advice
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Zhejiang University
Metabolic Syndrome
Double-blind and Placebo-controlled Study on Intervention Effect of Medium and Long Chain Fatty Acid Triglyceride on Glycolipid Homeostasis in Patients With Metabolic Syndrome and Mechanisms
Double-blind and placebo-controlled study on intervention effect of medium and long chain fatty acid triglyceride on glycolipid homeostasis in patients with metabolic syndrome and mechanisms
- Trial name
- NCT06210230
- Testing
- MLCT supplementation, Olive oil
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Zhejiang University
Polyunsaturated Fatty Acids, Mortality
Fish, Polyunsaturated Fatty Acids Intake and Mortality
Data linking fish, polyunsaturated fatty acids intake and mortality are lacking and conflicting. We aim to use data from the China Health and Nutrition Survey (CHNS) and National Health and Nutrition Examination Survey (NHANES)…
- Trial name
- NCT03155659
- Volunteers
- 50,145 people, healthy volunteers welcome
- Sponsor
- Zhejiang University
Type2 Diabetes
Fish, Polyunsaturated Fatty Acids Intake and Type 2 Diabetes
The role of fishery diet and polyunsaturated fatty acids (PUFA) in the development of type 2 diabetes (T2D) is heavily debated but evidence from large populations in China is scant.
- Trial name
- NCT03259321
- Volunteers
- 15,100 people, healthy volunteers welcome
- Sponsor
- Zhejiang University
Morality, Diabetes
Saturated Fatty Acids Intake and Mortality, Diabetes, Hypertension and Overweight
The role of saturated fatty acids (SFAs) intake in the development of total death, cardiovascular diseases, diabetes, hypertension and overweight are in great controversy but evidence from large population in China is scant.The…
- Conditions
- Morality, Diabetes, Hypertension, Overweight
- Trial name
- NCT03281512
- Volunteers
- 14,383 people, healthy volunteers welcome
- Sponsor
- Zhejiang University
Mets, Death
Association of Egg and Dietary Cholesterol Consumption With Mortality and Diseases
To assess the associations between egg and dietary cholesterol consumption with mortality and metabolic syndrome (MetS).
- Trial name
- NCT04104308
- Volunteers
- 33,453 people
- Sponsor
- Zhejiang University
Liver Transplant; Complications
Influence of Intraoperative Blood Salvage and Autotransfusion on Tumor Recurrence After Deceased Donor Liver Transplantation
The practice of intraoperative blood salvage and autotransfusion (IBSA) during deceased donor liver transplantation (DDLT) for hepatocellular carcinoma (HCC) can potentially reduce the need for allogeneic blood transfusion.
- Trial name
- NCT06307158
- Volunteers
- 998 people
- Sponsor
- Zhejiang University