Clinical trials: sponsored by Zhejiang University
Healthy Hematopoietic Stem Cell Donor, Healthy Allogeneic Hematopoietic Stem Cell Donor
Single-Dose vs. Divided-Dose G-CSF for Stem Cell Mobilization in Healthy Allogeneic Donors
National and international guidelines/consensus recommend G-CSF (granulocyte colony-stimulating factor) at 10 μg/kg/day as a single daily dose or divided into two daily doses for mobilization in healthy donors for allogeneic…
- Trial name
- NCT07692841
- Testing
- Single-dose Granulocyte colony-stimulating factor (G-CSF), Divided-dose Granulocyte colony-stimulating factor (G-CSF)
- Where
- 8 sites in China
- Volunteers
- 560 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
ER+/HER2- Breast Cancer
Neoadjuvant High-Intensity Focused Ultrasound (HIFU) Combined With Toripalimab and Chemotherapy for ER-Positive /HER2-Negative Breast Cancer
The purpose of this study is to evaluate the efficacy and safety of high-intensity focused ultrasound (HIFU) combined with toripalimab and chemotherapy as neoadjuvant therapy for ER+/HER2- breast cancer.
- Trial name
- NeoHunter (NCT06964906)
- Testing
- HIFU, Toripalimab, nab-Paclitaxel (nab-P)
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Dilated Cardiomyopathy (DCM), Heart Failure
Safety and Efficacy of FAP iCDC in End-stage Dilated Cardiomyopathy
To study the safety and efficacy of fibroblast activation protein (FAP)-targeted immunosuppressive chimeric antigen receptor-dendritic cell (CAR-DC) in the treatment of end-stage dilated cardiomyopathy and provide a new method…
- Trial name
- NCT06902896
- Testing
- FAP immunosuppressive CAR-DC
- Where
- China
- Volunteers
- 43 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Primary, Sarcoma
Comparison of the Effects of Needle Biopsy Tract Resection and Non-resection on Recurrence Rate in Patients With Primary Extremity Sarcoma
This randomized, non-inferiority clinical trial aims to evaluate whether non-resection of needle biopsy tract is non-inferior to routine biopsy tract resection in terms of local recurrence in patients with primary extremity…
- Trial name
- NCT07575724
- Testing
- biopsy tract resection, biopsy tract non-resection
- Where
- 2 sites in China
- Volunteers
- 3,300 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Pneumocystis Jirovecii Pneumonia in Non-HIV Patients
TMP-SMX for Non-HIV PCP: A Prospective Multicenter Study
Pneumocystis jirovecii pneumonia (PCP) is a life-threatening opportunistic infection in immunocompromised patients. Non-HIV-related PCP has a rising incidence, faster progression, and higher mortality than HIV-associated cases.
- Trial name
- NCT07690410
- Testing
- low-dose TMP-SMX regimen
- Volunteers
- 480 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Coronary Artery Calcification, Intravascular Lithotripsy
Prognostic Impact of Coronary Microvascular Dysfunction After IVL Versus RA in Patients With Severe Coronary Calcification Undergoing PCI
The goal of this observational study is to lean that whether the distinct mechanisms by which intravascular lithotripsy (IVL) and rotational atherectomy (RA) treat severe coronary calcification differentially affect the…
- Conditions
- Coronary Artery Calcification, Intravascular Lithotripsy, Coronary Microcirculation Dysfunction
- Trial name
- NCT07699965
- Where
- China
- Volunteers
- 590 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Develop an Oral Care Plan and Verify it
Development and Application of an Oral Care Protocol for Stroke Patients With Orotracheal Intubation
Develop a standardized oral care protocol for stroke patients undergoing orotracheal intubation based on evidence-based practice, and validate its effectiveness through clinical trials.
- Trial name
- NCT07690475
- Testing
- Standardized oral care protocol, Regular oral care
- Volunteers
- 60 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Postoperative Nausea and Vomiting (PONV), Enhanced Recovery After Surgery
Efficacy and Safety Between Tegileridine and Sufentanil in Laparoscopic Surgery Patients at High Risk of Postoperative Nausea and Vomiting
Postoperative nausea and vomiting (PONV) is one of the most common and distressing perioperative adverse events in patients undergoing laparoscopic surgery.1 Although laparoscopic procedures are minimally invasive, PONV can still…
- Conditions
- Postoperative Nausea and Vomiting (PONV), Enhanced Recovery After Surgery, Laparoscopic Surgery
- Trial name
- NCT07691086
- Testing
- analgesic drugs and methods
- Volunteers
- 800 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Alzheimer Disease
Evaluation System for Lecanemab Efficacy Using Gold Electrode ECL to Monitor Alzheimer's Biomarkers
This study aims to evaluate the therapeutic efficacy of Lecanemab in patients with Alzheimer's disease. The researchers will use a novel detection method based on mesoporous gold electrode surface-enhanced…
- Trial name
- ECL-Lecanemab (NCT07688460)
- Testing
- Lecanemab
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Graft vs Host Disease
Ruxolitinib Plus Etanercept vs Ruxolitinib for Steroid-Refractory Severe Acute GVHD
This is a prospective, multicenter, randomized controlled trial designed to evaluate whether the combination of ruxolitinib and etanercept provides superior efficacy compared with ruxolitinib monotherapy in patients with severe…
- Trial name
- RESCUE (NCT07184853)
- Testing
- Ruxolitinib (JAKAVI®), Etanercept (Enbrel)
- Where
- China
- Volunteers
- 122 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
NSCLC
SKB264 Plus Glecirasib in Advanced KRAS G12C-Mutant NSCLC: A Phase II Study
This is a multicenter, single-arm, phase II (Simon two-stage) prospective interventional clinical study. The primary objective is to evaluate the efficacy and safety of SKB264 in combination with Glecirasib (a KRAS G12C…
- Trial name
- NCT07670013
- Testing
- SKB264, Goleirex
- Where
- China
- Volunteers
- 43 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Postoperative Pain
Clinical Pharmacist-Led Perioperative Pain Management in Orthopedic Surgery: An Effectiveness Evaluation
This study aims to evaluate the effectiveness of a clinical pharmacist-led perioperative pain management model in orthopedic surgery. It is a randomized controlled trial involving patients undergoing major orthopedic procedures.
- Trial name
- NCT07688486
- Testing
- Clinical Pharmacist-Led Pain Management, Standard Perioperative Care
- Volunteers
- 600 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Orthopedic Nursing, Education, Nursing
A Practical Exploration of Developing a Full-English Orthopedic Nursing Curriculum Based on DeepSeek Intelligence
This educational reform study aims to explore whether a full English course built on the DeepSeek artificial intelligence platform can improve orthopedic nurses' professional English competence.
- Conditions
- Orthopedic Nursing, Education, Nursing, Artificial Intelligence, Language
- Trial name
- NCT07688499
- Testing
- Based on the all-English courses of DeepSeek
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Frozen Shoulder
Comparison of Ultrasound-Guided Subacromial vs. Systemic Steroid Injections for Frozen Shoulder: a Multicenter Pilot Study
The goal of this multicenter pilot study is to validate the effectiveness of extending the injection interval between betamethasone doses from one to two weeks for treating frozen shoulder (adhesive capsulitis) in adults aged 18…
- Trial name
- CUSIS-FS-Pilot (NCT06626568)
- Testing
- Compound betamethasone Injection(Gluteal muscle injection), Compound betamethasone Injection(Subacromial Ultrasound Guided injection), home exercise
- Where
- 9 sites in China
- Volunteers
- 40 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Keloids, Fibroblast
Keloid Pathogenesis And Fibroblast Activation Study
Keloids are benign fibroproliferative skin disorders characterized by excessive fibroblast activation and extracellular matrix deposition. The molecular mechanisms underlying keloid formation remain incompletely understood.
- Trial name
- KPS (NCT07682636)
- Testing
- Tissue Collection
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Overweight , Obesity
Research on the Needs, Feasibility, and Intervention Effects of AI Health Coach-based Just-in-Time Adaptive Intervention (JITAI) in Weight Management for Overweight/Obese Adults
This pilot study evaluates the needs, feasibility, and preliminary effects of an artificial intelligence (AI) health coach-based just-in-time adaptive intervention for weight management in adults with overweight or obesity.
- Trial name
- NCT07682571
- Testing
- AI Health Coach-based Just-in-Time Adaptive Intervention
- Where
- China
- Volunteers
- 31 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Non-suicidal Self-injury (NSSI)
Non-Suicidal Self-Injury Digital Psychotherapy Trial
The goal of this randomized, parallel-controlled clinical trial is to investigate multi-dimensional biomarkers (blood, brain imaging, clinical information, and symptom assessment) in adolescents with Non-Suicidal Self-Injury…
- Trial name
- NSSI-DPT (NCT07683234)
- Testing
- digital psychotherapy, Treatment as Usual (TAU)
- Volunteers
- 110 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Ischemic Cardiomyopathy, Cell Therapy
Safety and Efficacy of FAP iCDC in Ischemic Cardiomyopathy
This study aims to evaluate the safety and efficacy of fibroblast activation protein (FAP)-targeted autologous immunosuppressive chimeric antigen receptor dendritic cell (iCDC) therapy in patients with ischemic cardiomyopathy…
- Trial name
- NCT07505199
- Testing
- autologus FAP-targeted immunosuppressive CAR-DCs (iCDC), Standard medical treatment
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Dilated Cardiomyopathy (DCM), Heart Failure
Safety and Efficacy of Second Infusion of FAP iCDC in End-stage Dilated Cardiomyopathy
This study aims to evaluate the safety and preliminary efficacy of a second administration of fibroblast activation protein (FAP)-targeted immunosuppressive chimeric antigen receptor dendritic cells (CAR-DC) in patients with…
- Trial name
- NCT07516288
- Testing
- FAP immunosuppressive CAR-DC
- Where
- China
- Volunteers
- 5 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Plantar Wart
A Self-controlled Study of Bleomycin and Pingyangmycin Injection in the Treatment of Plantar Warts
All patients were treated as self-control. Half of the warts received bleomycin injection and the other half received pingyangmycin injection for 24 weeks.
- Trial name
- NCT07197541
- Testing
- Hyperthermia Therapy, Pingyangmycin Injection, Bleomycin injection
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
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