Clinical trials: sponsored by Zhujiang Hospital
Hepatocellular Carcinoma Resectable, Surgery
Compare the Accuracy of ctDNA-MRD and MVI Result in Predicting Postoperative Recurrence of Hepatocellular Carcinoma
The aim of this study was to compare the accuracy of ctDNA-MRD longitudinal surveillance model and internationally accepted pathological MVI results in predicting recurrence after radical hepatectomy.
- Conditions
- Hepatocellular Carcinoma Resectable, Surgery, Recurrence
- Trial name
- NCT06449846
- Testing
- circulating tumor cell DNA detection
- Where
- 4 sites in China
- Volunteers
- 152 people
- Sponsor
- Zhujiang Hospital
Hepatolithiasis, Hepatectomy
Application of Three- Dimensional Visualization Combined With ICG Molecular Fluorescence Imaging in Hepatolithiasis
This study adopted a retrospective study method to explore the clinical application value of 3D visualization combined with ICG molecular fluorescence imaging technology in hepatolithiasis, and further analyze whether 3D…
- Trial name
- NCT06447181
- Testing
- 3D visualization technology ; ICG fluorescence technology .
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Zhujiang Hospital
Acute Ischemic Stroke
The Correlation Between CITED2 and Collateral Circulation in Acute Ischemic Stroke
Evaluating the collateral circulation of acute ischemic stroke (AIS) mainly depends on the imaging examination. At present, there is no effective and sensitive biomarker for collateral circulation.
- Trial name
- NCT05345366
- Testing
- non-applicable
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Zhujiang Hospital
Recurrent Glioblastoma
Sintilimab in Combination With Bevacizumab and Temozolomide in Recurrent Glioblastoma (GBM) Patients
The purpose of this study is to evaluate the efficacy and safety of Sintilimab in combination with Bevacizumab and Temozolomide in subjects with recurrent glioblastoma.
- Trial name
- NCT05638451
- Testing
- Sintilimab plus Bevacizumab and Temozolomide
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Zhujiang Hospital
Diabetic Autonomic Neuropathy Type 2, Perioperative Complication
Effect of Diabetes Mellitus on Cardiac Autonomic Function in Surgical Patients Undergoing General Anesthesia
Because autonomic neuropathy affects the constriction of thermoregulatory blood vessels, it is more difficult for diabetic patients to maintain their own body temperature in cold environments than normal people, and therefore it…
- Conditions
- Diabetic Autonomic Neuropathy Type 2, Perioperative Complication, Temperature Change, Body
- Trial name
- NCT06432270
- Volunteers
- 388 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Obesity
Effects of TRE With Lactobacillus Plantarum LP-KFY04 Supplementation on Overweight / Obese Individuals
With the improvement of the quality of life, multi-nutritional dietary intake today has provided people with a solid foundation for their health profiles.
- Trial name
- TRELO (NCT06423287)
- Testing
- Lactobacillus plantarum LP-KFY04
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Zhujiang Hospital
Congenital Biliary Dilatation, Choledochal Cyst
The Application of Digital Intelligent Diagnostic and Therapeutic Technology in Biliary Dilation Diagnosis
This research discusses the clinical application value of augmented reality navigation technology combined with three-dimensional visualization technology in improving surgical safety and promoting the development of precision…
- Trial name
- DIIBD (NCT06418490)
- Testing
- Three-dimensional visualization technology
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Zhujiang Hospital
Bacterial Vaginosis
Precision Vaginal Microbiome Transplantation in Women With Bacterial Vaginosis
The aim of this study was to explore the efficacy and safety of a new vaginal microbiome transplantation technique, using Lactobacillus cispatus from healthy donors as a treatment of bacterial vaginosis.
- Trial name
- NCT06263465
- Testing
- Lactobacillus cispatus
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Zhujiang Hospital
Colorectal Cancer
A Cross-sectional Study on the Association of Peptidoglycan Fragments Derived From Gut Microbiota With Colorectal Cancer
The goal of this observational study is to explore the association of peptidoglycan fragments derived from gut microbiota with colorectal cancer (CRC).
- Trial name
- NCT06379412
- Testing
- observational study, no intervention
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Acute Ischaemic Stroke, Depression
Screening of New Markers of Gut Microbiota in Stroke and Depression: a Cross-sectional Study
Objectives of Study： Through the cross-sectional study of stroke and depression, key biomarkers are targeted by screening disease-associated intestinal bacteria, metabolites and immune factors through multi-omics techniques.
- Trial name
- NCT06379464
- Where
- China
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Fusobacterium Infections
Developing a Real-Time PCR Assay for Fusobacterium and Epidemiological Analysis of Tumor Patients
This study presents an academic approach to developing a fluorescence quantitative PCR detection method capable of accurately measuring the presence of Fusobacterium (specifically F. nucleatum, F. mortiferium, F. varium, F.
- Trial name
- NCT06168513
- Where
- China
- Volunteers
- 490 people
- Sponsor
- Zhujiang Hospital
Hepatocellular Carcinoma, Circulating Tumor Cell
Value of Dynamic Monitoring of Early Recurrence of Hepatocellular Carcinoma After Radical Resection Based on CTCS
On the basis of previous retrospective studies, the Task Force will further optimize the CTCs longitudinal surveillance model and initially validate the subclonal origin (CTC-DNA) of recurrent/metastatic foci derived from CTCs at…
- Conditions
- Hepatocellular Carcinoma, Circulating Tumor Cell, Recurrence, Surgery
- Trial name
- NCT06317896
- Testing
- circulating tumor cells
- Where
- 3 sites in China
- Volunteers
- 82 people
- Sponsor
- Zhujiang Hospital
Sepsis, Septic Shock
Nasal and Gut Microbiota Combined Clinical Events Predicts the Prognosis of Septic Patients
In this prospective, multicentered , diagnostic trial, nasal and fecal specimens will collected from patients with sepsis in two critical care units(ICU) at the enrollment day ,the third, seventh, and fourteen days after…
- Trial name
- NCT05143736
- Testing
- gut and nasal microbiota detection
- Where
- 2 sites in China
- Volunteers
- 300 people
- Sponsor
- Zhujiang Hospital
High-Risk and Oligometastatic Prostate Cancer
An Evaluation of the Efficacy and Safety of Apalutamide as Neoadjuvant Endocrine Therapy in High-Risk and Oligometastatic Prostate Cancer
The neoadjuvant therapy with apalutamide can significantly improve the prognosis of patients with high-risk and oligometastatic prostate cancer, lower the rate of positive margins, reduce recurrence, and show high safety.
- Trial name
- NCT04997252
- Testing
- Apalutamide
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Zhujiang Hospital
B-Cell Leukemia, B-Cell Lymphoma
Interleukin-2 Following 4SCAR19/22 T Cells Targeting Refractory and/or Recurrent B Cell Malignancies
Clinical studies of CD19 CAR-T cells in the treatment of blood and lymphatic system tumors have achieved unprecedented successes.
- Trial name
- NCT03098355
- Testing
- 4SCAR19/22 T cells, Interleukin-2
- Where
- China
- Sponsor
- Zhujiang Hospital
B-cell Acute Lymphoblastic Leukemia, B-Cell Lymphoma, Unspecified
CD19 CAR T-cell Target Relapsed/Refractory Acute B Cell Leukemia/Lymphoma
This study aims to evaluate the safety and efficacy of humanized Anti-CD19 Chimeric Antigen Receptor-T cell (CAR19T2 T cell) in children with refractory/relapsed B-cell acute lymphoblastic leukemia/lymphoma.
- Trial name
- CAR19T2 (NCT05613348)
- Testing
- CD19 CAR T-Cell(CAT19T2)
- Where
- 2 sites in China
- Sponsor
- Zhujiang Hospital
Type 2 Diabetes Mellitus
Study of Efficacy, Weight Control, and Safety in Newly-diagnosed Type 2 Diabetes With Different Antidiabetic Therapy
Study Hypothesis：Compared with premixed insulin, triple oral combination therapy has similar hypoglycemic effect, better weight control and lower incidence of hypoglycemia.
- Trial name
- NCT03700801
- Testing
- Triple combination therapy group, Premixed insulin therapy group
- Where
- China
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Type 2 Diabetes Mellitus, Overweight and Obesity
Safety and Efficacy of Human Microbiota Transplantation for Overweight and Obese Type 2 Diabetes Mellitus
The main purpose is to evaluate whether the percentage of body weight change from baseline to week 12 is higher than that in the placebo group.
- Trial name
- SETOM (NCT05253768)
- Testing
- Fecal microbiota transplant (FMT), normal saline and glycerin/food coloring
- Where
- China
- Volunteers
- 39 people
- Sponsor
- Zhujiang Hospital
Papillary Thyroid Cancer
Treatment Efficacy and Safety of Low-dose Radioiodine Ablation for Intermediate-risk Differentiated Thyroid Carcinoma
Primary objective: The 3-years disease-free survival was compared between low-dose group (30 mCi) and high-dose group (100 mCi).
- Trial name
- NCT04354324
- Testing
- Radioiodine
- Where
- China
- Volunteers
- 254 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Leukemia, Acute Lymphocytic (ALL), Leukemia, Acute Myelogenous (AML)
CAR-T Cells Combined With Peptide Specific Dendritic Cell in Relapsed/Refractory Leukemia/MDS
The main purpose of this study is to verify the safety and potential effectiveness of CART cells combined with peptide specific dendritic cell in relapsed/refractory leukemia.
- Conditions
- Leukemia, Acute Lymphocytic (ALL), Leukemia, Acute Myelogenous (AML), Myelodysplastic Syndromes
- Trial name
- NCT03291444
- Testing
- Chimeric antigen receptor T cells, peptide specific dendritic cell
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Zhujiang Hospital