Clinical trials: sponsored by Zhujiang Hospital
Neuroblastoma, Effects of Immunotherapy
Anti-GD2 4th Generation CART Cells Targeting Refractory and/or Recurrent Neuroblastoma
Patients with refractory and/or recurrent neuroblastoma have poor prognosis despite complex multimodel therapy and therefore, novel approaches are urgently needed.
- Trial name
- 4SCAR-GD2 (NCT02765243)
- Testing
- Anti-GD2 CART
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Zhujiang Hospital
Therapy Related Leukemia
Sequential Treatment With CD20/CD22/CD10-CART After CD19-CART Treatment Base on MRD in Relapsed/Refractory B-ALL
CD19-negative B-ALL relapses after CD19 CAR T-cell treatment have occurred in some patients. CD20/CD22/CD10 is still expressed in CD19 negative B-ALL cells which means these CD molecules may become new targets in treatment of…
- Trial name
- NCT03407859
- Testing
- Sequential Treatment With different CART
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Zhujiang Hospital
Protein; Disease
Pilot Study on Proteomics of Erythrocyte Proteins in Patients With COPD Based on TMT Technology
Chronic obstructive pulmonary disease (COPD), a common and complex disease characterized by persistent airflow limitation, is a leading cause of mortality worldwide. COPD and its comorbidity are associated with hypoxia condition.
- Trial name
- NCT05376618
- Testing
- no intervention
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Relapsed/Refractory Multiple Myeloma(MM)
CAR-T Cells Therapy in Relapsed/Refractory Multiple Myeloma
Multiple myeloma（MM） is one of the most common malignant diseases in the blood system.There is still no cure for the disease which only control the development of the disease in various ways.Chimeric Antigen Receptor-transduced T…
- Trial name
- MM (NCT03473496)
- Testing
- CART therapy in Relapsed/Refractory multiple myeloma
- Where
- China
- Volunteers
- 2 people
- Sponsor
- Zhujiang Hospital
Radiation Toxicity, MRI Simulated Positioning
A Novel Target Delineation Scheme in High-grade Glioma Patients: a Randomized Single-blind Clinical Trial
The main question it aims to answer are: 1. whether the new target delineation scheme can improve Progression-free Survival 2. whether it can reduce the incidence of radiation complications in high-grade glioma patients.
- Conditions
- Radiation Toxicity, MRI Simulated Positioning, High Grade Glioma, Progression-free Survival
- Trial name
- NCT06215495
- Testing
- reduced target volume, EORTC (European organisation for research and treatment of cancer) target volume
- Where
- China
- Volunteers
- 88 people
- Sponsor
- Zhujiang Hospital
Prostate Cancer With ≤10 Bone Metastases
Efficacy and Safety of Apalutamide in Combination With 89Sr as Neoadjuvant Therapy in Prostate Cancer With ≤10 Bone Metastases
The aim of this study is to evaluate the efficacy and safety of apalutamide in combination with 89Sr as neoadjuvant therapy in prostate cancer with ≤10 bone metastases.
- Trial name
- NCT05740488
- Testing
- Apalutamide, 89Sr, Luteinizing Hormone-Releasing Hormone Analog
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Zhujiang Hospital
Liver Fibrosis, Cirrhosis
Quantitative Diagnosis of Liver Fibrosis on Multiparametric MRI
Early diagnosis and treatment of liver fibrosis can repress or delay the development of cirrhosis and hepatocellular carcinoma. The purpose of this pilot study is to evaluate non-invasive multiparametric magnetic resonance…
- Trial name
- NCT03176797
- Testing
- Liver MRI
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Chronic Obstructive Pulmonary Disease, Type 2 Diabetes Mellitus
The Early Predictors for Developing Type 2 Diabetes Mellitus in Patients With Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease(COPD), characterized by persistent airflow limitation, associated with an progressive chronic inflammatory response of the lung to noxious particles or gases, can lead to dyspnea and limited…
- Trial name
- NCT03152994
- Testing
- Checking fasting blood glucose(FBG)
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Zhujiang Hospital
Infection
Clinical Application of High-throughput Sequencing Technology for the Diagnosis of Patients With Severe Infection
The purpose of this study is to evaluate the clinical value of high throughput sequencing of infectious pathogens for patients with severe infection, and to establish foundation for high throughput sequencing to be the clinical…
- Trial name
- NCT04217252
- Testing
- PMseqTM high-throughput sequencing technology
- Sponsor
- Zhujiang Hospital
Chronic Obstructive Pulmonary Disease (COPD)
Effects of Different Modes of Respiratory MuscleTraining on Respiratory Mechanics and NRD in Patient With Stable COPD.
Chronic Obstructive Pulmonary Disease (COPD) is a chronic respiratory disease characterized by persistent airflow limitation. The patients are suffering dyspnea year by year, resulting in the decreased exercise tolerance and…
- Trial name
- NCT03500042
- Testing
- inspiratory pressure threshold device
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Zhujiang Hospital
Chronic Obstructive Pulmonary Disease (COPD)
Surface EMGdi Evaluate the Efficacy of Pulmonary Rehabilitation in Patients With COPD: a Multi Center Prospective Study
Pulmonary rehabilitation is recognized as a core component of the management of individuals with chronic obstructive respiratory disease, which has become first-line treatment besides drug therapy.
- Trial name
- NCT03082924
- Testing
- Control group, Calibrated cycle ergometer, Threshold loading device
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Zhujiang Hospital
Chronic Obstructive Pulmonary Disease
Effects of Non-invasive Ventilation on Respiratory Mechanics and NRD in Patients With Stable COPD
Chronic obstructive pulmonary disease (COPD) is a chronic respiratory disease characterized by persistent respiratory symptoms and airflow limitation.
- Trial name
- NCT03555097
- Testing
- incremental pressure support
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Zhujiang Hospital
Pulmonary Rehabilitation
Effect of Combined IMT and CPAP in Pulmonary Rehabilitation for COPD
Inspiratory muscle training(IMT) was one of the widely used pulmonary rehabilitation method in COPD patients.However, when the respiratory muscles are fatigue without sufficient rest, IMT may increase muscle fatigue and aggravate…
- Trial name
- NCT03919513
- Testing
- inspiratory pressure threshold device
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Acute Exacerbation of Chronic Obstructive Pulmonary Disease
The Effect of EDP on Diaphragmatic Function and Neural Respiratory Drive in Patient With AECOPD
Chronic Obstructive Pulmonary Disease (COPD) is a common respiratory disease characterized by airflow limitation that is progressive and not fully reversible.
- Trial name
- NCT03083418
- Testing
- control group, EDP
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Zhujiang Hospital
Chronic Obstructive Pulmonary Disease
Acute Effects of Incremental Inspiratory Loads on Respiratory Mechanics and NRD in Patient With Stable COPD.
Inspiratory muscle training has been an important part of pulmonary rehabilitation program directed at patients with COPD. It can increase respiratory muscle strength, relieve dyspnea ,improve the quality of life in COPD…
- Trial name
- NCT03532243
- Testing
- incremental inspiratory load
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Zhujiang Hospital
Sepsis, Septic Shock
Improvement of Organ Function by Apigenin in Elderly Patients With Sepsis
In this single-center, randomized, single-blind, placebo-controlled pilot clinical trial. The effect of apigenin on the improvement of organ function will be investigated in elderly patients with sepsis.
- Trial name
- NCT05999682
- Testing
- apigenin, sterilized water
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Zhujiang Hospital
Knee Osteoarthritis, Effusion Synovial
Methotrexate in the Treatment of Advanced Knee Osteoarthritis With Effusion-synovitis
This multicentre randomized placebo-controlled clinical trial aims to evaluate whether methotrexate (MTX) has effects of relieving symptoms and reducing inflammation on advanced knee osteoarthritis (OA) with inflammatory…
- Conditions
- Knee Osteoarthritis, Effusion Synovial, Knee Pain
- Trial name
- NCT03815448
- Testing
- Methotrexate
- Where
- 11 sites in China
- Volunteers
- 215 people
- Sponsor
- Zhujiang Hospital
Endometriosis
A Study on the Correlation Between Endometriosis and Intra-tissue Microbiota
Endometriosis (EM) is a common gynecological condition, but the pathogenesis of it has not yet been clarified. Here, the investigators wanted to investigate the correlation between endometriosis and the intra-tissue microbiota.
- Trial name
- NCT06266897
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Hyperthermic Intraperitoneal Chemotherapy, Hepatocellular Carcinoma
Surgical Resection Combined With Intraperitoneal Hyperthermic Chemotherapy
Patients with ruptured liver cancer and bleeding after surgical resection were included according to the criteria of admission, and the patients were divided into experimental and control groups.
- Conditions
- Hyperthermic Intraperitoneal Chemotherapy, Hepatocellular Carcinoma, Ruptured Liver
- Trial name
- NCT06247293
- Testing
- intraperitoneal hyperthermic perfusion chemotherapy
- Volunteers
- 100 people
- Sponsor
- Zhujiang Hospital
Acute Ischemic Stroke
Dynamic Changes in Human Microbiome Predict the Risk of Adverse Outcomes in Patients With Acute Ischemic Stroke: a Multicenter Prospective Cohort Study
(1) The main purpose To explore the predictive value of human microbiome and its metabolome for adverse prognosis in patients with acute ischemic stroke (AIS). (2) Secondary purposes 1.
- Trial name
- NCT06240468
- Testing
- not have
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital