Clinical trials: Phase 4, open to volunteers
Menstrual Regulation, Menstrual Health Intervention
Period Pills for Menstrual Regulation: A New Reproductive Health Option
The Period Pills Study is a prospective observational study among people who decide to use a combination of mifepristone and misoprostol for menstrual regulation.
- Trial name
- Period Pills (NCT07671989)
- Testing
- Mifepristone + Misoprostol
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Consciousness, Level Altered
The Electroencephalographic Mechanisms of Anesthesia and Human Consciousness
In the field of general anesthesia research, the neural mechanism underlying the loss of consciousness has long been a highly core issue. It remains unclear what consciousness is and how it emerges from brain activity.
- Trial name
- NCT07145697
- Testing
- Dexmedetomidine
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
ADHD - Combined Type
Multimodal Brain Imaging of the Neural Effects of Methylphenidate in Patients With ADHD
The investigators' goal is to develop neuroimaging biomarkers to predict response to treatment with methylphenidate, which then can be used in the development of novel pharmacological treatments for…
- Trial name
- NCT04781972
- Testing
- Methylphenidate
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Johns Hopkins University
Melasma (Facial Melasma)
Microneedling-Assisted Metformin, Tranexamic Acid, and Modified Kligman's Formula for Melasma
Melasma is a common skin condition characterized by brown or gray patches on sun-exposed areas of the face. Although several topical treatments are available, treatment outcomes are often unsatisfactory, and recurrence is common.
- Trial name
- NCT07696806
- Testing
- Metformin 30% Topical Lotion, Tranexamic Acid 0.5% Topical Solution, Modified Kligman's Formula
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Sameh Sarsik
Spinal Surgery, Spinal Fusion
Comparing Outcomes in Patients Who Have Spinal Surgery Who Have No-Ice Cold and Compression Therapy Using the NICE1 Device Versus Standard of Care
A two-arm randomized controlled trial design will be used for this study to evaluate health outcomes of patients who receive Nice1 cryotherapy with compression (cryopneumatic) therapy (intervention group) versus those who receive…
- Conditions
- Spinal Surgery, Spinal Fusion, Laminectomy
- Trial name
- NCT07542470
- Testing
- ice-free cryopneumatic therapy device
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- Sarasota Memorial Health Care System
Alpha 1-Antitrypsin, COPD
Genetic Variation in IgG in Alpha 1 Antitrypsin Deficiency
The goal of this study is to learn whether patients who have a genetic mutation in the genes that cause alpha 1 antitrypsin deficiency also have genetic variation in nearby genes that can increase risk for reduced immune function…
- Conditions
- Alpha 1-Antitrypsin, COPD, Antibody Deficiency
- Trial name
- IgG in AATD (NCT07135427)
- Testing
- 20-valent pneumococcal conjugate vaccine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Alabama at Birmingham
Cataract, Surgery
Evaluating a Dropless Postoperative Regimen After Cataract Surgery in a Vulnerable, County-hospital Population
The current postoperative cataract surgery eye drop regimen used at Zuckerberg San Francisco General Hospital (ZSFG) is a significant burden for its patient population, contributing to high rates of non-adherence and the…
- Conditions
- Cataract, Surgery, Compliance, Patient, Compliance, Medication
- Trial name
- NCT05157113
- Testing
- Dropless Regimen, Standard Regimen
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of California, San Francisco
Cervical Insufficiency
Azithromycin for Cerclage Prophylaxis
The primary goal is to assess the effectiveness in pregnancy prolongation utilizing azithromycin at the time of transvaginal cervical cerclage placement.
- Trial name
- NCT07608562
- Testing
- Azithromycin Prophylaxis, Cefazolin, Progesterone
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Wake Forest University Health Sciences
Hernia Abdominal Wall, Botox Injection
Preoperative BOTOX® Injection for Large Ventral Hernia Repair
This study is for adults who need open surgery to repair a very large abdominal (ventral) hernia. This study tests whether a one-time, image-guided injection of a medicine commonly known as "BOTOX®" (onabotulinumtoxinA) into the…
- Conditions
- Hernia Abdominal Wall, Botox Injection, Hernia Incisional Ventral, Hernia Repair With Compartment Syndrome
- Trial name
- PRETOX (NCT07220382)
- Testing
- OnabotulinumtoxinA Injection, OnabotulinumtoxinA, 0.9 % Normal Saline
- Where
- United States
- Volunteers
- 188 people
- Sponsor
- The Cleveland Clinic
Class I/II Obesity
Translational Health Research Into Vascular and Neurocognitive Effects of Weight Loss
The goal of this clinical trial is to learn about the nature of brain abnormalities associated with excess body fat in healthy adults aged 35-55.
- Trial name
- THRIVE (NCT07592546)
- Testing
- semaglutide
- Where
- Canada
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Alain Dagher
Crohn Disease
PATHFINDER: Evaluating the Optimal First-Line Treatment Strategy for Moderate-to-Severely Active Ileal-dominant Crohn's Disease
There are currently three classes of biologic treatments approved in Canada for the management of moderate-to-severe Crohn's disease: anti-tumor necrosis factor [TNF] alpha, anti-integrin, and anti-interleukin [IL]-23 targeted…
- Trial name
- PATHFINDER (NCT05928039)
- Testing
- TNFa Antagonist - Infliximab, TNFa Antagonist - Adalimumab, Anti-IL12/23 or anti-IL23 - Ustekinumab
- Where
- 23 sites in Canada
- Volunteers
- 210 people
- Sponsor
- University of Calgary
No Condition
Comparing Intravitreal Injection Pain Scores Using Iheezo (Chloroprocaine Hcl Ophthalmic Gel 3%) Versus Subconjunctival Lidocaine (2%): A Randomized, Controlled Trial
This will be a prospective, randomized, controlled non-inferiority trial comparing the efficacy of Iheezo versus subconjunctival 2% lidocaine in reducing intravitreal injection pain scores up to 24 hours after injection.
- Trial name
- NCT07895420
- Testing
- chloroprocaine HCL 3%, Subconjunctival Lidocaine
- Where
- 4 sites in United States
- Volunteers
- 80 people
- Sponsor
- Retina Research Institute, LLC
Astigmatism
Arcuate Incisions With Light Adjustable Lens for Astigmatism Correction in Lens Surgery
This study aims to evaluate the safety and effectiveness of femtosecond laser arcuate corneal relaxing incisions (AK) combined with Light Adjustable Lens (LAL) implantation for correcting pre-existing corneal astigmatism in…
- Trial name
- NCT07140653
- Testing
- Femto arcs, Light Adjustable Lens (LAL)
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Center For Sight
Portal Hypertension, Hepatic Decompensation
Non-selective Beta-blocker in Compensated Advanced Chronic Liver Disease
The goal of this randomised controlled trial is to evaluate the effect of carvedilol (a non-selective beta-blocker) in patients with compensated advanced chronic liver disease under clinically significant portal hypertension or…
- Conditions
- Portal Hypertension, Hepatic Decompensation, Advanced Chronic Liver Disease
- Trial name
- BB_cACLD (NCT06449339)
- Testing
- Carvedilol
- Where
- Hong Kong
- Volunteers
- 474 people
- Sponsor
- Chinese University of Hong Kong
Delayed Sleep Phase Syndrome
Lemborexant in Delayed Sleep Phase Syndrome
The purpose of the study is to evaluate whether Lemborexant is more effective than placebo in shortening sleep onset latency in patients with delayed sleep phase syndrome (both type 1 and type 2).
- Trial name
- NCT05463861
- Testing
- Lemborexant
- Where
- 2 sites in United States
- Volunteers
- 86 people
- Sponsor
- Stanford University
Unruptured Intracranial Aneurysms, Cerebrovascular Event
Efficacy and Safety of Methylprednisolone After Flow-Diverter Stent Implantation in Unruptured Intracranial Aneurysms
Study Title: Testing Methylprednisolone to Prevent Strokes After a Stent Procedure for Brain Aneurysms What is the purpose of this study? This study aims to find out if a short course of a steroid medicine called…
- Conditions
- Unruptured Intracranial Aneurysms, Cerebrovascular Event, Hemorrhagic Stroke, Methylprednisolone
- Trial name
- NCT07353749
- Testing
- Methylprednisolone (Injectable Form)
- Where
- China
- Volunteers
- 864 people
- Sponsor
- Duan Chuanzhi
Aesthetic
PLLA and CaHA-R for Aesthetic Rejuvenation
Skin ageing is intricately linked to collagen degradation caused by internal and external factors. External factors contributing to ageing include ultraviolet rays, smoking, heat, and air pollution, and follow a distribution…
- Trial name
- NCT07202117
- Testing
- Sculptra Aesthetic, Radiesse
- Where
- Canada
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Erevna Innovations Inc.
Postoperative Pain
ESP Blocks for Posterior Spinal Fusion
This prospective randomized double-blind study evaluates the efficacy of erector spinae plane (ESP) blocks on postoperative pain in patients undergoing cervical or lumbar posterior spinal fusion.
- Trial name
- NCT07228039
- Testing
- ESP Block with Bupivacaine, ESP Block with Bupivacaine + Liposomal Bupivacaine
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Duke University
Dry Eye
Cooling Eyedrops for Dry Eye
In dry eye (DE), either insufficient aqueous tears are produced or the tears evaporate off the ocular surface too quickly. Meibomian gland dysfunction (MGD) results in poor quality or insufficient meibum being expressed during…
- Trial name
- NCT07888452
- Testing
- TRYPTYR Eye Drops, Purilens Plus Non-Preserved Saline Eye Drops
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, Berkeley
Wrist Fracture
Wrist Reduction Intervention: Supracondylar Technique for Radial Nerve Block vs. Hematoma Block (WRIST Block Study)
The purpose of this study is to compare different types of local anesthesia-a supracondylar radial nerve block, a hematoma block, or a combination of the two-for reducing pain in people with a broken wrist (distal radius…
- Trial name
- NCT07268547
- Testing
- Supracondylar radial nerve block, Hematoma block, Combination of blocks
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Sarasota Memorial Health Care System
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.