Clinical trials: sponsored by Case Comprehensive Cancer Center
Basal Cell Carcinoma, Basal Cell Nevus Syndrome
Vitamin D as a Nutritional Neoadjuvant During Photodynamic Therapy of Basal Cell Carcinoma
The purpose of this study is to study 50 patients with multiple Basal Cell Carcinoma (BCC) who will be receiving Photodynamic Therapy (PDT) as treatment for their tumors.
- Trial name
- NCT03467789
- Testing
- Dietary Vitamin D3 pre-treatment, Photodynamic therapy, Serum Maintenance Vitamin D3
- Where
- 2 sites in United States
- Volunteers
- 37 people
- Sponsor
- Case Comprehensive Cancer Center
Pancreatic Fistula
eXtended Antibiotic Prophylaxis for Intermediate- and High-risk Glands After Pancreatoduodenectomy to Reduce CR-POPF
The purpose of this clinical trial is to investigate if prolonged antibiotics after pancreatoduodenectomy can prevent the development of a pancreatic fistula and related complications.
- Trial name
- NCT05753735
- Testing
- Piperacillin/Tazobactam, Amoxicillin/ Clavulanic acid
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Case Comprehensive Cancer Center
DCIS, Invasive Breast Cancer
Assessing the Impact of the Microbiome on Breast Cancer Radiotherapy Toxicity
Microorganisms in the human body (such as virus, bacteria, fungus) may have an important role in breast cancer side effects. In this study, microorganisms will be analyzed to determine which, if any,are present.
- Trial name
- NCT04245150
- Testing
- Stool sample, Skin Swab Sample
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Case Comprehensive Cancer Center
Pancreatic Neoplasms, Periampullary Carcinoma
Multidimensional Prehabilitation in Pancreatic Surgery for Pancreatic and Periampullary Neoplasms
Randomized Clinical Trial Investigating Multidimensional Prehabilitation in Pancreatic Surgery for participants with Pancreatic and Periampullary Neoplasms
- Trial name
- NCT05225038
- Testing
- Exercise, Nutritional, Behavioral Medicine
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Case Comprehensive Cancer Center
Lung Cancer, Non-small Cell Lung Cancer
Rational EpigenetiC Immunotherapy for SEcond Line Therapy in Patients With NSCLC: PRECISE Trial
The purpose of this study is to assess whether treatment with the study drug tetrahydrouridine-decitabine (THU-Dec) in combination with nivolumab is more effective than treatment with nivolumab alone in patients with NSCLC.
- Trial name
- PRECISE (NCT02664181)
- Testing
- Nivolumab, oral decitabine, Tetrahydrouridine
- Where
- 2 sites in United States
- Volunteers
- 13 people
- Sponsor
- Case Comprehensive Cancer Center
Recurrent Glioblastoma
Study of Pembrolizumab Plus SurVaxM for Glioblastoma at First Recurrence
The main purpose of this study is to assess the clinical activity of Pembrolizumab and SurVaxM in participants with recurrent glioblastoma.
- Trial name
- NCT04013672
- Testing
- Pembrolizumab, SurVaxM, Sargramostim
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- David Peereboom
Invasive Breast Cancer
Evaluation of an Integrated Imaging System For In Vivo Detection of Fluorescently Labeled Lesions
This is a pilot study to test and characterize the ability of the Smart Goggles system to detect fluorescently labeled sentinel lymph nodes (SLNs).
- Trial name
- NCT02802553
- Testing
- Smart Goggle, Cardio-Green, SPY Elite Imaging system
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Case Comprehensive Cancer Center
Head and Neck Cancer
Erlotinib, Docetaxel, and Radiation Therapy in Stage III or Stage IV Squamous Cell Carcinoma of the Head and Neck
RATIONALE: Erlotinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as docetaxel, work in different ways to stop the growth of tumor cells, either by…
- Trial name
- NCT00720304
- Testing
- docetaxel, erlotinib hydrochloride, fluorescence in situ hybridization
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Case Comprehensive Cancer Center
HR-positive Breast Cancer
Vitamin B12 for Aromatase Inhibitors Associated Musculoskeletal Symptoms in Breast Cancer
Treatment of hormone receptor (HR)-positive breast cancer with Aromatase Inhibitors (AIs) can lead to associated musculoskeletal pain and may cause patients to discontinue important treatment.
- Trial name
- NCT04205786
- Testing
- Vitamin B12, Blood collection, Brief Pain Inventory - Short Form survey
- Where
- United States
- Sponsor
- Case Comprehensive Cancer Center
Pancreas Cancer, Pancreas Adenocarcinoma
CAPEcitabine eXtension of Adjuvant Therapy for Pancreatic Adenocarcinoma: (CAPE-X)
This study is being done to find out if extending adjuvant chemotherapy for patients by giving additional chemotherapy can lengthen the amount of time before their cancer comes back.
- Trial name
- NCT06110598
- Testing
- Capecitabine
- Where
- United States
- Sponsor
- Case Comprehensive Cancer Center
Myelodysplastic Syndrome (MDS)
CPX-351 Therapy for MDS After Hypomethylating Agent Failure
The purpose of this study is to evaluate the efficacy of treatment with CPX-351 (an FDA approved drug for the treatment of AML) in individuals with MDS while using a new stratification tool to predict outcomes of participants…
- Trial name
- NCT03957876
- Testing
- CPX-351
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Case Comprehensive Cancer Center
Stage III Melanoma, Stage IV Cutaneous Melanoma
Leveraging ctDNA Analysis to Improve Early Detection of Cancer Recurrence in the High-Risk Melanoma Setting
To generate meaningful data regarding ctDNA that would infer risk of recurrence in stage III melanoma patients.
- Trial name
- NCT05079113
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- Case Comprehensive Cancer Center
Recurrent Squamous Cell Carcinoma of the Head and Neck, Metastatic Squamous Cell Carcinoma
ASTX727 and Nivolumab in Squamous Cell Carcinoma of the Head and Neck
The goal of this clinical trial is to see if the combination of experimental drug ASTX727 and Nivolumab enhances the antitumor immune response in participants will recurrent or metastatic squamous cell carcinoma of the head and…
- Conditions
- Recurrent Squamous Cell Carcinoma of the Head and Neck, Metastatic Squamous Cell Carcinoma, Head and Neck Squamous Cell Carcinoma
- Trial name
- NCT06357858
- Testing
- INQOVI (decitabine and cedazuridine), Nivolumab
- Where
- United States
- Sponsor
- Case Comprehensive Cancer Center
Breast Reconstruction
The Impact of Functional Medicine On Wound Healing From Delayed Autologous Breast Reconstruction
This study will examine if a functional medicine approach, delivered as an adjunct to standard of care, is feasible, safe, clinically beneficial and cost-effective for patients undergoing autologous breast reconstruction.
- Trial name
- NCT05028101
- Testing
- Delayed autologous breast reconstruction, Perioperative Functional Medicine (FM) Care
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Case Comprehensive Cancer Center
Breast Cancer
Role of Magnetic Resonance Fingerprinting and Quantitative MR Imaging in Breast Cancer
The purpose of this study is to determine if new methods of MRI imaging can better measure participants' response to chemotherapy treatment.
- Trial name
- NCT03650803
- Testing
- 3D MR Fingerprinting scan
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Case Comprehensive Cancer Center
Contiguous Stage II Adult Diffuse Large Cell Lymphoma, Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma
Carfilzomib, Rituximab, and Combination Chemotherapy in Treating Patients With Diffuse Large B-Cell Lymphoma
This phase I/II trial studies the side effects and best dose of carfilzomib when given together with rituximab and combination chemotherapy and to see how well they work in treating patients with diffuse large B-cell lymphoma.
- Conditions
- Contiguous Stage II Adult Diffuse Large Cell Lymphoma, Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma, Stage I Adult Diffuse Large Cell Lymphoma, Stage III Adult Diffuse Large Cell Lymphoma
- Trial name
- NCT02073097
- Testing
- Carfilzomib, Rituximab, Cyclophosphamide
- Where
- 3 sites in United States
- Volunteers
- 48 people
- Sponsor
- Case Comprehensive Cancer Center
Rectal Neoplasms
Safety and Feasibility of PD-1 Blockade in the Treatment of dMMR or MSI-H Rectal Cancer
Colorectal cancer is the third most common cancer worldwide and the second leading cause of cancer mortality in the United States.
- Trial name
- NCT04357587
- Testing
- Pembrolizumab, External beam radiation, Capecitabine
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Case Comprehensive Cancer Center
Acute Myeloid Leukemia
A Trial to Evaluate Two Schedules of MS275 in Combination With 5AC in Elderly Patients With Acute Myeloid Leukemia (AML)
This research is being done to help us learn how to best use new drugs which may be active against acute myeloid leukemia (AML). Two study drugs will be tested: 5AC (5-azacitidine) and entinostat.
- Trial name
- NCT01305499
- Testing
- Entinostat days 3, 10, 5AC, Entinostat days 10,17
- Where
- 4 sites in United States
- Volunteers
- 52 people
- Sponsor
- Hetty Carraway
Multiple Myeloma
Vactosertib in Combination w/ Pomalidomide in Relapsed or Relapsed and Refractory Multiple Myeloma
The purpose of this study is to see if the study drug, called Vactosertib, is safe and determine what the best dose is to treat future patients when given in combination with pomalidomide (POM).
- Trial name
- NCT03143985
- Testing
- Vactosertib, Pomalidomide
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Koen van Besien
Spinal Tumor
Optimal Timing of Postoperative Magnetic Resonance Imaging (MRI) in Patients With Extradural Spinal
This research study is evaluating suitability of a delayed magnetic resonance imaging (MRI) in management of spine tumors. Currently the standard of care is obtaining an MRI scan in the early postoperative period (within 72 hours…
- Trial name
- NCT02790294
- Testing
- Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Case Comprehensive Cancer Center