Clinical trials: sponsored by Unity Health Toronto
Disease Due to BK Polyomavirus, Kidney Transplant Infection
Quinolone Prophylaxis for the Prevention of BK Virus Infection in Kidney Transplantation: A Pilot Study
Primary Research Questions: Efficacy, safety and feasibility of a 3-month course of levofloxacin in a pilot study will be assessed. 1.
- Trial name
- NCT01353339
- Testing
- Levofloxacin
- Where
- 11 sites in Canada
- Volunteers
- 154 people
- Sponsor
- Ottawa Hospital Research Institute
Cardiovascular Diseases, Cardiovascular Risk Factor
The Use of Icosapent Ethyl on Vascular Progenitor Cells in Individuals With Elevated Cardiovascular Risk
IPE-PREVENTION is a prospective, randomized, 3-month long, open-label study. A total of 70 individuals with elevated cardio-metabolic risk and heightened triglyceride levels, and who are on stable statin therapy will be…
- Conditions
- Cardiovascular Diseases, Cardiovascular Risk Factor, Triglycerides High, Diabetes Mellitus, Type 2
- Trial name
- IPE-PREVENTION (NCT04562467)
- Testing
- Icosapent Ethyl 1000 MG Oral Capsule [Vascepa]
- Where
- 3 sites in Canada
- Volunteers
- 70 people
- Sponsor
- Canadian Medical and Surgical Knowledge Translation Research Group
HIV/AIDS, Aging
Psychosocial Intervention for Older HIV+ Adults With HAND
CTNPT 029 will test the feasibility and acceptability of cognitive remediation group therapy in older adults living with HIV who have been diagnosed with HIV-associated neurocognitive disorder (HAND).
- Conditions
- HIV/AIDS, Aging, Mild Cognitive Impairment, Group, Peer
- Trial name
- IN-HAND (NCT03483740)
- Testing
- CRGT, HIV group therapy
- Where
- 3 sites in Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Recurrent Urinary Tract Infection
Phage Therapy for the Treatment of Urinary Tract Infection
This is a single-patient, phase I/II clinical trial that aims to evaluate the potential of bacteriophage therapy to treat and prevent the recurrence of a drug-resistant urinary tract infection with serious long-term effects.
- Trial name
- NCT05537519
- Testing
- Phage Therapy
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- Unity Health Toronto
Fluid Overload, Critical Illness
Role of Active Deresuscitation After Resuscitation:
The RADAR-Canada trial is a pilot RCT undertaken to assess the acceptability of, compliance with, and biologic consequences of a deresuscitation protocol designed to expedite the removal of excess interstitial fluid in patients…
- Conditions
- Fluid Overload, Critical Illness, Sepsis, ARDS
- Trial name
- RADAR-Canada (NCT06326112)
- Testing
- Furosemide Injection, Metolazone Tablets
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Unity Health Toronto
Acute Respiratory Distress Syndrome
Prediction of Duration of Mechanical Ventilation in ARDS
The investigators are planning to perform a secondary analysis of an academic dataset of 1,303 patients with moderate-to-severe acute respiratory distress syndrome (ARDS) included in several published cohorts (NCT00736892…
- Trial name
- PIONEER (NCT05993377)
- Testing
- Logistic regression Cross validation Area under the RIC curves Machine learning analysis. .
- Where
- 20 sites in Spain, United Kingdom
- Volunteers
- 1,303 people
- Sponsor
- Hospital Universitario de Gran Canaria Doctor Negrín
Traumatic Brain Injury, Trauma, Nervous System
Remote Ischemic Conditioning as a Treatment for Traumatic Brain Injury
The prevention of secondary brain injury is a primary goal in treating patients with severe traumatic brain injury (TBI). Secondary brain injury results from tissue ischemia induced by increased vascular resistance in the at-risk…
- Conditions
- Traumatic Brain Injury, Trauma, Nervous System, Reperfusion Injury, Ischemia, Brain
- Trial name
- NCT03176823
- Testing
- CellAegis Technologies autoRIC device, Best Practice Management of Traumatic Brain Injury
- Where
- Canada
- Volunteers
- 44 people
- Sponsor
- Unity Health Toronto
Monkeypox
Mpox Prospective Observational Cohort Study
The goal of this multicentre prospective observational cohort study is to shed light on the following unknowns: 1. The clinical manifestations of Mpox infection since the 2022 outbreak in Canada. 2.
- Trial name
- MPOCS (NCT06291259)
- Where
- 3 sites in Canada
- Volunteers
- 250 people
- Sponsor
- Unity Health Toronto
Distress, Emotional, Stress Response Among Nursing Professionals During the COVID-19
Digital Interventions to Understand and Mitigate Stress Response
Stress, anxiety, distress, and burnout are exceptionally high among healthcare workers at the frontline of the COVID-19 pandemic.
- Conditions
- Distress, Emotional, Stress Response Among Nursing Professionals During the COVID-19, Stress Reaction; Acute
- Trial name
- NCT05923398
- Testing
- Digital Intervention Group
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Cardiovascular Diseases, Hypercholesterolemia
The Combined Portfolio Diet and Exercise Study
The purpose of this study is to determine whether a dietary portfolio of cholesterol-lowering foods (viscous fibres, soy protein, plant sterols and nuts) further enhanced by increased levels of monounsaturated fatty acids (MUFA)…
- Conditions
- Cardiovascular Diseases, Hypercholesterolemia, Type 2 Diabetes, Metabolic Syndrome
- Trial name
- PortfolioEx (NCT02481466)
- Testing
- Portfolio diet and structured exercise, DASH-like diet and structured exercise, Portfolio diet and routine exercise
- Where
- 4 sites in Canada
- Volunteers
- 232 people
- Sponsor
- Unity Health Toronto
Treatment Resistant Depression, Major Depressive Disorder
Stellate Ganglion Block for Major Depressive Disorder.
This is a feasibility study, to investigate a new treatment option for major depressive disorders by performing a Stellate Ganglion Block (SGB).
- Trial name
- NCT04727229
- Testing
- Bupivacaine Hydrochloride, Normal Saline
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Unity Health Toronto
C5 Palsy
Conventional-therapy & FES-therapy In-Veritas Effects Study
This randomized clinical trial will primarily compare the effectiveness of conventional physiotherapy alone with combined conventional physiotherapy and FES-t along with task-specific training in terms of the improvement of the…
- Trial name
- C-FIVE (NCT05247450)
- Testing
- Functional electrical stimulation therapy (FES-t), Conventional physiotherapy
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- University Health Network, Toronto
Sudden Cardiac Death, Sudden Cardiac Arrest
Canadian Sudden Cardiac Arrest Network
The overall aim of the project is to develop a national registry to accurately measure the burden of Sudden Cardiac Arrest (SCA) among the general Canadian population.
- Trial name
- C-SCAN (NCT03642587)
- Testing
- There is no intervention in this study.
- Where
- 6 sites in Canada
- Volunteers
- 82,054 people
- Sponsor
- Unity Health Toronto
Operating Room Efficiency
Minimizing Peri-operative Time Delays, Maximizing Operating Room Efficiency: A Pilot Study
The primary objective is to prospectively identify Operating Room (OR) time delays from the time the patient who is undergoing total laparoscopic hysterectomy enters the OR to exiting the OR.
- Trial name
- NCT03257384
- Testing
- Black box recording of surgery
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Unity Health Toronto
Vaginal Speculum Examination
Gynaecological Speculum Examination: Straight Horizontal Insertion Versus Vertical Insertion and Rotation.
This study compares two different types of speculum insertion to determine the level of discomfort they might cause. This study compares the straight horizontal insertion (SHI) of the speculum and the vertical insertion and…
- Trial name
- NCT02708615
- Testing
- Type of speculum vaginal insertion method
- Where
- Canada
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Stroke
Development and Evaluation of iWalk: A Guide to Facilitate Evidence-informed Assessment of Walking After Stroke
Stroke remains a major health concern and the second highest cause of disability worldwide. After experiencing a stroke, many people lose the ability to walk independently.
- Trial name
- NCT04184843
- Testing
- iWalk Toolkit
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Gastric Varices Bleeding, Endoscopic Ultrasound
Primary Prevention of Gastric Varices Bleed
Primary prophylaxis of gastric varices is an important area of research, as gastric varices are a common complication of cirrhosis of the liver.
- Trial name
- NCT05859009
- Testing
- EUS-Guided Therapy of Glue and Coil, Non-Selective Beta Blockers (Propanolol)
- Sponsor
- Unity Health Toronto
Uterine Fibroid
Design of an Intra-operative Blood Conservation Pathway at Open Myomectomy
Uterine fibroids are benign uterine masses that can be removed through a surgical procedure called a myomectomy. Myomectomy is often associated with a significant amount of blood loss for the patient.
- Trial name
- NCT03211481
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Unity Health Toronto
Obesity, Childhood
Cow Milk Fat Obesity pRevention Trial
Cow's milk is a dietary staple for children in North America. Though clinical guidelines suggest children transition from whole (3.25% fat) milk to reduced (1%) fat milk at age 2 years, recent epidemiological evidence supports a…
- Trial name
- CoMFORT (NCT03914807)
- Testing
- Whole (3.25%) cow's milk recommendation, Reduced (1%) fat milk
- Where
- Canada
- Volunteers
- 534 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Pelvic Inflammatory Disease
Rate of Pelvic Inflammatory Disease at St. Michael's Hospital
A retrospective review of women who came through the ER at SMH with a pelvic inflammatory disease (PID) or tubo-ovarian abscess (TOA) between 1995-2005.
- Trial name
- NCT00783419
- Where
- Canada
- Volunteers
- 55 people
- Sponsor
- Unity Health Toronto