Clinical trials: not yet recruiting
Acute Myeloid Leukemia, Acute Myeloid Leukaemia Recurrent
A Study of CLEC2A CAR T for Pediatric and Adult Patients With Relapsed or Refractory AML
This is a phase I, open-label, non-randomized clinical trial that will enroll pediatric and adult research participants with CLEC2A+ acute myeloid leukemia (AML) that does not go away with treatment (is refractory) or comes back…
- Conditions
- Acute Myeloid Leukemia, Acute Myeloid Leukaemia Recurrent, Acute Myeloid Leukaemia Refractory
- Trial name
- ADVANCE-01 (NCT07905027)
- Testing
- Biological SC-CAR.CLEC2Av1
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Seattle Children's Hospital
Autism Spectrum Disorder, TMS
Transcranial Magnetic Stimulation (TMS) for Autism Spectrum Disorder
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by persistent difficulties in social communication and interaction, as well as restricted and repetitive patterns of behavior.
- Trial name
- TMS for ASD (NCT07910305)
- Testing
- Individualized Cerebellar-Targeted Repetitive Transcranial Magnetic Stimulation
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Sir Run Run Shaw Hospital
B-cell Leukemia
CAR-T Immunotherapy Targeting CD19- ALL
This study will evaluate safety and efficacy of a combination of 4th generation chimeric antigen receptor gene-modified T cells targeting CD19 negative ALL that express CD22, CD123, CD38, CD10, CD20 and TSLPR, as many patients…
- Trial name
- NCT04016129
- Testing
- 4SCAR-CD22/CD123/CD38/CD10/CD20/TSLPR
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shenzhen Geno-Immune Medical Institute
Hypertrophic Cardiomyopathy, Left Ventricular Outflow Obstruction
NHLBI SESAME (SEptal Scoring Along Midline Endocardium) Multi-Center Prospective Study Using Improvised Off-Label Devices
This is an early study of a catheter-based minimally invasive procedure called SESAME to slice thick heart muscle as described below.
- Conditions
- Hypertrophic Cardiomyopathy, Left Ventricular Outflow Obstruction, Systolic Anterior Motion
- Trial name
- NCT07806149
- Testing
- SESAME Procedure
- Where
- 8 sites in United States
- Volunteers
- 200 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Locally Advanced /Metastatic Solid Tumors, Locally Advanced / Metastatic Solid Tumors
SI-B036-ST-101 in Advanced/Metastatic Solid Tumors
The objective of the study is to evaluate the safety and tolerability of SI-B036 in participants with solid tumors who have received at least one prior line of therapy for advanced disease.
- Conditions
- Locally Advanced /Metastatic Solid Tumors, Locally Advanced / Metastatic Solid Tumors, Metastatic Solid Cancers, Non Small Cell Lung Cancer
- Trial name
- NCT07857616
- Testing
- SI-B036
- Where
- 7 sites in United States
- Volunteers
- 424 people
- Sponsor
- SystImmune Inc.
Temporomandibular Joint Internal Derangement, TMJ-ID
Comparing Dextrose Prolotherapy vs. Sodium Hyaluronic Acid Injections for Jaw Joint Internal Derangement
This is a randomized comparative study to evaluate the effectiveness of two intra-articular injections for the management of Temporomandibular Joint (TMJ) internal derangement.
- Conditions
- Temporomandibular Joint Internal Derangement, TMJ-ID, TMPDS, Disc Displacement
- Trial name
- TMJ-ID (NCT07911358)
- Testing
- Dextrose Prolotherapy, Sodium Hyaluronic Acid
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Allama Iqbal Medical College
Myeloid Leukemia
Phase 1/2 FLAG-IDA, VEN and Asciminib in CML and Ph+ AML
The goal of Phase 1b is to establish the safety of asciminib in combination with FLAG-Ida and venetoclax in patients with CML-MBP, CML-LBP, and Ph+ AML.
- Trial name
- NCT07604233
- Testing
- Fludarabine, Cytarabine, Idarubicin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- M.D. Anderson Cancer Center
Perioperative Hypothermia, Inadvertent Perioperative Hypothermia
Resistive Versus Forced-Air Warming for Prevention of Perioperative Hypothermia
Perioperative hypothermia (core temperature below 36.0 °C) is a common complication of surgery and is associated with increased blood loss, wound infection, cardiovascular events and patient discomfort.
- Conditions
- Perioperative Hypothermia, Inadvertent Perioperative Hypothermia, Hypothermia
- Trial name
- WARM-NI (NCT07909252)
- Testing
- Forced-air warming, Resistive conductive warming
- Where
- Czechia
- Volunteers
- 680 people
- Sponsor
- Masarykova Nemocnice v Usti nad Labem, Krajska Zdravotni a.s.
High-risk Myeloid Malignancy, Allogenic Stem Cell Transplantation
Maintenance Treatment With Imetelstat in Patients With High-Risk Myeloid Neoplasms After Allo-SCT
The purpose of this clinical trial is to learn if imetelstat is safe to use in participants with high-risk myeloid malignancies who have received an allogenic hematologic stem cell transplantation (allo-SCT).
- Conditions
- High-risk Myeloid Malignancy, Allogenic Stem Cell Transplantation, Acute Myeloid Leukemia (AML), Chronic Myeloid Leukemia (CML)
- Trial name
- NCT07909733
- Testing
- imetelstat
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Wisconsin, Madison
Metachromatic Leukodystrophy (MLD)
Direct Lentiviral Injection Gene Therapy for MLD
This is a Phase I/II clinical trial of gene therapy for treating Metachromatic leukodystrophy (MLD) using a safety and efficacy improved self-inactivating lentiviral vector TYF-ARSA to functionally correct the genetic defect.
- Trial name
- NCT03725670
- Testing
- Intrathecal and intravenous LV gene therapy
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Shenzhen Geno-Immune Medical Institute
Renal Tumors
The Edison™ System for Treatment of Renal Tumors Using Histotripsy (Histo-Renal Trial)
This is a prospective single-center, single-arm, feasibility trial designed to evaluate the safety of the HistoSonics Histotripsy System for treatment of renal tumors.
- Trial name
- NCT07911527
- Testing
- HistoSonics® Edison System (US)
- Volunteers
- 15 people
- Sponsor
- Chinese University of Hong Kong
Extensive-stage Small Cell Lung Cancer
A Study of TRB191 in Patients With Extensive-stage Small Cell Lung Cancer
The purpose of this study is to characterize the safety, tolerability, pharmacokinetics (PK), immunogenicity (IG) and preliminary anti-tumor activity and to determine a recommended dose (RD) of TRB191 in patients with…
- Trial name
- NCT07908667
- Testing
- TRB191
- Volunteers
- 120 people
- Sponsor
- Novartis Pharmaceuticals
Sleep
Stress, Coping, and Sleep Health Study
Background: Poor sleep is common among refugee groups worldwide. It can lead to an increased risk of heart disease, diabetes, cancer, and premature death. It can also worsen mental health disorders.
- Trial name
- NCT07566481
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Preoperative Anxiety Score
Virtual Reality to Reduce Anxiety During Thoracic Epidural Placement.
The purpose of this study is to investigate whether using a Virtual Reality (VR) headset can help young people relax during the placement of an epidural catheter for pain control after pectus surgery.
- Trial name
- NCT07911436
- Testing
- VR- headset
- Volunteers
- 78 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Melanoma, Li-Fraumeni Syndrome
Clinical Genetics Branch Eligibility Screening Survey
Background: Clinical Genetics Branch (CGB) researchers study individuals and populations at high genetic risk of cancer in order to improve our understanding of cancer and to improve cancer care.
- Conditions
- Melanoma, Li-Fraumeni Syndrome, Pulmonary Blastoma, Chordoma
- Trial name
- NCT07005297
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- National Cancer Institute (NCI)
Sickle Cell Anaemia, Sickle Cell Anemia Crisis
Hypoxic Red Blood Cells in Sickle Cell Anemia
The overall objective of this study is to evaluate the effectiveness and safety of transfusing hypoxic red blood cells manufactured with the Hemanext ONE system in patients with sickle cell anemia.
- Conditions
- Sickle Cell Anaemia, Sickle Cell Anemia Crisis, Sickle Cell Anemia in Children, Sickle Cell Anemia (HbSS, or HbSβ-thalassemia0)
- Trial name
- NCT06743113
- Testing
- Hemanext ONE System, Conventional RBCs
- Where
- 5 sites in United States
- Volunteers
- 48 people
- Sponsor
- Hemanext
Lumbar Spondylosis
Comparative Effectiveness of Two Different Approaches to Radiofrequency Ablation of Lumbar Medial Branch Nerves
The purpose of this voluntary research study is to determine whether the parasagittal approach to lumbar medial branch (LMB) nerve radio frequency ablation (RFA) will have greater efficacy than the traditional approach to lumbar…
- Trial name
- LMB-RFA (NCT06283628)
- Testing
- Radiofrequency ablation of lumbar medial branch nerves.
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Milton S. Hershey Medical Center
Autoimmune Diseases
CAR-T Cells Targeting Autoimmune Diseases
The purpose of this study is to assess the feasibility, safety and efficacy of CAR-T cell therapy in patients with autoimmune disease.
- Trial name
- NCT05459870
- Testing
- 4SCAR T cells
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shenzhen Geno-Immune Medical Institute
Lobular Breast Carcinoma
FES PET/MRI for Occult Disease in Lobular Breast Cancer
The investigators hope to learn if lobular breast cancer can be identified using a special procedure called a positron emission tomography (PET) magnetic resonance image (MRI) scan, collectively a PET/MRI scan, that uses a…
- Trial name
- NCT07910474
- Testing
- 18Fluoroestradiol (18F-FES), MRI, Gadolinium-based contrast agent
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Wisconsin, Madison
Metastatic Castration-resistant Prostate Cancer
MK-2870-U01 Substudy 1: A Clinical Trial of Sacituzumab Tirumotecan to Treat Prostate Cancer (MK-2870-01A)
Researchers are looking for new ways to treat metastatic castration-resistant prostate cancer/androgen pathway modulator refractory (mCRPC/APMR). Current treatment for mCRPC includes chemotherapy, such as docetaxel.
- Trial name
- TroFuse-01A (NCT07908524)
- Testing
- Sacituzumab tirumotecan, Rescue medication, Docetaxel
- Volunteers
- 290 people
- Sponsor
- Merck Sharp & Dohme LLC
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